Gene: MAP2

4133
MAP2A|MAP2B|MAP2C
microtubule associated protein 2
protein-coding
2q34
Ensembl:ENSG00000078018 MIM:157130 Vega:OTTHUMG00000132962 UniprotKB:P11137
NG_052836.1
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.205e-2 (AD)  4.971e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FGF130.96
MYO5A0.958
HPCAL40.955
PTPRN20.95
TTC7B0.945
FAM20B0.945
DLG20.944
PNMA20.943
APBA10.939
SEPT30.938

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.572
OR4F29-0.519
CSAG1-0.493
CDA-0.441
MAGEA12-0.432
RUNX3-0.43
SH2D2A-0.428
CNN2-0.428
TFPI2-0.426
NFE2-0.424

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01196EstramustineSmall Molecule2998-57-4Approved|InvestigationalTarget
DB01229PaclitaxelSmall Molecule33069-62-4ApprovedTarget
DB01248DocetaxelSmall Molecule114977-28-5Approved|InvestigationalTarget
ID Drug Name Action PubMed
C02017516 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione"16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased expression of MAP2 mRNA"20519331
C0363611-amino-1,3-dicarboxycyclopentane"1-amino-1,3-dicarboxycyclopentane results in increased phosphorylation of MAP2 protein"15893642
C0363611-amino-1,3-dicarboxycyclopentane"Ammonia inhibits the reaction [1-amino-1,3-dicarboxycyclopentane results in increased phosphorylation of MAP2 protein]"15893642
C4086042-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole results in increased expression of MAP2 mRNA16424397
C0112692,5-hexanedione"2,5-hexanedione results in decreased expression of MAP2 protein modified form"20554699
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of MAP2 mRNA"20406850
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MAP2 mRNA"28973690
C0792153,5-dihydroxyphenylglycine"[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased phosphorylation of MAP2 protein"15893642
C0792153,5-dihydroxyphenylglycine"3,5-dihydroxyphenylglycine results in increased phosphorylation of MAP2 protein"15893642
C0792153,5-dihydroxyphenylglycine"Ammonia inhibits the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAP2 protein]"15893642
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of MAP2 mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP2 mRNA"27188386
C0005950156,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in increased expression of MAP2 protein"28073004
C5605976,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide"6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide inhibits the reaction [Scopolamine Hydrobromide results in decreased expression of MAP2 protein]"22096544
D000082AcetaminophenAcetaminophen results in increased expression of MAP2 mRNA29067470
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of MAP2 mRNA]28153600
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Streptozocin results in decreased expression of MAP2 protein]28499986
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MAP2 gene27153756
C103303alitretinoinalitretinoin results in increased expression of MAP2 protein23500671
C041524aluminum sulfatealuminum sulfate inhibits the reaction [Excitatory Amino Acid Agents results in increased metabolism of MAP2 protein]10428068
D000641Ammonia"Ammonia inhibits the reaction [1-amino-1,3-dicarboxycyclopentane results in increased phosphorylation of MAP2 protein]"15893642
D000641Ammonia"Ammonia inhibits the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of MAP2 protein]"15893642
D000641Ammonia"Ammonia inhibits the reaction [azetidine-2,4-dicarboxylic acid results in increased phosphorylation of MAP2 protein]"15893642
D000641AmmoniaAmmonia inhibits the reaction [GRM1 protein results in increased phosphorylation of MAP2 protein]15893642
D000641AmmoniaAmmonia inhibits the reaction [GRM5 protein results in increased phosphorylation of MAP2 protein]15893642
D000641AmmoniaAmmonia results in increased phosphorylation of MAP2 protein15893642
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MAP2 mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of MAP2 protein16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MAP2 mRNA24449571
D001151ArsenicArsenic affects the methylation of MAP2 gene25304211
D001151ArsenicArsenic results in decreased expression of MAP2 mRNA24019935
C006632arsenic trioxidearsenic trioxide results in decreased expression of MAP2 protein15894607
D001205Ascorbic AcidAscorbic Acid results in decreased expression of MAP2 protein15372504
C030693AshwagandhaAshwagandha inhibits the reaction [Scopolamine Hydrobromide results in decreased expression of MAP2 protein]22096544
D001280AtrazineAtrazine results in decreased expression of MAP2 mRNA25929836
