Gene: MANBA

4126
MANB1
mannosidase beta
protein-coding
4q24
Ensembl:ENSG00000109323 MIM:609489 Vega:OTTHUMG00000131123 UniprotKB:O00462
NG_012804.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.458e-1 (AD)  2.250e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FKBP150.854
TIAL10.824
NUP2050.824
TTC170.822
CREG10.822
DDX50.812
XRN20.808
GATAD10.805
ZFC3H10.804
REV10.804

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.492
OR4F29-0.472
HES5-0.257
PLA2G5-0.25
WNT7B-0.225
SLC22A6-0.224
NANOGNB-0.218
AVP-0.205
OXT-0.197
PTGDR2-0.192

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of MANBA mRNA"28903501
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MANBA mRNA"25614096
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MANBA mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MANBA mRNA"21346803
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of MANBA mRNA16788091
D000082AcetaminophenAcetaminophen affects the expression of MANBA mRNA25458485
D000082AcetaminophenAcetaminophen results in increased expression of MANBA mRNA22230336
D000393Air PollutantsAir Pollutants analog results in decreased expression of MANBA mRNA21757418
D000638AmiodaroneAmiodarone affects the expression of MANBA mRNA18355885
D000639AmitriptylineAmitriptyline affects the expression of MANBA mRNA18355885
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MANBA mRNA24449571
D001280AtrazineAtrazine results in increased expression of MANBA mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MANBA mRNA19770486
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of MANBA mRNA28628672
C006780bisphenol Abisphenol A affects the expression of MANBA mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of MANBA mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MANBA mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of MANBA mRNA24586524
C006780bisphenol Abisphenol A results in decreased expression of MANBA mRNA25270620
C006780bisphenol Abisphenol A affects the expression of MANBA mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MANBA mRNA28628672
D019256Cadmium Chloride[nickel chloride co-treated with Cadmium Chloride] results in increased expression of MANBA mRNA19187980
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MANBA mRNA23741332
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MANBA mRNA17484886
D002997ClomipramineClomipramine affects the expression of MANBA mRNA18355885
D019327Copper SulfateCopper Sulfate results in decreased expression of MANBA mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of MANBA mRNA20106945
C093628cyproconazole[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of MANBA mRNA29038839
C093628cyproconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of MANBA mRNA29038839
C093628cyproconazolecyproconazole results in increased expression of MANBA mRNA29038839
C014347decitabinedecitabine affects the expression of MANBA mRNA23300844
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of MANBA mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MANBA mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MANBA mRNA28628672
D002945CisplatinCisplatin affects the expression of MANBA mRNA23300844
D004041Dietary FatsDietary Fats results in decreased expression of MANBA mRNA28031460
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of MANBA mRNA29038839
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of MANBA mRNA29038839
C082360fipronilfipronil results in increased expression of MANBA mRNA23962444
C546771gardiquimodgardiquimod results in decreased expression of MANBA mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of MANBA mRNA]28003376
D017313FenretinideFenretinide results in increased expression of MANBA mRNA28973697
D007099ImipramineImipramine affects the expression of MANBA mRNA18355885
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of MANBA mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MANBA mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MANBA mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MANBA mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of MANBA mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MANBA mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MANBA mRNA28628672
C410337K 7174K 7174 results in increased expression of MANBA mRNA24086573
D007654KetoconazoleKetoconazole affects the expression of MANBA mRNA18355885
D007854LeadLead affects the expression of MANBA mRNA28903495
C017461lead nitrate[nickel chloride co-treated with lead nitrate] results in increased expression of MANBA mRNA19187980
D064704LevofloxacinLevofloxacin results in decreased expression of MANBA mRNA24136188
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MANBA mRNA23649840
C022838nickel chloride[nickel chloride co-treated with Cadmium Chloride] results in increased expression of MANBA mRNA19187980
C022838nickel chloride[nickel chloride co-treated with lead nitrate] results in increased expression of MANBA mRNA19187980
C006253pirinixic acidpirinixic acid results in decreased expression of MANBA mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of MANBA mRNA18301758|2381119
C045362prochloraz[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of MANBA mRNA29038839
D011441PropylthiouracilPropylthiouracil results in decreased expression of MANBA mRNA24780913
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of MANBA mRNA]28003376
C513428pyrachlostrobinpyrachlostrobin results in increased expression of MANBA mRNA27029645
D012969Sodium FluorideSodium Fluoride results in increased expression of MANBA protein28918527
D013629TamoxifenTamoxifen affects the expression of MANBA mRNA20937368
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of MANBA mRNA25975270
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MANBA mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of MANBA mRNA23411599
D014520UrethaneUrethane results in increased expression of MANBA mRNA28818685
C406224valdecoxibvaldecoxib results in increased expression of MANBA mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of MANBA mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MANBA mRNA23179753|2718838
C025643vinclozolinvinclozolin results in decreased expression of MANBA mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of MANBA mRNA20566332

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004567beta-mannosidase activity-IBA21873635  
GO:0004567beta-mannosidase activity-TAS-  
GO:0005537mannose binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006464cellular protein modification process-NAS9384606  
GO:0006516glycoprotein catabolic process-IBA21873635  
GO:0009313oligosaccharide catabolic process-TAS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0046355mannan catabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005764lysosome-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0035577azurophil granule membrane-TAS-  
GO:0043202lysosomal lumen-TAS-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa00511Other glycan degradation
hsa04142Lysosome
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-71387Metabolism of carbohydratesTAS
R-HSA-8853383Lysosomal oligosaccharide catabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27164557Genetic Relationship between Schizophrenia and Nicotine Dependence. (2016 May 10)Chen JSci Rep