Gene info: ID 4129

Gene: MAOB

GENE ID: 4129

Synonyms: -

Description: monoamine oxidase B

Gene type: protein-coding

Location: Xp11.3

dbXrefs: Ensembl:ENSG00000069535 MIM:309860 Vega:OTTHUMG00000021388 UniprotKB:P27338

RefSeq: NG_008723.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 20

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TMED10	0.84
CAPZA1	0.823
SORBS1	0.816
KDELR1	0.809
CYB5B	0.809
DPYSL3	0.805
CD59	0.8
USP39	0.791
IMPDH2	0.789
STAT5B	0.785

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.657
OR4F29	-0.628
EDN3	-0.238
RERGL	-0.232
TDGF1	-0.227
HCRTR1	-0.226
HES5	-0.193
CYP1A1	-0.187
ACY3	-0.184
CRH	-0.179

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00182	Amphetamine	Small Molecule	300-62-9	Approved\|Illicit\|Investigational	Target
DB00191	Phentermine	Small Molecule	122-09-8	Approved\|Illicit	Target
DB00752	Tranylcypromine	Small Molecule	155-09-9	Approved\|Investigational	Target
DB00780	Phenelzine	Small Molecule	51-71-8	Approved	Target
DB00909	Zonisamide	Small Molecule	68291-97-4	Approved\|Investigational	Target
DB01037	Selegiline	Small Molecule	14611-51-9	Approved\|Investigational	Target
DB01132	Pioglitazone	Small Molecule	111025-46-8	Approved\|Investigational	Target
DB01171	Moclobemide	Small Molecule	71320-77-9	Approved\|Investigational	Target
DB01247	Isocarboxazid	Small Molecule	59-63-2	Approved	Target
DB01363	Ephedra	Small Molecule	-	Approved\|Nutraceutical\|Withdrawn	Target
DB01367	Rasagiline	Small Molecule	136236-51-6	Approved	Target
DB01442	MMDA	Small Molecule	13674-05-0	Experimental\|Illicit	Target
DB01472	4-Methoxyamphetamine	Small Molecule	64-13-1	Experimental\|Illicit	Target
DB01577	Methamphetamine	Small Molecule	537-46-2	Approved\|Illicit	Target
DB01626	Pargyline	Small Molecule	555-57-7	Approved	Target
DB02095	Isatin	Small Molecule	91-56-5	Experimental	Target
DB02211	N-Methyl-N-Propargyl-1(R)-Aminoindan	Small Molecule		Experimental	Target
DB02509	Farnesol	Small Molecule	4602-84-0	Experimental	Target
DB02643	N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate	Small Molecule		Experimental	Target
DB03147	Flavin adenine dinucleotide	Small Molecule	146-14-5	Approved	Target
DB03894	N-Propargyl-1(S)-Aminoindan	Small Molecule		Experimental	Target
DB04147	Lauryl Dimethylamine-N-Oxide	Small Molecule		Experimental	Target
DB04307	5-Hydroxy-N-Propargyl-1(R)-Aminoindan	Small Molecule		Experimental	Target
DB04677	N-METHYL-N-[(1R)-1-METHYL-2-PHENYLETHYL]PROP-2-EN-1-AMINE	Small Molecule		Experimental	Target
DB04820	Nialamide	Small Molecule	51-12-7	Withdrawn	Target
DB04821	Nomifensine	Small Molecule	24526-64-5	Withdrawn	Target
DB04832	Zimelidine	Small Molecule	56775-88-3	Withdrawn	Target
DB06654	Safinamide	Small Molecule	133865-89-1	Approved\|Investigational	Target
DB07512	7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE	Small Molecule		Experimental	Target
DB07513	7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE	Small Molecule		Experimental	Target
DB08082	N-(2-AMINOETHYL)-P-CHLOROBENZAMIDE	Small Molecule		Experimental	Target
DB08176	(1Z)-4-(4-FLUOROPHENYL)-2-METHYLIDENEBUTAN-1-IMINE	Small Molecule		Experimental	Target
DB08480	4-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN	Small Molecule		Experimental	Target
DB08516	(S)-(+)-2-[4-(FLUOROBENZYLOXY-BENZYLAMINO)PROPIONAMIDE]	Small Molecule		Experimental	Target
DB00182	Amphetamine	Small Molecule	300-62-9	Approved\|Illicit\|Investigational	Target
DB00721	Procaine	Small Molecule	59-46-1	Approved\|Investigational	Target
DB01168	Procarbazine	Small Molecule	671-16-9	Approved\|Investigational	Target
DB01171	Moclobemide	Small Molecule	71320-77-9	Approved\|Investigational	Target
DB00184	Nicotine	Small Molecule	54-11-5	Approved	Enzyme
DB00191	Phentermine	Small Molecule	122-09-8	Approved\|Illicit	Enzyme
DB00601	Linezolid	Small Molecule	165800-03-3	Approved\|Investigational	Enzyme
DB00614	Furazolidone	Small Molecule	67-45-8	Approved\|Investigational	Enzyme
DB00780	Phenelzine	Small Molecule	51-71-8	Approved	Enzyme
DB00915	Amantadine	Small Molecule	768-94-5	Approved	Enzyme
DB00988	Dopamine	Small Molecule	51-61-6	Approved	Enzyme
DB01104	Sertraline	Small Molecule	79617-96-2	Approved	Enzyme
DB01171	Moclobemide	Small Molecule	71320-77-9	Approved\|Investigational	Enzyme
DB01445	Bufotenine	Small Molecule	487-93-4	Experimental\|Illicit	Enzyme
DB02095	Isatin	Small Molecule	91-56-5	Experimental	Enzyme
DB02211	N-Methyl-N-Propargyl-1(R)-Aminoindan	Small Molecule		Experimental	Enzyme
DB02509	Farnesol	Small Molecule	4602-84-0	Experimental	Enzyme
DB03147	Flavin adenine dinucleotide	Small Molecule	146-14-5	Approved	Enzyme
DB03894	N-Propargyl-1(S)-Aminoindan	Small Molecule		Experimental	Enzyme
DB04147	Lauryl Dimethylamine-N-Oxide	Small Molecule		Experimental	Enzyme
DB04307	5-Hydroxy-N-Propargyl-1(R)-Aminoindan	Small Molecule		Experimental	Enzyme
DB04818	Iproniazid	Small Molecule	54-92-2	Withdrawn	Enzyme
DB04889	Bicifadine	Small Molecule	71195-57-8	Investigational	Enzyme
DB08804	Nandrolone decanoate	Small Molecule	360-70-3	Approved\|Illicit	Enzyme
DB06778	Cupric sulfate	Small Molecule	7758-98-7	Approved	Enzyme
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Enzyme
DB09363	Rauwolfia serpentina root	Small Molecule	8063-17-0	Investigational	Enzyme