C083095azetidine-2,4-dicarboxylic acid"Ammonia inhibits the reaction [azetidine-2,4-dicarboxylic acid results in increased phosphorylation of MAP2 protein]"15893642
C083095azetidine-2,4-dicarboxylic acid"[azetidine-2,4-dicarboxylic acid results in increased activity of GRM5 protein] which results in increased phosphorylation of MAP2 protein"15893642
C083095azetidine-2,4-dicarboxylic acid"azetidine-2,4-dicarboxylic acid results in increased phosphorylation of MAP2 protein"15893642
C547126AZM551248AZM551248 results in decreased expression of MAP2 mRNA22323515
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of MAP2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MAP2 mRNA20713471
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MAP2 mRNA22610609
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MAP2 protein21467743
C044887beta-methylcholinebeta-methylcholine affects the expression of MAP2 mRNA21179406
C095105bexarotenebexarotene results in increased expression of MAP2 mRNA16648578
C006780bisphenol Abisphenol A results in decreased expression of MAP2 mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of MAP2 mRNA20678512|2768578
C006780bisphenol Abisphenol A affects the expression of MAP2 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of MAP2 mRNA26079696
D002104CadmiumCadmium results in increased expression of MAP2 mRNA21172416
D002211CapsaicinCapsaicin results in increased expression of MAP2 mRNA18405923
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MAP2 mRNA17484886
D010133p-Chloroamphetaminep-Chloroamphetamine results in decreased expression of MAP2 mRNA17407499
D010133p-Chloroamphetaminep-Chloroamphetamine results in decreased expression of MAP2 protein17407499
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of MAP2 protein22013134
D002746ChlorpromazineChlorpromazine results in increased expression of MAP2 mRNA15079866
D004390ChlorpyrifosChlorpyrifos results in decreased expression of MAP2 mRNA20350560
D004390ChlorpyrifosChlorpyrifos results in increased expression of MAP2 protein26018426
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MAP2 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of MAP2 protein16772336
D003042CocaineCocaine affects the expression of MAP2 mRNA20187946
D003042CocaineCocaine results in decreased expression of MAP2 mRNA16076954
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of MAP2 mRNA20971185
D003471CuprizoneCuprizone results in decreased expression of MAP2 mRNA26577399
C000541cyclopaminecyclopamine inhibits the reaction [resveratrol results in increased expression of MAP2 protein]24464877
D016572CyclosporineCyclosporine results in increased expression of MAP2 mRNA20106945
C017160cypermethrincypermethrin results in decreased expression of MAP2 mRNA22528246
C093628cyproconazolecyproconazole results in increased expression of MAP2 mRNA22045034
D003561CytarabineCytarabine results in decreased expression of MAP2 protein21198554
D003561CytarabineCytarabine results in increased expression of MAP2 mRNA21198554
D003671DEET[DEET co-treated with Permethrin] results in decreased expression of MAP2 protein11681848
D003671DEETDEET results in decreased expression of MAP2 protein11681848
D013759DronabinolDronabinol results in decreased expression of MAP2 mRNA12237329
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MAP2 mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased expression of MAP2 protein11311531
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MAP2 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of MAP2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of MAP2 mRNA22023808
D004006DichlorvosDichlorvos results in increased phosphorylation of MAP2 protein11282359|1663510
D004006DichlorvosNimodipine inhibits the reaction [Dichlorvos results in increased phosphorylation of MAP2 protein]16635102
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of MAP2 mRNA19638242
C015144dihydrolipoic aciddihydrolipoic acid inhibits the reaction [NGF protein results in increased expression of MAP2 protein]21462292
D004178DiquatDiquat results in increased expression of MAP2 mRNA21172416
D004237DiuronDiuron results in decreased expression of MAP2 mRNA21551480
D004237DiuronDiuron results in increased expression of MAP2 mRNA25152437
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in increased expression of MAP2 mRNA19272428
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in increased expression of MAP2 protein19272428
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of MAP2 mRNA22872703
D000431EthanolEthanol results in decreased expression of MAP2 protein23500890
D000431EthanolTLR4 gene mutant form inhibits the reaction [Ethanol results in decreased expression of MAP2 protein]23500890
