Gene info: ID 4128

Gene: MAOA

GENE ID: 4128

Synonyms: BRNRS|MAO-A

Description: monoamine oxidase A

Gene type: protein-coding

Location: Xp11.3

dbXrefs: Ensembl:ENSG00000189221 MIM:309850 Vega:OTTHUMG00000021387 UniprotKB:P21397

RefSeq: NG_008957.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 57

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
AHCYL1	0.908
MSI2	0.904
UNG	0.9
FERMT2	0.896
WLS	0.892
SDC2	0.891
RHOBTB3	0.889
GRAMD1C	0.888
HSDL2	0.886
ALDH9A1	0.884

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.486
OR4F29	-0.483
DUSP27	-0.418
ABCC12	-0.411
ADTRP	-0.402
AGMAT	-0.395
CALHM1	-0.386
QRFPR	-0.379
MCHR1	-0.379
GALNT14	-0.379

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00191	Phentermine	Small Molecule	122-09-8	Approved\|Illicit	Target
DB00752	Tranylcypromine	Small Molecule	155-09-9	Approved\|Investigational	Target
DB00780	Phenelzine	Small Molecule	51-71-8	Approved	Target
DB00805	Minaprine	Small Molecule	25905-77-5	Approved	Target
DB00909	Zonisamide	Small Molecule	68291-97-4	Approved\|Investigational	Target
DB01037	Selegiline	Small Molecule	14611-51-9	Approved\|Investigational	Target
DB01171	Moclobemide	Small Molecule	71320-77-9	Approved\|Investigational	Target
DB01247	Isocarboxazid	Small Molecule	59-63-2	Approved	Target
DB01363	Ephedra	Small Molecule	-	Approved\|Nutraceutical\|Withdrawn	Target
DB01442	MMDA	Small Molecule	13674-05-0	Experimental\|Illicit	Target
DB01472	4-Methoxyamphetamine	Small Molecule	64-13-1	Experimental\|Illicit	Target
DB01577	Methamphetamine	Small Molecule	537-46-2	Approved\|Illicit	Target
DB01626	Pargyline	Small Molecule	555-57-7	Approved	Target
DB03147	Flavin adenine dinucleotide	Small Molecule	146-14-5	Approved	Target
DB04017	N-Methyl-N-Propargyl-3-(2,4-Dichlorophenoxy)Propylamine	Small Molecule		Experimental	Target
DB04820	Nialamide	Small Molecule	51-12-7	Withdrawn	Target
DB04821	Nomifensine	Small Molecule	24526-64-5	Withdrawn	Target
DB04832	Zimelidine	Small Molecule	56775-88-3	Withdrawn	Target
DB04850	Posizolid	Small Molecule	252260-06-3	Investigational	Target
DB05205	CX157	Small Molecule	-	Investigational	Target
DB07641	DECYL(DIMETHYL)PHOSPHINE OXIDE	Small Molecule		Experimental	Target
DB07919	7-METHOXY-1-METHYL-9H-BETA-CARBOLINE	Small Molecule		Experimental	Target
DB09244	Pirlindole	Small Molecule	60762-57-4	Approved	Target
DB09245	Toloxatone	Small Molecule	29218-27-7	Approved	Target
DB13876	Brofaromine	Small Molecule	63638-91-5	Experimental	Target
DB00182	Amphetamine	Small Molecule	300-62-9	Approved\|Illicit\|Investigational	Target
DB00721	Procaine	Small Molecule	59-46-1	Approved\|Investigational	Target
DB01168	Procarbazine	Small Molecule	671-16-9	Approved\|Investigational	Target
DB01171	Moclobemide	Small Molecule	71320-77-9	Approved\|Investigational	Target
DB00140	Riboflavin	Small Molecule	83-88-5	Approved\|Investigational\|Nutraceutical	Enzyme
DB00184	Nicotine	Small Molecule	54-11-5	Approved	Enzyme
DB00191	Phentermine	Small Molecule	122-09-8	Approved\|Illicit	Enzyme
DB00315	Zolmitriptan	Small Molecule	139264-17-8	Approved\|Investigational	Enzyme
DB00388	Phenylephrine	Small Molecule	59-42-7	Approved	Enzyme
DB00397	Phenylpropanolamine	Small Molecule	14838-15-4	Approved\|Withdrawn	Enzyme
DB00601	Linezolid	Small Molecule	165800-03-3	Approved\|Investigational	Enzyme
DB00614	Furazolidone	Small Molecule	67-45-8	Approved\|Investigational	Enzyme
DB00624	Testosterone	Small Molecule	58-22-0	Approved\|Investigational	Enzyme
DB00669	Sumatriptan	Small Molecule	103628-46-2	Approved\|Investigational	Enzyme
DB00780	Phenelzine	Small Molecule	51-71-8	Approved	Enzyme
DB00852	Pseudoephedrine	Small Molecule	90-82-4	Approved	Enzyme
DB00918	Almotriptan	Small Molecule	154323-57-6	Approved\|Investigational	Enzyme
DB00952	Naratriptan	Small Molecule	121679-13-8	Approved\|Investigational	Enzyme
DB00953	Rizatriptan	Small Molecule	144034-80-0	Approved	Enzyme
DB00988	Dopamine	Small Molecule	51-61-6	Approved	Enzyme
DB01104	Sertraline	Small Molecule	79617-96-2	Approved	Enzyme
DB01171	Moclobemide	Small Molecule	71320-77-9	Approved\|Investigational	Enzyme
DB01445	Bufotenine	Small Molecule	487-93-4	Experimental\|Illicit	Enzyme
DB06412	Oxymetholone	Small Molecule	434-07-1	Approved\|Illicit	Enzyme
DB06654	Safinamide	Small Molecule	133865-89-1	Approved\|Investigational	Enzyme
DB06774	Capsaicin	Small Molecule	404-86-4	Approved	Enzyme
DB08804	Nandrolone decanoate	Small Molecule	360-70-3	Approved\|Illicit	Enzyme
DB09244	Pirlindole	Small Molecule	60762-57-4	Approved	Enzyme
DB09245	Toloxatone	Small Molecule	29218-27-7	Approved	Enzyme
DB13943	Testosterone cypionate	Small Molecule	58-20-8	Approved	Enzyme
DB13944	Testosterone enanthate	Small Molecule	315-37-7	Approved	Enzyme
DB13946	Testosterone undecanoate	Small Molecule	5949-44-0	Approved\|Investigational	Enzyme
DB06778	Cupric sulfate	Small Molecule	7758-98-7	Approved	Enzyme
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Enzyme
DB09363	Rauwolfia serpentina root	Small Molecule	8063-17-0	Investigational	Enzyme

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of MAOA mRNA	19933214
C505449	2,3-dimercaptosuccinic acid monocyclohexyl ester	"2,3-dimercaptosuccinic acid monocyclohexyl ester inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]"	23376091
C030769	2-methylharmine	2-methylharmine analog binds to MAOA protein	9290071
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of MAOA mRNA"	19692669
C019132	3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole	"3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in decreased activity of MAOA protein"	3404091
C019132	3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole	"3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in decreased activity of MAOA protein"	7931246
C019133	3-amino-1-methyl-5H-pyrido(4,3-b)indole	"3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of MAOA protein"	3404091
C019133	3-amino-1-methyl-5H-pyrido(4,3-b)indole	"3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of MAOA protein"	7931246
C492672	3-methoxymethyl-7-(4,4,4-trifluorobutoxy)-3,3a,4,5-tetrahydro-1,3-oxazolo(3,4-a)quinolin-1-one	"3-methoxymethyl-7-(4,4,4-trifluorobutoxy)-3,3a,4,5-tetrahydro-1,3-oxazolo(3,4-a)quinolin-1-one results in decreased activity of MAOA protein"	15178694
C008745	4,4'-bisphenol F	"4,4'-bisphenol F results in decreased expression of MAOA mRNA"	26186136
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in increased expression of MAOA mRNA"	25912373
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAOA mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAOA mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Thimerosal co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAOA mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAOA mRNA"	27188386