ID	Drug Name	Action	PubMed
C053052	1,4-dinitrobenzene	"1,4-dinitrobenzene results in decreased activity of MAOB protein"	6814441
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of MAOB protein"	16904659
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[methylmercury hydroxide co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased activity of MAOB protein"	16904659
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of MAOB mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of MAOB mRNA"	21346803
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MAOB mRNA"	15059925
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of MAOB mRNA]"	19467301
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of MAOB mRNA"	19692669
C081078	3-bromopropylamine	3-bromopropylamine results in decreased activity of MAOB protein	11361012
C492672	3-methoxymethyl-7-(4,4,4-trifluorobutoxy)-3,3a,4,5-tetrahydro-1,3-oxazolo(3,4-a)quinolin-1-one	"3-methoxymethyl-7-(4,4,4-trifluorobutoxy)-3,3a,4,5-tetrahydro-1,3-oxazolo(3,4-a)quinolin-1-one results in decreased activity of MAOB protein"	15178694
C008745	4,4'-bisphenol F	"4,4'-bisphenol F results in decreased expression of MAOB mRNA"	26186136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAOB mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAOB mRNA"	27188386
C035815	4-dimethylaminobenzylamine	MAOB protein results in increased oxidation of 4-dimethylaminobenzylamine	6814441
C008629	4-nitrobenzoic acid	4-nitrobenzoic acid results in decreased activity of MAOB protein	6814441
C530840	5-nitroindazole	"5-nitroindazole inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]"	21554916
C530840	5-nitroindazole	5-nitroindazole results in decreased activity of MAOB protein	21554916
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAOB mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAOB mRNA"	27188386
C111855	6-formylindolo(3,2-b)carbazole	"Glutathione inhibits the reaction [MAOB protein results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole]"	26686552
C111855	6-formylindolo(3,2-b)carbazole	"[[MAOB protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indoleacetaldehyde] which results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole"	26686552
C111855	6-formylindolo(3,2-b)carbazole	"MAOB protein results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole"	26686552
C111855	6-formylindolo(3,2-b)carbazole	"Phenelzine inhibits the reaction [MAOB protein results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole]"	26686552
C568951	6-methoxy-3-(4-methylphenyl)coumarin	6-methoxy-3-(4-methylphenyl)coumarin results in decreased activity of MAOB protein	21923181
C110418	9-mono-N'-methylnorharman	"9-mono-N'-methylnorharman inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]"	21554916
C110418	9-mono-N'-methylnorharman	9-mono-N'-methylnorharman results in decreased activity of MAOB protein	21554916
D000082	Acetaminophen	Acetaminophen results in decreased expression of MAOB mRNA	25704631\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of MAOB mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in decreased expression of MAOB mRNA	17522070
D020106	Acrylamide	Acrylamide results in decreased expression of MAOB mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of MAOB gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of MAOB mRNA	19770486
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of MAOB mRNA	28522335
C067527	aluminum maltolate	aluminum maltolate results in increased activity of MAOB protein	16087240
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MAOB mRNA	16483693
D003913	Dextroamphetamine	Dextroamphetamine results in increased expression of MAOB mRNA	12205029
D003913	Dextroamphetamine	SOD1 inhibits the reaction [Dextroamphetamine results in increased expression of MAOB mRNA]	12205029
D000661	Amphetamine	Baclofen affects the reaction [MAOB gene mutant form results in decreased susceptibility to Amphetamine]	16983645
D000661	Amphetamine	MAOB gene mutant form results in decreased susceptibility to Amphetamine	16983645
D000781	Anethole Trithione	Anethole Trithione results in decreased activity of MAOB protein	16252076
D000068180	Aripiprazole	Aripiprazole results in increased expression of MAOB mRNA	17868501
C022870	asoxime chloride	asoxime chloride results in decreased activity of MAOB protein	21195145
D001280	Atrazine	Atrazine results in decreased expression of MAOB mRNA	25929836
C547126	AZM551248	AZM551248 results in decreased expression of MAOB mRNA	22323515
D001418	Baclofen	Baclofen affects the reaction [MAOB gene mutant form results in decreased susceptibility to Amphetamine]	16983645
C032232	barbituric acid	barbituric acid analog results in decreased activity of MAOB protein	24300193
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MAOB mRNA	26238291
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MAOB mRNA	20713471
C030796	benzylamine	MAOB protein results in decreased amination of benzylamine	22023459
C030796	benzylamine	MAOB protein results in increased metabolism of benzylamine	21405131
C006723	benzyl benzoate	benzyl benzoate results in decreased activity of MAOB protein	27270453