D000431EthanolEthanol results in decreased expression of MAP2 protein20829428
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MAP2 mRNA14976129
D018683Excitatory Amino Acid Agentsaluminum sulfate inhibits the reaction [Excitatory Amino Acid Agents results in increased metabolism of MAP2 protein]10428068
D018683Excitatory Amino Acid AgentsExcitatory Amino Acid Agents results in increased metabolism of MAP2 protein10428068
D005472FluorouracilFluorouracil results in increased expression of MAP2 mRNA16510598
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MAP2 mRNA20938992
C442759ginsenoside Rb1ginsenoside Rb1 results in increased expression of MAP2 mRNA24599032
C049863ginsenoside Rdginsenoside Rd results in increased expression of MAP2 mRNA24599032
C049863ginsenoside Rdginsenoside Rd results in increased expression of MAP2 protein24599032
C049864ginsenoside Reginsenoside Re results in increased expression of MAP2 mRNA24599032
C049864ginsenoside Reginsenoside Re results in increased expression of MAP2 protein24599032
C035054ginsenoside Rg1ginsenoside Rg1 results in increased expression of MAP2 mRNA24599032
C097367ginsenoside Rg3ginsenoside Rg3 results in increased expression of MAP2 mRNA24599032
D005978GlutathioneGlutathione inhibits the reaction [Particulate Matter results in decreased expression of MAP2 mRNA]28153600
D006220HaloperidolHaloperidol results in increased expression of MAP2 mRNA15079866
D006843Hydrocarbons, Chlorinated"Hydrocarbons, Chlorinated results in decreased expression of MAP2 mRNA"22872703
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of MAP2 protein21179406
D002112CalcifediolCalcifediol deficiency results in decreased expression of MAP2 mRNA17293106
D007538IsoniazidIsoniazid affects the expression of MAP2 mRNA22131109
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of MAP2 mRNA15182950
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of MAP2 mRNA15618438
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MAP2 mRNA23430699
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of MAP2 mRNA21889194|2675264
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of MAP2 protein26830473
D007608Kainic AcidKainic Acid results in increased expression of MAP2 mRNA21589914
D007608Kainic AcidPTGS2 affects the reaction [Kainic Acid results in increased expression of MAP2 mRNA]21589914
C008261lead acetatelead acetate results in decreased expression of MAP2 mRNA22013134
C045463leflunomideleflunomide results in decreased expression of MAP2 mRNA28988120
D008344Maneb[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA23963992
D008344ManebMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA]23963992
D008344ManebSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA]23963992
D008550MelatoninMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA]23963992
D008694MethamphetamineMethamphetamine results in decreased expression of MAP2 mRNA17407499
D008694MethamphetamineMethamphetamine results in decreased expression of MAP2 protein17407499
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MAP2 mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of MAP2 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MAP2 mRNA22555245
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MAP2 mRNA23179753
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MAP2 mRNA21385734|2255524
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of MAP2 mRNA19150642
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of MAP2 mRNA17980949
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of MAP2 protein19000711
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MAP2 mRNA"20188158
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MAP2 mRNA"15329391
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of MAP2 mRNA23876855
D009020MorphineMorphine results in decreased expression of MAP2 mRNA15183518
D009525NiacinNiacin results in increased expression of MAP2 mRNA20303128
C022838nickel chloridenickel chloride promotes the reaction [Tretinoin results in increased expression of MAP2 mRNA]25614230
D009553NimodipineNimodipine inhibits the reaction [Dichlorvos results in increased phosphorylation of MAP2 protein]16635102
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [rhodioloside results in increased expression of MAP2 mRNA]"24929042
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of MAP2 mRNA20971185
C076029olanzapineolanzapine results in increased expression of MAP2 mRNA15079866
C030110oxaliplatinoxaliplatin results in increased expression of MAP2 mRNA16510598
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of MAP2 mRNA26272509
D010269Paraquat[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA23963992
