Gene: MAOA

4128
BRNRS|MAO-A
monoamine oxidase A
protein-coding
Xp11.3
Ensembl:ENSG00000189221 MIM:309850 Vega:OTTHUMG00000021387 UniprotKB:P21397
NG_008957.2
PubMed
CD|ND|AD
57   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AHCYL10.908
MSI20.904
UNG0.9
FERMT20.896
WLS0.892
SDC20.891
RHOBTB30.889
GRAMD1C0.888
HSDL20.886
ALDH9A10.884

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.486
OR4F29-0.483
DUSP27-0.418
ABCC12-0.411
ADTRP-0.402
AGMAT-0.395
CALHM1-0.386
QRFPR-0.379
MCHR1-0.379
GALNT14-0.379

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00191PhentermineSmall Molecule122-09-8Approved|IllicitTarget
DB00752TranylcypromineSmall Molecule155-09-9Approved|InvestigationalTarget
DB00780PhenelzineSmall Molecule51-71-8ApprovedTarget
DB00805MinaprineSmall Molecule25905-77-5ApprovedTarget
DB00909ZonisamideSmall Molecule68291-97-4Approved|InvestigationalTarget
DB01037SelegilineSmall Molecule14611-51-9Approved|InvestigationalTarget
DB01171MoclobemideSmall Molecule71320-77-9Approved|InvestigationalTarget
DB01247IsocarboxazidSmall Molecule59-63-2ApprovedTarget
DB01363EphedraSmall Molecule-Approved|Nutraceutical|WithdrawnTarget
DB01442MMDASmall Molecule13674-05-0Experimental|IllicitTarget
DB014724-MethoxyamphetamineSmall Molecule64-13-1Experimental|IllicitTarget
DB01577MethamphetamineSmall Molecule537-46-2Approved|IllicitTarget
DB01626PargylineSmall Molecule555-57-7ApprovedTarget
DB03147Flavin adenine dinucleotideSmall Molecule146-14-5ApprovedTarget
DB04017N-Methyl-N-Propargyl-3-(2,4-Dichlorophenoxy)PropylamineSmall MoleculeExperimentalTarget
DB04820NialamideSmall Molecule51-12-7WithdrawnTarget
DB04821NomifensineSmall Molecule24526-64-5WithdrawnTarget
DB04832ZimelidineSmall Molecule56775-88-3WithdrawnTarget
DB04850PosizolidSmall Molecule252260-06-3InvestigationalTarget
DB05205CX157Small Molecule-InvestigationalTarget
DB07641DECYL(DIMETHYL)PHOSPHINE OXIDESmall MoleculeExperimentalTarget
DB079197-METHOXY-1-METHYL-9H-BETA-CARBOLINESmall MoleculeExperimentalTarget
DB09244PirlindoleSmall Molecule60762-57-4ApprovedTarget
DB09245ToloxatoneSmall Molecule29218-27-7ApprovedTarget
DB13876BrofaromineSmall Molecule63638-91-5ExperimentalTarget
DB00182AmphetamineSmall Molecule300-62-9Approved|Illicit|InvestigationalTarget
DB00721ProcaineSmall Molecule59-46-1Approved|InvestigationalTarget
DB01168ProcarbazineSmall Molecule671-16-9Approved|InvestigationalTarget
DB01171MoclobemideSmall Molecule71320-77-9Approved|InvestigationalTarget
DB00140RiboflavinSmall Molecule83-88-5Approved|Investigational|NutraceuticalEnzyme
DB00184NicotineSmall Molecule54-11-5ApprovedEnzyme
DB00191PhentermineSmall Molecule122-09-8Approved|IllicitEnzyme
DB00315ZolmitriptanSmall Molecule139264-17-8Approved|InvestigationalEnzyme
DB00388PhenylephrineSmall Molecule59-42-7ApprovedEnzyme
DB00397PhenylpropanolamineSmall Molecule14838-15-4Approved|WithdrawnEnzyme
DB00601LinezolidSmall Molecule165800-03-3Approved|InvestigationalEnzyme
DB00614FurazolidoneSmall Molecule67-45-8Approved|InvestigationalEnzyme
DB00624TestosteroneSmall Molecule58-22-0Approved|InvestigationalEnzyme
DB00669SumatriptanSmall Molecule103628-46-2Approved|InvestigationalEnzyme
DB00780PhenelzineSmall Molecule51-71-8ApprovedEnzyme
DB00852PseudoephedrineSmall Molecule90-82-4ApprovedEnzyme
DB00918AlmotriptanSmall Molecule154323-57-6Approved|InvestigationalEnzyme
DB00952NaratriptanSmall Molecule121679-13-8Approved|InvestigationalEnzyme
DB00953RizatriptanSmall Molecule144034-80-0ApprovedEnzyme
DB00988DopamineSmall Molecule51-61-6ApprovedEnzyme
DB01104SertralineSmall Molecule79617-96-2ApprovedEnzyme
DB01171MoclobemideSmall Molecule71320-77-9Approved|InvestigationalEnzyme
DB01445BufotenineSmall Molecule487-93-4Experimental|IllicitEnzyme
DB06412OxymetholoneSmall Molecule434-07-1Approved|IllicitEnzyme
DB06654SafinamideSmall Molecule133865-89-1Approved|InvestigationalEnzyme
DB06774CapsaicinSmall Molecule404-86-4ApprovedEnzyme
DB08804Nandrolone decanoateSmall Molecule360-70-3Approved|IllicitEnzyme
DB09244PirlindoleSmall Molecule60762-57-4ApprovedEnzyme
DB09245ToloxatoneSmall Molecule29218-27-7ApprovedEnzyme
DB13943Testosterone cypionateSmall Molecule58-20-8ApprovedEnzyme
DB13944Testosterone enanthateSmall Molecule315-37-7ApprovedEnzyme
DB13946Testosterone undecanoateSmall Molecule5949-44-0Approved|InvestigationalEnzyme
DB06778Cupric sulfateSmall Molecule7758-98-7ApprovedEnzyme
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalEnzyme
DB09363Rauwolfia serpentina rootSmall Molecule8063-17-0InvestigationalEnzyme
ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of MAOA mRNA19933214
C5054492,3-dimercaptosuccinic acid monocyclohexyl ester"2,3-dimercaptosuccinic acid monocyclohexyl ester inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]"23376091
C0307692-methylharmine2-methylharmine analog binds to MAOA protein9290071
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of MAOA mRNA"19692669
C0191323-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole"3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in decreased activity of MAOA protein"3404091
C0191323-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole"3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in decreased activity of MAOA protein"7931246
C0191333-amino-1-methyl-5H-pyrido(4,3-b)indole"3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of MAOA protein"3404091
C0191333-amino-1-methyl-5H-pyrido(4,3-b)indole"3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of MAOA protein"7931246
C4926723-methoxymethyl-7-(4,4,4-trifluorobutoxy)-3,3a,4,5-tetrahydro-1,3-oxazolo(3,4-a)quinolin-1-one"3-methoxymethyl-7-(4,4,4-trifluorobutoxy)-3,3a,4,5-tetrahydro-1,3-oxazolo(3,4-a)quinolin-1-one results in decreased activity of MAOA protein"15178694
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of MAOA mRNA"26186136
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of MAOA mRNA"25912373
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAOA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAOA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Thimerosal co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAOA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAOA mRNA"27188386
C5830095-(2-aminopropyl)indole5-(2-aminopropyl)indole results in decreased activity of MAOA protein28302559
