Gene info: ID 4137

Gene: MAPT

GENE ID: 4137

Description: microtubule associated protein tau

Gene type: protein-coding

Location: 17q21.31

dbXrefs: Ensembl:ENSG00000186868 MIM:157140 Vega:OTTHUMG00000168833 UniprotKB:P10636

RefSeq: NG_007398.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) 3.322e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg15690475	chr17:44101453	MAPT		1.540e-8	Smoking	28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ATP6V0A1	0.978
CLSTN1	0.977
RUSC2	0.977
NUDCD3	0.976
MADD	0.971
SYNGR1	0.97
STXBP1	0.969
CLCN6	0.969
PGBD5	0.969
PI4KA	0.967

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.606
OR4F29	-0.571
TFPI2	-0.553
IL18RAP	-0.488
KCNJ15	-0.476
CST7	-0.471
WWTR1	-0.463
KLRB1	-0.463
C9orf135	-0.462
SIX1	-0.46

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00448	Lansoprazole	Small Molecule	103577-45-3	Approved\|Investigational	Target
DB00637	Astemizole	Small Molecule	68844-77-9	Approved\|Withdrawn	Target
DB01229	Paclitaxel	Small Molecule	33069-62-4	Approved	Target
DB01248	Docetaxel	Small Molecule	114977-28-5	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of MAPT mRNA"	16269432
C048792	1,2-diacetylbenzene	"1,2-diacetylbenzene results in increased phosphorylation of MAPT protein"	28734998
C048792	1,2-diacetylbenzene	"2-thio(3-iodobenzyl)-5-(1-pyridyl)-(1,3,4)oxadiazole inhibits the reaction [1,2-diacetylbenzene results in increased phosphorylation of MAPT protein]"	28734998
C048792	1,2-diacetylbenzene	"Acetylcysteine inhibits the reaction [1,2-diacetylbenzene results in increased phosphorylation of MAPT protein]"	28734998
C048792	1,2-diacetylbenzene	"1,2-diacetylbenzene results in increased phosphorylation of MAPT protein"	28734998
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone affects the phosphorylation of MAPT protein"	27026707
C021279	(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester	"(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester inhibits the reaction [Methamphetamine results in decreased expression of MAPT mRNA]"	11756511
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased phosphorylation of MAPT protein]	20937724
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lithium Chloride inhibits the reaction [Okadaic Acid affects the phosphorylation of MAPT protein]]	27050422
C011269	2,5-hexanedione	"2,5-hexanedione results in decreased expression of MAPT protein modified form"	20554699
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in increased expression of MAPT protein modified form	20157255
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in increased phosphorylation of MAPT protein	20157255
C076996	27-hydroxycholesterol	LEP protein inhibits the reaction [27-hydroxycholesterol results in increased expression of MAPT protein modified form]	20157255
C076996	27-hydroxycholesterol	LEP protein inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of MAPT protein]	20157255
C529548	2-thio(3-iodobenzyl)-5-(1-pyridyl)-(1,3,4)oxadiazole	"2-thio(3-iodobenzyl)-5-(1-pyridyl)-(1,3,4)oxadiazole inhibits the reaction [1,2-diacetylbenzene results in increased phosphorylation of MAPT protein]"	28734998
C530773	3,5-diethoxycarbonyl-1,4-dihydrocollidine	"3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MAPT mRNA"	10051481
C530773	3,5-diethoxycarbonyl-1,4-dihydrocollidine	"3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MAPT mRNA alternative form"	10051481
C530773	3,5-diethoxycarbonyl-1,4-dihydrocollidine	"3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MAPT protein"	10051481
C015392	3-nitropropionic acid	3-nitropropionic acid affects the localization of MAPT protein	17634376
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAPT mRNA"	27188386
C494356	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	"4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione affects the phosphorylation of MAPT protein"	24254769
C426745	5-iodo-3-(2-azetidinylmethoxy)pyridine	[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein]	21715663
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAPT mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of MAPT mRNA	17562736
D000111	Acetylcysteine	"Acetylcysteine inhibits the reaction [1,2-diacetylbenzene results in increased phosphorylation of MAPT protein]"	28734998
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [cyanoginosin LR results in increased phosphorylation of MAPT protein]	24142891
D000171	Acrolein	Acrolein results in increased phosphorylation of MAPT protein	12605413
D000171	Acrolein	Lithium inhibits the reaction [Acrolein results in increased phosphorylation of MAPT protein]	12605413
D000171	Acrolein	SB 203580 inhibits the reaction [Acrolein results in increased phosphorylation of MAPT protein]	12605413
D000171	Acrolein	Acrolein promotes the reaction [MAPT protein binds to MAPT protein]	17082178
D000171	Acrolein	Acrolein results in increased phosphorylation of MAPT protein	12605413
D020106	Acrylamide	Acrylamide results in decreased expression of MAPT mRNA	28959563
D000255	Adenosine Triphosphate	[annonacin results in decreased abundance of Adenosine Triphosphate] which affects the localization of MAPT protein	17634376
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of MAPT protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of MAPT mRNA	21641981\|2210060
D015766	Albendazole	Albendazole results in decreased expression of MAPT mRNA	16930453
D015766	Albendazole	Albendazole results in decreased expression of MAPT protein	16930453
D000447	Aldehydes	Aldehydes results in increased expression of MAPT mRNA	25014914
C001570	alexidine	alexidine results in decreased expression of MAPT protein	16930453
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of MAPT mRNA	28522335
D043582	5-alpha-Dihydroprogesterone	5-alpha-Dihydroprogesterone results in decreased expression of MAPT protein	17443805
D043582	5-alpha-Dihydroprogesterone	5-alpha-Dihydroprogesterone results in increased phosphorylation of MAPT protein	17443805
D000535	Aluminum	Aluminum results in increased phosphorylation of MAPT protein	17662457
D000535	Aluminum	Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA]	29170048
D000535	Aluminum	[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA	29170048
D000535	Aluminum	Aluminum affects the expression of and affects the phosphorylation of and affects the localization of MAPT protein	29385627
D000535	Aluminum	[Aluminum binds to YWHAZ protein] inhibits the reaction [YWHAZ protein binds to MAPT protein]	29385627
D000535	Aluminum	Aluminum inhibits the reaction [MAPT protein binds to YWHAZ protein]	29385627
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of MAPT mRNA	21298039
C104223	aluminum lactate	aluminum lactate results in increased phosphorylation of MAPT protein	26493151
C104223	aluminum lactate	Quercetin inhibits the reaction [aluminum lactate results in increased phosphorylation of MAPT protein]	26493151
C041524	aluminum sulfate	aluminum sulfate results in increased phosphorylation of MAPT protein	11388372
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MAPT mRNA	16483693
D000643	Ammonium Chloride	Ammonium Chloride results in decreased expression of MAPT protein modified form	16483693