C583009	5-(2-aminopropyl)indole	5-(2-aminopropyl)indole results in decreased activity of MAOA protein	28302559
C040997	5-bromotryptamine	5-bromotryptamine results in decreased activity of MAOA protein	28302559
C529169	5-chlorotryptamine	5-chlorotryptamine results in decreased activity of MAOA protein	28302559
C051101	5-fluoro-alpha-methyltryptamine	5-fluoro-alpha-methyltryptamine results in decreased activity of MAOA protein	28302559
C027552	5-methyltryptamine	5-methyltryptamine results in decreased activity of MAOA protein	28302559
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAOA mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAOA mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Thimerosal co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAOA mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAOA mRNA"	27188386
C111855	6-formylindolo(3,2-b)carbazole	"[[MAOA protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indoleacetaldehyde] which results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole"	26686552
C111855	6-formylindolo(3,2-b)carbazole	"MAOA protein results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole"	26686552
C036696	7-methyltryptamine	7-methyltryptamine results in decreased activity of MAOA protein	28302559
D000082	Acetaminophen	Acetaminophen results in decreased expression of MAOA mRNA	21420995\|2570463
D000082	Acetaminophen	Acetaminophen affects the expression of MAOA mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of MAOA gene	27153756
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of MAOA mRNA	21757418
C409045	almotriptan	MAOA protein results in increased metabolism of almotriptan	12642466
C067527	aluminum maltolate	aluminum maltolate results in increased activity of MAOA protein	16087240
C514068	amifuraline	amifuraline results in decreased activity of MAOA protein	22017497
D000639	Amitriptyline	Amitriptyline affects the expression of MAOA mRNA	21820738
C018824	ammonium acetate	ammonium acetate results in increased activity of MAOA protein	12885441
C018824	ammonium acetate	Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased activity of MAOA protein]	12885441
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MAOA mRNA	16483693
D001115	Arecoline	Arecoline results in decreased expression of MAOA mRNA	17682004
D001151	Arsenic	Arsenic affects the methylation of MAOA gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in increased expression of MAOA mRNA	15761015\|2252195
C022870	asoxime chloride	asoxime chloride results in decreased activity of MAOA protein	21195145
D016589	Astemizole	Astemizole results in decreased expression of MAOA mRNA	20221588
D001280	Atrazine	[Atrazine co-treated with Diuron co-treated with isoproturon] affects the expression of MAOA mRNA	15245914
D001280	Atrazine	Atrazine results in increased expression of MAOA mRNA	22378314
D001280	Atrazine	Atrazine results in increased expression of MAOA mRNA	28341570
C090014	befloxatone	befloxatone results in decreased activity of MAOA protein	15178694
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MAOA mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MAOA mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MAOA mRNA	22316170
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MAOA mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MAOA mRNA	19770486\|2156981
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MAOA mRNA	20127859
C006723	benzyl benzoate	benzyl benzoate results in decreased activity of MAOA protein	27270453
C526327	benzyl cinnamate	benzyl cinnamate results in decreased activity of MAOA protein	27270453
C038328	BEP protocol	BEP protocol results in increased expression of MAOA mRNA	18987330
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of MAOA mRNA	20660070
D004958	Estradiol	Estradiol results in decreased expression of MAOA mRNA	21185374
D004958	Estradiol	Estradiol results in increased expression of MAOA mRNA	10811566\|1133165
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of MAOA mRNA	17404688
D004958	Estradiol	Estradiol results in decreased expression of MAOA mRNA	15289156
D004958	Estradiol	Estradiol results in decreased expression of MAOA mRNA	20068009
C044887	beta-methylcholine	beta-methylcholine affects the expression of MAOA mRNA	21179406
D015306	Biogenic Monoamines	MAOA protein results in increased degradation of Biogenic Monoamines	10206825
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of MAOA mRNA	25912373
C006780	bisphenol A	bisphenol A results in increased expression of MAOA mRNA	11331657
C006780	bisphenol A	bisphenol A results in decreased expression of MAOA mRNA	26063408
C006780	bisphenol A	bisphenol A results in increased expression of MAOA mRNA	23567477
C006780	bisphenol A	bisphenol A affects the expression of MAOA mRNA	25181051
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in decreased expression of MAOA mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased expression of MAOA mRNA	26186136
C006780	bisphenol A	[Fructose co-treated with bisphenol A] results in increased expression of MAOA protein	26930160
C038213	brofaromine	brofaromine results in decreased activity of MAOA protein	15178694
C038213	brofaromine	brofaromine results in decreased activity of MAOA protein	22017497
D002104	Cadmium	Cadmium results in increased expression of MAOA mRNA	24067728
C040048	caffeic acid	caffeic acid results in decreased activity of MAOA protein	27270453
D002110	Caffeine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MAOA mRNA"	20230807
D002110	Caffeine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA]"	20230807
D002220	Carbamazepine	Carbamazepine affects the expression of MAOA mRNA	24752500
D002220	Carbamazepine	Carbamazepine results in increased expression of MAOA mRNA	17112801
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of MAOA mRNA	27339419
D002395	Catecholamines	MAOA protein affects the metabolism of Catecholamines	15946989
D002726	Chlorogenic Acid	Chlorogenic Acid results in decreased activity of MAOA protein	27270453
C100187	chloropicrin	chloropicrin results in increased expression of MAOA mRNA	28476498
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MAOA mRNA	20938992
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MAOA mRNA	27858113
C026234	cimoxatone	cimoxatone results in decreased activity of MAOA protein	15178694
D003010	Clorgyline	Clorgyline results in decreased activity of MAOA protein	21923181\|2727045