C526327	benzyl cinnamate	benzyl cinnamate results in decreased activity of MAOB protein	27270453
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of MAOB mRNA	20660070
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of MAOB mRNA	17404688
D004958	Estradiol	Estradiol results in decreased expression of MAOB mRNA	21966433
C095105	bexarotene	bexarotene results in decreased expression of MAOB mRNA	16648578
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of MAOB mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased activity of MAOB protein	22760093
C006780	bisphenol A	bisphenol A results in decreased expression of MAOB mRNA	25181051\|2618613
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MAOB mRNA	28628672
C013418	bromfenacoum	bromfenacoum results in increased expression of MAOB protein	28903499
C018475	butyraldehyde	butyraldehyde results in decreased expression of MAOB mRNA	26079696
D002104	Cadmium	Cadmium results in increased expression of MAOB mRNA	23369406
C040048	caffeic acid	caffeic acid results in decreased activity of MAOB protein	27270453
D002220	Carbamazepine	Carbamazepine affects the expression of MAOB mRNA	24752500
D002220	Carbamazepine	Carbamazepine results in increased expression of MAOB mRNA	17112801
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of MAOB mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of MAOB mRNA	17522070
D002725	Chloroform	Chloroform results in decreased expression of MAOB mRNA	17522070
D002726	Chlorogenic Acid	Chlorogenic Acid results in decreased activity of MAOB protein	27270453
D003010	Clorgyline	[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]	23499958
D003010	Clorgyline	[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]	23499958
D003010	Clorgyline	Clorgyline results in decreased activity of MAOB protein	23943324
D003024	Clozapine	Clozapine results in increased expression of MAOB mRNA	17266109
D003042	Cocaine	[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]	23499958
D003042	Cocaine	[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]	23499958
D003407	Creosote	Creosote results in increased expression of MAOB mRNA	19389177
D003471	Cuprizone	Cuprizone results in increased expression of MAOB mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of MAOB mRNA	20106945\|2383089
D016572	Cyclosporine	Cyclosporine results in decreased expression of MAOB mRNA	19770486\|2383089
D013759	Dronabinol	Dronabinol results in increased expression of MAOB mRNA	17578508
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of MAOB mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MAOB mRNA	28628672
D003907	Dexamethasone	Dexamethasone affects the expression of MAOB protein	19969022
D064730	Dexrazoxane	[Doxorubicin co-treated with Dexrazoxane] results in increased expression of MAOB mRNA	26873546
D003976	Diazinon	Diazinon results in decreased expression of MAOB mRNA	18812211\|1883540
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of MAOB mRNA	21266533
D004006	Dichlorvos	Dichlorvos results in decreased activity of MAOB protein	12018584
D004008	Diclofenac	Diclofenac affects the expression of MAOB mRNA	24752500
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of MAOB mRNA	26924002
D004041	Dietary Fats	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of MAOB mRNA]"	19467301
D004041	Dietary Fats	Dietary Fats results in increased expression of MAOB mRNA	19467301\|2501614
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MAOB mRNA	18544905
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid] results in increased expression of MAOB mRNA	18544905
D004052	Diethylnitrosamine	[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of MAOB mRNA	18253720
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of MAOB mRNA	17394237
D002117	Calcitriol	Calcitriol results in increased expression of MAOB mRNA	26485663
D015102	3,4-Dihydroxyphenylacetic Acid	"[Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid"	16012872
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of MAOB mRNA	26924002
D004237	Diuron	Diuron results in increased expression of MAOB mRNA	21551480
D004298	Dopamine	MAOB protein results in decreased amination of Dopamine	26721607
D004298	Dopamine	"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOB protein results in decreased amination of Dopamine]"	26721607
D004298	Dopamine	Selegiline inhibits the reaction [MAOB protein results in decreased amination of Dopamine]	26721607
D004298	Dopamine	[Ro 16-6491 results in decreased activity of MAOB protein] which results in decreased susceptibility to Dopamine	20875051
D004298	Dopamine	[Selegiline results in decreased activity of MAOB protein] which results in increased abundance of Dopamine	16012872
D004298	Dopamine	MAOB protein affects the metabolism of Dopamine	7430361
D004298	Dopamine	MAOB protein results in increased metabolism of Dopamine	21405131
D004298	Dopamine	MAOB protein results in increased oxidation of Dopamine	21923198
D004317	Doxorubicin	[Doxorubicin co-treated with Dexrazoxane] results in increased expression of MAOB mRNA	26873546
D004317	Doxorubicin	Doxorubicin results in decreased expression of MAOB mRNA	26873546
D004642	Emodin	Emodin results in decreased activity of MAOB protein	15120460