C053442	annonacin	annonacin results in increased expression of MAPT protein alternative form	25402454
C053442	annonacin	annonacin results in increased phosphorylation of MAPT protein mutant form	27569447
C053442	annonacin	annonacin results in increased splicing of MAPT mRNA	25402454
C053442	annonacin	MAPT gene mutant form results in increased susceptibility to annonacin	27569447
C053442	annonacin	SRSF2 promotes the reaction [annonacin results in increased expression of MAPT protein alternative form]	25402454
C053442	annonacin	SRSF2 promotes the reaction [annonacin results in increased splicing of MAPT mRNA]	25402454
C053442	annonacin	annonacin results in decreased degradation of and results in increased phosphorylation of and affects the localization of MAPT protein mutant form	24389273
C053442	annonacin	annonacin results in increased phosphorylation of MAPT protein	27569447
C053442	annonacin	annonacin affects the localization of MAPT protein	17634376
C053442	annonacin	[annonacin results in decreased abundance of Adenosine Triphosphate] which affects the localization of MAPT protein	17634376
C053442	annonacin	Paclitaxel inhibits the reaction [annonacin affects the localization of MAPT protein]	17634376
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of MAPT mRNA	24449571
D016718	Arachidonic Acid	Arachidonic Acid results in increased phosphorylation of MAPT protein	12605413
D016718	Arachidonic Acid	Ro 31-8220 inhibits the reaction [Arachidonic Acid results in increased phosphorylation of MAPT protein]	12605413
D001151	Arsenic	Arsenic affects the methylation of MAPT gene	25304211
D001151	Arsenic	Arsenic metabolite affects the expression of MAPT mRNA	17553662
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [cyanoginosin LR results in increased phosphorylation of MAPT protein]	24142891
D016589	Astemizole	Astemizole binds to MAPT protein alternative form	20110603
D001374	Azacitidine	Azacitidine results in decreased expression of MAPT protein	16930453
D001375	Azaguanine	Azaguanine results in decreased expression of MAPT protein	16930453
C547126	AZM551248	AZM551248 results in decreased expression of MAPT mRNA	22323515
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of MAPT mRNA	18164116
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MAPT mRNA	21871943\|2623829
D001564	Benzo(a)pyrene	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of MAPT mRNA]	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MAPT mRNA	23735875
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MAPT mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MAPT mRNA"	26238291
D001599	Berberine	Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA]	29170048
D004958	Estradiol	Estradiol results in increased expression of MAPT protein	20579400
D004958	Estradiol	Estradiol results in increased phosphorylation of MAPT protein	27026707
D004958	Estradiol	Tamoxifen inhibits the reaction [Estradiol results in increased expression of MAPT protein]	20579400
C044887	beta-methylcholine	beta-methylcholine affects the expression of MAPT mRNA	21179406
C006780	bisphenol A	bisphenol A results in decreased expression of MAPT mRNA	22576693
C006780	bisphenol A	bisphenol A results in increased methylation of MAPT gene	22576693
C006780	bisphenol A	bisphenol A results in increased phosphorylation of MAPT protein	26779933\|2692323
C006780	bisphenol A	bisphenol A affects the expression of MAPT mRNA	25181051
C006780	bisphenol A	[bisphenol A co-treated with Genistein] results in increased methylation of MAPT gene	28505145
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of MAPT mRNA	22079614
C018475	butyraldehyde	butyraldehyde results in increased expression of MAPT mRNA	26079696
D002104	Cadmium	Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA]	29170048
D002104	Cadmium	[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA	29170048
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of MAPT mRNA	23741332
D019256	Cadmium Chloride	ACHE mRNA promotes the reaction [Cadmium Chloride results in increased expression of MAPT protein]	27377441
D019256	Cadmium Chloride	ACHE mRNA promotes the reaction [Cadmium Chloride results in increased expression of MAPT protein modified form]	27377441
D019256	Cadmium Chloride	[[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE mRNA alternative form] which results in increased expression of MAPT protein	27377441
D019256	Cadmium Chloride	[[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE mRNA alternative form] which results in increased expression of MAPT protein modified form	27377441
D019256	Cadmium Chloride	[Cadmium Chloride results in decreased activity of CHRM1 protein] which results in increased expression of MAPT protein	27377441
D019256	Cadmium Chloride	[Cadmium Chloride results in decreased activity of CHRM1 protein] which results in increased expression of MAPT protein modified form	27377441
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of and results in increased phosphorylation of MAPT protein	26026611
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MAPT protein	27377441
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MAPT protein modified form	27377441
D019256	Cadmium Chloride	CHRM1 mRNA inhibits the reaction [Cadmium Chloride results in increased expression of MAPT protein]	27377441
D019256	Cadmium Chloride	CHRM1 mRNA inhibits the reaction [Cadmium Chloride results in increased expression of MAPT protein modified form]	27377441
D019256	Cadmium Chloride	GSK3B mutant form inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of MAPT protein]	26026611
D002110	Caffeine	Caffeine results in decreased phosphorylation of MAPT protein	20838929
D002166	Camptothecin	Camptothecin results in decreased expression of MAPT mRNA	16930453
D002166	Camptothecin	Camptothecin results in decreased expression of MAPT protein	16930453
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of MAPT mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of MAPT mRNA	16644059
D002258	Carbonyl Cyanide m-Chlorophenyl Hydrazone	Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of MAPT protein	17634376
C062047	chelidonine	chelidonine results in decreased expression of MAPT protein	16930453
C084597	chlorcyclizine	chlorcyclizine results in increased expression of MAPT mRNA	21058326
D002738	Chloroquine	Chloroquine affects the expression of MAPT mRNA	9690670
D002738	Chloroquine	Chloroquine affects the expression of MAPT protein	9690670
D002738	Chloroquine	Chloroquine affects the localization of and affects the degradation of MAPT protein	9690670
D002738	Chloroquine	Chloroquine affects the expression of and affects the localization of MAPT protein	9704973
D002738	Chloroquine	Chloroquine affects the expression of MAPT mRNA	9704973
C011585	ciclopirox	ciclopirox results in decreased expression of MAPT protein	16930453
D002922	Ciguatoxins	Ciguatoxins affects the expression of MAPT mRNA	18353800
C045645	cilostazol	cilostazol affects the acetylation of and affects the phosphorylation of MAPT protein	24254769
C045645	cilostazol	SIRT1 protein affects the reaction [cilostazol affects the acetylation of and affects the phosphorylation of MAPT protein]	24254769