D010269ParaquatMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA]23963992
D010269ParaquatSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA]23963992
D052638Particulate MatterAcetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of MAP2 mRNA]28153600
D052638Particulate MatterGlutathione inhibits the reaction [Particulate Matter results in decreased expression of MAP2 mRNA]28153600
D052638Particulate MatterParticulate Matter results in decreased expression of MAP2 mRNA28153600
C073402PD 123319PD 123319 inhibits the reaction [AGT protein results in increased expression of MAP2 protein]17068200
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of MAP2 mRNA27294297
D026023Permethrin[DEET co-treated with Permethrin] results in decreased expression of MAP2 protein11681848
D026023PermethrinPermethrin results in decreased expression of MAP2 protein11681848
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of MAP2 mRNA17616710
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MAP2 mRNA26272509
D010830PhysostigminePhysostigmine inhibits the reaction [Streptozocin results in decreased expression of MAP2 protein]28499986
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MAP2 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in decreased expression of MAP2 mRNA23608068
D045542PQQ CofactorPQQ Cofactor results in decreased expression of MAP2 mRNA28578007
D011374ProgesteroneProgesterone results in increased expression of MAP2 mRNA23012394
D011374ProgesteroneProgesterone results in decreased expression of MAP2 mRNA21795739
D011374ProgesteroneProgesterone results in increased expression of MAP2 mRNA18037150
D011374ProgesteroneProgesterone results in increased expression of MAP2 protein16054770
C059514resveratrolcyclopamine inhibits the reaction [resveratrol results in increased expression of MAP2 protein]24464877
C059514resveratrolresveratrol results in increased expression of MAP2 protein24464877
C009172rhodioloside"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [rhodioloside results in increased expression of MAP2 mRNA]"24929042
C009172rhodiolosideNOG protein inhibits the reaction [rhodioloside results in increased expression of MAP2 mRNA]24929042
C009172rhodiolosideNOG protein inhibits the reaction [rhodioloside results in increased expression of MAP2 protein]24929042
C009172rhodiolosiderhodioloside results in increased expression of MAP2 mRNA24929042
C009172rhodiolosiderhodioloside results in increased expression of MAP2 protein24929042
D018967RisperidoneRisperidone results in increased expression of MAP2 mRNA15079866
C084711S 20098S 20098 results in increased expression of and results in increased phosphorylation of MAP2 protein22160164
C468918SAG compoundSAG compound results in increased expression of MAP2 protein24464877
D012524SarinSarin results in decreased expression of MAP2 protein27639427
D012601Scopolamine Hydrobromide"6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide inhibits the reaction [Scopolamine Hydrobromide results in decreased expression of MAP2 protein]"22096544
D012601Scopolamine HydrobromideAshwagandha inhibits the reaction [Scopolamine Hydrobromide results in decreased expression of MAP2 protein]22096544
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in decreased expression of MAP2 protein22096544
D012834SilverSilver results in decreased expression of MAP2 protein27593553
D012838SilymarinSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA]23963992
C009277sodium arsenatesodium arsenate results in decreased expression of MAP2 mRNA22131109
C017947sodium arsenitesodium arsenite results in increased expression of MAP2 mRNA22714537
C017947sodium arsenitesodium arsenite results in decreased expression of MAP2 mRNA22131109
D013311StreptozocinAcetylcysteine inhibits the reaction [Streptozocin results in decreased expression of MAP2 protein]28499986
D013311StreptozocinPhysostigmine inhibits the reaction [Streptozocin results in decreased expression of MAP2 protein]28499986
D013311StreptozocinStreptozocin results in decreased expression of MAP2 protein28499986
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of MAP2 mRNA27914987
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAP2 mRNA21570461
C024746tobacco tartobacco tar results in decreased expression of MAP2 mRNA19559774
D014118Toxins, Biological"Toxins, Biological affects the expression of MAP2 mRNA"19682533
D014212Tretinoinnickel chloride promotes the reaction [Tretinoin results in increased expression of MAP2 mRNA]25614230
D014212Tretinoin[NTF3 protein co-treated with Tretinoin] results in increased expression of MAP2 protein16996685
D014212TretinoinTretinoin results in decreased expression of MAP2 mRNA21934132