C0409975-bromotryptamine5-bromotryptamine results in decreased activity of MAOA protein28302559
C5291695-chlorotryptamine5-chlorotryptamine results in decreased activity of MAOA protein28302559
C0511015-fluoro-alpha-methyltryptamine5-fluoro-alpha-methyltryptamine results in decreased activity of MAOA protein28302559
C0275525-methyltryptamine5-methyltryptamine results in decreased activity of MAOA protein28302559
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAOA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAOA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Thimerosal co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAOA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAOA mRNA"27188386
C1118556-formylindolo(3,2-b)carbazole"[[MAOA protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indoleacetaldehyde] which results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole"26686552
C1118556-formylindolo(3,2-b)carbazole"MAOA protein results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole"26686552
C0366967-methyltryptamine7-methyltryptamine results in decreased activity of MAOA protein28302559
D000082AcetaminophenAcetaminophen results in decreased expression of MAOA mRNA21420995|2570463
D000082AcetaminophenAcetaminophen affects the expression of MAOA mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MAOA gene27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of MAOA mRNA21757418
C409045almotriptanMAOA protein results in increased metabolism of almotriptan12642466
C067527aluminum maltolatealuminum maltolate results in increased activity of MAOA protein16087240
C514068amifuralineamifuraline results in decreased activity of MAOA protein22017497
D000639AmitriptylineAmitriptyline affects the expression of MAOA mRNA21820738
C018824ammonium acetateammonium acetate results in increased activity of MAOA protein12885441
C018824ammonium acetateDizocilpine Maleate inhibits the reaction [ammonium acetate results in increased activity of MAOA protein]12885441
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MAOA mRNA16483693
D001115ArecolineArecoline results in decreased expression of MAOA mRNA17682004
D001151ArsenicArsenic affects the methylation of MAOA gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of MAOA mRNA15761015|2252195
C022870asoxime chlorideasoxime chloride results in decreased activity of MAOA protein21195145
D016589AstemizoleAstemizole results in decreased expression of MAOA mRNA20221588
D001280Atrazine[Atrazine co-treated with Diuron co-treated with isoproturon] affects the expression of MAOA mRNA15245914
D001280AtrazineAtrazine results in increased expression of MAOA mRNA22378314
D001280AtrazineAtrazine results in increased expression of MAOA mRNA28341570
C090014befloxatonebefloxatone results in decreased activity of MAOA protein15178694
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MAOA mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MAOA mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MAOA mRNA22316170
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MAOA mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MAOA mRNA19770486|2156981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MAOA mRNA20127859
C006723benzyl benzoatebenzyl benzoate results in decreased activity of MAOA protein27270453
C526327benzyl cinnamatebenzyl cinnamate results in decreased activity of MAOA protein27270453
C038328BEP protocolBEP protocol results in increased expression of MAOA mRNA18987330
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of MAOA mRNA20660070
D004958EstradiolEstradiol results in decreased expression of MAOA mRNA21185374
D004958EstradiolEstradiol results in increased expression of MAOA mRNA10811566|1133165
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of MAOA mRNA17404688
D004958EstradiolEstradiol results in decreased expression of MAOA mRNA15289156
D004958EstradiolEstradiol results in decreased expression of MAOA mRNA20068009
C044887beta-methylcholinebeta-methylcholine affects the expression of MAOA mRNA21179406
D015306Biogenic MonoaminesMAOA protein results in increased degradation of Biogenic Monoamines10206825
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of MAOA mRNA25912373
C006780bisphenol Abisphenol A results in increased expression of MAOA mRNA11331657
C006780bisphenol Abisphenol A results in decreased expression of MAOA mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of MAOA mRNA23567477
C006780bisphenol Abisphenol A affects the expression of MAOA mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of MAOA mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of MAOA mRNA26186136
C006780bisphenol A[Fructose co-treated with bisphenol A] results in increased expression of MAOA protein26930160
C038213brofarominebrofaromine results in decreased activity of MAOA protein15178694
C038213brofarominebrofaromine results in decreased activity of MAOA protein22017497
D002104CadmiumCadmium results in increased expression of MAOA mRNA24067728
C040048caffeic acidcaffeic acid results in decreased activity of MAOA protein27270453
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MAOA mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA]"20230807
D002220CarbamazepineCarbamazepine affects the expression of MAOA mRNA24752500
D002220CarbamazepineCarbamazepine results in increased expression of MAOA mRNA17112801
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MAOA mRNA27339419
D002395CatecholaminesMAOA protein affects the metabolism of Catecholamines15946989
D002726Chlorogenic AcidChlorogenic Acid results in decreased activity of MAOA protein27270453
C100187chloropicrinchloropicrin results in increased expression of MAOA mRNA28476498
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MAOA mRNA20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MAOA mRNA27858113
C026234cimoxatonecimoxatone results in decreased activity of MAOA protein15178694
D003010ClorgylineClorgyline results in decreased activity of MAOA protein21923181|2727045
D003010ClorgylineClorgyline results in decreased activity of MAOA protein23009399
D003010Clorgyline[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]23499958