D003078	Colchicine	Colchicine results in decreased expression of MAPT protein	16930453
D003300	Copper	[Copper binds to Thiosemicarbazones analog] which results in decreased phosphorylation of MAPT protein	19122148
D003300	Copper	Copper results in increased phosphorylation of MAPT protein	25671100
D003300	Copper	tetrathiomolybdate inhibits the reaction [Copper results in increased phosphorylation of MAPT protein]	25671100
D003300	Copper	[Zinc Acetate results in decreased abundance of Copper] which results in decreased phosphorylation of MAPT protein	25671100
D003300	Copper	Copper promotes the reaction [[PSEN1 gene mutant form co-treated with APP gene mutant form co-treated with MAPT gene mutant form] results in decreased expression of CPLX1 protein]	25352456
D003300	Copper	Copper promotes the reaction [[PSEN1 gene mutant form co-treated with APP gene mutant form co-treated with MAPT gene mutant form] results in decreased expression of CPLX2 protein]	25352456
D003300	Copper	Copper results in decreased expression of MAPT mRNA	22465980
C057862	cyanoginosin LR	cyanoginosin LR results in increased phosphorylation of MAPT protein	23929704\|2739315
C057862	cyanoginosin LR	SB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of MAPT protein]	23929704
C057862	cyanoginosin LR	cyanoginosin LR affects the phosphorylation of MAPT protein	21934130
C057862	cyanoginosin LR	Acetylcysteine inhibits the reaction [cyanoginosin LR results in increased phosphorylation of MAPT protein]	24142891
C057862	cyanoginosin LR	Ascorbic Acid inhibits the reaction [cyanoginosin LR results in increased phosphorylation of MAPT protein]	24142891
C057862	cyanoginosin LR	cyanoginosin LR results in increased localization of MAPT protein	22000993
C057862	cyanoginosin LR	cyanoginosin LR results in increased phosphorylation of MAPT protein	22000993\|2414289
C057862	cyanoginosin LR	SB 203580 inhibits the reaction [cyanoginosin LR results in increased localization of MAPT protein]	22000993
C057862	cyanoginosin LR	SB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of MAPT protein]	22000993
D003520	Cyclophosphamide	MAPT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]	16896004
D016572	Cyclosporine	Cyclosporine results in decreased expression of MAPT mRNA	20106945\|2798913
C017160	cypermethrin	[Okadaic Acid co-treated with cypermethrin] results in increased phosphorylation of MAPT protein	7723735
C017160	cypermethrin	cypermethrin results in increased expression of MAPT protein	26143737
C017160	cypermethrin	cypermethrin results in decreased expression of MAPT mRNA	22528246
D003630	Daunorubicin	Daunorubicin results in decreased expression of MAPT mRNA	16930453
D003630	Daunorubicin	Daunorubicin results in decreased expression of MAPT protein	16930453
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of MAPT protein	25194327
C029108	diaziquone	diaziquone results in decreased expression of MAPT protein	16930453
C000944	dicrotophos	dicrotophos results in increased expression of MAPT mRNA	28302478
D004026	Dieldrin	Dieldrin results in increased expression of MAPT protein	20584760
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased phosphorylation of MAPT protein	22610992
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of MAPT mRNA	18164116
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of and results in increased phosphorylation of MAPT protein	19542621\|2038727
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of MAPT mRNA	17005392
D002117	Calcitriol	Calcitriol results in increased expression of MAPT mRNA	26485663
D004178	Diquat	Diquat affects the expression of MAPT mRNA	22814884
D016291	Dizocilpine Maleate	Dizocilpine Maleate inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPT protein]	21976409
D004298	Dopamine	Dopamine metabolite promotes the reaction [MAPT protein binds to MAPT protein]	16180106
D004298	Dopamine	Dopamine promotes the reaction [MAPT protein binds to MAPT protein]	16180106
D004317	Doxorubicin	Doxorubicin results in decreased expression of MAPT protein	16930453
D004317	Doxorubicin	MAPT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]	16896004
D004640	Emetine	Emetine results in decreased expression of MAPT protein	16930453
D004642	Emodin	Emodin results in decreased expression of MAPT mRNA	16045814
D004726	Endosulfan	Endosulfan affects the expression of MAPT protein	26143737
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of MAPT mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of MAPT mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAPT mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of MAPT mRNA	20381887
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of MAPT protein	20381887
C063007	exoenzyme C3, Clostridium botulinum	"exoenzyme C3, Clostridium botulinum inhibits the reaction [methylmercuric chloride results in decreased expression of MAPT protein]"	20869980
C049347	fasudil	fasudil inhibits the reaction [methylmercuric chloride results in decreased expression of MAPT protein]	20869980
D005273	Fenbendazole	Fenbendazole results in decreased expression of MAPT protein	16930453
D005411	Flame Retardants	Flame Retardants results in decreased expression of MAPT protein	18550172
D005411	Flame Retardants	Flame Retardants results in increased expression of MAPT protein	18550172
D005459	Fluorides	Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA]	29170048
D005459	Fluorides	[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA	29170048
D005472	Fluorouracil	MAPT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]	16896004
D005557	Formaldehyde	Formaldehyde affects the reaction [MAPT protein binds to MAPT protein]	17637844
D005557	Formaldehyde	Formaldehyde promotes the reaction [MAPT protein binds to MAPT protein]	17241479
C070081	fulvestrant	fulvestrant results in decreased expression of MAPT protein	20579400
C005023	fulvic acid	fulvic acid affects the folding of [MAPT protein binds to MAPT protein]	24191153
C005023	fulvic acid	fulvic acid inhibits the reaction [MAPT protein binds to and affects the folding of MAPT protein]	21785188
D019833	Genistein	[bisphenol A co-treated with Genistein] results in increased methylation of MAPT gene	28505145
D006037	Glyoxal	Glyoxal promotes the reaction [MAPT protein binds to MAPT protein]	17082178
D006096	Gramicidin	Gramicidin results in decreased expression of MAPT protein	16930453
D006118	Griseofulvin	Griseofulvin results in increased expression of MAPT mRNA	10051481
D006118	Griseofulvin	Griseofulvin results in increased expression of MAPT mRNA alternative form	10051481
D006118	Griseofulvin	Griseofulvin results in increased expression of MAPT protein	10051481
D006247	Harmine	Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein]	21573099
D006493	Heparin	Heparin promotes the reaction [MAPT protein binds to MAPT protein]	20665688
D006493	Heparin	Mercuric Chloride promotes the reaction [Heparin promotes the reaction [MAPT protein binds to MAPT protein]]	20665688
D017313	Fenretinide	Fenretinide results in increased expression of MAPT mRNA	16570282
D017313	Fenretinide	Fenretinide results in increased expression of MAPT mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide promotes the reaction [MAPT results in decreased expression of BCL2 protein]	28526263
