Gene: MAT1A

4143
MAT|MATA1|SAMS|SAMS1
methionine adenosyltransferase 1A
protein-coding
10q22.3
Ensembl:ENSG00000151224 MIM:610550 Vega:OTTHUMG00000018613 UniprotKB:Q00266
NG_008083.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.630e-1 (AD)  4.871e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
B3GALT50.66
DRD30.658
SAG0.657
AMBN0.657
INSRR0.656
TMPRSS60.652
GPR1010.652
GPR10.651
OTOF0.651
PRLR0.649

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NANOS3-0.241
RNF182-0.236
MTRNR2L9-0.222
TNNT1-0.221
SYTL2-0.22
MTRNR2L2-0.212
HPSE2-0.21
MTRNR2L10-0.209
MTRNR2L8-0.208
RLBP1-0.201

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00118AdemetionineSmall Molecule29908-03-0Approved|Investigational|NutraceuticalTarget
DB031913-Oxiran-2ylalanineSmall MoleculeExperimentalTarget
DB03611L-2-amino-4-methoxy-cis-but-3-enoic acidSmall MoleculeExperimentalTarget
DB00134MethionineSmall Molecule63-68-3Approved|NutraceuticalEnzyme
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of MAT1A mRNA"28903501
C0364231-aminomethylphosphonic acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of MAT1A mRNA"20566314
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MAT1A mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of MAT1A mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MAT1A mRNA"21346803
C0832532-amino-4-methylthio-3-butenoic acid2-amino-4-methylthio-3-butenoic acid results in decreased activity of MAT1A protein8373829
C0832532-amino-4-methylthio-3-butenoic acidMAT1A protein results in increased metabolism of 2-amino-4-methylthio-3-butenoic acid8373829
C0194992-nitrofluorene2-nitrofluorene results in decreased expression of MAT1A mRNA14600272
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of MAT1A mRNA]"19467301
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of MAT1A mRNA14600272
D000082AcetaminophenAcetaminophen results in decreased expression of MAT1A mRNA29067470
D000082Acetaminophen[CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of MAT1A protein25499718
C043377acetochlor"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of MAT1A mRNA"20566314
D012436S-AdenosylmethionineMAT1A affects the abundance of S-Adenosylmethionine12060674
D012436S-AdenosylmethionineMAT1A protein results in increased chemical synthesis of S-Adenosylmethionine8373829
D012436S-Adenosylmethionine[MAT1A protein results in increased metabolism of Methionine] which results in increased chemical synthesis of S-Adenosylmethionine23665415
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MAT1A protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MAT1A mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MAT1A mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MAT1A mRNA14600272
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MAT1A mRNA16483693
D001151ArsenicArsenic affects the methylation of MAT1A gene25304211
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MAT1A mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MAT1A mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MAT1A mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MAT1A mRNA19770486
D004958EstradiolEstradiol results in decreased expression of MAT1A mRNA20106945
C006780bisphenol Abisphenol A affects the expression of MAT1A mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of MAT1A mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of MAT1A mRNA24449424
C006780bisphenol Abisphenol A results in increased expression of MAT1A protein24449424
C006780bisphenol Abisphenol A results in increased methylation of MAT1A gene28505145
D002065BuspironeBuspirone results in increased expression of MAT1A mRNA24136188
C018475butyraldehydebutyraldehyde results in decreased expression of MAT1A mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MAT1A protein21667247
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of MAT1A promoter22457795
D002251Carbon TetrachlorideMAT1A results in decreased susceptibility to Carbon Tetrachloride12060674
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MAT1A mRNA12734012
D002330CarmustineCarmustine results in decreased expression of MAT1A mRNA15980968
C026690cerous chloridecerous chloride results in increased expression of MAT1A mRNA23573234
D002794Choline[Choline deficiency co-treated with Folic Acid deficiency] affects the expression of MAT1A mRNA23439872
D002794Choline[Choline deficiency co-treated with Folic Acid deficiency] inhibits the reaction [CEBPB protein binds to MAT1A promoter]23439872
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MAT1A mRNA27858113
D002922CiguatoxinsCiguatoxins affects the expression of MAT1A mRNA18353800
D019327Copper SulfateCopper Sulfate results in decreased expression of MAT1A mRNA19549813
C030123coumarincoumarin affects the expression of MAT1A mRNA16963487
D016572CyclosporineCyclosporine results in decreased expression of MAT1A mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of MAT1A mRNA27989131
D0150842,4-Dichlorophenoxyacetic Acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of MAT1A mRNA"20566314
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MAT1A mRNA]27941970
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of MAT1A mRNA28962523
D002945Cisplatin[Cisplatin co-treated with panobinostat] affects the expression of MAT1A mRNA21791302
D002945CisplatinCisplatin results in decreased expression of MAT1A mRNA22023808
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of MAT1A mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of MAT1A mRNA19467301
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of MAT1A mRNA28943392
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of MAT1A mRNA14600272
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased activity of MAT1A protein8373829
D004221DisulfiramDisulfiram results in increased expression of MAT1A mRNA20530235
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of MAT1A mRNA20064776
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of MAT1A mRNA17108234
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MAT1A mRNA23649840
D0150732-Acetylaminofluorene2-Acetylaminofluorene affects the acetylation of MAT1A exon22213190
D0150732-Acetylaminofluorene2-Acetylaminofluorene affects the acetylation of MAT1A promoter22213190
D0150732-Acetylaminofluorene2-Acetylaminofluorene affects the methylation of MAT1A exon22213190
D0150732-Acetylaminofluorene2-Acetylaminofluorene affects the methylation of MAT1A promoter22213190