D004918	Erythromycin Estolate	Erythromycin Estolate results in decreased expression of MAOB mRNA	17522070
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of MAOB mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAOB mRNA	17942748
D011345	Fenofibrate	[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of MAOB mRNA	18253720
D005419	Flavonoids	Flavonoids results in decreased expression of MAOB mRNA	18035473
D005485	Flutamide	Flutamide results in decreased expression of MAOB mRNA	24136188\|2479361
D005897	Glafenine	Glafenine results in decreased expression of MAOB mRNA	24136188
D005978	Glutathione	"Glutathione inhibits the reaction [MAOB protein results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole]"	26686552
D006220	Haloperidol	Haloperidol results in decreased activity of MAOB protein	8160492
C010178	heliotrine	heliotrine results in decreased expression of MAOB mRNA	26100227
D006533	Heptachlor	Heptachlor results in decreased expression of MAOB mRNA	23153324
C089796	hexabromocyclododecane	hexabromocyclododecane results in decreased expression of MAOB protein	28214749
D006719	Homovanillic Acid	[Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of Homovanillic Acid	16012872
D017313	Fenretinide	Fenretinide results in decreased expression of MAOB mRNA	28973697
D012701	Serotonin	"3,4-Methylenedioxyamphetamine inhibits the reaction [MAOB protein results in decreased amination of Serotonin]"	26721607
D012701	Serotonin	MAOB protein results in decreased amination of Serotonin	26721607
D012701	Serotonin	"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOB protein results in decreased amination of Serotonin]"	26721607
D012701	Serotonin	MAOB mutant form results in increased abundance of Serotonin	11834493
C001655	indoleacetaldehyde	[MAOB protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indoleacetaldehyde	26686552
C001655	indoleacetaldehyde	"[[MAOB protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indoleacetaldehyde] which results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole"	26686552
C001655	indoleacetaldehyde	MAOB protein results in increased chemical synthesis of indoleacetaldehyde	26686552
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of MAOB mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MAOB mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of MAOB mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MAOB mRNA	28628672
C098607	JP8 aviation fuel	JP8 aviation fuel results in increased expression of MAOB protein	17337753
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MAOB mRNA	18544905
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid] results in increased expression of MAOB mRNA	18544905
C059303	lazabemide	lazabemide binds to and results in decreased activity of MAOB protein	7816197
C059303	lazabemide	lazabemide binds to MAOB protein	21075085\|9045087
C059303	lazabemide	lazabemide results in decreased activity of MAOB protein	10626094\|7931245
C059303	lazabemide	lazabemide binds to MAOB protein	9045087
C059303	lazabemide	lazabemide results in decreased activity of MAOB protein	12818349\|1517869
C059303	lazabemide	lazabemide results in decreased activity of MAOB protein	10927030\|2201749
C052901	lemongrass oil	lemongrass oil affects the expression of MAOB mRNA	25976427
D000069349	Linezolid	Linezolid results in decreased activity of MAOB protein	14531724
C482199	lipopolysaccharide, E coli O55-B5	"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of MAOB mRNA"	20371263
D008694	Methamphetamine	MAOB protein affects the susceptibility to Methamphetamine	1905457
D008694	Methamphetamine	[Selegiline results in decreased activity of MAOB protein] which results in increased susceptibility to Methamphetamine	1905457
D008701	Methapyrilene	Methapyrilene results in decreased expression of MAOB mRNA	16393664
D008727	Methotrexate	Methotrexate results in increased expression of MAOB mRNA	21678067
D008751	Methylene Blue	"Methylene Blue inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]"	21554916
D008751	Methylene Blue	Methylene Blue results in decreased activity of MAOB protein	21554916
D015104	3,4-Methylenedioxyamphetamine	"3,4-Methylenedioxyamphetamine inhibits the reaction [MAOB protein results in decreased amination of Serotonin]"	26721607
C004925	methylmercuric chloride	methylmercuric chloride affects the expression of MAOB protein	27012723
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of MAOB mRNA	28001369
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of MAOB protein	26056851
C020771	methylmercury hydroxide	"[methylmercury hydroxide co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased activity of MAOB protein"	16904659
C020771	methylmercury hydroxide	methylmercury hydroxide results in decreased activity of MAOB protein	16904659
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOB protein results in decreased amination of Dopamine]"	26721607
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOB protein results in decreased amination of Serotonin]"	26721607
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of MAOB mRNA"	26251327
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of MAOB protein	26056851