D006861	Hydrogen Peroxide	Hydrogen Peroxide promotes the reaction [MAPT results in increased expression of CDKN2A protein]	28526263
D006861	Hydrogen Peroxide	Hydrogen Peroxide promotes the reaction [MAPT results in increased expression of RB1 protein]	28526263
D006861	Hydrogen Peroxide	Hydrogen Peroxide promotes the reaction [MAPT results in increased expression of TP53 protein]	28526263
C058028	immunomycin	[Okadaic Acid co-treated with immunomycin] results in increased phosphorylation of MAPT protein	7723735
C058028	immunomycin	[Okadaic Acid co-treated with immunomycin] results in increased phosphorylation of MAPT protein	7723735
C058028	immunomycin	[Okadaic Acid co-treated with immunomycin] results in increased phosphorylation of MAPT protein	7723735
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of MAPT mRNA	21396975
C503753	Indolinone A	Indolinone A results in decreased phosphorylation of MAPT protein	15712243
D015759	Ionomycin	Ionomycin results in decreased phosphorylation of MAPT protein	9200503
D015759	Ionomycin	Okadaic Acid inhibits the reaction [Ionomycin results in decreased phosphorylation of MAPT protein]	9200503
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of MAPT mRNA	25613284
D015759	Ionomycin	Ionomycin results in decreased phosphorylation of MAPT protein	9200503
D015759	Ionomycin	Okadaic Acid inhibits the reaction [Ionomycin results in decreased phosphorylation of MAPT protein]	9200503
C544151	jinfukang	jinfukang results in increased expression of MAPT mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of MAPT mRNA	24796395
D007649	Ketamine	Ketamine results in increased phosphorylation of MAPT protein	20093173
D007649	Ketamine	Ketamine results in increased phosphorylation of MAPT protein	20093173
D064747	Lansoprazole	Lansoprazole binds to MAPT protein alternative form	20110603
D007832	Lasalocid	Lasalocid results in decreased expression of MAPT protein	16930453
D007854	Lead	Lead affects the phosphorylation of MAPT protein	22342405
C008261	lead acetate	lead acetate results in increased expression of and results in increased phosphorylation of MAPT protein	27293183
C008261	lead acetate	lead acetate results in increased expression of and results in increased phosphorylation of MAPT protein	23973560
C008261	lead acetate	lead acetate affects the reaction [MAPT protein affects the abundance of CDK5R1 protein modified form]	29203278
C008261	lead acetate	lead acetate results in increased expression of and results in increased phosphorylation of MAPT protein	24954411
C008261	lead acetate	lead acetate results in increased expression of MAPT mRNA	24954411
C008261	lead acetate	lead acetate results in decreased expression of and results in increased phosphorylation of MAPT protein	23134599
C008261	lead acetate	lead acetate results in increased expression of and results in increased phosphorylation of MAPT protein	27012722
C008261	lead acetate	lead acetate results in increased phosphorylation of MAPT protein	22811615\|2508829
C008261	lead acetate	Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of MAPT protein]	25088297
C029433	lead tetraacetate	lead tetraacetate results in decreased expression of MAPT mRNA	20865013
C045463	leflunomide	leflunomide results in increased expression of MAPT mRNA	28988120
C027820	ligustilide	ligustilide results in decreased phosphorylation of MAPT protein	23973442
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of MAPT mRNA"	24972896
D008094	Lithium	Lithium inhibits the reaction [Acrolein results in increased phosphorylation of MAPT protein]	12605413
D018021	Lithium Chloride	Lithium Chloride results in decreased expression of MAPT mRNA	23527032
D018021	Lithium Chloride	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lithium Chloride inhibits the reaction [Okadaic Acid affects the phosphorylation of MAPT protein]]	27050422
D018021	Lithium Chloride	Lithium Chloride inhibits the reaction [Okadaic Acid affects the phosphorylation of MAPT protein]	27050422
D018021	Lithium Chloride	[Lithium Chloride results in decreased activity of GSK3B protein] inhibits the reaction [manganese chloride results in increased phosphorylation of MAPT protein]	20937724
D019808	Losartan	Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of MAPT protein]	22982863
D008315	Malondialdehyde	Malondialdehyde promotes the reaction [MAPT protein binds to MAPT protein]	17082178
D008344	Maneb	[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA	23963992
D008344	Maneb	Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA]	23963992
D008344	Maneb	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA]	23963992
C025340	manganese chloride	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased phosphorylation of MAPT protein]	20937724
C025340	manganese chloride	GSK3B protein affects the reaction [manganese chloride results in increased phosphorylation of MAPT protein]	20937724
C025340	manganese chloride	[Lithium Chloride results in decreased activity of GSK3B protein] inhibits the reaction [manganese chloride results in increased phosphorylation of MAPT protein]	20937724
C025340	manganese chloride	manganese chloride results in increased phosphorylation of MAPT protein	20937724
D008463	Mebendazole	Mebendazole results in decreased expression of MAPT protein	16930453
D008550	Melatonin	Melatonin inhibits the reaction [Mercuric Chloride results in increased phosphorylation of MAPT protein]	10617124
D008550	Melatonin	Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA]	23963992
D008550	Melatonin	Melatonin inhibits the reaction [wortmannin results in increased phosphorylation of MAPT protein]	15842767
D008627	Mercuric Chloride	Melatonin inhibits the reaction [Mercuric Chloride results in increased phosphorylation of MAPT protein]	10617124
D008627	Mercuric Chloride	Mercuric Chloride binds to and affects the folding of MAPT protein	20665688
D008627	Mercuric Chloride	Mercuric Chloride promotes the reaction [Heparin promotes the reaction [MAPT protein binds to MAPT protein]]	20665688
D008627	Mercuric Chloride	Mercuric Chloride results in increased phosphorylation of MAPT protein	10617124
D008694	Methamphetamine	"(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester inhibits the reaction [Methamphetamine results in decreased expression of MAPT mRNA]"	11756511
D008694	Methamphetamine	Methamphetamine results in decreased expression of MAPT mRNA	11756511
D008694	Methamphetamine	Methamphetamine results in increased expression of MAPT mRNA	26307267
D008751	Methylene Blue	Methylene Blue results in decreased expression of MAPT protein	16930453
D008751	Methylene Blue	Methylene Blue results in decreased phosphorylation of MAPT protein modified form	24556215
D008751	Methylene Blue	Methylene Blue results in increased expression of MAPT mRNA	16930453
D008751	Methylene Blue	Methylene Blue affects the reaction [MAPT protein mutant form affects the expression of TXNRD1 mRNA]	24556215
D008751	Methylene Blue	Methylene Blue affects the reaction [MAPT protein mutant form results in increased expression of TXN mRNA]	24556215
D008751	Methylene Blue	[Methylene Blue co-treated with MAPT protein mutant form] affects the localization of NFE2L2 protein	24556215
