Gene info: ID 4151

Gene: MB

GENE ID: 4151

Synonyms: PVALB|myoglobgin

Description: myoglobin

Gene type: protein-coding

Location: 22q12.3

dbXrefs: Ensembl:ENSG00000198125 MIM:160000 Vega:OTTHUMG00000150606 UniprotKB:P02144

RefSeq: NG_007075.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 69

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.519e-1 (AD) 1.449e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TNNC1	0.923
CKM	0.922
MYL2	0.873
TNNI1	0.849
ACTA1	0.847
LMOD2	0.831
MYL1	0.795
TNNI2	0.769
NRAP	0.769
MYH7	0.768

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SAC3D1	-0.286
ZNF575	-0.283
FCHO1	-0.277
ZNF835	-0.275
PTGES3L	-0.264
FTCD	-0.263
TEX29	-0.262
SLC22A14	-0.262
HIST1H1A	-0.256
ABCA7	-0.255

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01710	Porphyrin Fe(III)	Small Molecule		Experimental	Target
DB01826	N-Butyl Isocyanide	Small Molecule	2769-64-4	Experimental	Target
DB02073	Biliverdine IX Alpha	Small Molecule	114-25-0	Experimental	Target
DB02379	Beta-D-Glucose	Small Molecule	492-61-5	Experimental	Target
DB02396	Methylethylamine	Small Molecule	624-78-2	Experimental	Target
DB02528	Tetrazolyl Histidine	Small Molecule		Experimental	Target
DB02646	Nitrosoethane	Small Molecule	925-91-7	Experimental	Target
DB02671	1-Methylimidazole	Small Molecule	616-47-7	Experimental	Target
DB03366	Imidazole	Small Molecule	288-32-4	Experimental\|Investigational	Target
DB03385	4-Methylimidazole	Small Molecule		Experimental	Target
DB03399	Ethyl Isocyanide	Small Molecule		Experimental	Target
DB04050	N-Propyl Isocyanide	Small Molecule		Experimental	Target
DB04337	Methyl Isocyanide	Small Molecule		Experimental	Target
DB09112	Nitrous acid	Small Molecule	7782-77-6	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C000598216	13-methylarachidonic acid	MB protein modified form results in increased oxidation of 13-methylarachidonic acid	2498331
C468114	1-palmitoyl-2-arachidonyl-3-phosphorylcholine	MB protein modified form results in increased oxidation of 1-palmitoyl-2-arachidonyl-3-phosphorylcholine	2498331
C549240	2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid	2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid results in increased secretion of MB protein	19628585
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of MB mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of MB mRNA"	21346803
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MB mRNA"	27188386
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of MB mRNA"	21346803
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MB mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of MB mRNA	17585979
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of MB mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MB mRNA]	17585979
C464485	acetamiprid	acetamiprid results in decreased expression of MB mRNA	27782041
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Uric Acid]	3199797
D020106	Acrylamide	Acrylamide results in decreased expression of MB mRNA	28606764\|2895956
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of MB mRNA	27153756
D024502	alpha-Tocopherol	alpha-Tocopherol inhibits the reaction [MB modified form results in decreased secretion of very low density lipoprotein triglyceride]	17478120
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MB mRNA	16483693
D016718	Arachidonic Acid	ALB protein inhibits the reaction [MB protein modified form results in increased oxidation of Arachidonic Acid]	2498331
D016718	Arachidonic Acid	Butylated Hydroxytoluene inhibits the reaction [MB protein modified form results in increased oxidation of Arachidonic Acid]	2498331
D016718	Arachidonic Acid	Butylated Hydroxytoluene inhibits the reaction [[MB protein modified form results in increased oxidation of Arachidonic Acid] which results in increased chemical synthesis of Malondialdehyde]	2498331
D016718	Arachidonic Acid	Masoprocol inhibits the reaction [MB protein modified form results in increased oxidation of Arachidonic Acid]	2498331
D016718	Arachidonic Acid	Masoprocol inhibits the reaction [[MB protein modified form results in increased oxidation of Arachidonic Acid] which results in increased chemical synthesis of Malondialdehyde]	2498331
D016718	Arachidonic Acid	[MB protein modified form co-treated with Arachidonic Acid] results in increased metabolism of Oxygen	2498331