D015655	1-Methyl-4-phenylpyridinium	MAOB protein results in increased abundance of 1-Methyl-4-phenylpyridinium	23665943
D015655	1-Methyl-4-phenylpyridinium	"[MAOB protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased abundance of 1-Methyl-4-phenylpyridinium"	23665943
D015655	1-Methyl-4-phenylpyridinium	"[MAOB protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased chemical synthesis of 1-Methyl-4-phenylpyridinium"	19948168
D015655	1-Methyl-4-phenylpyridinium	"zonisamide inhibits the reaction [[MAOB protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased chemical synthesis of 1-Methyl-4-phenylpyridinium]"	19948168
D015655	1-Methyl-4-phenylpyridinium	"[[Selegiline results in decreased activity of MAOB protein] which results in decreased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in decreased chemical synthesis of 1-Methyl-4-phenylpyridinium"	16099847
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"5-nitroindazole inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]"	21554916
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"9-mono-N'-methylnorharman inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]"	21554916
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"	21554916
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Methylene Blue inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]"	21554916
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"norharman inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]"	21554916
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Vitamin K 3 inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]"	21554916
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"MAOB protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"	19948168\|2366594
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[MAOB protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased abundance of 1-Methyl-4-phenylpyridinium"	23665943
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[MAOB protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased chemical synthesis of 1-Methyl-4-phenylpyridinium"	19948168
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"zonisamide inhibits the reaction [[MAOB protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased chemical synthesis of 1-Methyl-4-phenylpyridinium]"	19948168
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"MAOB protein results in increased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"	19647008
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Selegiline results in decreased activity of MAOB protein] which results in decreased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"	16099847
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[[Selegiline results in decreased activity of MAOB protein] which results in decreased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in decreased chemical synthesis of 1-Methyl-4-phenylpyridinium"	16099847
D008999	Monocrotophos	Monocrotophos results in decreased activity of MAOB protein	12018584
D009002	Monomethylhydrazine	Monomethylhydrazine results in increased activity of MAOB protein	8583353
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of MAOB mRNA	26924002
C568948	N-(1-fluoro-3-phenylpropan-2-yl)-N-methylprop-2-yn-1-amine	N-(1-fluoro-3-phenylpropan-2-yl)-N-methylprop-2-yn-1-amine results in decreased activity of MAOB protein	21923198
C470996	N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine	N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine results in decreased activity of MAOB protein	11215752
C570530	N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine	N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine results in decreased activity of MAOB protein	22023459
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of MAOB mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of MAOB mRNA"	25554681\|2562005
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in decreased expression of MAOB mRNA	17522070
D009583	Nitrofurazone	Nitrofurazone results in decreased activity of MAOB protein	6814441
D005996	Nitroglycerin	Nitroglycerin results in increased expression of MAOB mRNA	12102619
D009599	Nitroprusside	[MAOB protein co-treated with MAOA protein] affects the susceptibility to Nitroprusside	11834493
C043554	N,N-dimethylphenylethylamine	"MAOB protein affects the metabolism of N,N-dimethylphenylethylamine"	2551855
D009638	Norepinephrine	MAOB mutant form results in increased abundance of Norepinephrine	11834493
C010262	norharman	"norharman inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]"	21554916
C010262	norharman	norharman results in decreased activity of MAOB protein	21554916
C423264	(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate	(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate results in decreased activity of MAOB protein	16086033
C076029	olanzapine	olanzapine results in increased expression of MAOB mRNA	15964593
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of MAOB mRNA	25729387
C013638	paeonol	paeonol results in decreased activity of MAOB protein	15120460
D010293	Pargyline	Pargyline results in decreased activity of MAOB protein	27270453