D003010	Clorgyline	Clorgyline results in decreased activity of MAOA protein	23009399
D003010	Clorgyline	[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]	23499958
D003010	Clorgyline	[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]	23499958
D003010	Clorgyline	[Clorgyline results in decreased activity of MAOA protein] which results in increased susceptibility to Methamphetamine	1905457
D003010	Clorgyline	Clorgyline results in decreased activity of MAOA protein	6443171
D003010	Clorgyline	Clorgyline results in decreased activity of MAOA protein	12818349\|1625207
D003010	Clorgyline	Phenylpropanolamine inhibits the reaction [Clorgyline results in decreased activity of MAOA protein]	3961266
D003010	Clorgyline	Clorgyline results in decreased activity of MAOA protein	11245920\|1905457
D003042	Cocaine	[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]	23499958
D003042	Cocaine	[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]	23499958
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of MAOA mRNA	24690739
D003300	Copper	Copper results in increased expression of MAOA mRNA	19781568
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of MAOA mRNA	19549813
D003407	Creosote	Creosote results in increased expression of MAOA mRNA	19389177
D003474	Curcumin	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of MAOA mRNA]	18200517
C551866	CX157	CX157 results in decreased activity of MAOA protein	22017497
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of MAOA mRNA	17403535
D016572	Cyclosporine	Cyclosporine results in decreased expression of MAOA mRNA	20106945
C017160	cypermethrin	cypermethrin results in decreased activity of MAOA protein	8385837
C014347	decitabine	decitabine affects the expression of MAOA mRNA	23300844
D003907	Dexamethasone	Dexamethasone results in increased expression of MAOA mRNA	15679045\|1594698
D003907	Dexamethasone	Dexamethasone results in increased expression of MAOA protein	15679045\|1594698
D003907	Dexamethasone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of MAOA mRNA]	15946989
D003907	Dexamethasone	Plicamycin inhibits the reaction [Dexamethasone results in increased expression of MAOA mRNA]	15946989
D003907	Dexamethasone	Dexamethasone affects the expression of MAOA protein	19969022
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of MAOA mRNA	17361019\|2126653
D002945	Cisplatin	Cisplatin affects the expression of MAOA mRNA	23300844
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of MAOA mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of MAOA mRNA	15464296\|1547189
D004006	Dichlorvos	[Dichlorvos results in decreased abundance of Oxygen] which results in decreased activity of MAOA protein	6443171
D004006	Dichlorvos	Dichlorvos results in decreased activity of MAOA protein	12018584
D004008	Diclofenac	Diclofenac affects the expression of MAOA mRNA	24752500
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of MAOA mRNA	19850644
D004051	Diethylhexyl Phthalate	PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of MAOA mRNA]	19850644
C014476	diethyl maleate	diethyl maleate results in increased expression of MAOA mRNA	25270620
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of MAOA mRNA	24535843
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MAOA mRNA	18544905
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of MAOA mRNA	10811566\|1133165
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of MAOA mRNA	15289156
D002117	Calcitriol	[Calcitriol co-treated with VDR protein] results in decreased expression of MAOA mRNA	27450565
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in increased expression of MAOA mRNA	27638505
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of MAOA mRNA	24690739
D004237	Diuron	[Atrazine co-treated with Diuron co-treated with isoproturon] affects the expression of MAOA mRNA	15245914
D004237	Diuron	Diuron results in decreased expression of MAOA mRNA	25152437
D004237	Diuron	Diuron results in increased expression of MAOA mRNA	21551480
D016291	Dizocilpine Maleate	Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased activity of MAOA protein]	12885441
D004298	Dopamine	"3,4-Methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Dopamine]"	26721607
D004298	Dopamine	MAOA protein results in decreased amination of Dopamine	26721607
D004298	Dopamine	"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Dopamine]"	26721607
D004298	Dopamine	MAOA mutant form results in increased abundance of Dopamine	11834493
D004298	Dopamine	MAOA protein affects the metabolism of Dopamine	7430361
D004298	Dopamine	MAOA protein results in increased metabolism of Dopamine	18361446\|2140513
D004298	Dopamine	MAOA protein results in increased oxidation of Dopamine	21923198
D004317	Doxorubicin	Doxorubicin results in increased expression of MAOA mRNA	19915844
D004726	Endosulfan	Endosulfan results in decreased expression of MAOA mRNA	26615145
D004726	Endosulfan	Endosulfan results in increased expression of MAOA mRNA	26615145
C118739	entinostat	entinostat results in increased expression of MAOA mRNA	26272509\|2718838
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAOA mRNA"	27188386
D004837	Epinephrine	MAOA protein results in decreased amination of Epinephrine	22023459
D004837	Epinephrine	MAOA protein results in increased metabolism of Epinephrine	18361446\|2140513
D004837	Epinephrine	MAOA protein results in increased oxidation of Epinephrine	21923198
C107376	esuprone	esuprone results in decreased activity of MAOA protein	21923181
D000431	Ethanol	Ethanol results in decreased activity of MAOA protein	28057462
D000431	Ethanol	Ethanol affects the expression of MAOA mRNA	11772933
C017690	fenvalerate	fenvalerate results in decreased activity of MAOA protein	8385837
D018120	Finasteride	Finasteride results in increased expression of MAOA mRNA	24136188
C028610	flavanone	flavanone results in decreased activity of MAOA protein	23009399
C043562	flavone	flavone results in decreased activity of MAOA protein	23009399
D005473	Fluoxetine	MAOA gene polymorphism affects the susceptibility to Fluoxetine	25369145
D005485	Flutamide	Flutamide results in decreased expression of MAOA mRNA	24793618
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MAOA mRNA	20938992
D005632	Fructose	[Fructose co-treated with bisphenol A] results in increased expression of MAOA protein	26930160
D019833	Genistein	Genistein results in increased expression of MAOA mRNA	11331657
D019833	Genistein	Genistein results in decreased expression of MAOA mRNA	15289156
C010974	glyphosate	glyphosate affects the expression of MAOA mRNA	15245914