D008751	Methylene Blue	[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLC mRNA	24556215
D008751	Methylene Blue	[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLM mRNA	24556215
D008751	Methylene Blue	[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX2 mRNA	24556215
D008751	Methylene Blue	[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX mRNA	24556215
D008751	Methylene Blue	[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of HMOX1 mRNA	24556215
D008751	Methylene Blue	[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NFE2L2 mRNA	24556215
D008751	Methylene Blue	Methylene Blue co-treated with [MAPT protein mutant form results in increased expression of NOS2 mRNA]	24556215
D008751	Methylene Blue	[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NQO1 mRNA	24556215
D008751	Methylene Blue	[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of PRDX6 mRNA	24556215
D008751	Methylene Blue	[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXN2 mRNA	24556215
D008751	Methylene Blue	[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXNRD2 mRNA	24556215
D008751	Methylene Blue	Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP mRNA]	24556215
D008751	Methylene Blue	Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP protein]	24556215
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of MAPT mRNA	20061341
C004925	methylmercuric chloride	"exoenzyme C3, Clostridium botulinum inhibits the reaction [methylmercuric chloride results in decreased expression of MAPT protein]"	20869980
C004925	methylmercuric chloride	fasudil inhibits the reaction [methylmercuric chloride results in decreased expression of MAPT protein]	20869980
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of MAPT protein	20869980
C004925	methylmercuric chloride	methylmercuric chloride results in increased phosphorylation of MAPT protein	28821999
C004925	methylmercuric chloride	Y 27632 inhibits the reaction [methylmercuric chloride results in decreased expression of MAPT protein]	20869980
D008767	Methylmercury Compounds	Dizocilpine Maleate inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPT protein]	21976409
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased phosphorylation of MAPT protein	21976409
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of MAPT mRNA	26558463
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased phosphorylation of MAPT protein	19666049
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of MAPT protein alternative form	25402454
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased splicing of MAPT mRNA	25402454
D015655	1-Methyl-4-phenylpyridinium	SRSF2 promotes the reaction [1-Methyl-4-phenylpyridinium results in increased splicing of MAPT mRNA]	25402454
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of MAPT mRNA	26558463
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium affects the localization of MAPT protein	17634376
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAPT mRNA"	15329391
C008493	methylselenic acid	methylselenic acid results in decreased expression of MAPT mRNA	12517777
C524165	microcystin-LF	microcystin-LF affects the phosphorylation of MAPT protein	21934130
D052998	Microcystins	Microcystins results in increased phosphorylation of MAPT protein	22430071
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of MAPT mRNA	22401849
D009020	Morphine	Morphine results in increased expression of MAPT mRNA	15183518
D009173	Mycophenolic Acid	Mycophenolic Acid results in decreased expression of MAPT protein	16930453
C479831	N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea	"[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein]"	21715663
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of MAPT mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of MAPT mRNA"	25554681\|2562005
C495860	naphthol AS-E phosphate	naphthol AS-E phosphate results in decreased expression of MAPT protein	25150140
D009532	Nickel	Nickel results in decreased expression of MAPT mRNA	24768652\|2558310
D009532	Nickel	Nickel results in decreased expression of MAPT mRNA	12540486
C029938	nickel sulfate	nickel sulfate results in decreased expression of MAPT mRNA	16100012
D015739	Nocodazole	Nocodazole results in decreased expression of MAPT protein	16930453
D009640	Norethindrone	Norethindrone results in decreased expression of MAPT protein	16930453
D016627	Oxidopamine	Oxidopamine results in increased cleavage of and results in decreased phosphorylation of MAPT protein	12686375
D019319	Okadaic Acid	[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein]	21715663
D019319	Okadaic Acid	"[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein]"	21715663
D019319	Okadaic Acid	[Okadaic Acid co-treated with immunomycin] results in increased phosphorylation of MAPT protein	7723735
D019319	Okadaic Acid	Okadaic Acid results in increased phosphorylation of MAPT protein	21715663\|7723735
D019319	Okadaic Acid	[PNU-282987 binds to and results in increased activity of CHRNA7 protein] inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein]	21715663
D019319	Okadaic Acid	[Okadaic Acid co-treated with cypermethrin] results in increased phosphorylation of MAPT protein	7723735
D019319	Okadaic Acid	[Okadaic Acid co-treated with immunomycin] results in increased phosphorylation of MAPT protein	7723735
D019319	Okadaic Acid	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lithium Chloride inhibits the reaction [Okadaic Acid affects the phosphorylation of MAPT protein]]	27050422
D019319	Okadaic Acid	Lithium Chloride inhibits the reaction [Okadaic Acid affects the phosphorylation of MAPT protein]	27050422
D019319	Okadaic Acid	Okadaic Acid affects the phosphorylation of MAPT protein	21934130\|2705042
D019319	Okadaic Acid	Okadaic Acid inhibits the reaction [Ionomycin results in decreased phosphorylation of MAPT protein]	9200503
D019319	Okadaic Acid	Quercetin inhibits the reaction [Okadaic Acid affects the phosphorylation of MAPT protein]	27050422
D019319	Okadaic Acid	[Okadaic Acid co-treated with immunomycin] results in increased phosphorylation of MAPT protein	7723735
D019319	Okadaic Acid	Okadaic Acid inhibits the reaction [Ionomycin results in decreased phosphorylation of MAPT protein]	9200503
D019319	Okadaic Acid	Okadaic Acid inhibits the reaction [Potassium Chloride results in decreased phosphorylation of MAPT protein]	9200503
D019319	Okadaic Acid	Okadaic Acid results in increased phosphorylation of MAPT protein	26732598\|7723735
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of MAPT mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of MAPT mRNA	25729387
C029341	oxophenylarsine	[oxophenylarsine results in increased activity of MARK1 protein] which results in increased phosphorylation of MAPT protein	10737602
C029341	oxophenylarsine	oxophenylarsine results in increased phosphorylation of MAPT protein	10737602
C029341	oxophenylarsine	Staurosporine inhibits the reaction [oxophenylarsine results in increased phosphorylation of MAPT protein]	10737602
C029341	oxophenylarsine	oxophenylarsine results in increased phosphorylation of MAPT protein	10737602