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased expression of MAT1A mRNA22213190
D005485FlutamideFlutamide results in decreased expression of MAT1A mRNA24136188
D005492Folic Acid[Choline deficiency co-treated with Folic Acid deficiency] affects the expression of MAT1A mRNA23439872
D005492Folic Acid[Choline deficiency co-treated with Folic Acid deficiency] inhibits the reaction [CEBPB protein binds to MAT1A promoter]23439872
C039281furanfuran binds to MAT1A protein22240984
D006540Herbicides"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of MAT1A mRNA"20566314
C410337K 7174K 7174 results in decreased expression of MAT1A mRNA24086573
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of MAT1A mRNA"24972896
C008340mecoprop"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of MAT1A mRNA"20566314
D008715MethionineMAT1A protein results in increased metabolism of Methionine23665415
D008715Methionine[MAT1A protein results in increased metabolism of Methionine] which results in increased chemical synthesis of S-Adenosylmethionine23665415
D008727MethotrexateMethotrexate results in decreased expression of MAT1A mRNA22193356
D008727MethotrexateMethotrexate results in decreased expression of MAT1A protein22193356
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of MAT1A mRNA22100608
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of MAT1A mRNA27544571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MAT1A mRNA22100608
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MAT1A mRNA23649840
C500085muraglitazarmuraglitazar results in increased expression of MAT1A mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MAT1A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MAT1A mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of MAT1A mRNA19167457
C002741N-nitrosomorpholineN-nitrosomorpholine affects the expression of MAT1A protein19716841
D010126OzoneOzone results in increased expression of MAT1A mRNA17095637|2154328
C496932panobinostat[Cisplatin co-treated with panobinostat] affects the expression of MAT1A mRNA21791302
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of MAT1A mRNA23602845
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of MAT1A mRNA18281256
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of MAT1A mRNA17097637
D010634PhenobarbitalPhenobarbital results in decreased expression of MAT1A mRNA19162173
D010882Piperonyl ButoxidePiperonyl Butoxide results in decreased expression of MAT1A mRNA22484513
D011192Potassium DichromatePotassium Dichromate results in decreased expression of MAT1A mRNA23608068
C045950propiconazolepropiconazole results in decreased expression of MAT1A mRNA21278054
C005556propionaldehydepropionaldehyde results in decreased expression of MAT1A mRNA26079696
D011794QuercetinQuercetin results in decreased expression of MAT1A mRNA21632981
D011794QuercetinQuercetin results in increased expression of MAT1A mRNA16455785
D012645SelenomethionineSelenomethionine results in decreased expression of MAT1A mRNA23399444|2896252
C009250sevofluranesevoflurane affects the expression of MAT1A mRNA15967596
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MAT1A mRNA25895662
C016104sodium bichromatesodium bichromate results in decreased expression of MAT1A mRNA24612858
D053260SootSoot results in increased expression of MAT1A mRNA22461453|2655175
D013629TamoxifenTamoxifen results in decreased expression of MAT1A mRNA15590111
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MAT1A mRNA16443690
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MAT1A mRNA11489354|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAT1A mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MAT1A mRNA17949056|1977048
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MAT1A mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of MAT1A mRNA28973375
D013752TetracyclineTetracycline results in decreased expression of MAT1A mRNA24489787
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of MAT1A mRNA28943392
D013853ThioacetamideThioacetamide results in decreased expression of MAT1A protein10216131
D013893ThiramThiram results in increased expression of MAT1A mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of MAT1A mRNA20133372
C012589trichostatin Atrichostatin A results in decreased expression of MAT1A mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MAT1A mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of MAT1A mRNA21515302
D014520UrethaneUrethane results in decreased expression of MAT1A mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of MAT1A mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of MAT1A mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of MAT1A mRNA24489787
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of MAT1A mRNA"23246600
D015034Zinc OxideZinc Oxide analog results in decreased expression of MAT1A mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004478methionine adenosyltransferase activity-IBA21873635  
GO:0004478methionine adenosyltransferase activity-IDA10677294  
GO:0004478methionine adenosyltransferase activity-TAS-  
GO:0005524ATP binding-IEA-  
GO:0042802identical protein binding-IPI25416956  
GO:0046872metal ion binding-IEA-  
GO:0098601selenomethionine adenosyltransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000096sulfur amino acid metabolic process-TAS-  
GO:0001887selenium compound metabolic process-TAS-  
GO:0006556S-adenosylmethionine biosynthetic process-IEA-  
GO:0006556S-adenosylmethionine biosynthetic process-IMP10677294  
GO:0006730one-carbon metabolic process-IEA-  
GO:0009087methionine catabolic process-IMP10677294  
GO:0032259methylation-TAS-  
GO:0051289protein homotetramerization-IDA23425511  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00270Cysteine and methionine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156581MethylationTAS
R-HSA-1614635Sulfur amino acid metabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-2408508Metabolism of ingested SeMet, Sec, MeSec into H2SeTAS
R-HSA-2408522Selenoamino acid metabolismTAS
R-HSA-5579024Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)TAS
R-HSA-5579029Metabolic disorders of biological oxidation enzymesTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22724053One-carbon metabolism nutrient status and plasma S-adenosylmethionine concentrations in middle-aged and older Chinese in Singapore. (2012)Inoue-Choi MInt J Mol Epidemiol Genet