D010293	Pargyline	[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]	23499958
D010293	Pargyline	[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]	23499958
D010293	Pargyline	Pargyline results in decreased activity of MAOB protein	20716577
D010293	Pargyline	Pargyline results in decreased activity of MAOB protein	23499958\|6493360
D052638	Particulate Matter	Particulate Matter results in increased expression of MAOB mRNA	24769257
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of MAOB protein	26879310
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of MAOB mRNA	19162173
D010622	Phencyclidine	Phencyclidine results in increased expression of MAOB mRNA	17266109
D010624	Phenelzine	"Phenelzine inhibits the reaction [MAOB protein results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole]"	26686552
C029261	phenethylamine	Phenylpropanolamine inhibits the reaction [MAOB protein results in increased degradation of phenethylamine]	3961266
C029261	phenethylamine	phenethylamine results in increased activity of MAOB protein	17561096
C029261	phenethylamine	MAOB protein results in decreased amination of phenethylamine	22023459
C029261	phenethylamine	MAOB protein results in increased metabolism of phenethylamine	21405131
C029261	phenethylamine	MAOB protein results in increased oxidation of phenethylamine	21923198
D010627	Phenethylamines	MAOB mutant form results in increased abundance of Phenethylamines	11834493
D010627	Phenethylamines	MAOB protein affects the metabolism of Phenethylamines	7430361
D010656	Phenylephrine	[MAOB protein co-treated with MAOA protein] affects the susceptibility to Phenylephrine	11834493
D010665	Phenylpropanolamine	Phenylpropanolamine inhibits the reaction [MAOB protein results in increased degradation of phenethylamine]	3961266
D010665	Phenylpropanolamine	Phenylpropanolamine results in decreased activity of MAOB protein	3961266
D010695	Phlorhizin	Phlorhizin results in decreased expression of MAOB mRNA	22538082
D010707	Phosphamidon	Phosphamidon results in decreased activity of MAOB protein	12018584
C060836	pioglitazone	pioglitazone binds to and results in decreased activity of MAOB protein	22282722
C008922	piperine	piperine results in decreased activity of MAOB protein	15120460
C006253	pirinixic acid	pirinixic acid results in decreased expression of MAOB mRNA	19162173
D010936	Plant Extracts	Plant Extracts results in increased expression of MAOB mRNA	21297082
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Smoke results in decreased activity of MAOB protein]	24257033
D010936	Plant Extracts	Plant Extracts results in decreased expression of MAOB mRNA	28533734
D011084	Polycyclic Aromatic Hydrocarbons	Polycyclic Aromatic Hydrocarbons affects the expression of MAOB mRNA	22579512
D059808	Polyphenols	Polyphenols results in decreased expression of MAOB mRNA	16293270
C028797	pralidoxime	pralidoxime results in decreased activity of MAOB protein	21195145
D011374	Progesterone	Progesterone results in decreased expression of MAOB mRNA	23012394
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of MAOB mRNA	20660070
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of MAOB mRNA	17404688
D011374	Progesterone	Progesterone results in increased expression of MAOB mRNA	17404688\|2086464
D011374	Progesterone	Progesterone results in increased expression of MAOB mRNA	22238285
D011763	Pyrrolizidine Alkaloids	Pyrrolizidine Alkaloids results in decreased expression of MAOB mRNA	26100227
D011794	Quercetin	Quercetin results in decreased expression of MAOB mRNA	21632981
C031967	rasagiline	rasagiline results in decreased activity of MAOB protein	21923181
C031967	rasagiline	rasagiline binds to and results in decreased activity of MAOB protein	9564629
C031967	rasagiline	rasagiline results in decreased activity of MAOB protein	19728752\|2169615
C059514	resveratrol	[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]	23499958
C059514	resveratrol	resveratrol results in increased expression of MAOB mRNA	22610192
C059514	resveratrol	resveratrol results in decreased activity of MAOB protein	23174668
C059514	resveratrol	resveratrol results in decreased activity of MAOB protein	23499958
D018967	Risperidone	Risperidone results in increased expression of MAOB mRNA	15964593
C051040	Ro 16-6491	Ro 16-6491 results in decreased activity of MAOB protein	20875051
C051040	Ro 16-6491	[Ro 16-6491 results in decreased activity of MAOB protein] which results in decreased susceptibility to Dopamine	20875051
C089730	rosiglitazone	rosiglitazone results in decreased activity of MAOB protein	22282722
C041376	rosmarinic acid	rosmarinic acid results in decreased activity of MAOB protein	27270453
C092797	safinamide	safinamide results in decreased activity of MAOB protein	21777011\|2201749
D012642	Selegiline	Selegiline binds to MAOB protein	21405131
D012642	Selegiline	Selegiline inhibits the reaction [MAOB protein results in decreased amination of Dopamine]	26721607
D012642	Selegiline	Selegiline inhibits the reaction [Smoke analog results in increased activity of MAOB protein]	28108387
D012642	Selegiline	Selegiline results in decreased activity of MAOB protein	21696156\|2192318
D012642	Selegiline	Selegiline binds to MAOB protein	19948168
