Gene: MARK1

4139
MARK|Par-1c|Par1c
microtubule affinity regulating kinase 1
protein-coding
1q41
Ensembl:ENSG00000116141 MIM:606511 Vega:OTTHUMG00000037351 UniprotKB:Q9P0L2
NC_000001.11
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.152e-1 (AD)  1.241e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14154859chr1:220702826MARK12.350e-9Maternal smoking in pregnancy27040690
cg14154859chr1:220702826MARK14.630e-10Maternal smoking in pregnancy27040690
cg14154859chr1:220702826MARK13.890e-10Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIF3A0.968
MAP2K40.963
GSK3B0.963
ATP6V1A0.962
MTMR90.958
MAPK80.958
KIFAP30.957
REEP10.956
FAM49A0.956
ATP6V1C10.956

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.512
OR4F5-0.504
RHOD-0.492
ASB4-0.484
RAB13-0.48
RAI14-0.476
YES1-0.472
HEY2-0.471
COPZ2-0.47
REST-0.47

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of MARK1 mRNA17562736
C103303alitretinoinalitretinoin results in increased expression of MARK1 mRNA16648578
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MARK1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MARK1 mRNA24449571
C015001arsenitearsenite results in decreased expression of MARK1 mRNA23974009
D001280AtrazineAtrazine affects the expression of MARK1 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of MARK1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MARK1 mRNA26001963
D004958EstradiolEstradiol results in increased expression of MARK1 mRNA19484750
C095105bexarotenebexarotene results in increased expression of MARK1 mRNA16648578
C006780bisphenol Abisphenol A results in decreased expression of MARK1 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of MARK1 gene22576693
C006780bisphenol Abisphenol A results in increased expression of MARK1 mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of MARK1 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MARK1 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MARK1 gene20938992
D003042CocaineCocaine affects the expression of MARK1 mRNA20187946
D016572CyclosporineCyclosporine results in increased expression of MARK1 mRNA20106945
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of MARK1 mRNA24317228
C014347decitabinedecitabine results in increased expression of MARK1 mRNA16367923
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MARK1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of MARK1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of MARK1 mRNA27392435
C118739entinostatentinostat results in decreased expression of MARK1 mRNA27188386
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MARK1 mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MARK1 gene20938992
D017313FenretinideFenretinide results in increased expression of MARK1 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of MARK1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of MARK1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MARK1 mRNA26644586
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MARK1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MARK1 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MARK1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MARK1 mRNA"25554681
D009532NickelNickel affects the expression of MARK1 mRNA14575637
D009532NickelNickel results in decreased expression of MARK1 mRNA25583101
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of MARK1 mRNA]14575637
C029341oxophenylarsineoxophenylarsine results in increased activity of MARK1 protein10737602
C029341oxophenylarsine[oxophenylarsine results in increased activity of MARK1 protein] which results in increased phosphorylation of MAPT protein10737602
C029341oxophenylarsineStaurosporine inhibits the reaction [oxophenylarsine results in increased activity of MARK1 protein]10737602
D059808PolyphenolsPolyphenols results in decreased expression of MARK1 mRNA16293270
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of MARK1 mRNA22714537
D019311StaurosporineStaurosporine inhibits the reaction [oxophenylarsine results in increased activity of MARK1 protein]10737602
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of MARK1 mRNA"26680231
D013629TamoxifenTamoxifen results in increased expression of MARK1 mRNA25123088
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MARK1 mRNA17942748
C011559tributyltintributyltin results in increased expression of MARK1 mRNA29191790
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of MARK1 mRNA]14575637
C012589trichostatin Atrichostatin A results in increased expression of MARK1 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of MARK1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MARK1 mRNA28001369
D014635Valproic AcidValproic Acid results in decreased methylation of MARK1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of MARK1 mRNA23179753
D014638VanadatesVanadates results in decreased expression of MARK1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MARK1 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of MARK1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IDA14976552  
GO:0001786phosphatidylserine binding-IDA21145462  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA14976552  
GO:0004674protein serine/threonine kinase activity-NAS28386764  
GO:0005515protein binding-IPI23666762  
GO:0005524ATP binding-IDA14976552  
GO:0005546phosphatidylinositol-4,5-bisphosphate binding-IDA21145462  
GO:0050321tau-protein kinase activity-IBA21873635  
GO:0050321tau-protein kinase activity-IMP23666762  
GO:0050321tau-protein kinase activity-ISS-  
GO:0070300phosphatidic acid binding-IDA21145462  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-IBA21873635  
GO:0000226microtubule cytoskeleton organization-ISS-  
GO:0001764neuron migration-ISS-  
GO:0006468protein phosphorylation-IDA14976552  
GO:0006468protein phosphorylation-IMP23666762  
GO:0007010cytoskeleton organization-ISS-  
GO:0010975regulation of neuron projection development-ISS-  
GO:0016055Wnt signaling pathway-IEA-  
GO:0018105peptidyl-serine phosphorylation-NAS10542369  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0035556intracellular signal transduction-IDA14976552  
GO:0050773regulation of dendrite development-ISS-  
GO:0051654establishment of mitochondrion localization-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA23666762  
GO:0005737cytoplasm-ISS-  
GO:0005856cytoskeleton-ISS-  
GO:0005886plasma membrane-IDA21145462  
GO:0015630microtubule cytoskeleton-TAS9108484  
GO:0030425dendrite-IDA23666762  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
10842574Breastfeeding and asthma in children: findings from a West Australian study. (2000 Mar)Oddy WHBreastfeed Rev
20166940Primate-accelerated evolutionary genes: novel routes to drug discovery in psychiatric disorders. (2010)Moalic JMCurr Med Chem
22205951Genome-wide association study in bipolar patients stratified by co-morbidity. (2011)Kerner BPLoS One