Gene: MAT2A

4144
MATA2|MATII|SAMS2
methionine adenosyltransferase 2A
protein-coding
2p11.2
Ensembl:ENSG00000168906 MIM:601468 Vega:OTTHUMG00000130174 UniprotKB:P31153
NG_029183.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.787e-1 (AD)  2.380e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg09363733chr2:85767277MAT2AGene body4.213e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZC3H11A0.903
STX160.902
HP1BP30.901
ADNP0.898
CPSF70.897
SF3B10.892
NCSTN0.891
RAF10.891
DDX170.888
ZNF3840.885

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.726
OR4F29-0.679
KLRC2-0.237
CLEC6A-0.23
NANOGNB-0.224
OR6C74-0.205
HMHB1-0.203
GZMK-0.19
CD8B-0.184
SPRR2B-0.18

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00118AdemetionineSmall Molecule29908-03-0Approved|Investigational|NutraceuticalTarget
DB00134MethionineSmall Molecule63-68-3Approved|NutraceuticalEnzyme
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of MAT2A mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MAT2A mRNA"22698814
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of MAT2A mRNA"19095052
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MAT2A mRNA"20816883
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of MAT2A mRNA"20816883
C0832532-amino-4-methylthio-3-butenoic acid2-amino-4-methylthio-3-butenoic acid results in decreased activity of MAT2A protein8373829
C0832532-amino-4-methylthio-3-butenoic acidMAT2A protein results in increased metabolism of 2-amino-4-methylthio-3-butenoic acid8373829
C0127962-butenal2-butenal results in decreased expression of MAT2A mRNA20471460
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of MAT2A protein26194647
C0757734-phenylbutyric acid4-phenylbutyric acid results in decreased expression of MAT2A mRNA14583596
D000079AcetaldehydeAcetaldehyde results in decreased expression of MAT2A mRNA23416264
D000082AcetaminophenAcetaminophen affects the expression of MAT2A mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of MAT2A mRNA19103213
D020106AcrylamideAcrylamide results in increased expression of MAT2A mRNA28959563
D012436S-AdenosylmethionineMAT2A protein results in increased chemical synthesis of S-Adenosylmethionine8373829
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MAT2A mRNA27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of MAT2A mRNA"23195993
D001151ArsenicArsenic affects the expression of MAT2A mRNA18487201
C547126AZM551248AZM551248 results in decreased expression of MAT2A mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of MAT2A mRNA26377693
D001554BenzeneBenzene results in increased expression of MAT2A mRNA19162166
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of MAT2A mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of MAT2A mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MAT2A mRNA20106945|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of MAT2A mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MAT2A mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MAT2A mRNA21569818|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MAT2A mRNA"19150397
D004958EstradiolEstradiol results in increased expression of MAT2A mRNA19167446|2301914
C006780bisphenol Abisphenol A results in decreased expression of MAT2A mRNA21932408|2651296
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of MAT2A promoter23359474
C006780bisphenol Abisphenol A results in increased expression of MAT2A mRNA24449424|2518105
C006780bisphenol Abisphenol A results in increased expression of MAT2A protein24449424
C037123cadmium sulfatecadmium sulfate results in decreased expression of MAT2A mRNA12064557|1467641
D002185CannabidiolCannabidiol results in decreased expression of MAT2A mRNA21542829
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MAT2A mRNA17485851
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of MAT2A mRNA23650126
C100187chloropicrinchloropicrin results in decreased expression of MAT2A mRNA26352163
D002737ChloropreneChloroprene results in increased expression of MAT2A mRNA23125180
D002737ChloropreneChloroprene results in increased expression of MAT2A mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MAT2A mRNA20938992
C031180chrysenechrysene results in increased expression of MAT2A mRNA26377693
D002994ClofibrateClofibrate results in decreased expression of MAT2A mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of MAT2A mRNA19320972
D003042CocaineCocaine affects the expression of MAT2A mRNA20187946
D003300CopperCopper results in decreased expression of MAT2A mRNA22465980
D019327Copper SulfateCopper Sulfate results in increased expression of MAT2A mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of MAT2A mRNA25562108
D013759DronabinolDronabinol results in decreased expression of MAT2A mRNA12237329
D003907DexamethasoneDexamethasone results in increased expression of MAT2A mRNA22193356