C029341	oxophenylarsine	Staurosporine inhibits the reaction [oxophenylarsine results in increased phosphorylation of MAPT protein]	10737602
C029341	oxophenylarsine	oxophenylarsine affects the phosphorylation of and affects the localization of MAPT protein	10537042
C029341	oxophenylarsine	Staurosporine affects the reaction [oxophenylarsine affects the phosphorylation of MAPT protein]	10537042
D010126	Ozone	Ozone results in decreased expression of MAPT mRNA	12763052
D017239	Paclitaxel	MAPT mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]	16896004
D017239	Paclitaxel	Paclitaxel results in decreased expression of MAPT mRNA	16930453
D017239	Paclitaxel	Paclitaxel results in decreased expression of MAPT protein	16930453
D017239	Paclitaxel	Paclitaxel inhibits the reaction [annonacin affects the localization of MAPT protein]	17634376
D010269	Paraquat	[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA	23963992
D010269	Paraquat	Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA]	23963992
D010269	Paraquat	Paraquat results in increased phosphorylation of and results in increased expression of MAPT protein	22292029
D010269	Paraquat	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA]	23963992
D010269	Paraquat	Paraquat results in decreased expression of MAPT protein	24521700
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of MAPT protein	18550172
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of MAPT protein	18550172
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of MAPT protein	19954255
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of MAPT mRNA	23892564
C046012	pentanal	pentanal results in increased expression of MAPT mRNA	26079696
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of MAPT protein	19211617
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of and results in increased phosphorylation of MAPT protein	27018931
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of MAPT mRNA	27018931
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of MAPT protein	19211617
D010705	Phosgene	Phosgene affects the expression of MAPT mRNA	16300373
C100213	piericidin A	MAPT protein polymorphism results in increased susceptibility to piericidin A	25437199
C100213	piericidin A	piericidin A results in increased phosphorylation of MAPT protein polymorphism	25437199
C006253	pirinixic acid	pirinixic acid results in decreased expression of MAPT mRNA	23811191
C498513	PNU-282987	[PNU-282987 binds to and results in increased activity of CHRNA7 protein] inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein]	21715663
D011034	Podophyllotoxin	Podophyllotoxin results in decreased expression of MAPT protein	16930453
D011189	Potassium Chloride	Okadaic Acid inhibits the reaction [Potassium Chloride results in decreased phosphorylation of MAPT protein]	9200503
D011189	Potassium Chloride	Potassium Chloride results in decreased phosphorylation of MAPT protein	9200503
D017035	Pravastatin	Pravastatin affects the expression of MAPT	19461118
D017035	Pravastatin	Pravastatin results in decreased expression of MAPT mRNA	27225895
D017035	Pravastatin	Pravastatin results in decreased expression of MAPT mRNA	27225895
D011280	Pregnanolone	Pregnanolone results in decreased expression of MAPT protein	17443805
D011280	Pregnanolone	Pregnanolone results in increased phosphorylation of MAPT protein	17443805
D044945	Proanthocyanidins	Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of MAPT protein]	25088297
D011374	Progesterone	Progesterone results in decreased expression of MAPT protein	17443805
D011374	Progesterone	Progesterone results in increased phosphorylation of MAPT protein	17443805
C005556	propionaldehyde	propionaldehyde results in increased expression of MAPT mRNA	26079696
C008704	pyrithione	GSK3B protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein]	17098228
C008704	pyrithione	[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein	17098228
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid results in decreased phosphorylation of MAPT protein	17409235
D011765	Pyruvaldehyde	Pyruvaldehyde promotes the reaction [MAPT protein binds to MAPT protein]	17082178
D011794	Quercetin	Quercetin inhibits the reaction [Okadaic Acid affects the phosphorylation of MAPT protein]	27050422
D011794	Quercetin	Quercetin inhibits the reaction [aluminum lactate results in increased phosphorylation of MAPT protein]	26493151
C004532	quinone	quinone promotes the reaction [MAPT protein binds to MAPT protein]	16180106
C059514	resveratrol	resveratrol results in decreased expression of MAPT mRNA	12569576
C059514	resveratrol	resveratrol affects the acetylation of and affects the phosphorylation of MAPT protein	24254769
C059514	resveratrol	resveratrol results in decreased phosphorylation of MAPT protein	23129026
C059514	resveratrol	resveratrol results in increased expression of MAPT mRNA	22610192
C059514	resveratrol	resveratrol inhibits the reaction [APP protein modified form results in increased expression of MAPT protein]	25654502
C059514	resveratrol	resveratrol inhibits the reaction [APP protein modified form results in increased expression of MAPT protein modified form]	25654502
C064758	Ro 31-8220	Ro 31-8220 inhibits the reaction [Arachidonic Acid results in increased phosphorylation of MAPT protein]	12605413
D012402	Rotenone	Rotenone results in decreased expression of MAPT protein	16930453
D012402	Rotenone	Rotenone results in increased expression of MAPT protein	16219024
D012402	Rotenone	Rotenone results in increased phosphorylation of MAPT protein	16219024
D012524	Sarin	Sarin results in decreased expression of MAPT mRNA	19522546
C093642	SB 203580	SB 203580 inhibits the reaction [Acrolein results in increased phosphorylation of MAPT protein]	12605413
C093642	SB 203580	SB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of MAPT protein]	23929704
C093642	SB 203580	SB 203580 inhibits the reaction [cyanoginosin LR results in increased localization of MAPT protein]	22000993
C093642	SB 203580	SB 203580 inhibits the reaction [cyanoginosin LR results in increased phosphorylation of MAPT protein]	22000993
C417521	SB 216763	SB 216763 inhibits the reaction [AGT protein modified form results in increased phosphorylation of MAPT protein]	22982863
D012601	Scopolamine Hydrobromide	Scopolamine Hydrobromide results in decreased expression of MAPT mRNA	12818353
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in decreased expression of MAPT mRNA"	16251409
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased phosphorylation of MAPT protein	24831964
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased phosphorylation of MAPT protein	24831964
D012834	Silver	Silver results in decreased expression of MAPT protein	27593553
D012834	Silver	Silver results in increased expression of MAPT protein modified form	27593553
D012838	Silymarin	Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA]	23963992
D019821	Simvastatin	Simvastatin affects the expression of MAPT	19461118
C009277	sodium arsenate	sodium arsenate results in decreased expression of MAPT mRNA	21795629
C017947	sodium arsenite	sodium arsenite affects the methylation of MAPT gene	28589171
C017947	sodium arsenite	sodium arsenite results in decreased expression of MAPT mRNA	23022324