D003010Clorgyline[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]23499958
D003010Clorgyline[Clorgyline results in decreased activity of MAOA protein] which results in increased susceptibility to Methamphetamine1905457
D003010ClorgylineClorgyline results in decreased activity of MAOA protein6443171
D003010ClorgylineClorgyline results in decreased activity of MAOA protein12818349|1625207
D003010ClorgylinePhenylpropanolamine inhibits the reaction [Clorgyline results in decreased activity of MAOA protein]3961266
D003010ClorgylineClorgyline results in decreased activity of MAOA protein11245920|1905457
D003042Cocaine[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]23499958
D003042Cocaine[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]23499958
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of MAOA mRNA24690739
D003300CopperCopper results in increased expression of MAOA mRNA19781568
D019327Copper SulfateCopper Sulfate results in decreased expression of MAOA mRNA19549813
D003407CreosoteCreosote results in increased expression of MAOA mRNA19389177
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of MAOA mRNA]18200517
C551866CX157CX157 results in decreased activity of MAOA protein22017497
D003520CyclophosphamideCyclophosphamide results in increased expression of MAOA mRNA17403535
D016572CyclosporineCyclosporine results in decreased expression of MAOA mRNA20106945
C017160cypermethrincypermethrin results in decreased activity of MAOA protein8385837
C014347decitabinedecitabine affects the expression of MAOA mRNA23300844
D003907DexamethasoneDexamethasone results in increased expression of MAOA mRNA15679045|1594698
D003907DexamethasoneDexamethasone results in increased expression of MAOA protein15679045|1594698
D003907DexamethasoneMifepristone inhibits the reaction [Dexamethasone results in increased expression of MAOA mRNA]15946989
D003907DexamethasonePlicamycin inhibits the reaction [Dexamethasone results in increased expression of MAOA mRNA]15946989
D003907DexamethasoneDexamethasone affects the expression of MAOA protein19969022
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MAOA mRNA17361019|2126653
D002945CisplatinCisplatin affects the expression of MAOA mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MAOA mRNA27392435
D002945CisplatinCisplatin results in increased expression of MAOA mRNA15464296|1547189
D004006Dichlorvos[Dichlorvos results in decreased abundance of Oxygen] which results in decreased activity of MAOA protein6443171
D004006DichlorvosDichlorvos results in decreased activity of MAOA protein12018584
D004008DiclofenacDiclofenac affects the expression of MAOA mRNA24752500
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of MAOA mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of MAOA mRNA]19850644
C014476diethyl maleatediethyl maleate results in increased expression of MAOA mRNA25270620
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of MAOA mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MAOA mRNA18544905
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of MAOA mRNA10811566|1133165
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of MAOA mRNA15289156
D002117Calcitriol[Calcitriol co-treated with VDR protein] results in decreased expression of MAOA mRNA27450565
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of MAOA mRNA27638505
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of MAOA mRNA24690739
D004237Diuron[Atrazine co-treated with Diuron co-treated with isoproturon] affects the expression of MAOA mRNA15245914
D004237DiuronDiuron results in decreased expression of MAOA mRNA25152437
D004237DiuronDiuron results in increased expression of MAOA mRNA21551480
D016291Dizocilpine MaleateDizocilpine Maleate inhibits the reaction [ammonium acetate results in increased activity of MAOA protein]12885441
D004298Dopamine"3,4-Methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Dopamine]"26721607
D004298DopamineMAOA protein results in decreased amination of Dopamine26721607
D004298Dopamine"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Dopamine]"26721607
D004298DopamineMAOA mutant form results in increased abundance of Dopamine11834493
D004298DopamineMAOA protein affects the metabolism of Dopamine7430361
D004298DopamineMAOA protein results in increased metabolism of Dopamine18361446|2140513
D004298DopamineMAOA protein results in increased oxidation of Dopamine21923198
D004317DoxorubicinDoxorubicin results in increased expression of MAOA mRNA19915844
D004726EndosulfanEndosulfan results in decreased expression of MAOA mRNA26615145
D004726EndosulfanEndosulfan results in increased expression of MAOA mRNA26615145
C118739entinostatentinostat results in increased expression of MAOA mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAOA mRNA"27188386
D004837EpinephrineMAOA protein results in decreased amination of Epinephrine22023459
D004837EpinephrineMAOA protein results in increased metabolism of Epinephrine18361446|2140513
D004837EpinephrineMAOA protein results in increased oxidation of Epinephrine21923198
C107376esuproneesuprone results in decreased activity of MAOA protein21923181
D000431EthanolEthanol results in decreased activity of MAOA protein28057462
D000431EthanolEthanol affects the expression of MAOA mRNA11772933
C017690fenvaleratefenvalerate results in decreased activity of MAOA protein8385837
D018120FinasterideFinasteride results in increased expression of MAOA mRNA24136188
C028610flavanoneflavanone results in decreased activity of MAOA protein23009399
C043562flavoneflavone results in decreased activity of MAOA protein23009399
D005473FluoxetineMAOA gene polymorphism affects the susceptibility to Fluoxetine25369145
D005485FlutamideFlutamide results in decreased expression of MAOA mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MAOA mRNA20938992
D005632Fructose[Fructose co-treated with bisphenol A] results in increased expression of MAOA protein26930160
D019833GenisteinGenistein results in increased expression of MAOA mRNA11331657
D019833GenisteinGenistein results in decreased expression of MAOA mRNA15289156
C010974glyphosateglyphosate affects the expression of MAOA mRNA15245914
D006220HaloperidolHaloperidol results in increased activity of MAOA protein8160492