D014212TretinoinTretinoin results in increased expression of MAP2 mRNA23903816|2561423
D014212TretinoinTretinoin results in increased expression of MAP2 protein15464216|2697201
D014212Tretinoin[Tretinoin co-treated with BDNF protein co-treated with NTF3 protein] results in decreased expression of MAP2 protein16646665
D014212TretinoinTretinoin results in increased expression of MAP2 mRNA16424397
D014212TretinoinTretinoin results in decreased expression of MAP2 mRNA24977338
D014212TretinoinTretinoin results in increased expression of MAP2 protein16944780|1713047
C012589trichostatin Atrichostatin A affects the expression of MAP2 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of MAP2 mRNA24935251
C046243tryptanthrinetryptanthrine results in increased expression of MAP2 protein23500671
D014635Valproic AcidValproic Acid affects the expression of MAP2 mRNA25979313|2607246
D014635Valproic AcidValproic Acid results in increased expression of MAP225524013
D014635Valproic AcidValproic Acid results in increased expression of MAP2 mRNA24383497|2484967
D014635Valproic AcidValproic Acid affects the expression of MAP2 mRNA26072468
D014635Valproic AcidValproic Acid results in decreased expression of MAP2 mRNA22131109
D014635Valproic AcidValproic Acid results in increased expression of MAP2 mRNA22045034
D000068756ValsartanValsartan promotes the reaction [AGT protein results in increased expression of MAP2 protein]17068200
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of MAP2 mRNA25423262
C029297vinylidene chloridevinylidene chloride results in decreased expression of MAP2 mRNA26682919
C070417Win 55212-2Win 55212-2 results in decreased expression of MAP2 mRNA12237329
D015032ZincZinc deficiency results in increased expression of MAP2 mRNA20932299
C088658zoledronic acidzoledronic acid results in decreased expression of MAP2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002162dystroglycan binding-IPI18341635  
GO:0005198structural molecule activity-NAS9588626  
GO:0005515protein binding-IPI15536091  20195357  
GO:0005516calmodulin binding-IEA-  
GO:0008017microtubule binding-IBA21873635  
GO:0008017microtubule binding-TAS26609151  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-IBA21873635  
GO:0000226microtubule cytoskeleton organization-ISS-  
GO:0001578microtubule bundle formation-IEA-  
GO:0007409axonogenesis-IEA-  
GO:0016358dendrite development-TAS26609151  
GO:0021954central nervous system neuron development-IEP20846339  
GO:0030010establishment of cell polarity-IEA-  
GO:0030517negative regulation of axon extension-ISS-  
GO:0031113regulation of microtubule polymerization-TAS10640627  
GO:0031115negative regulation of microtubule polymerization-ISS-  
GO:0031175neuron projection development-IBA21873635  
GO:0031175neuron projection development-IEP20846339  
GO:0048813dendrite morphogenesis-IEP20846339  
GO:0071310cellular response to organic substance-IEA-  
GO:1901953positive regulation of anterograde dense core granule transport-ISS-  
GO:1902513regulation of organelle transport along microtubule-ISS-  
GO:1903744positive regulation of anterograde synaptic vesicle transport-ISS-  
GO:1903827regulation of cellular protein localization-ISS-  
GO:1904527negative regulation of microtubule binding-ISS-  
GO:2000575negative regulation of microtubule motor activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-ISS-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-ISS-  
GO:0005874microtubule-IEA-  
GO:0005875microtubule associated complex-TAS9588626  
GO:0014069postsynaptic density-IEA-  
GO:0030425dendrite-ISS-  
GO:0032839dendrite cytoplasm-ISS-  
GO:0034399nuclear periphery-IEA-  
GO:0043005neuron projection-IBA21873635  
GO:0043025neuronal cell body-ISS-  
GO:0043194axon initial segment-ISS-  
GO:0043198dendritic shaft-ISS-  
GO:0043203axon hillock-ISS-  
GO:0044294dendritic growth cone-ISS-  
GO:0044304main axonNOTISS-  
GO:0044307dendritic branch-ISS-  
GO:0097441basal dendrite-ISS-  
GO:0097442CA3 pyramidal cell dendrite-IEA-  
GO:0150001primary dendrite-ISS-  
GO:0150002distal dendrite-ISS-  
GO:0150014apical distal dendrite-ISS-  
GO:1902737dendritic filopodium-ISS-  
GO:1990635proximal dendrite-ISS-  
GO:1990769proximal neuron projection-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16385227The effect of ethanol on cell fate determination of neural stem cells. (2005 Dec)Tateno MAlcohol Clin Exp Res
15948156Changes in neuronal protein 22 expression and cytoskeletal association in the alcohol-dependent and withdrawn rat brain. (2005 Jul 15)Depaz IMJ Neurosci Res
18541031The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration. (2008 Jun 9)Zhang HBMC Med Genet