D006220	Haloperidol	Haloperidol results in increased activity of MAOA protein	8160492
D006246	Harmaline	Harmaline results in decreased activity of MAOA protein	28302559
D006246	Harmaline	Harmaline results in decreased activity of MAOA protein	15178694\|2437388
C005010	harman	harman results in decreased activity of MAOA protein	28057462
D006247	Harmine	Harmine results in decreased activity of MAOA protein	28302559
D006247	Harmine	Harmine analog binds to MAOA protein	9290071
D006247	Harmine	Harmine results in decreased activity of MAOA protein	24373881
C010178	heliotrine	heliotrine results in decreased expression of MAOA mRNA	26100227
D012701	Serotonin	"3,4-Methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Serotonin]"	26721607
D012701	Serotonin	MAOA gene polymorphism results in increased abundance of Serotonin	18405062
D012701	Serotonin	MAOA protein results in decreased amination of Serotonin	26721607
D012701	Serotonin	MAOA protein results in increased metabolism of Serotonin	10647887
D012701	Serotonin	Moclobemide inhibits the reaction [MAOA protein results in decreased amination of Serotonin]	26721607
D012701	Serotonin	"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Serotonin]"	26721607
D012701	Serotonin	Phenylpropanolamine inhibits the reaction [MAOA protein results in increased degradation of Serotonin]	3961266
D012701	Serotonin	Luteolin inhibits the reaction [MAOA protein results in increased metabolism of Serotonin]	23009399
D012701	Serotonin	Luteolin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]	23009399
D012701	Serotonin	MAOA mutant form results in increased abundance of Serotonin	11834493
D012701	Serotonin	MAOA protein results in increased metabolism of Serotonin	23009399
D012701	Serotonin	[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde	23009399
D012701	Serotonin	Quercetin inhibits the reaction [MAOA protein results in increased metabolism of Serotonin]	23009399
D012701	Serotonin	Quercetin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]	23009399
D012701	Serotonin	Serotonin results in increased activity of MAOA protein	17561096
D012701	Serotonin	MAOA protein results in decreased amination of Serotonin	22023459
D012701	Serotonin	MAOA protein results in increased metabolism of Serotonin	18361446\|2140513
D012701	Serotonin	MAOA protein results in increased oxidation of Serotonin	21923198\|7430361
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of MAOA mRNA	17183730
D006838	Hydrocarbons	Hydrocarbons results in increased expression of MAOA mRNA	15245914
D006854	Hydrocortisone	Hydrocortisone results in increased expression of MAOA mRNA	21267416
C004277	hydroxyindoleacetaldehyde	Luteolin inhibits the reaction [MAOA protein results in increased abundance of hydroxyindoleacetaldehyde]	23009399
C004277	hydroxyindoleacetaldehyde	Luteolin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]	23009399
C004277	hydroxyindoleacetaldehyde	MAOA protein results in increased abundance of hydroxyindoleacetaldehyde	23009399
C004277	hydroxyindoleacetaldehyde	[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde	23009399
C004277	hydroxyindoleacetaldehyde	Quercetin inhibits the reaction [MAOA protein results in increased abundance of hydroxyindoleacetaldehyde]	23009399
C004277	hydroxyindoleacetaldehyde	Quercetin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]	23009399
C001655	indoleacetaldehyde	[MAOA protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indoleacetaldehyde	26686552
C001655	indoleacetaldehyde	"[[MAOA protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indoleacetaldehyde] which results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole"	26686552
C001655	indoleacetaldehyde	MAOA protein results in increased chemical synthesis of indoleacetaldehyde	26686552
C015293	indopan	indopan results in decreased activity of MAOA protein	28302559
D007501	Iron	MAOA gene polymorphism affects the susceptibility to Iron deficiency	22340208
D007501	Iron	Iron deficiency results in decreased expression of MAOA mRNA	16629162
D019266	Iron, Dietary	"MAOA gene polymorphism affects the susceptibility to Iron, Dietary"	25351859
D019266	Iron, Dietary	"Iron, Dietary affects the expression of MAOA mRNA"	15637178
D007529	Isoflavones	Isoflavones results in decreased expression of MAOA mRNA	17374662
C028904	isoproturon	[Atrazine co-treated with Diuron co-treated with isoproturon] affects the expression of MAOA mRNA	15245914
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of MAOA mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of MAOA mRNA	26752646
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MAOA mRNA	18544905
D007854	Lead	Lead affects the activity of MAOA protein	11460677
C052901	lemongrass oil	lemongrass oil results in decreased expression of MAOA mRNA	25660481
D000069349	Linezolid	Linezolid results in decreased activity of MAOA protein	14531724
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of MAOA mRNA"	24972896
D047311	Luteolin	Luteolin results in decreased activity of MAOA protein	23009399
D047311	Luteolin	Luteolin inhibits the reaction [MAOA protein results in increased abundance of hydroxyindoleacetaldehyde]	23009399
D047311	Luteolin	Luteolin inhibits the reaction [MAOA protein results in increased metabolism of Serotonin]	23009399
D047311	Luteolin	Luteolin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]	23009399
D047311	Luteolin	Luteolin results in decreased activity of MAOA protein	23009399
D008676	Metanephrine	MAOA protein affects the abundance of Metanephrine	22569243
D008694	Methamphetamine	[Clorgyline results in decreased activity of MAOA protein] which results in increased susceptibility to Methamphetamine	1905457
D008694	Methamphetamine	MAOA protein affects the susceptibility to Methamphetamine	1905457
D008694	Methamphetamine	Methamphetamine results in increased expression of MAOA mRNA	19149911
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MAOA mRNA	20938992
D008727	Methotrexate	Methotrexate results in increased expression of MAOA mRNA	21678067
C005219	methyl cellosolve	methyl cellosolve results in increased expression of MAOA mRNA	21061450
D015104	3,4-Methylenedioxyamphetamine	"3,4-Methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Dopamine]"	26721607
D015104	3,4-Methylenedioxyamphetamine	"3,4-Methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Serotonin]"	26721607
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Dopamine]"	26721607
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Serotonin]"	26721607
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased activity of MAOA protein"	26721607