D006246HarmalineHarmaline results in decreased activity of MAOA protein28302559
D006246HarmalineHarmaline results in decreased activity of MAOA protein15178694|2437388
C005010harmanharman results in decreased activity of MAOA protein28057462
D006247HarmineHarmine results in decreased activity of MAOA protein28302559
D006247HarmineHarmine analog binds to MAOA protein9290071
D006247HarmineHarmine results in decreased activity of MAOA protein24373881
C010178heliotrineheliotrine results in decreased expression of MAOA mRNA26100227
D012701Serotonin"3,4-Methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Serotonin]"26721607
D012701SerotoninMAOA gene polymorphism results in increased abundance of Serotonin18405062
D012701SerotoninMAOA protein results in decreased amination of Serotonin26721607
D012701SerotoninMAOA protein results in increased metabolism of Serotonin10647887
D012701SerotoninMoclobemide inhibits the reaction [MAOA protein results in decreased amination of Serotonin]26721607
D012701Serotonin"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Serotonin]"26721607
D012701SerotoninPhenylpropanolamine inhibits the reaction [MAOA protein results in increased degradation of Serotonin]3961266
D012701SerotoninLuteolin inhibits the reaction [MAOA protein results in increased metabolism of Serotonin]23009399
D012701SerotoninLuteolin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]23009399
D012701SerotoninMAOA mutant form results in increased abundance of Serotonin11834493
D012701SerotoninMAOA protein results in increased metabolism of Serotonin23009399
D012701Serotonin[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde23009399
D012701SerotoninQuercetin inhibits the reaction [MAOA protein results in increased metabolism of Serotonin]23009399
D012701SerotoninQuercetin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]23009399
D012701SerotoninSerotonin results in increased activity of MAOA protein17561096
D012701SerotoninMAOA protein results in decreased amination of Serotonin22023459
D012701SerotoninMAOA protein results in increased metabolism of Serotonin18361446|2140513
D012701SerotoninMAOA protein results in increased oxidation of Serotonin21923198|7430361
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of MAOA mRNA17183730
D006838HydrocarbonsHydrocarbons results in increased expression of MAOA mRNA15245914
D006854HydrocortisoneHydrocortisone results in increased expression of MAOA mRNA21267416
C004277hydroxyindoleacetaldehydeLuteolin inhibits the reaction [MAOA protein results in increased abundance of hydroxyindoleacetaldehyde]23009399
C004277hydroxyindoleacetaldehydeLuteolin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]23009399
C004277hydroxyindoleacetaldehydeMAOA protein results in increased abundance of hydroxyindoleacetaldehyde23009399
C004277hydroxyindoleacetaldehyde[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde23009399
C004277hydroxyindoleacetaldehydeQuercetin inhibits the reaction [MAOA protein results in increased abundance of hydroxyindoleacetaldehyde]23009399
C004277hydroxyindoleacetaldehydeQuercetin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]23009399
C001655indoleacetaldehyde[MAOA protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indoleacetaldehyde26686552
C001655indoleacetaldehyde"[[MAOA protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indoleacetaldehyde] which results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole"26686552
C001655indoleacetaldehydeMAOA protein results in increased chemical synthesis of indoleacetaldehyde26686552
C015293indopanindopan results in decreased activity of MAOA protein28302559
D007501IronMAOA gene polymorphism affects the susceptibility to Iron deficiency22340208
D007501IronIron deficiency results in decreased expression of MAOA mRNA16629162
D019266Iron, Dietary"MAOA gene polymorphism affects the susceptibility to Iron, Dietary"25351859
D019266Iron, Dietary"Iron, Dietary affects the expression of MAOA mRNA"15637178
D007529IsoflavonesIsoflavones results in decreased expression of MAOA mRNA17374662
C028904isoproturon[Atrazine co-treated with Diuron co-treated with isoproturon] affects the expression of MAOA mRNA15245914
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MAOA mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MAOA mRNA26752646
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MAOA mRNA18544905
D007854LeadLead affects the activity of MAOA protein11460677
C052901lemongrass oillemongrass oil results in decreased expression of MAOA mRNA25660481
D000069349LinezolidLinezolid results in decreased activity of MAOA protein14531724
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of MAOA mRNA"24972896
D047311LuteolinLuteolin results in decreased activity of MAOA protein23009399
D047311LuteolinLuteolin inhibits the reaction [MAOA protein results in increased abundance of hydroxyindoleacetaldehyde]23009399
D047311LuteolinLuteolin inhibits the reaction [MAOA protein results in increased metabolism of Serotonin]23009399
D047311LuteolinLuteolin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]23009399
D047311LuteolinLuteolin results in decreased activity of MAOA protein23009399
D008676MetanephrineMAOA protein affects the abundance of Metanephrine22569243
D008694Methamphetamine[Clorgyline results in decreased activity of MAOA protein] which results in increased susceptibility to Methamphetamine1905457
D008694MethamphetamineMAOA protein affects the susceptibility to Methamphetamine1905457
D008694MethamphetamineMethamphetamine results in increased expression of MAOA mRNA19149911
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MAOA mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of MAOA mRNA21678067
C005219methyl cellosolvemethyl cellosolve results in increased expression of MAOA mRNA21061450
D0151043,4-Methylenedioxyamphetamine"3,4-Methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Dopamine]"26721607
D0151043,4-Methylenedioxyamphetamine"3,4-Methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Serotonin]"26721607
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Dopamine]"26721607
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Serotonin]"26721607
