Gene: MAP1B

4131
FUTSCH|MAP5|PPP1R102
microtubule associated protein 1B
protein-coding
5q13.2
Ensembl:ENSG00000131711 MIM:157129 Vega:OTTHUMG00000100952 UniprotKB:P46821
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
1.504e-1 (AD)  2.724e-1 (ND)   (Frontal_Cortex)
7.833e-2 (AD)  5.272e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HSPA12A0.945
YWHAG0.945
PAFAH1B10.943
SRPK20.942
BCAP290.941
MAPK90.94
NAPB0.939
SNCA0.938
EPB41L30.938
PIK3CB0.936

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.546
OR4F29-0.542
RHOD-0.447
ASB4-0.433
RNF135-0.414
CHST14-0.411
C22orf31-0.405
LRAT-0.402
CSAG1-0.395
MDFI-0.395

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of MAP1B mRNA"19162173
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of MAP1B mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MAP1B mRNA"25510870
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of MAP1B protein"21673325
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of MAP1B mRNA"21394737
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of MAP1B mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MAP1B mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MAP1B mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MAP1B mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MAP1B mRNA"25510870
C0112692,5-hexanedione"2,5-hexanedione results in decreased expression of MAP1B protein modified form"20554699
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of MAP1B mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP1B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP1B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP1B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP1B mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of MAP1B mRNA21420995|2906747
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MAP1B gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MAP1B mRNA23630614
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of MAP1B mRNA28522335
D006710HomocysteineHomocysteine results in decreased expression of MAP1B mRNA17326132
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MAP1B mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of MAP1B protein16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MAP1B mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of MAP1B mRNA20458559
D001379AzathioprineAzathioprine results in increased expression of MAP1B mRNA22623647
C547126AZM551248AZM551248 results in increased expression of MAP1B mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MAP1B mRNA26001963
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MAP1B mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MAP1B mRNA]25566086
D004958EstradiolEstradiol results in decreased expression of MAP1B mRNA19167446
D004958EstradiolEstradiol results in increased expression of MAP1B mRNA20106945
C044887beta-methylcholinebeta-methylcholine affects the expression of MAP1B mRNA21179406
C095105bexarotenebexarotene results in increased expression of MAP1B mRNA16648578
C006780bisphenol Abisphenol A affects the expression of MAP1B mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of MAP1B mRNA23557687
C006780bisphenol Abisphenol A affects the expression of MAP1B mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of MAP1B protein28903499
C018475butyraldehydebutyraldehyde results in increased expression of MAP1B mRNA26079696
D002104CadmiumCadmium results in increased expression of MAP1B mRNA21120746|2336940
C018021cobaltous chloridecobaltous chloride results in increased expression of MAP1B mRNA19376846
D003042CocaineCocaine results in decreased expression of MAP1B mRNA12629581
D003042CocaineCocaine affects the expression of MAP1B mRNA20187946
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of MAP1B mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of MAP1B mRNA21595052
D019327Copper SulfateCopper Sulfate results in increased expression of MAP1B mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of MAP1B mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of MAP1B mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of MAP1B mRNA19167446
D016578Crack CocaineCrack Cocaine results in increased expression of MAP1B mRNA12629581
C030973cupric oxidecupric oxide affects the phosphorylation of MAP1B protein25470785
D016572CyclosporineCyclosporine results in increased expression of MAP1B mRNA21632981|2556210
D003630DaunorubicinMAP1B affects the susceptibility to Daunorubicin17545624
D013759Dronabinol[Dronabinol co-treated with Ethanol] results in increased expression of MAP1B mRNA17618662
D013759DronabinolDronabinol results in decreased expression of MAP1B mRNA17578508
D013759DronabinolDronabinol results in increased expression of MAP1B mRNA17618662
D003907DexamethasoneDexamethasone results in increased expression of MAP1B mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of MAP1B mRNA]20032058
D003976DiazinonDiazinon results in decreased expression of MAP1B protein17239417
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MAP1B mRNA21266533
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of MAP1B mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of MAP1B mRNA25016146
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of MAP1B mRNA20920545
D004237DiuronDiuron results in decreased expression of MAP1B mRNA25152437
D004317DoxorubicinDoxorubicin affects the expression of MAP1B protein29385562
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MAP1B protein23301498
D000431Ethanol[Dronabinol co-treated with Ethanol] results in increased expression of MAP1B mRNA17618662
D000431EthanolEthanol results in increased expression of MAP1B mRNA17618662
D005473FluoxetineFluoxetine results in increased expression of MAP1B mRNA17033635
D005492Folic AcidFolic Acid affects the expression of MAP1B mRNA17320366
C001277geldanamycingeldanamycin results in increased expression of MAP1B mRNA26705709