D008743	Methyl Parathion	Methyl Parathion results in increased activity of MAOA protein	11495289
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of MAOA mRNA	25234470
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of MAOA mRNA	25234470
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MAOA mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA]"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAOA mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA]"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"MAOA protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"	21696156
D015741	Metribolone	Metribolone promotes the reaction [NDRG1 protein binds to MAOA protein]	17220478
D015735	Mifepristone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of MAOA mRNA]	15946989
D020912	Moclobemide	Moclobemide inhibits the reaction [MAOA protein results in decreased amination of Serotonin]	26721607
D020912	Moclobemide	Moclobemide results in decreased activity of MAOA protein	21923181
D020912	Moclobemide	Moclobemide results in decreased activity of MAOA protein	23943324
D020912	Moclobemide	Moclobemide results in decreased activity of MAOA protein	15178694\|1554529
D020912	Moclobemide	Moclobemide results in decreased activity of MAOA protein	21696156\|2201749
D008999	Monocrotophos	Monocrotophos results in decreased activity of MAOA protein	12018584
C091888	monoisoamyl-2,3-dimercaptosuccinate	"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]"	23376091
C091888	monoisoamyl-2,3-dimercaptosuccinate	"monoisoamyl-2,3-dimercaptosuccinate promotes the reaction [Succimer inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]]"	23376091
C091888	monoisoamyl-2,3-dimercaptosuccinate	"Succimer promotes the reaction [monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]]"	23376091
D009002	Monomethylhydrazine	Monomethylhydrazine results in increased activity of MAOA protein	8583353
C523799	MRK 003	MAOA results in decreased susceptibility to MRK 003	19903844
C570530	N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine	N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine results in decreased activity of MAOA protein	22023459
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of MAOA mRNA"	25554681
C051752	nefazodone	nefazodone results in increased expression of MAOA mRNA	24136188
D009532	Nickel	Nickel results in decreased expression of MAOA mRNA	25583101
C029938	nickel sulfate	nickel sulfate results in increased expression of MAOA mRNA	16780908
D009538	Nicotine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAOA mRNA"	20230807
D009538	Nicotine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA]"	20230807
D009599	Nitroprusside	[MAOB protein co-treated with MAOA protein] affects the susceptibility to Nitroprusside	11834493
C005514	N,N'-monomethylenebis(pyridiniumaldoxime)	"N,N'-monomethylenebis(pyridiniumaldoxime) results in decreased activity of MAOA protein"	21195145
D009638	Norepinephrine	MAOA protein results in increased metabolism of Norepinephrine	10647887
D009638	Norepinephrine	MAOA mutant form results in increased abundance of Norepinephrine	11834493
D009638	Norepinephrine	MAOA protein results in decreased amination of Norepinephrine	22023459
D009638	Norepinephrine	MAOA protein results in increased metabolism of Norepinephrine	18361446\|2140513
D009638	Norepinephrine	MAOA protein results in increased oxidation of Norepinephrine	21923198\|7430361
C010262	norharman	norharman results in decreased activity of MAOA protein	28057462
C423264	(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate	(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate results in decreased activity of MAOA protein	16086033
D009768	Obidoxime Chloride	Obidoxime Chloride results in decreased activity of MAOA protein	21195145
C025589	ochratoxin A	ochratoxin A results in increased methylation of MAOA gene	26431795
C076029	olanzapine	olanzapine results in increased expression of MAOA mRNA	15964593
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of MAOA mRNA"	21673326
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of MAOA mRNA]"	21673326
D010100	Oxygen	Oxygen deficiency results in decreased expression of MAOA mRNA	19695866
D010100	Oxygen	[Dichlorvos results in decreased abundance of Oxygen] which results in decreased activity of MAOA protein	6443171
D010100	Oxygen	Oxygen deficiency results in decreased activity of MAOA protein	6443171
C013638	paeonol	paeonol results in decreased activity of MAOA protein	15120460
D010293	Pargyline	[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]	23499958
D010293	Pargyline	[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]	23499958
D010293	Pargyline	Pargyline results in decreased activity of MAOA protein	20716577
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of MAOA protein	26879310
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of MAOA mRNA	19162173
D010627	Phenethylamines	MAOA mutant form results in increased abundance of Phenethylamines	11834493
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of MAOA mRNA	24535843
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MAOA mRNA]	19482888
D010634	Phenobarbital	Phenobarbital affects the expression of MAOA mRNA	19136022
D010634	Phenobarbital	Phenobarbital results in increased expression of MAOA mRNA	19482888
D010656	Phenylephrine	[MAOB protein co-treated with MAOA protein] affects the susceptibility to Phenylephrine	11834493
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAOA mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of MAOA mRNA	26272509
D010665	Phenylpropanolamine	Phenylpropanolamine inhibits the reaction [MAOA protein results in increased degradation of Serotonin]	3961266
D010665	Phenylpropanolamine	Phenylpropanolamine results in decreased activity of MAOA protein	3961266
D010665	Phenylpropanolamine	Phenylpropanolamine inhibits the reaction [Clorgyline results in decreased activity of MAOA protein]	3961266
D010665	Phenylpropanolamine	Phenylpropanolamine results in decreased activity of MAOA protein	3961266
D010707	Phosphamidon	Phosphamidon results in decreased activity of MAOA protein	12018584
D010795	Phthalic Acids	Phthalic Acids results in increased expression of MAOA mRNA	21061450
C008922	piperine	[resveratrol co-treated with piperine] results in decreased activity of MAOA protein	23943324
C008922	piperine	piperine results in decreased activity of MAOA protein	15120460
C006253	pirinixic acid	pirinixic acid affects the expression of MAOA mRNA	19136022
C006253	pirinixic acid	pirinixic acid results in increased expression of MAOA mRNA	18301758\|2381119