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased activity of MAOA protein"26721607
D008743Methyl ParathionMethyl Parathion results in increased activity of MAOA protein11495289
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of MAOA mRNA25234470
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of MAOA mRNA25234470
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MAOA mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAOA mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"MAOA protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"21696156
D015741MetriboloneMetribolone promotes the reaction [NDRG1 protein binds to MAOA protein]17220478
D015735MifepristoneMifepristone inhibits the reaction [Dexamethasone results in increased expression of MAOA mRNA]15946989
D020912MoclobemideMoclobemide inhibits the reaction [MAOA protein results in decreased amination of Serotonin]26721607
D020912MoclobemideMoclobemide results in decreased activity of MAOA protein21923181
D020912MoclobemideMoclobemide results in decreased activity of MAOA protein23943324
D020912MoclobemideMoclobemide results in decreased activity of MAOA protein15178694|1554529
D020912MoclobemideMoclobemide results in decreased activity of MAOA protein21696156|2201749
D008999MonocrotophosMonocrotophos results in decreased activity of MAOA protein12018584
C091888monoisoamyl-2,3-dimercaptosuccinate"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]"23376091
C091888monoisoamyl-2,3-dimercaptosuccinate"monoisoamyl-2,3-dimercaptosuccinate promotes the reaction [Succimer inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]]"23376091
C091888monoisoamyl-2,3-dimercaptosuccinate"Succimer promotes the reaction [monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]]"23376091
D009002MonomethylhydrazineMonomethylhydrazine results in increased activity of MAOA protein8583353
C523799MRK 003MAOA results in decreased susceptibility to MRK 00319903844
C570530N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amineN-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine results in decreased activity of MAOA protein22023459
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MAOA mRNA"25554681
C051752nefazodonenefazodone results in increased expression of MAOA mRNA24136188
D009532NickelNickel results in decreased expression of MAOA mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of MAOA mRNA16780908
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAOA mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA]"20230807
D009599Nitroprusside[MAOB protein co-treated with MAOA protein] affects the susceptibility to Nitroprusside11834493
C005514N,N'-monomethylenebis(pyridiniumaldoxime)"N,N'-monomethylenebis(pyridiniumaldoxime) results in decreased activity of MAOA protein"21195145
D009638NorepinephrineMAOA protein results in increased metabolism of Norepinephrine10647887
D009638NorepinephrineMAOA mutant form results in increased abundance of Norepinephrine11834493
D009638NorepinephrineMAOA protein results in decreased amination of Norepinephrine22023459
D009638NorepinephrineMAOA protein results in increased metabolism of Norepinephrine18361446|2140513
D009638NorepinephrineMAOA protein results in increased oxidation of Norepinephrine21923198|7430361
C010262norharmannorharman results in decreased activity of MAOA protein28057462
C423264(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate results in decreased activity of MAOA protein16086033
D009768Obidoxime ChlorideObidoxime Chloride results in decreased activity of MAOA protein21195145
C025589ochratoxin Aochratoxin A results in increased methylation of MAOA gene26431795
C076029olanzapineolanzapine results in increased expression of MAOA mRNA15964593
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of MAOA mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of MAOA mRNA]"21673326
D010100OxygenOxygen deficiency results in decreased expression of MAOA mRNA19695866
D010100Oxygen[Dichlorvos results in decreased abundance of Oxygen] which results in decreased activity of MAOA protein6443171
D010100OxygenOxygen deficiency results in decreased activity of MAOA protein6443171
C013638paeonolpaeonol results in decreased activity of MAOA protein15120460
D010293Pargyline[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]23499958
D010293Pargyline[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]23499958
D010293PargylinePargyline results in decreased activity of MAOA protein20716577
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MAOA protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MAOA mRNA19162173
D010627PhenethylaminesMAOA mutant form results in increased abundance of Phenethylamines11834493
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of MAOA mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of MAOA mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of MAOA mRNA19136022
D010634PhenobarbitalPhenobarbital results in increased expression of MAOA mRNA19482888
D010656Phenylephrine[MAOB protein co-treated with MAOA protein] affects the susceptibility to Phenylephrine11834493
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAOA mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of MAOA mRNA26272509
D010665PhenylpropanolaminePhenylpropanolamine inhibits the reaction [MAOA protein results in increased degradation of Serotonin]3961266
D010665PhenylpropanolaminePhenylpropanolamine results in decreased activity of MAOA protein3961266
D010665PhenylpropanolaminePhenylpropanolamine inhibits the reaction [Clorgyline results in decreased activity of MAOA protein]3961266
D010665PhenylpropanolaminePhenylpropanolamine results in decreased activity of MAOA protein3961266
D010707PhosphamidonPhosphamidon results in decreased activity of MAOA protein12018584
D010795Phthalic AcidsPhthalic Acids results in increased expression of MAOA mRNA21061450
C008922piperine[resveratrol co-treated with piperine] results in decreased activity of MAOA protein23943324
C008922piperinepiperine results in decreased activity of MAOA protein15120460
C006253pirinixic acidpirinixic acid affects the expression of MAOA mRNA19136022
C006253pirinixic acidpirinixic acid results in increased expression of MAOA mRNA18301758|2381119