D016718	Arachidonic Acid	MB protein modified form results in increased oxidation of Arachidonic Acid	2498331
D016718	Arachidonic Acid	[MB protein modified form results in increased oxidation of Arachidonic Acid] which results in increased chemical synthesis of Malondialdehyde	2498331
D016718	Arachidonic Acid	Nonidet P-40 inhibits the reaction [[MB protein modified form co-treated with Arachidonic Acid] results in increased metabolism of Oxygen]	2498331
D016718	Arachidonic Acid	Nonidet P-40 inhibits the reaction [MB protein modified form results in increased oxidation of Arachidonic Acid]	2498331
D016718	Arachidonic Acid	Octoxynol inhibits the reaction [[MB protein modified form co-treated with Arachidonic Acid] results in increased metabolism of Oxygen]	2498331
D016718	Arachidonic Acid	Octoxynol inhibits the reaction [MB protein modified form results in increased oxidation of Arachidonic Acid]	2498331
D016718	Arachidonic Acid	Polysorbates inhibits the reaction [[MB protein modified form co-treated with Arachidonic Acid] results in increased metabolism of Oxygen]	2498331
D016718	Arachidonic Acid	Polysorbates inhibits the reaction [MB protein modified form results in increased oxidation of Arachidonic Acid]	2498331
D016718	Arachidonic Acid	Protons promotes the reaction [MB protein modified form results in increased oxidation of Arachidonic Acid]	2498331
D016718	Arachidonic Acid	Protons promotes the reaction [[MB protein modified form results in increased oxidation of Arachidonic Acid] which results in increased chemical synthesis of Malondialdehyde]	2498331
D016718	Arachidonic Acid	Sodium Dodecyl Sulfate inhibits the reaction [[MB protein modified form co-treated with Arachidonic Acid] results in increased metabolism of Oxygen]	2498331
D016718	Arachidonic Acid	Sodium Dodecyl Sulfate inhibits the reaction [MB protein modified form results in increased oxidation of Arachidonic Acid]	2498331
D016718	Arachidonic Acid	Sulfhydryl Compounds inhibits the reaction [MB protein modified form results in increased oxidation of Arachidonic Acid]	2498331
D016718	Arachidonic Acid	Sulfhydryl Compounds inhibits the reaction [[MB protein modified form results in increased oxidation of Arachidonic Acid] which results in increased chemical synthesis of Malondialdehyde]	2498331
D016718	Arachidonic Acid	Cysteine inhibits the reaction [[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Arachidonic Acid]	3199797
D016718	Arachidonic Acid	Glutathione inhibits the reaction [[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Arachidonic Acid]	3199797
D016718	Arachidonic Acid	[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Arachidonic Acid	3199797
D016718	Arachidonic Acid	Tiopronin inhibits the reaction [[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Arachidonic Acid]	3199797
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in increased expression of MB protein	27815113
D001280	Atrazine	Atrazine results in increased expression of MB protein	1916698
D001507	Beclomethasone	Beclomethasone results in increased expression of MB mRNA	23656298
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of MB mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MB mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MB mRNA	22228805
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MB mRNA	25566086
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	MYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MB mRNA]	25566086
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of MB mRNA	19619570
D004958	Estradiol	Estradiol results in decreased expression of MB mRNA	19619570\|2532141
D004958	Estradiol	Estradiol results in decreased expression of MB mRNA	19484750
C006780	bisphenol A	bisphenol A affects the expression of MB mRNA	21786754
C006780	bisphenol A	[bisphenol A co-treated with Genistein] results in increased methylation of MB gene	28505145
C006780	bisphenol A	bisphenol A results in decreased expression of MB mRNA	25181051\|2717856
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene inhibits the reaction [MB protein modified form results in increased oxidation of Arachidonic Acid]	2498331
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene inhibits the reaction [[MB protein modified form results in increased oxidation of Arachidonic Acid] which results in increased chemical synthesis of Malondialdehyde]	2498331