C017947	sodium arsenite	sodium arsenite results in increased phosphorylation of MAPT protein	18674524
D012999	Soman	Soman results in decreased expression of MAPT mRNA	19281266
D053260	Soot	Soot results in decreased expression of MAPT mRNA	22461453
C075117	squalestatin 1	squalestatin 1 results in decreased expression of MAPT mRNA	27225895
C075117	squalestatin 1	squalestatin 1 results in increased expression of MAPT mRNA	27225895
D019311	Staurosporine	Staurosporine inhibits the reaction [oxophenylarsine results in increased phosphorylation of MAPT protein]	10737602
D019311	Staurosporine	Staurosporine inhibits the reaction [oxophenylarsine results in increased phosphorylation of MAPT protein]	10737602
D019311	Staurosporine	Staurosporine affects the reaction [oxophenylarsine affects the phosphorylation of MAPT protein]	10537042
D013311	Streptozocin	SOD2 protein inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein]	20976160
D013311	Streptozocin	Streptozocin results in increased phosphorylation of MAPT protein	20976160
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Estradiol results in increased expression of MAPT protein]	20579400
D013629	Tamoxifen	Tamoxifen results in increased expression of MAPT protein	20579400
D013629	Tamoxifen	Tamoxifen affects the expression of MAPT mRNA	17555576
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid inhibits the reaction [[APP protein modified form results in increased activity of CASP3 protein] which results in increased cleavage of MAPT protein]	18368144
C004648	testosterone enanthate	testosterone enanthate affects the expression of MAPT mRNA	17440010
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MAPT mRNA	20106945\|2623829
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAPT mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MAPT mRNA	16922920\|1794274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased phosphorylation of MAPT protein	18996433
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of MAPT mRNA	25613284
C020809	tetrathiomolybdate	tetrathiomolybdate inhibits the reaction [Copper results in increased phosphorylation of MAPT protein]	25671100
D013882	Thiosemicarbazones	[Copper binds to Thiosemicarbazones analog] which results in decreased phosphorylation of MAPT protein	19122148
C009495	titanium dioxide	titanium dioxide results in decreased expression of MAPT mRNA	23557971\|2776080
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of MAPT mRNA	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of MAPT protein	21778470
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of MAPT protein modified form	21778470
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of MAPT mRNA	25729387
D014118	Toxins, Biological	"Toxins, Biological affects the expression of MAPT mRNA"	19682533
D014212	Tretinoin	MAPT protein affects the susceptibility to Tretinoin	16417947
D014212	Tretinoin	MAPT protein promotes the reaction [Tretinoin affects the localization of MAPT protein]	16417947
D014212	Tretinoin	Tretinoin promotes the reaction [MAPT protein affects the localization of [MAPT protein binds to RARG protein]]	16417947
D014212	Tretinoin	Tretinoin promotes the reaction [ZMYND8 protein binds to MAPT gene]	26655721
D014212	Tretinoin	Tretinoin promotes the reaction [ZMYND8 protein binds to MAPT promoter]	26655721
D014212	Tretinoin	Tretinoin results in increased expression of MAPT mRNA	23903816\|2665572
D014212	Tretinoin	Tretinoin results in increased expression of MAPT mRNA alternative form	9131769
D014212	Tretinoin	Tretinoin results in increased expression of MAPT protein	26655721
D014212	Tretinoin	ZMYND8 protein affects the reaction [Tretinoin results in increased expression of MAPT mRNA]	26655721
D014212	Tretinoin	MAPT protein promotes the reaction [Tretinoin results in increased activity of CASP3 protein]	16417947
D014212	Tretinoin	Tretinoin results in increased expression of MAPT protein	17130476
C011559	tributyltin	tributyltin results in increased cleavage of MAPT protein	23743147
C012589	trichostatin A	trichostatin A results in increased expression of MAPT mRNA	24935251
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MAPT mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of MAPT mRNA	28973697
C046243	tryptanthrine	tryptanthrine results in increased expression of MAPT mRNA	23500671
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAPT mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of MAPT mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of MAPT	25524013
D014635	Valproic Acid	Valproic Acid results in increased expression of MAPT mRNA	19101580\|2317975
D014635	Valproic Acid	Valproic Acid results in increased methylation of MAPT gene	29154799
D014640	Vancomycin	Vancomycin results in increased expression of MAPT mRNA	18930951
C025643	vinclozolin	vinclozolin results in increased expression of MAPT mRNA	23034163
D014810	Vitamin E	Vitamin E inhibits the reaction [wortmannin results in increased phosphorylation of MAPT protein]	15842767
C070417	Win 55212-2	Win 55212-2 results in increased expression of MAPT mRNA	12237329
C009687	wortmannin	Melatonin inhibits the reaction [wortmannin results in increased phosphorylation of MAPT protein]	15842767
C009687	wortmannin	Vitamin E inhibits the reaction [wortmannin results in increased phosphorylation of MAPT protein]	15842767
C009687	wortmannin	wortmannin results in increased phosphorylation of MAPT protein	15842767
C108830	Y 27632	Y 27632 inhibits the reaction [methylmercuric chloride results in decreased expression of MAPT protein]	20869980
D015032	Zinc	GSK3B protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein]	17098228
D015032	Zinc	[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein	17098228
D019345	Zinc Acetate	[Zinc Acetate results in decreased abundance of Copper] which results in decreased phosphorylation of MAPT protein	25671100
D015034	Zinc Oxide	Zinc Oxide analog results in decreased expression of MAPT mRNA	27215404

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003677	DNA binding	-	ISS	-
GO:0003677	DNA binding	-	TAS	28386764
GO:0003680	AT DNA binding	-	TAS	28386764
GO:0003690	double-stranded DNA binding	-	TAS	28386764
GO:0003697	single-stranded DNA binding	-	TAS	28386764
GO:0003723	RNA binding	-	TAS	28386764
GO:0003779	actin binding	-	TAS	22920254 27306859 28386764
GO:0005515	protein binding	-	IPI	3111527 7566652 9689133 10987820 14697667 15953362 16275660 16446437 17078951 17317006 18292230 19138662 19527721 19647741 20655099 22367970 23001711 23399914 23589030 23666762 24028865 24251416 25051234 28755476
GO:0008017	microtubule binding	-	IBA	21873635
GO:0008017	microtubule binding	-	IDA	1918161 28377597
GO:0008017	microtubule binding	-	IMP	10747907
GO:0008017	microtubule binding	-	NAS	28386764
GO:0008017	microtubule binding	-	TAS	26363795 26609151
GO:0017124	SH3 domain binding	-	IPI	9763511
GO:0019899	enzyme binding	-	IPI	9736630 12888622 20133804
GO:0019899	enzyme binding	-	ISS	23362255
GO:0019901	protein kinase binding	-	IPI	24251416
GO:0019901	protein kinase binding	-	ISS	17906291
GO:0030674	protein binding, bridging	-	TAS	28386764
GO:0034185	apolipoprotein binding	-	IPI	7566652