C006253pirinixic acidpirinixic acid results in increased expression of MAOA mRNA19162173
C009830pirlindolepirlindole results in decreased activity of MAOA protein21923198
D010936Plant ExtractsPlant Extracts inhibits the reaction [Smoke results in decreased activity of MAOA protein]24257033
D008926PlicamycinPlicamycin inhibits the reaction [Dexamethasone results in increased expression of MAOA mRNA]15946989
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons affects the expression of MAOA mRNA22579512
C028797pralidoximepralidoxime results in decreased activity of MAOA protein21195145
D011344ProcarbazineProcarbazine results in increased activity of MAOA protein8583353
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of MAOA mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of MAOA mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of MAOA mRNA17404688|2086464
D011374ProgesteroneProgesterone results in decreased expression of MAOA17510236
C005556propionaldehydepropionaldehyde results in increased expression of MAOA mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of MAOA mRNA24780913
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of MAOA mRNA26100227
D011794QuercetinQuercetin results in decreased expression of MAOA mRNA21632981
D011794QuercetinQuercetin inhibits the reaction [MAOA protein results in increased abundance of hydroxyindoleacetaldehyde]23009399
D011794QuercetinQuercetin inhibits the reaction [MAOA protein results in increased metabolism of Serotonin]23009399
D011794QuercetinQuercetin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]23009399
D011794QuercetinQuercetin results in decreased activity of MAOA protein23009399
D017382Reactive Oxygen Species[Tyramine results in increased activity of MAOA protein] promotes the reaction [[Reactive Oxygen Species results in increased activity of MMP2 protein] which results in increased activity of SMPD3 protein]17561096
C059514resveratrol[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]23499958
C059514resveratrol[resveratrol co-treated with piperine] results in decreased activity of MAOA protein23943324
C059514resveratrolresveratrol results in decreased activity of MAOA protein23499958
D018967RisperidoneMAOA gene polymorphism affects the susceptibility to Risperidone22544010
D018967RisperidoneMAOA protein results in increased susceptibility to Risperidone22544010
C063456Ro 41-1049Ro 41-1049 binds to and results in decreased activity of MAOA protein7816197
C063456Ro 41-1049Ro 41-1049 binds to MAOA protein21075085|9045087
C063456Ro 41-1049Ro 41-1049 results in decreased activity of MAOA protein12818349
C089730rosiglitazonerosiglitazone results in decreased activity of MAOA protein22282722
C041376rosmarinic acidrosmarinic acid results in decreased activity of MAOA protein27270453
C009237senecioninesenecionine results in decreased expression of MAOA mRNA26100227
C009238senkirkinesenkirkine results in decreased expression of MAOA mRNA26100227
D020280SertralineMAOA protein results in decreased amination of and results in increased metabolism of Sertraline15547048
D012906SmokePlant Extracts inhibits the reaction [Smoke results in decreased activity of MAOA protein]24257033
D012906SmokeSmoke results in decreased activity of MAOA protein24257033
C017947sodium arsenite"2,3-dimercaptosuccinic acid monocyclohexyl ester inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]"23376091
C017947sodium arsenite"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]"23376091
C017947sodium arsenite"monoisoamyl-2,3-dimercaptosuccinate promotes the reaction [Succimer inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]]"23376091
C017947sodium arsenitesodium arsenite results in increased expression of MAOA protein23376091
C017947sodium arseniteSuccimer inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]23376091
C017947sodium arsenite"Succimer promotes the reaction [monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]]"23376091
C017947sodium arsenitesodium arsenite results in increased expression of MAOA mRNA22714537
C017947sodium arsenitesodium arsenite promotes the reaction [Sodium Fluoride results in increased activity of MAOA protein]19635623
D012969Sodium Fluoridesodium arsenite promotes the reaction [Sodium Fluoride results in increased activity of MAOA protein]19635623
D012969Sodium FluorideSodium Fluoride results in decreased expression of MAOA protein27548804
D012969Sodium FluorideSodium Fluoride results in increased activity of MAOA protein19635623
C051273SR 95191SR 95191 binds to and results in decreased activity of MAOA protein3100770
D004113Succimer"monoisoamyl-2,3-dimercaptosuccinate promotes the reaction [Succimer inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]]"23376091
D004113SuccimerSuccimer inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]23376091
D004113Succimer"Succimer promotes the reaction [monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]]"23376091
D013467SulindacSulindac results in decreased expression of MAOA mRNA24136188
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of MAOA mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MAOA mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MAOA mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MAOA mRNA19770486|1993321
D019284ThapsigarginThapsigargin results in decreased expression of MAOA mRNA22378314
D013849Thimerosal"[NOG protein co-treated with Thimerosal co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAOA mRNA"27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased activity of MAOA protein28057462
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MAOA mRNA28065790
C010798toloxatonetoloxatone results in decreased activity of MAOA protein15178694
C010798toloxatonetoloxatone results in decreased activity of MAOA protein22017497
D014050TolueneToluene affects the expression of MAOA mRNA21827849
D014191TranylcypromineTranylcypromine results in decreased activity of MAOA protein6443171
D014212TretinoinTretinoin results in decreased expression of MAOA mRNA23724009
C039776tribulintribulin results in decreased activity of MAOA protein8744988
C012589trichostatin Atrichostatin A results in increased expression of MAOA mRNA24935251