D002104	Cadmium	Cadmium results in decreased expression of MB mRNA	24084258
C086276	cerivastatin	cerivastatin results in increased secretion of MB protein	19628585
C026690	cerous chloride	[cerous chloride co-treated with lanthanum chloride] results in increased expression of MB mRNA	28954213
C026690	cerous chloride	cerous chloride results in increased expression of MB mRNA	28954213
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of MB mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MB mRNA]	17585979
C018021	cobaltous chloride	cobaltous chloride results in increased secretion of MB protein	19628585
D003300	Copper	Copper deficiency results in decreased expression of MB protein	24708542
D003345	Corticosterone	Corticosterone results in decreased expression of MB mRNA	15755911
C007164	cumene hydroperoxide	MB protein mutant form affects the metabolism of cumene hydroperoxide	8855949
C029892	cupric chloride	cupric chloride results in decreased expression of MB mRNA	22699969
C017160	cypermethrin	cypermethrin results in increased expression of MB mRNA	21142847
D003545	Cysteine	Cysteine inhibits the reaction [[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Arachidonic Acid]	3199797
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of MB mRNA	24317228
C016366	dibenzothiophene	dibenzothiophene results in decreased expression of MB mRNA	23656968
D004041	Dietary Fats	Dietary Fats results in increased expression of MB mRNA	18042831
D004121	Dimethyl Sulfoxide	[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Dimethyl Sulfoxide	3199797
D004121	Dimethyl Sulfoxide	[[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Dimethyl Sulfoxide] which results in increased chemical synthesis of Formaldehyde	3199797
D004280	Dobutamine	MB protein affects the susceptibility to Dobutamine	10468637
D004317	Doxorubicin	Doxorubicin results in decreased expression of MB mRNA	28940058
D004317	Doxorubicin	[Doxorubicin co-treated with MT2A protein] results in decreased expression of MB protein	16144979
D004317	Doxorubicin	Doxorubicin results in increased expression of MB protein	21251210
D004317	Doxorubicin	sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of MB protein]	21251210
C118739	entinostat	entinostat results in increased expression of MB mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MB mRNA"	27188386
D000431	Ethanol	Ethanol results in increased expression of MB protein	23200777
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of MB mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of MB mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of MB mRNA	17942748
D005557	Formaldehyde	[[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Dimethyl Sulfoxide] which results in increased chemical synthesis of Formaldehyde	3199797
C069837	fullerene C60	fullerene C60 results in decreased expression of MB mRNA	19167457
D019833	Genistein	[bisphenol A co-treated with Genistein] results in increased methylation of MB gene	28505145
D005978	Glutathione	Glutathione inhibits the reaction [[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Arachidonic Acid]	3199797
D005978	Glutathione	Glutathione inhibits the reaction [[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Uric Acid]	3199797
D005990	Glycerol	Glycerol results in increased expression of MB protein	27329933
D005990	Glycerol	PTI protein promotes the reaction [Glycerol results in increased expression of MB protein]	27329933
C010974	glyphosate	glyphosate results in decreased expression of MB mRNA	27916585
D006108	Graphite	Graphite results in increased expression of MB mRNA	27440207
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased activity of MB protein mutant form	8855949
D006861	Hydrogen Peroxide	Acetylcysteine inhibits the reaction [[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Uric Acid]	3199797
D006861	Hydrogen Peroxide	Cysteine inhibits the reaction [[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Arachidonic Acid]	3199797
D006861	Hydrogen Peroxide	Glutathione inhibits the reaction [[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Arachidonic Acid]	3199797
D006861	Hydrogen Peroxide	Glutathione inhibits the reaction [[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Uric Acid]	3199797
D006861	Hydrogen Peroxide	[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Arachidonic Acid	3199797