GO:0034452	dynactin binding	-	TAS	26363795
GO:0035091	phosphatidylinositol binding	-	TAS	28386764
GO:0042802	identical protein binding	-	IMP	7929085 14769047
GO:0042803	protein homodimerization activity	-	IMP	15654759
GO:0043565	sequence-specific DNA binding	-	TAS	28386764
GO:0048018	receptor ligand activity	-	IDA	18272392
GO:0051087	chaperone binding	-	IPI	25051234
GO:0051721	protein phosphatase 2A binding	-	TAS	26363795
GO:0051879	Hsp90 protein binding	-	IPI	17517623
GO:0071813	lipoprotein particle binding	-	IPI	7972031
GO:0099077	histone-dependent DNA binding	-	TAS	28386764
GO:0099609	microtubule lateral binding	-	IMP	15147841
GO:1902936	phosphatidylinositol bisphosphate binding	-	TAS	28386764

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000226	microtubule cytoskeleton organization	-	IBA	21873635
GO:0000226	microtubule cytoskeleton organization	-	IDA	1057175
GO:0000226	microtubule cytoskeleton organization	-	NAS	28377597
GO:0001774	microglial cell activation	-	TAS	26363795
GO:0006475	internal protein amino acid acetylation	-	TAS	28386764
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	-	TAS	26363795
GO:0007267	cell-cell signaling	-	NAS	28386764
GO:0007613	memory	-	IMP	20655099
GO:0010288	response to lead ion	-	ISS	-
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0010506	regulation of autophagy	-	IGI	19074461
GO:0010629	negative regulation of gene expression	-	IMP	23164821
GO:0010917	negative regulation of mitochondrial membrane potential	-	IMP	22920254
GO:0016072	rRNA metabolic process	-	TAS	28386764
GO:0019896	axonal transport of mitochondrion	-	TAS	26363795
GO:0021954	central nervous system neuron development	-	TAS	28386764
GO:0031110	regulation of microtubule polymerization or depolymerization	-	IMP	27356871
GO:0031113	regulation of microtubule polymerization	-	NAS	1057175
GO:0031113	regulation of microtubule polymerization	-	TAS	10640627 28386764
GO:0031116	positive regulation of microtubule polymerization	-	IDA	1421571 7706316
GO:0031122	cytoplasmic microtubule organization	-	TAS	26363795
GO:0031175	neuron projection development	-	IBA	21873635
GO:0031175	neuron projection development	-	TAS	26363795
GO:0032930	positive regulation of superoxide anion generation	-	IMP	22920254
GO:0033044	regulation of chromosome organization	-	TAS	28386764
GO:0033673	negative regulation of kinase activity	-	IMP	20655099
GO:0034063	stress granule assembly	-	TAS	28386764
GO:0034605	cellular response to heat	-	TAS	26363795
GO:0034614	cellular response to reactive oxygen species	-	TAS	28386764
GO:0045773	positive regulation of axon extension	-	IDA	1389180
GO:0046785	microtubule polymerization	-	TAS	26996940
GO:0048143	astrocyte activation	-	TAS	26363795
GO:0048167	regulation of synaptic plasticity	-	TAS	28386764
GO:0048312	intracellular distribution of mitochondria	-	IMP	21854751
GO:0048699	generation of neurons	-	NAS	8522593
GO:0050808	synapse organization	-	IMP	17270732
GO:0050848	regulation of calcium-mediated signaling	-	IDA	18272392
GO:0051259	protein complex oligomerization	-	TAS	26363795
GO:0061564	axon development	-	TAS	26609151
GO:0070507	regulation of microtubule cytoskeleton organization	-	IMP	15147841
GO:0070507	regulation of microtubule cytoskeleton organization	-	TAS	28386764
GO:0072386	plus-end-directed organelle transport along microtubule	-	TAS	26363795
GO:0090140	regulation of mitochondrial fission	-	IC	22367970
GO:0090258	negative regulation of mitochondrial fission	-	IMP	22920254
GO:0097435	supramolecular fiber organization	-	IMP	14769047 15654759
GO:0098930	axonal transport	-	NAS	28377597
GO:0098930	axonal transport	-	TAS	26363795
GO:1900034	regulation of cellular response to heat	-	IMP	21131359
GO:1900452	regulation of long term synaptic depression	-	TAS	28386764
GO:1901216	positive regulation of neuron death	-	IMP	22920254
GO:1902474	positive regulation of protein localization to synapse	-	IMP	20655099
GO:1902988	neurofibrillary tangle assembly	-	NAS	26363795
GO:1903748	negative regulation of establishment of protein localization to mitochondrion	-	IMP	22920254
GO:1903829	positive regulation of cellular protein localization	-	IMP	27356871
GO:1904428	negative regulation of tubulin deacetylation	-	IGI	19457097
GO:1904428	negative regulation of tubulin deacetylation	-	TAS	28386764
GO:1905689	positive regulation of diacylglycerol kinase activity	-	ISS	-
GO:1990000	amyloid fibril formation	-	IMP	7929085
GO:1990090	cellular response to nerve growth factor stimulus	-	TAS	28386764
GO:1990416	cellular response to brain-derived neurotrophic factor stimulus	-	TAS	28386764
GO:2001020	regulation of response to DNA damage stimulus	-	IMP	21131359

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	NAS	28386764
GO:0005622	intracellular	-	NAS	28386764
GO:0005622	intracellular	-	TAS	26996940
GO:0005634	nucleus	-	ISS	-
GO:0005634	nucleus	-	TAS	28386764
GO:0005737	cytoplasm	-	IDA	23666762 27356871
GO:0005737	cytoplasm	-	ISS	-
GO:0005739	mitochondrion	-	TAS	28386764
GO:0005829	cytosol	-	IDA	10747907
GO:0005829	cytosol	-	ISS	-
GO:0005829	cytosol	-	TAS	-
GO:0005874	microtubule	colocalizes_with	ISS	-
GO:0005886	plasma membrane	-	IDA	8522593 10747907
GO:0005886	plasma membrane	-	TAS	28386764
GO:0015630	microtubule cytoskeleton	-	IDA	15147841 27356871 28377597
GO:0015630	microtubule cytoskeleton	-	NAS	26363795 28386764
GO:0016020	membrane	colocalizes_with	IMP	20655099
GO:0016607	nuclear speck	-	IDA	-
GO:0030424	axon	-	IDA	8642405
GO:0030424	axon	-	NAS	26363795
GO:0030424	axon	-	TAS	28386764
GO:0030425	dendrite	-	IDA	23666762 25620700
GO:0030426	growth cone	-	IDA	8642405
GO:0030673	axolemma	-	IDA	10747907
GO:0034399	nuclear periphery	-	IDA	19157893
GO:0036464	cytoplasmic ribonucleoprotein granule	-	IDA	15121898
GO:0036477	somatodendritic compartment	-	IMP	20655099
GO:0036477	somatodendritic compartment	-	TAS	28386764
GO:0043005	neuron projection	-	IBA	21873635
GO:0043025	neuronal cell body	-	IMP	20655099
GO:0043197	dendritic spine	-	TAS	28386764
GO:0044297	cell body	-	IDA	25620700
GO:0044297	cell body	-	ISS	-
GO:0044304	main axon	-	ISS	-
GO:0045121	membrane raft	-	ISS	-
GO:0045298	tubulin complex	-	IDA	8642405
GO:0097386	glial cell projection	-	ISS	-
GO:0097418	neurofibrillary tangle	-	IDA	2484340
GO:0097418	neurofibrillary tangle	-	NAS	25620700
GO:1904115	axon cytoplasm	-	IEA	-

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa05010	Alzheimer's disease

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	TAS
R-HSA-111465	Apoptotic cleavage of cellular proteins	TAS
R-HSA-264870	Caspase-mediated cleavage of cytoskeletal proteins	TAS
R-HSA-5357801	Programmed Cell Death	TAS
R-HSA-75153	Apoptotic execution phase	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20876472	A comprehensive analysis of deletions, multiplications, and copy number variations in PARK2. (2010 Sep 28)	Kay DM	Neurology
27142338	Prostate tumor DNA methylation is associated with cigarette smoking and adverse prostate cancer outcomes. (2016 Jul 15)	Shui IM	Cancer
22763023	An exploratory analysis on gene-environment interactions for Parkinson disease. (2012 Oct)	Gao J	Neurobiol Aging
18210157	Exploring gene-environment interactions in Parkinson's disease. (2008 Apr)	McCulloch CC	Hum Genet