D014289TrimedoximeTrimedoxime results in decreased activity of MAOA protein21195145
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of MAOA mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of MAOA mRNA18200517
C057693troglitazonetroglitazone results in decreased activity of MAOA protein22282722
C057693troglitazonetroglitazone results in increased expression of MAOA mRNA19140230
C030820tryptamineMAOA protein results in decreased amination of tryptamine26686552
C030820tryptamine[MAOA protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indoleacetaldehyde26686552
C030820tryptamine"[[MAOA protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indoleacetaldehyde] which results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole"26686552
C030820tryptamineMAOA protein results in increased metabolism of tryptamine21405131
C030820tryptamineMAOA protein results in increased oxidation of tryptamine21923198
D014439TyramineMAOA protein results in increased metabolism of Tyramine10647887
D014439Tyramine[Tyramine results in increased activity of MAOA protein] promotes the reaction [[Reactive Oxygen Species results in increased activity of MMP2 protein] which results in increased activity of SMPD3 protein]17561096
D014439TyramineMAOA protein results in increased metabolism of Tyramine21405131
D014439TyramineMAOA protein results in increased oxidation of Tyramine21923198
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of MAOA mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAOA mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MAOA mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MAOA mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of MAOA gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MAOA gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of MAOA mRNA26682919
C111237vorinostatvorinostat results in increased expression of MAOA mRNA27188386
D015016YohimbineYohimbine results in decreased activity of MAOA protein28302559
D015029ZeranolZeranol results in increased expression of MAOA mRNA10811566|1133165

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008131primary amine oxidase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006576cellular biogenic amine metabolic process-TAS8211186  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0042133neurotransmitter metabolic process-TAS-  
GO:0042135neurotransmitter catabolic process-IEA-  
GO:0042420dopamine catabolic process-TAS24252804  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-HDA20833797  
GO:0005739mitochondrion-IDA-  
GO:0005741mitochondrial outer membrane-TAS24252804  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00260Glycine, serine and threonine metabolism
hsa00330Arginine and proline metabolism
hsa00340Histidine metabolism
hsa00350Tyrosine metabolism
hsa00360Phenylalanine metabolism
hsa00380Tryptophan metabolism
hsa00982Drug metabolism - cytochrome P450
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112311Neurotransmitter clearanceTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-140179Amine Oxidase reactionsTAS
R-HSA-141333Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOBTAS
R-HSA-1430728MetabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-168256Immune SystemTAS
R-HSA-181430Norepinephrine Neurotransmitter Release CycleTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-379397Enzymatic degradation of dopamine by COMTTAS
R-HSA-379398Enzymatic degradation of Dopamine by monoamine oxidaseTAS
R-HSA-379401Dopamine clearance from the synaptic cleftTAS
R-HSA-380612Metabolism of serotoninTAS
R-HSA-380615Serotonin clearance from the synaptic cleftTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-5579012Defective MAOA causes Brunner syndrome (BRUNS)TAS
R-HSA-5579029Metabolic disorders of biological oxidation enzymesTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19247474Genome-wide and candidate gene association study of cigarette smoking behaviors. (2009)Caporaso NPLoS One
18405071Alcohol dependence and polymorphisms of serotonin-related genes: association studies. (2008 Jan)Mokrovic GColl Antropol
9326944Increased stress response and beta-phenylethylamine in MAOB-deficient mice. (1997 Oct)Grimsby JNat Genet
18827956Serotonin transporter (5-HTTLPR) and monoamine oxidase (MAOA) promoter polymorphisms in women with severe alcoholism. (2008 Dec)Gokturk CArch Womens Ment Health
18188752Interactions between genotype and retrospective ADHD symptoms predict lifetime smoking risk in a sample of young adults. (2008 Jan)McClernon FJNicotine Tob Res
16526025MAOA-uVNTR polymorphism in a Brazilian sample: further support for the association with impulsive behaviors and alcohol dependence. (2006 Apr 5)Contini VAm J Med Genet B Neuropsychiatr Genet
11134668Pharmacogenetics and the serotonin system: initial studies and future directions. (2000 Dec 27)Veenstra-VanderWeele JEur J Pharmacol
26447226Influence of Dopaminergic System Genetic Variation and Lifestyle Factors on Excessive Alcohol Consumption. (2016 May)Celorrio DAlcohol Alcohol
25655461Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. (2015 Apr 15)Manzardo AMGene
22297589Moderating role of the MAOA genotype in antisocial behaviour. (2012 Feb)Fergusson DMBr J Psychiatry
27613936High Prevalence of Smoking in the Roma Population Seems to Have No Genetic Background. (2016 Dec)Fiatal SNicotine Tob Res
21778150A preliminary analysis of interactions between genotype, retrospective ADHD symptoms, and initial reactions to smoking in a sample of young adults. (2012 Feb)Bidwell LCNicotine Tob Res
10943908Different allele distribution of a regulatory MAOA gene promoter polymorphism in antisocial and anxious-depressive alcoholics. (2000)Schmidt LGJ Neural Transm (Vienna)
18454435MAOA methylation is associated with nicotine and alcohol dependence in women. (2008 Jul 5)Philibert RAAm J Med Genet B Neuropsychiatr Genet
24837582Monoamine polygenic liability in health and cocaine dependence: imaging genetics study of aversive processing and associations with depression symptomatology. (2014 Jul 1)Moeller SJDrug Alcohol Depend
19302089MAOA-uVNTR polymorphism may modify the protective effect of ALDH2 gene against alcohol dependence in antisocial personality disorder. (2009 Jun)Lee SYAlcohol Clin Exp Res