C006253	pirinixic acid	pirinixic acid results in increased expression of MAOA mRNA	19162173
C009830	pirlindole	pirlindole results in decreased activity of MAOA protein	21923198
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Smoke results in decreased activity of MAOA protein]	24257033
D008926	Plicamycin	Plicamycin inhibits the reaction [Dexamethasone results in increased expression of MAOA mRNA]	15946989
D011084	Polycyclic Aromatic Hydrocarbons	Polycyclic Aromatic Hydrocarbons affects the expression of MAOA mRNA	22579512
C028797	pralidoxime	pralidoxime results in decreased activity of MAOA protein	21195145
D011344	Procarbazine	Procarbazine results in increased activity of MAOA protein	8583353
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of MAOA mRNA	20660070
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of MAOA mRNA	17404688
D011374	Progesterone	Progesterone results in increased expression of MAOA mRNA	17404688\|2086464
D011374	Progesterone	Progesterone results in decreased expression of MAOA	17510236
C005556	propionaldehyde	propionaldehyde results in increased expression of MAOA mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of MAOA mRNA	24780913
D011763	Pyrrolizidine Alkaloids	Pyrrolizidine Alkaloids results in decreased expression of MAOA mRNA	26100227
D011794	Quercetin	Quercetin results in decreased expression of MAOA mRNA	21632981
D011794	Quercetin	Quercetin inhibits the reaction [MAOA protein results in increased abundance of hydroxyindoleacetaldehyde]	23009399
D011794	Quercetin	Quercetin inhibits the reaction [MAOA protein results in increased metabolism of Serotonin]	23009399
D011794	Quercetin	Quercetin inhibits the reaction [[MAOA protein results in increased metabolism of Serotonin] which results in increased abundance of hydroxyindoleacetaldehyde]	23009399
D011794	Quercetin	Quercetin results in decreased activity of MAOA protein	23009399
D017382	Reactive Oxygen Species	[Tyramine results in increased activity of MAOA protein] promotes the reaction [[Reactive Oxygen Species results in increased activity of MMP2 protein] which results in increased activity of SMPD3 protein]	17561096
C059514	resveratrol	[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]	23499958
C059514	resveratrol	[resveratrol co-treated with piperine] results in decreased activity of MAOA protein	23943324
C059514	resveratrol	resveratrol results in decreased activity of MAOA protein	23499958
D018967	Risperidone	MAOA gene polymorphism affects the susceptibility to Risperidone	22544010
D018967	Risperidone	MAOA protein results in increased susceptibility to Risperidone	22544010
C063456	Ro 41-1049	Ro 41-1049 binds to and results in decreased activity of MAOA protein	7816197
C063456	Ro 41-1049	Ro 41-1049 binds to MAOA protein	21075085\|9045087
C063456	Ro 41-1049	Ro 41-1049 results in decreased activity of MAOA protein	12818349
C089730	rosiglitazone	rosiglitazone results in decreased activity of MAOA protein	22282722
C041376	rosmarinic acid	rosmarinic acid results in decreased activity of MAOA protein	27270453
C009237	senecionine	senecionine results in decreased expression of MAOA mRNA	26100227
C009238	senkirkine	senkirkine results in decreased expression of MAOA mRNA	26100227
D020280	Sertraline	MAOA protein results in decreased amination of and results in increased metabolism of Sertraline	15547048
D012906	Smoke	Plant Extracts inhibits the reaction [Smoke results in decreased activity of MAOA protein]	24257033
D012906	Smoke	Smoke results in decreased activity of MAOA protein	24257033
C017947	sodium arsenite	"2,3-dimercaptosuccinic acid monocyclohexyl ester inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]"	23376091
C017947	sodium arsenite	"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]"	23376091
C017947	sodium arsenite	"monoisoamyl-2,3-dimercaptosuccinate promotes the reaction [Succimer inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]]"	23376091
C017947	sodium arsenite	sodium arsenite results in increased expression of MAOA protein	23376091
C017947	sodium arsenite	Succimer inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]	23376091
C017947	sodium arsenite	"Succimer promotes the reaction [monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]]"	23376091
C017947	sodium arsenite	sodium arsenite results in increased expression of MAOA mRNA	22714537
C017947	sodium arsenite	sodium arsenite promotes the reaction [Sodium Fluoride results in increased activity of MAOA protein]	19635623
D012969	Sodium Fluoride	sodium arsenite promotes the reaction [Sodium Fluoride results in increased activity of MAOA protein]	19635623
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of MAOA protein	27548804
D012969	Sodium Fluoride	Sodium Fluoride results in increased activity of MAOA protein	19635623
C051273	SR 95191	SR 95191 binds to and results in decreased activity of MAOA protein	3100770
D004113	Succimer	"monoisoamyl-2,3-dimercaptosuccinate promotes the reaction [Succimer inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]]"	23376091
D004113	Succimer	Succimer inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]	23376091
D004113	Succimer	"Succimer promotes the reaction [monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in increased expression of MAOA protein]]"	23376091
D013467	Sulindac	Sulindac results in decreased expression of MAOA mRNA	24136188
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in decreased expression of MAOA mRNA	26496021
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MAOA mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MAOA mRNA	23152189
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MAOA mRNA	19770486\|1993321
D019284	Thapsigargin	Thapsigargin results in decreased expression of MAOA mRNA	22378314
D013849	Thimerosal	"[NOG protein co-treated with Thimerosal co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAOA mRNA"	27188386
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased activity of MAOA protein	28057462
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of MAOA mRNA	28065790
C010798	toloxatone	toloxatone results in decreased activity of MAOA protein	15178694
C010798	toloxatone	toloxatone results in decreased activity of MAOA protein	22017497
D014050	Toluene	Toluene affects the expression of MAOA mRNA	21827849
D014191	Tranylcypromine	Tranylcypromine results in decreased activity of MAOA protein	6443171
D014212	Tretinoin	Tretinoin results in decreased expression of MAOA mRNA	23724009
C039776	tribulin	tribulin results in decreased activity of MAOA protein	8744988
C012589	trichostatin A	trichostatin A results in increased expression of MAOA mRNA	24935251