D003907DexamethasoneMethotrexate inhibits the reaction [Dexamethasone results in increased expression of MAT2A mRNA]22193356
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of MAT2A promoter23359474
D003997DicarbethoxydihydrocollidineDicarbethoxydihydrocollidine results in increased expression of MAT2A mRNA18098314
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MAT2A mRNA27392435
D002945CisplatinCisplatin results in decreased expression of MAT2A mRNA27594783
D002945CisplatinCisplatin results in increased expression of MAT2A mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of MAT2A mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of MAT2A mRNA26924002
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of MAT2A promoter23359474
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of MAT2A mRNA25374375
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of MAT2A promoter25374375
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene affects the expression of MAT2A mRNA"21785161
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased activity of MAT2A protein8373829
D004317DoxorubicinDoxorubicin results in decreased expression of MAT2A mRNA28865727
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MAT2A protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MAT2A mRNA22079256
D000431EthanolEthanol results in decreased expression of MAT2A mRNA17869084
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of MAT2A mRNA23649840
D011345FenofibrateFenofibrate results in decreased expression of MAT2A mRNA16569247
C000499ferric oxideferric oxide analog results in decreased expression of MAT2A mRNA25086211
C000499ferric oxideferric oxide analog results in increased expression of MAT2A mRNA24525745
C082360fipronilfipronil results in increased expression of MAT2A mRNA23962444
D005419FlavonoidsFlavonoids results in decreased expression of MAT2A mRNA18035473
D005485FlutamideFlutamide results in increased expression of MAT2A mRNA24136188
D005492Folic AcidFolic Acid deficiency results in increased expression of MAT2A mRNA22193356
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MAT2A mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of MAT2A mRNA20655997|2364984
D002955LeucovorinLeucovorin inhibits the reaction [Methotrexate results in decreased expression of MAT2A mRNA]22193356
D005839GentamicinsGentamicins results in decreased expression of MAT2A protein22061828
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of MAT2A mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MAT2A mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MAT2A mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of MAT2A protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MAT2A mRNA22904298
D007854LeadLead results in increased expression of MAT2A mRNA27239543
D007854LeadLead results in increased expression of MAT2A protein27239543
C008261lead acetatelead acetate results in decreased expression of MAT2A mRNA21829687
C045463leflunomideleflunomide results in decreased expression of MAT2A mRNA28988120
D008627Mercuric ChlorideMercuric Chloride affects the expression of MAT2A mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MAT2A mRNA20938992
D008727MethotrexateLeucovorin inhibits the reaction [Methotrexate results in decreased expression of MAT2A mRNA]22193356
D008727MethotrexateMethotrexate inhibits the reaction [Dexamethasone results in increased expression of MAT2A mRNA]22193356
D008727MethotrexateMethotrexate results in decreased expression of MAT2A mRNA22193356
D008727MethotrexateMethotrexate results in decreased expression of MAT2A protein22193356
D008727MethotrexateMethotrexate results in decreased expression of MAT2A mRNA22193356
D008727MethotrexateMethotrexate results in decreased expression of MAT2A protein22193356
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MAT2A mRNA23103053
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MAT2A mRNA23649840
C517284monomethyl phthalatemonomethyl phthalate affects the expression of MAT2A mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MAT2A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MAT2A mRNA"25620056
D009281NaphthalenesNaphthalenes results in increased expression of MAT2A protein17337753
D009532NickelNickel results in decreased expression of MAT2A mRNA23195993
C022838nickel chloridenickel chloride results in decreased expression of MAT2A mRNA17312168
C016030pantogabpantogab results in increased expression of MAT2A mRNA17379144
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of MAT2A mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of MAT2A mRNA19095052
D010416PentachlorophenolPentachlorophenol results in increased expression of MAT2A mRNA23892564
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of MAT2A mRNA28558994