D017313FenretinideFenretinide results in increased expression of MAP1B mRNA28973697
C492448ICG 001ICG 001 results in increased expression of MAP1B mRNA26191083
D007455IodineIodine deficiency results in decreased expression of MAP1B protein27444543
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MAP1B mRNA26644586
D007649KetamineKetamine results in decreased expression of MAP1B mRNA20080153
C045463leflunomideleflunomide results in increased expression of MAP1B mRNA28988120
C018091maduramicinmaduramicin results in increased expression of MAP1B mRNA29128925
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MAP1B mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP1B mRNA"27188386
C008493methylselenic acidmethylselenic acid affects the expression of MAP1B mRNA14617803
C008493methylselenic acidmethylselenic acid results in increased expression of MAP1B mRNA18548127
D015735MifepristoneMifepristone results in increased expression of MAP1B mRNA17584828
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of MAP1B mRNA16809437
C119536nickel acetatenickel acetate affects the expression of MAP1B mRNA12915101
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of MAP1B mRNA20971185
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of MAP1B mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of MAP1B mRNA]"21673326
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MAP1B mRNA"25510870
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of MAP1B mRNA23602845
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MAP1B protein26879310
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP1B mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MAP1B mRNA26272509
D010672PhenytoinPhenytoin results in increased expression of MAP1B mRNA14741686
D010795Phthalic AcidsPhthalic Acids results in increased expression of MAP1B mRNA21061450
D010936Plant ExtractsPlant Extracts results in decreased expression of MAP1B mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MAP1B mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of MAP1B mRNA20726854
C005556propionaldehydepropionaldehyde results in increased expression of MAP1B mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of MAP1B mRNA24780913
D011794QuercetinQuercetin results in increased expression of MAP1B mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of MAP1B mRNA19167446
C059514resveratrolresveratrol results in decreased expression of MAP1B mRNA19167446
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of MAP1B mRNA25895662
D012906SmokeSmoke affects the expression of MAP1B mRNA23693141
C009277sodium arsenatesodium arsenate results in increased expression of MAP1B mRNA21795629
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of MAP1B mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAP1B mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MAP1B mRNA21632981|2180250
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAP1B mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MAP1B mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAP1B mRNA22298810
C014215tetrahydropalmatinetetrahydropalmatine results in increased expression of MAP1B protein20109541
D013853ThioacetamideThioacetamide results in increased expression of MAP1B mRNA23411599
D014212TretinoinTretinoin results in decreased expression of MAP1B mRNA21934132
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MAP1B mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of MAP1B mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MAP1B mRNA23179753|2800136
D014638VanadatesVanadates results in increased expression of MAP1B mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MAP1B gene25560391
C025643vinclozolinvinclozolin affects the expression of MAP1B mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of MAP1B mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of MAP1B mRNA26682919
C111237vorinostatvorinostat results in decreased expression of MAP1B mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IBA21873635  
GO:0005198structural molecule activity-NAS1881920  
GO:0005515protein binding-IPI12147674  15525354  18656471  24089205  
GO:0008017microtubule binding-IBA21873635  
GO:0008017microtubule binding-ISS-  
GO:0008017microtubule binding-TAS26609151  
GO:0015631tubulin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-IBA21873635  
GO:0001578microtubule bundle formation-IEA-  
GO:0001764neuron migration-TAS26609151  
GO:0007409axonogenesis-IBA21873635  
GO:0009987cellular process-IDA19567321  
GO:0016358dendrite development-IBA21873635  
GO:0016358dendrite development-IEA-  
GO:0031114regulation of microtubule depolymerization-IBA21873635  
GO:0032387negative regulation of intracellular transport-IEA-  
GO:0045773positive regulation of axon extension-IEA-  
GO:0047497mitochondrion transport along microtubule-IEA-  
GO:0048675axon extension-TAS26609151  
GO:0061162establishment of monopolar cell polarity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001750photoreceptor outer segment-IEA-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005874microtubule-IBA21873635  
GO:0005874microtubule-ISS-  
GO:0005875microtubule associated complex-IBA21873635  
GO:0005875microtubule associated complex-TAS1881920  
GO:0005886plasma membrane-IDA19567321  
GO:0014069postsynaptic density-IEA-  
GO:0030054cell junction-IEA-  
GO:0030424axon-ISS-  
GO:0030425dendrite-IBA21873635  
GO:0030425dendrite-ISS-  
GO:0036477somatodendritic compartment-ISS-  
GO:0042995cell projection-IBA21873635  
GO:0043025neuronal cell body-IBA21873635  
GO:0043025neuronal cell body-ISS-  
GO:0043197dendritic spine-IEA-  
GO:0045202synapse-IBA21873635  
GO:0097440apical dendrite-ISS-  
GO:0097441basal dendrite-ISS-  
GO:0097457hippocampal mossy fiber-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26200272Epigenetic Repression of CCDC37 and MAP1B Links Chronic Obstructive Pulmonary Disease to Lung Cancer. (2015 Aug)Tessema MJ Thorac Oncol