D014289	Trimedoxime	Trimedoxime results in decreased activity of MAOA protein	21195145
D014302	Trinitrobenzenesulfonic Acid	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of MAOA mRNA]	18200517
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in decreased expression of MAOA mRNA	18200517
C057693	troglitazone	troglitazone results in decreased activity of MAOA protein	22282722
C057693	troglitazone	troglitazone results in increased expression of MAOA mRNA	19140230
C030820	tryptamine	MAOA protein results in decreased amination of tryptamine	26686552
C030820	tryptamine	[MAOA protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indoleacetaldehyde	26686552
C030820	tryptamine	"[[MAOA protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indoleacetaldehyde] which results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole"	26686552
C030820	tryptamine	MAOA protein results in increased metabolism of tryptamine	21405131
C030820	tryptamine	MAOA protein results in increased oxidation of tryptamine	21923198
D014439	Tyramine	MAOA protein results in increased metabolism of Tyramine	10647887
D014439	Tyramine	[Tyramine results in increased activity of MAOA protein] promotes the reaction [[Reactive Oxygen Species results in increased activity of MMP2 protein] which results in increased activity of SMPD3 protein]	17561096
D014439	Tyramine	MAOA protein results in increased metabolism of Tyramine	21405131
D014439	Tyramine	MAOA protein results in increased oxidation of Tyramine	21923198
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of MAOA mRNA	17183730
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAOA mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of MAOA mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of MAOA mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in increased methylation of MAOA gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of MAOA gene	25560391
C029297	vinylidene chloride	vinylidene chloride results in increased expression of MAOA mRNA	26682919
C111237	vorinostat	vorinostat results in increased expression of MAOA mRNA	27188386
D015016	Yohimbine	Yohimbine results in decreased activity of MAOA protein	28302559
D015029	Zeranol	Zeranol results in increased expression of MAOA mRNA	10811566\|1133165

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0008131	primary amine oxidase activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006576	cellular biogenic amine metabolic process	-	TAS	8211186
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0042133	neurotransmitter metabolic process	-	TAS	-
GO:0042135	neurotransmitter catabolic process	-	IEA	-
GO:0042420	dopamine catabolic process	-	TAS	24252804
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005739	mitochondrion	-	HDA	20833797
GO:0005739	mitochondrion	-	IDA	-
GO:0005741	mitochondrial outer membrane	-	TAS	24252804
GO:0016021	integral component of membrane	-	IEA	-

KEGG ID	KEGG Term
hsa00260	Glycine, serine and threonine metabolism
hsa00330	Arginine and proline metabolism
hsa00340	Histidine metabolism
hsa00350	Tyrosine metabolism
hsa00360	Phenylalanine metabolism
hsa00380	Tryptophan metabolism
hsa00982	Drug metabolism - cytochrome P450
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-112310	Neurotransmitter release cycle	TAS
R-HSA-112311	Neurotransmitter clearance	TAS
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112316	Neuronal System	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-140179	Amine Oxidase reactions	TAS
R-HSA-141333	Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-1643685	Disease	TAS
R-HSA-168256	Immune System	TAS
R-HSA-181430	Norepinephrine Neurotransmitter Release Cycle	TAS
R-HSA-211859	Biological oxidations	TAS
R-HSA-211945	Phase I - Functionalization of compounds	TAS
R-HSA-379397	Enzymatic degradation of dopamine by COMT	TAS
R-HSA-379398	Enzymatic degradation of Dopamine by monoamine oxidase	TAS
R-HSA-379401	Dopamine clearance from the synaptic cleft	TAS
R-HSA-380612	Metabolism of serotonin	TAS
R-HSA-380615	Serotonin clearance from the synaptic cleft	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-5579012	Defective MAOA causes Brunner syndrome (BRUNS)	TAS
R-HSA-5579029	Metabolic disorders of biological oxidation enzymes	TAS
R-HSA-5668914	Diseases of metabolism	TAS
R-HSA-6785807	Interleukin-4 and 13 signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19247474	Genome-wide and candidate gene association study of cigarette smoking behaviors. (2009)	Caporaso N	PLoS One
18405071	Alcohol dependence and polymorphisms of serotonin-related genes: association studies. (2008 Jan)	Mokrovic G	Coll Antropol
9326944	Increased stress response and beta-phenylethylamine in MAOB-deficient mice. (1997 Oct)	Grimsby J	Nat Genet
18827956	Serotonin transporter (5-HTTLPR) and monoamine oxidase (MAOA) promoter polymorphisms in women with severe alcoholism. (2008 Dec)	Gokturk C	Arch Womens Ment Health
18188752	Interactions between genotype and retrospective ADHD symptoms predict lifetime smoking risk in a sample of young adults. (2008 Jan)	McClernon FJ	Nicotine Tob Res
16526025	MAOA-uVNTR polymorphism in a Brazilian sample: further support for the association with impulsive behaviors and alcohol dependence. (2006 Apr 5)	Contini V	Am J Med Genet B Neuropsychiatr Genet
11134668	Pharmacogenetics and the serotonin system: initial studies and future directions. (2000 Dec 27)	Veenstra-VanderWeele J	Eur J Pharmacol
26447226	Influence of Dopaminergic System Genetic Variation and Lifestyle Factors on Excessive Alcohol Consumption. (2016 May)	Celorrio D	Alcohol Alcohol
25655461	Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. (2015 Apr 15)	Manzardo AM	Gene
22297589	Moderating role of the MAOA genotype in antisocial behaviour. (2012 Feb)	Fergusson DM	Br J Psychiatry
27613936	High Prevalence of Smoking in the Roma Population Seems to Have No Genetic Background. (2016 Dec)	Fiatal S	Nicotine Tob Res
21778150	A preliminary analysis of interactions between genotype, retrospective ADHD symptoms, and initial reactions to smoking in a sample of young adults. (2012 Feb)	Bidwell LC	Nicotine Tob Res
10943908	Different allele distribution of a regulatory MAOA gene promoter polymorphism in antisocial and anxious-depressive alcoholics. (2000)	Schmidt LG	J Neural Transm (Vienna)
18454435	MAOA methylation is associated with nicotine and alcohol dependence in women. (2008 Jul 5)	Philibert RA	Am J Med Genet B Neuropsychiatr Genet