D012642	Selegiline	[Selegiline results in decreased activity of MAOB protein] which results in increased susceptibility to Methamphetamine	1905457
D012642	Selegiline	zonisamide inhibits the reaction [Selegiline binds to MAOB protein]	19948168
D012642	Selegiline	Selegiline results in decreased activity of MAOB protein	15178694\|1554529
D012642	Selegiline	"[Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid"	16012872
D012642	Selegiline	[Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of Homovanillic Acid	16012872
D012642	Selegiline	[Selegiline results in decreased activity of MAOB protein] which results in increased abundance of Dopamine	16012872
D012642	Selegiline	Selegiline results in decreased activity of MAOB protein	10927030\|1124592
D012642	Selegiline	"[Selegiline results in decreased activity of MAOB protein] which results in decreased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"	16099847
D012642	Selegiline	"[[Selegiline results in decreased activity of MAOB protein] which results in decreased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in decreased chemical synthesis of 1-Methyl-4-phenylpyridinium"	16099847
C009238	senkirkine	senkirkine results in decreased expression of MAOB mRNA	26100227
D020280	Sertraline	MAOB protein results in decreased amination of and results in increased metabolism of Sertraline	15547048
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of MAOB mRNA	25895662
D012834	Silver	Silver results in increased expression of MAOB mRNA	27131904
D012906	Smoke	Selegiline inhibits the reaction [Smoke analog results in increased activity of MAOB protein]	28108387
D012906	Smoke	Smoke analog results in increased expression of and results in increased activity of MAOB protein	28108387
D012906	Smoke	Plant Extracts inhibits the reaction [Smoke results in decreased activity of MAOB protein]	24257033
D012906	Smoke	Smoke results in decreased activity of MAOB protein	24257033
C016104	sodium bichromate	sodium bichromate results in increased expression of MAOB mRNA	12325037
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of MAOB protein	28918527
D013467	Sulindac	"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of MAOB mRNA"	20371263
C021751	tanshinone	tanshinone results in increased expression of MAOB mRNA	15849732
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid results in decreased expression of MAOB mRNA	15885361
C020404	tele-methylhistamine	MAOB protein affects the metabolism of tele-methylhistamine	7430361
C020404	tele-methylhistamine	MAOB protein results in increased oxidation of tele-methylhistamine	21923198
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MAOB mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MAOB mRNA	26377647
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAOB mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to MAOB promoter]	19654925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MAOB mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MAOB mRNA	18796159\|2095900
D013752	Tetracycline	Tetracycline results in decreased expression of MAOB mRNA	24489787
D013752	Tetracycline	Tetracycline results in decreased expression of MAOB mRNA	17522070
D013889	Thiouracil	Thiouracil analog results in decreased activity of MAOB protein	24300193
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of MAOB mRNA	25729387
C039776	tribulin	tribulin results in decreased activity of MAOB protein	8744988
C012589	trichostatin A	trichostatin A results in decreased expression of MAOB mRNA	24935251
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of MAOB mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MAOB mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased activity of MAOB protein	22282722
C030820	tryptamine	MAOB protein results in decreased amination of tryptamine	26686552
C030820	tryptamine	[MAOB protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indoleacetaldehyde	26686552
C030820	tryptamine	"[[MAOB protein results in decreased amination of tryptamine] which results in increased chemical synthesis of indoleacetaldehyde] which results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole"	26686552
C030820	tryptamine	MAOB protein results in increased metabolism of tryptamine	21405131
C030820	tryptamine	MAOB protein results in increased oxidation of tryptamine	21923198
D014439	Tyramine	MAOB protein results in increased metabolism of Tyramine	21405131
D014439	Tyramine	MAOB protein results in increased oxidation of Tyramine	21923198
C022884	undecane	undecane results in increased expression of MAOB protein	17337753
D014520	Urethane	Urethane results in decreased expression of MAOB mRNA	28818685
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased expression of MAOB mRNA	15885361
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAOB mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of MAOB mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of MAOB mRNA	23179753\|2627250
D014635	Valproic Acid	Valproic Acid results in decreased methylation of MAOB gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of MAOB mRNA	28001369
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of MAOB gene	25560391