23215821Gene-environment interaction in externalizing problems among adolescents: evidence from the Pelotas 1993 Birth Cohort Study. (2013 Mar)Kieling CJ Child Psychol Psychiatry
21383264Gene x disease interaction on orbitofrontal gray matter in cocaine addiction. (2011 Mar)Alia-Klein NArch Gen Psychiatry
7485245Preliminary evidence for an association of a dinucleotide repeat polymorphism at the MAOA gene with early onset alcoholism/substance abuse. (1995 Apr 24)Vanyukov MMAm J Med Genet
17347351Genetic and environmental influences on the development of alcoholism: resilience vs. risk. (2006 Dec)Enoch MAAnn N Y Acad Sci
18592036Is fetal brain monoamine oxidase inhibition the missing link between maternal smoking and conduct disorders? (2008 May)Baler RDJ Psychiatry Neurosci
19777560The effect of smoking on MAOA promoter methylation in DNA prepared from lymphoblasts and whole blood. (2010 Mar 5)Philibert RAAm J Med Genet B Neuropsychiatr Genet
19415821Gene-gene interactions of CYP2A6 and MAOA polymorphisms on smoking behavior in Chinese male population. (2009 May)Tang XPharmacogenet Genomics
25660313Meta-analysis of six genes (BDNF, DRD1, DRD3, DRD4, GRIN2B and MAOA) involved in neuroplasticity and the risk for alcohol dependence. (2015 Apr 1)Forero DADrug Alcohol Depend
23044341Association study of DRD2 and MAOA genes with subtyped alcoholism comorbid with bipolar disorder in Han Chinese. (2013 Jan 10)Hu MCProg Neuropsychopharmacol Biol Psychiatry
16272956CYP2A6, MAOA, DBH, DRD4, and 5HT2A genotypes, smoking behaviour and cotinine levels in 1518 UK adolescents. (2005 Dec)Huang SPharmacogenet Genomics
15251892The use of adolescent nonhuman primates to model human alcohol intake: neurobiological, genetic, and psychological variables. (2004 Jun)Barr CSAnn N Y Acad Sci
19120058Effects of MAOA-genotype, alcohol consumption, and aging on violent behavior. (2009 Mar)Tikkanen RAlcohol Clin Exp Res
16207390Association between monoamine oxidase gene polymorphisms and smoking behaviour in Chinese males. (2006 Oct)Jin YInt J Neuropsychopharmacol
28163169Does MAOA increase susceptibility to prenatal stress in young children? (2017 May)Massey SHNeurotoxicol Teratol
17592478Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women. (2008 Mar)Ducci FMol Psychiatry
10359483Association of a regulatory polymorphism in the promoter region of the monoamine oxidase A gene with antisocial alcoholism. (1999 Apr 19)Samochowiec JPsychiatry Res
16770335A functional polymorphism in the MAOA gene promoter (MAOA-LPR) predicts central dopamine function and body mass index. (2006 Sep)Ducci FMol Psychiatry
23504072Association of VMAT2 gene polymorphisms with alcohol dependence. (2013 Aug)Fehr CJ Neural Transm (Vienna)
21445666Family-based association analysis of alcohol dependence in the COGA sample and replication in the Australian twin-family study. (2011 Sep)Wang KSJ Neural Transm (Vienna)
19615672Reduced monoamine oxidase A activity in pregnant smokers and in their newborns. (2009 Oct 15)Berlin IBiol Psychiatry
29600412Associations of monoamine oxidase A gene first exon methylation with sexual abuse and current depression in women. (2018 Mar 29)Checknita DJ Neural Transm (Vienna)
17885625Association study of monoamine oxidase and catechol-O-methyltransferase genes with smoking behavior. (2007 Oct)Tochigi MPharmacogenet Genomics
28858992The genotypes and methylation of MAO genes as factors behind smoking behavior. (2017 Nov)Tiili EMPharmacogenet Genomics
27112218Platelet monoamine oxidase type B, MAOB intron 13 and MAOA-uVNTR polymorphism and symptoms of post-traumatic stress disorder. (2016 Jul)Svob Strac DStress
24080236Variation of types of alcoholism: review and subtypes identified in Han Chinese. (2014 Jan 3)Lee SYProg Neuropsychopharmacol Biol Psychiatry
25809512Monoamine oxidase a promoter variable number of tandem repeats (MAOA-uVNTR) in alcoholics according to Lesch typology. (2015 Mar 19)Samochowiec AInt J Environ Res Public Health
8780428Association of monoamine oxidase A alleles with alcoholism among male Chinese in Taiwan. (1996 Sep)Hsu YPAm J Psychiatry
28259004Age-dependent role of pre- and perinatal factors in interaction with genes on ADHD symptoms across adolescence. (2017 Jul)Brinksma DMJ Psychiatr Res
20477771MAOA interacts with the ALDH2 gene in anxiety-depression alcohol dependence. (2010 Jul)Lee SYAlcohol Clin Exp Res
22494506The 'warrior gene' and the Maori people: the responsibility of the geneticists. (2013 Sep)Perbal LBioethics
26851573Monoamine oxidase and agitation in psychiatric patients. (2016 Aug 1)Nikolac Perkovic MProg Neuropsychopharmacol Biol Psychiatry
22544010Different impacts of aquaporin 4 and MAOA allele variation among olanzapine, risperidone, and paliperidone in schizophrenia. (2012 Jun)Chung TSJ Clin Psychopharmacol
22948232Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men. (2012 Oct)Shumay EEpigenetics
17007976Possible interaction between MAOA and DRD2 genes associated with antisocial alcoholism among Han Chinese men in Taiwan. (2007 Jan 30)Wang TJProg Neuropsychopharmacol Biol Psychiatry
22610759A latent modeling approach to genotype-phenotype relationships: maternal problem behavior clusters, prenatal smoking, and MAOA genotype. (2012 Aug)McGrath LMArch Womens Ment Health
11927135Analysis of monoamine oxidase A (MAOA) promoter polymorphism in Finnish male alcoholics. (2002 Mar 15)Saito TPsychiatry Res
11999895No association of the MAOA gene with alcoholism among Han Chinese males in Taiwan. (2002 Apr)Lu RBProg Neuropsychopharmacol Biol Psychiatry
26015071Effects of Interaction Between Dopamine D2 Receptor and Monoamine Oxidase A Genes on Smoking Status in Young Men. (2015 Jul)Huang CLBiol Res Nurs
27300740Interacting effect of MAOA genotype and maternal prenatal smoking on aggressive behavior in young adulthood. (2016 Aug)Hohmann SJ Neural Transm (Vienna)
17476365Monoamine oxidase-A polymorphisms might modify the association between the dopamine D2 receptor gene and alcohol dependence. (2007 May)Huang SYJ Psychiatry Neurosci
20810002Relationship of monoamine oxidase A binding to adaptive and maladaptive personality traits. (2011 May)Soliman APsychol Med