24837582	Monoamine polygenic liability in health and cocaine dependence: imaging genetics study of aversive processing and associations with depression symptomatology. (2014 Jul 1)	Moeller SJ	Drug Alcohol Depend
19302089	MAOA-uVNTR polymorphism may modify the protective effect of ALDH2 gene against alcohol dependence in antisocial personality disorder. (2009 Jun)	Lee SY	Alcohol Clin Exp Res
23215821	Gene-environment interaction in externalizing problems among adolescents: evidence from the Pelotas 1993 Birth Cohort Study. (2013 Mar)	Kieling C	J Child Psychol Psychiatry
21383264	Gene x disease interaction on orbitofrontal gray matter in cocaine addiction. (2011 Mar)	Alia-Klein N	Arch Gen Psychiatry
7485245	Preliminary evidence for an association of a dinucleotide repeat polymorphism at the MAOA gene with early onset alcoholism/substance abuse. (1995 Apr 24)	Vanyukov MM	Am J Med Genet
17347351	Genetic and environmental influences on the development of alcoholism: resilience vs. risk. (2006 Dec)	Enoch MA	Ann N Y Acad Sci
18592036	Is fetal brain monoamine oxidase inhibition the missing link between maternal smoking and conduct disorders? (2008 May)	Baler RD	J Psychiatry Neurosci
19777560	The effect of smoking on MAOA promoter methylation in DNA prepared from lymphoblasts and whole blood. (2010 Mar 5)	Philibert RA	Am J Med Genet B Neuropsychiatr Genet
19415821	Gene-gene interactions of CYP2A6 and MAOA polymorphisms on smoking behavior in Chinese male population. (2009 May)	Tang X	Pharmacogenet Genomics
25660313	Meta-analysis of six genes (BDNF, DRD1, DRD3, DRD4, GRIN2B and MAOA) involved in neuroplasticity and the risk for alcohol dependence. (2015 Apr 1)	Forero DA	Drug Alcohol Depend
23044341	Association study of DRD2 and MAOA genes with subtyped alcoholism comorbid with bipolar disorder in Han Chinese. (2013 Jan 10)	Hu MC	Prog Neuropsychopharmacol Biol Psychiatry
16272956	CYP2A6, MAOA, DBH, DRD4, and 5HT2A genotypes, smoking behaviour and cotinine levels in 1518 UK adolescents. (2005 Dec)	Huang S	Pharmacogenet Genomics
15251892	The use of adolescent nonhuman primates to model human alcohol intake: neurobiological, genetic, and psychological variables. (2004 Jun)	Barr CS	Ann N Y Acad Sci
19120058	Effects of MAOA-genotype, alcohol consumption, and aging on violent behavior. (2009 Mar)	Tikkanen R	Alcohol Clin Exp Res
16207390	Association between monoamine oxidase gene polymorphisms and smoking behaviour in Chinese males. (2006 Oct)	Jin Y	Int J Neuropsychopharmacol
28163169	Does MAOA increase susceptibility to prenatal stress in young children? (2017 May)	Massey SH	Neurotoxicol Teratol
17592478	Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women. (2008 Mar)	Ducci F	Mol Psychiatry
10359483	Association of a regulatory polymorphism in the promoter region of the monoamine oxidase A gene with antisocial alcoholism. (1999 Apr 19)	Samochowiec J	Psychiatry Res
16770335	A functional polymorphism in the MAOA gene promoter (MAOA-LPR) predicts central dopamine function and body mass index. (2006 Sep)	Ducci F	Mol Psychiatry
23504072	Association of VMAT2 gene polymorphisms with alcohol dependence. (2013 Aug)	Fehr C	J Neural Transm (Vienna)
21445666	Family-based association analysis of alcohol dependence in the COGA sample and replication in the Australian twin-family study. (2011 Sep)	Wang KS	J Neural Transm (Vienna)
19615672	Reduced monoamine oxidase A activity in pregnant smokers and in their newborns. (2009 Oct 15)	Berlin I	Biol Psychiatry
29600412	Associations of monoamine oxidase A gene first exon methylation with sexual abuse and current depression in women. (2018 Mar 29)	Checknita D	J Neural Transm (Vienna)
17885625	Association study of monoamine oxidase and catechol-O-methyltransferase genes with smoking behavior. (2007 Oct)	Tochigi M	Pharmacogenet Genomics
28858992	The genotypes and methylation of MAO genes as factors behind smoking behavior. (2017 Nov)	Tiili EM	Pharmacogenet Genomics
27112218	Platelet monoamine oxidase type B, MAOB intron 13 and MAOA-uVNTR polymorphism and symptoms of post-traumatic stress disorder. (2016 Jul)	Svob Strac D	Stress
24080236	Variation of types of alcoholism: review and subtypes identified in Han Chinese. (2014 Jan 3)	Lee SY	Prog Neuropsychopharmacol Biol Psychiatry
25809512	Monoamine oxidase a promoter variable number of tandem repeats (MAOA-uVNTR) in alcoholics according to Lesch typology. (2015 Mar 19)	Samochowiec A	Int J Environ Res Public Health
8780428	Association of monoamine oxidase A alleles with alcoholism among male Chinese in Taiwan. (1996 Sep)	Hsu YP	Am J Psychiatry
28259004	Age-dependent role of pre- and perinatal factors in interaction with genes on ADHD symptoms across adolescence. (2017 Jul)	Brinksma DM	J Psychiatr Res
20477771	MAOA interacts with the ALDH2 gene in anxiety-depression alcohol dependence. (2010 Jul)	Lee SY	Alcohol Clin Exp Res
22494506	The 'warrior gene' and the Maori people: the responsibility of the geneticists. (2013 Sep)	Perbal L	Bioethics
26851573	Monoamine oxidase and agitation in psychiatric patients. (2016 Aug 1)	Nikolac Perkovic M	Prog Neuropsychopharmacol Biol Psychiatry
22544010	Different impacts of aquaporin 4 and MAOA allele variation among olanzapine, risperidone, and paliperidone in schizophrenia. (2012 Jun)	Chung TS	J Clin Psychopharmacol
22948232	Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men. (2012 Oct)	Shumay E	Epigenetics
17007976	Possible interaction between MAOA and DRD2 genes associated with antisocial alcoholism among Han Chinese men in Taiwan. (2007 Jan 30)	Wang TJ	Prog Neuropsychopharmacol Biol Psychiatry
22610759	A latent modeling approach to genotype-phenotype relationships: maternal problem behavior clusters, prenatal smoking, and MAOA genotype. (2012 Aug)	McGrath LM	Arch Womens Ment Health
11927135	Analysis of monoamine oxidase A (MAOA) promoter polymorphism in Finnish male alcoholics. (2002 Mar 15)	Saito T	Psychiatry Res
11999895	No association of the MAOA gene with alcoholism among Han Chinese males in Taiwan. (2002 Apr)	Lu RB	Prog Neuropsychopharmacol Biol Psychiatry
26015071	Effects of Interaction Between Dopamine D2 Receptor and Monoamine Oxidase A Genes on Smoking Status in Young Men. (2015 Jul)	Huang CL	Biol Res Nurs
27300740	Interacting effect of MAOA genotype and maternal prenatal smoking on aggressive behavior in young adulthood. (2016 Aug)	Hohmann S	J Neural Transm (Vienna)
17476365	Monoamine oxidase-A polymorphisms might modify the association between the dopamine D2 receptor gene and alcohol dependence. (2007 May)	Huang SY	J Psychiatry Neurosci
20810002	Relationship of monoamine oxidase A binding to adaptive and maladaptive personality traits. (2011 May)	Soliman A	Psychol Med