C471071perfluorohexanesulfonic acidPPARA protein affects the reaction [perfluorohexanesulfonic acid results in increased expression of MAT2A mRNA]28558994
C584865perfluorononanoic acidperfluorononanoic acid results in increased expression of MAT2A mRNA28558994
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of MAT2A mRNA28558994
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of MAT2A mRNA23978341
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MAT2A mRNA28558994
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MAT2A mRNA19162173
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of MAT2A mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of MAT2A mRNA19482888
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of MAT2A mRNA25374375
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of MAT2A promoter25374375
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MAT2A mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of MAT2A mRNA17950772|1830175
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of MAT2A mRNA]17950772
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MAT2A mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MAT2A mRNA22079256
D011374ProgesteroneProgesterone results in decreased expression of MAT2A mRNA18037150
C010313pseudocumenepseudocumene results in increased expression of MAT2A protein17337753
C012526quercitrinquercitrin results in increased expression of MAT2A mRNA25193878
C005266quinomethionatequinomethionate affects the expression of MAT2A mRNA15387888
C059514resveratrolresveratrol inhibits the reaction [MAT2B protein binds to MAT2A protein]23814050
C059514resveratrolresveratrol results in increased expression of MAT2A mRNA19167446
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of MAT2A mRNA21427059
D012822Silicon DioxideSilicon Dioxide results in decreased expression of MAT2A mRNA25351596
D012834SilverSilver results in increased expression of MAT2A mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of MAT2A mRNA16882884
C016104sodium bichromatesodium bichromate results in increased expression of MAT2A mRNA25993096
C061133tamibarotenetamibarotene results in decreased expression of MAT2A mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAT2A mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MAT2A mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MAT2A mRNA16267337
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MAT2A mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of MAT2A mRNA10216131|2341159
D013853ThioacetamideThioacetamide results in increased expression of MAT2A protein10216131
D014212TretinoinTretinoin results in decreased expression of MAT2A mRNA15498508
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MAT2A mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of MAT2A mRNA28973697
D014520UrethaneUrethane results in decreased expression of MAT2A mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of MAT2A gene29154799
D014635Valproic AcidValproic Acid results in increased expression of MAT2A mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of MAT2A mRNA17292431|1796380
D014635Valproic AcidValproic Acid results in decreased expression of MAT2A mRNA20546886|2142705
C025643vinclozolinvinclozolin results in increased expression of MAT2A mRNA23034163
D024483Vitamin K 3Vitamin K 3 affects the expression of MAT2A mRNA20044591
C070417Win 55212-2Win 55212-2 results in decreased expression of MAT2A mRNA12237329
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of MAT2A mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004478methionine adenosyltransferase activity-IBA21873635  
GO:0004478methionine adenosyltransferase activity-IDA7665609  10644686  25075345  
GO:0005515protein binding-IPI10644686  25075345  25416956  27107014  
GO:0005524ATP binding-IEA-  
GO:0042802identical protein binding-IPI25416956  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006556S-adenosylmethionine biosynthetic process-IDA10644686  25075345  
GO:0006556S-adenosylmethionine biosynthetic process-IEA-  
GO:0006730one-carbon metabolic process-IEA-  
GO:0034214protein hexamerization-IDA25075345  
GO:0051291protein heterooligomerization-IDA25075345  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0048269methionine adenosyltransferase complex-IBA21873635  
GO:0048269methionine adenosyltransferase complex-IDA10644686  25075345  
KEGG ID KEGG Term
hsa00270Cysteine and methionine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156581MethylationTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22724053One-carbon metabolism nutrient status and plasma S-adenosylmethionine concentrations in middle-aged and older Chinese in Singapore. (2012)Inoue-Choi MInt J Mol Epidemiol Genet
28369960Chronic Alcohol Exposure Differentially Alters One-Carbon Metabolism in Rat Liver and Brain. (2017 Jun)Auta JAlcohol Clin Exp Res