C029297	vinylidene chloride	vinylidene chloride results in increased expression of MAOB mRNA	26682919
D014805	Vitamin B 12	Vitamin B 12 results in decreased activity of MAOB protein	7430361
D024483	Vitamin K 3	"Vitamin K 3 inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]"	21554916
D024483	Vitamin K 3	Vitamin K 3 results in decreased activity of MAOB protein	21554916
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAOB mRNA"	27188386
C022189	zonisamide	"zonisamide inhibits the reaction [[MAOB protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased chemical synthesis of 1-Methyl-4-phenylpyridinium]"	19948168
C022189	zonisamide	zonisamide inhibits the reaction [Selegiline binds to MAOB protein]	19948168
C022189	zonisamide	zonisamide results in decreased activity of MAOB protein	19948168

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0008131	primary amine oxidase activity	-	TAS	-
GO:0009055	electron transfer activity	-	TAS	8602220
GO:0042803	protein homodimerization activity	-	IEA	-
GO:0050660	flavin adenine dinucleotide binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0010044	response to aluminum ion	-	IEA	-
GO:0010269	response to selenium ion	-	IEA	-
GO:0014063	negative regulation of serotonin secretion	-	IEA	-
GO:0021762	substantia nigra development	-	HEP	22926577
GO:0022900	electron transport chain	-	IEA	-
GO:0032496	response to lipopolysaccharide	-	IEA	-
GO:0042135	neurotransmitter catabolic process	-	IEA	-
GO:0042420	dopamine catabolic process	-	TAS	24252804
GO:0045471	response to ethanol	-	IEA	-
GO:0045964	positive regulation of dopamine metabolic process	-	IEA	-
GO:0050665	hydrogen peroxide biosynthetic process	-	NAS	24252804
GO:0051412	response to corticosterone	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005739	mitochondrion	-	HDA	20833797
GO:0005740	mitochondrial envelope	-	TAS	7063850
GO:0005741	mitochondrial outer membrane	-	TAS	24252804
GO:0016021	integral component of membrane	-	IEA	-

KEGG ID	KEGG Term
hsa00260	Glycine, serine and threonine metabolism
hsa00330	Arginine and proline metabolism
hsa00340	Histidine metabolism
hsa00350	Tyrosine metabolism
hsa00360	Phenylalanine metabolism
hsa00380	Tryptophan metabolism
hsa00982	Drug metabolism - cytochrome P450
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-140179	Amine Oxidase reactions	TAS
R-HSA-141333	Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-211859	Biological oxidations	TAS
R-HSA-211945	Phase I - Functionalization of compounds	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
18405071	Alcohol dependence and polymorphisms of serotonin-related genes: association studies. (2008 Jan)	Mokrovic G	Coll Antropol
9326944	Increased stress response and beta-phenylethylamine in MAOB-deficient mice. (1997 Oct)	Grimsby J	Nat Genet
11072748	Platelet monoamine oxidase activity is related to MAOB intron 13 genotype. (2000)	Garpenstrand H	J Neural Transm (Vienna)
10597411	Assessing linkage of monoamine oxidase B in a genome-wide scan using a univariate variance components approach. (1999)	Barnholtz JS	Genet Epidemiol
10597455	Analysis of principal component based quantitative phenotypes for alcoholism. (1999)	Scholz M	Genet Epidemiol
12754156	Risk factors for the neurohumoral alterations underlying personality disturbances. (2002 Aug-Sep)	Oreland L	Neurotox Res
19956754	Smoking induces long-lasting effects through a monoamine-oxidase epigenetic regulation. (2009 Nov 23)	Launay JM	PLoS One
17592478	Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women. (2008 Mar)	Ducci F	Mol Psychiatry
28858992	The genotypes and methylation of MAO genes as factors behind smoking behavior. (2017 Nov)	Tiili EM	Pharmacogenet Genomics
17885625	Association study of monoamine oxidase and catechol-O-methyltransferase genes with smoking behavior. (2007 Oct)	Tochigi M	Pharmacogenet Genomics
10449149	Parkinson's disease, MAOB, and smoking. (1999 Aug 11)	Mellick GD	Neurology
12011284	MAOB intron 13 and COMT codon 158 polymorphisms, cigarette smoking, and the risk of PD. (2002 May 14)	Hernan MA	Neurology
27112218	Platelet monoamine oxidase type B, MAOB intron 13 and MAOA-uVNTR polymorphism and symptoms of post-traumatic stress disorder. (2016 Jul)	Svob Strac D	Stress
8780428	Association of monoamine oxidase A alleles with alcoholism among male Chinese in Taiwan. (1996 Sep)	Hsu YP	Am J Psychiatry
26000819	A meta-analysis on relationship of MAOB intron 13 polymorphisms, interactions with smoking/COMT H158L polymorphisms with the risk of PD. (2016)	Zhang Y	Int J Neurosci
8154672	Platelet MAO activity in type I and type II alcoholism. (1994 Feb 28)	Devor EJ	Ann N Y Acad Sci
10990520	Genetic polymorphism of dopamine D2 receptors in Parkinson's disease and interactions with cigarette smoking and MAO-B intron 13 polymorphism. (2000 Oct)	Costa-Mallen P	J Neurol Neurosurg Psychiatry
21781348	Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson's disease in a Japanese population. (2011 Jul 25)	Kiyohara C	BMC Neurol
26851573	Monoamine oxidase and agitation in psychiatric patients. (2016 Aug 1)	Nikolac Perkovic M	Prog Neuropsychopharmacol Biol Psychiatry
12359039	Lazabemide, a selective, reversible monoamine oxidase B inhibitor, as an aid to smoking cessation. (2002 Oct)	Berlin I	Addiction