Gene info: ID 4141

Gene: MARS

GENE ID: 4141

Description: methionyl-tRNA synthetase

Gene type: protein-coding

Location: 12q13.3

dbXrefs: Ensembl:ENSG00000166986 MIM:156560 Vega:OTTHUMG00000169996 UniprotKB:P56192

RefSeq: NG_034077.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.258e-1 (AD) 4.330e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SEC24C	0.946
AARS	0.945
GARS	0.944
ACAD8	0.944
NEU1	0.943
KDM1A	0.943
EFTUD2	0.943
SMG7	0.942
YARS	0.941
MBD1	0.941

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.657
OR4F29	-0.605
ASB4	-0.373
CTNNA3	-0.356
KLRB1	-0.354
MYOM1	-0.336
SH2D1A	-0.336
MBNL3	-0.315
PDE11A	-0.313
MTRNR2L9	-0.311

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C032668	1-nitropyrene	1-nitropyrene results in increased expression of MARS mRNA	19041380
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MARS mRNA"	25614096
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of MARS mRNA"	19095052
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARS mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARS mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of MARS mRNA	29067470
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of MARS mRNA	24449571
D001280	Atrazine	Atrazine results in decreased expression of MARS mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MARS mRNA	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MARS mRNA	21569818\|2222880
C006780	bisphenol A	bisphenol A affects the expression of MARS mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of MARS mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of MARS mRNA	25181051
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in increased expression of MARS protein	23736079
C584509	C646 compound	C646 compound results in increased expression of MARS mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MARS mRNA	23741332
D002220	Carbamazepine	Carbamazepine affects the expression of MARS mRNA	25979313
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARS mRNA"	27188386
C100187	chloropicrin	chloropicrin results in decreased expression of MARS mRNA	26352163
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MARS gene	20938992
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of MARS mRNA	28472532
D019327	Copper Sulfate	Copper Sulfate results in increased expression of MARS mRNA	19549813
C029892	cupric chloride	cupric chloride results in increased expression of MARS mRNA	24650576
D016572	Cyclosporine	Cyclosporine results in increased expression of MARS mRNA	20106945\|2163298
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of MARS mRNA	23640034
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of MARS mRNA	23914054
D002945	Cisplatin	Cisplatin inhibits the reaction [Piroxicam results in decreased expression of MARS mRNA]	21858171
D019259	Lamivudine	[Zidovudine co-treated with Lamivudine] results in increased expression of MARS mRNA	15784690
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in decreased expression of MARS mRNA]	15016801
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MARS gene	20938992
C056507	gemcitabine	gemcitabine results in increased expression of MARS mRNA	17039268
C492448	ICG 001	ICG 001 results in increased expression of MARS mRNA	26191083
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MARS mRNA	25613284
C410337	K 7174	K 7174 results in increased expression of MARS mRNA	24086573
C008261	lead acetate	lead acetate results in increased expression of MARS mRNA	11578147
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MARS gene	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of MARS mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of MARS mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of MARS mRNA	23649840
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of MARS mRNA	29191790
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of MARS mRNA	22321834
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of MARS mRNA	26924002
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of MARS mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of MARS mRNA"	25554681
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of MARS mRNA	20551477
D009532	Nickel	Nickel results in increased expression of MARS mRNA	25583101
C022838	nickel chloride	nickel chloride results in increased expression of MARS mRNA	17312168
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether analog results in increased expression of MARS mRNA	19095052
D010894	Piroxicam	Cisplatin inhibits the reaction [Piroxicam results in decreased expression of MARS mRNA]	21858171
D010894	Piroxicam	Piroxicam results in decreased expression of MARS mRNA	21858171
D010936	Plant Extracts	Plant Extracts results in increased expression of MARS mRNA	23557933
D010938	Plant Oils	Plant Oils results in decreased expression of MARS mRNA	23370395
D011374	Progesterone	Progesterone results in increased expression of MARS mRNA	18037150
C010327	salinomycin	salinomycin results in decreased expression of MARS mRNA	19682730
D012715	Sesame Oil	Sesame Oil results in increased expression of MARS mRNA	29191790
D012834	Silver	Silver results in increased expression of MARS mRNA	26014281
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MARS mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MARS mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of MARS mRNA	16214954
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MARS mRNA	21354282
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MARS mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in increased expression of MARS mRNA	22378314
C009495	titanium dioxide	titanium dioxide affects the expression of MARS mRNA	23557971
C009495	titanium dioxide	titanium dioxide results in increased expression of MARS mRNA	27760801
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of MARS mRNA	19042947
D014415	Tunicamycin	Tunicamycin results in increased expression of MARS mRNA	22378314
D014635	Valproic Acid	Valproic Acid results in increased expression of MARS mRNA	23179753
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of MARS gene	25560391
D014750	Vincristine	Vincristine results in decreased expression of MARS mRNA	23649840
C111237	vorinostat	vorinostat results in decreased expression of MARS mRNA	27188386
D015215	Zidovudine	[Zidovudine co-treated with Lamivudine] results in increased expression of MARS mRNA	15784690

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000049	tRNA binding	-	IEA	-
GO:0004825	methionine-tRNA ligase activity	-	IDA	11714285
GO:0004825	methionine-tRNA ligase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	17314511 17353931
GO:0005524	ATP binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006418	tRNA aminoacylation for protein translation	-	IBA	21873635
GO:0006418	tRNA aminoacylation for protein translation	-	TAS	-
GO:0006431	methionyl-tRNA aminoacylation	-	IDA	11714285
GO:0009267	cellular response to starvation	-	IDA	10791971
GO:0009303	rRNA transcription	-	IMP	10791971
GO:0032869	cellular response to insulin stimulus	-	IDA	10791971
GO:0036120	cellular response to platelet-derived growth factor stimulus	-	IDA	10791971
GO:0071364	cellular response to epidermal growth factor stimulus	-	IDA	10791971
GO:1901838	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	-	IMP	10791971

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005730	nucleolus	-	IDA	10791971
GO:0005737	cytoplasm	-	IDA	10791971 22424946
GO:0005829	cytosol	-	IBA	21873635
GO:0005829	cytosol	-	IDA	19289464
GO:0005829	cytosol	-	TAS	-
GO:0016020	membrane	-	HDA	19946888
GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	-	IDA	10791971 19131329
GO:0070062	extracellular exosome	-	HDA	20458337

KEGG ID	KEGG Term
hsa00450	Selenocompound metabolism
hsa00970	Aminoacyl-tRNA biosynthesis

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	IEA
R-HSA-2408517	SeMet incorporation into proteins	IEA
R-HSA-2408522	Selenoamino acid metabolism	IEA
R-HSA-379716	Cytosolic tRNA aminoacylation	TAS
R-HSA-379724	tRNA Aminoacylation	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	IEA
R-HSA-72766	Translation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23030796	The Holy Grail of outer space: pluralism, Druidry, and the religion of cinema in The Sky Ship. (2012 Oct)	Bjornvig T	Astrobiology
22393637	[Metabolic disorders and cardiovascular risk factors observed in patients infected by the HIV with antiretroviral therapy in Burkina Faso]. (2011 Dec)	Bognounou R	Med Trop (Mars)
1343613	The Monitored Atherosclerosis Regression Study (MARS). Design, methods and baseline results. (1992 Oct 23)	Cashin-Hemphill L	Online J Curr Clin Trials
19169232	Variations in five genes and the severity of age-related macular degeneration: results from the Muenster aging and retina study. (2009 Dec)	Farwick A	Eye (Lond)