D006861	Hydrogen Peroxide	[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Dimethyl Sulfoxide	3199797
D006861	Hydrogen Peroxide	[[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Dimethyl Sulfoxide] which results in increased chemical synthesis of Formaldehyde	3199797
D006861	Hydrogen Peroxide	[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Uric Acid	3199797
D006861	Hydrogen Peroxide	Tiopronin inhibits the reaction [[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Arachidonic Acid]	3199797
D006861	Hydrogen Peroxide	Tiopronin inhibits the reaction [[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Uric Acid]	3199797
C082359	imidacloprid	imidacloprid results in decreased expression of MB mRNA	27782041
C041508	indeno(1,2,3-cd)pyrene	"indeno(1,2,3-cd)pyrene results in decreased expression of MB mRNA"	26377693
D007501	Iron	Iron binds to MB protein	17173408
D007545	Isoproterenol	Isoproterenol results in increased expression of MB	20554997
D007545	Isoproterenol	tetrandrine inhibits the reaction [Isoproterenol results in increased expression of MB]	20554997
D007545	Isoproterenol	Isoproterenol results in increased expression of MB protein	533011
D007545	Isoproterenol	Isoproterenol results in increased secretion of MB protein	19628585
C028521	lanthanum chloride	[cerous chloride co-treated with lanthanum chloride] results in increased expression of MB mRNA	28954213
C028521	lanthanum chloride	lanthanum chloride results in increased expression of MB mRNA	28954213
C008261	lead acetate	lead acetate results in decreased expression of MB mRNA	22609695
D008070	Lipopolysaccharides	INS protein inhibits the reaction [Lipopolysaccharides results in increased expression of MB protein]	20699433
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MB protein	20699433
D014975	Lutein	Lutein results in increased expression of MB mRNA	24865317
D008315	Malondialdehyde	Butylated Hydroxytoluene inhibits the reaction [[MB protein modified form results in increased oxidation of Arachidonic Acid] which results in increased chemical synthesis of Malondialdehyde]	2498331
D008315	Malondialdehyde	Masoprocol inhibits the reaction [[MB protein modified form results in increased oxidation of Arachidonic Acid] which results in increased chemical synthesis of Malondialdehyde]	2498331
D008315	Malondialdehyde	MB protein modified form results in increased chemical synthesis of Malondialdehyde	2498331
D008315	Malondialdehyde	[MB protein modified form results in increased oxidation of Arachidonic Acid] which results in increased chemical synthesis of Malondialdehyde	2498331
D008315	Malondialdehyde	Protons promotes the reaction [[MB protein modified form results in increased oxidation of Arachidonic Acid] which results in increased chemical synthesis of Malondialdehyde]	2498331
D008315	Malondialdehyde	Sulfhydryl Compounds inhibits the reaction [[MB protein modified form results in increased oxidation of Arachidonic Acid] which results in increased chemical synthesis of Malondialdehyde]	2498331
D009637	Masoprocol	Masoprocol inhibits the reaction [MB protein modified form results in increased oxidation of Arachidonic Acid]	2498331
D009637	Masoprocol	Masoprocol inhibits the reaction [[MB protein modified form results in increased oxidation of Arachidonic Acid] which results in increased chemical synthesis of Malondialdehyde]	2498331
D008558	Melphalan	[Melphalan co-treated with TNF] results in increased expression of MB protein	9410682
D008665	Metalloporphyrins	Metalloporphyrins binds to MB protein	17173408
C544071	methyl 4-tolylsulfide	MB protein mutant form affects the metabolism of methyl 4-tolylsulfide	8855949
C020771	methylmercury hydroxide	methylmercury hydroxide results in decreased expression of MB mRNA	20493249
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased methylation of MB protein	15655799
D008770	Methylnitrosourea	Methylnitrosourea results in increased carbamoylation of MB protein	15655799
C059539	midostaurin	midostaurin results in increased expression of MB mRNA	20980353
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of MB mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of MB mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of MB mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of MB mRNA"	25620056
D009532	Nickel	Nickel results in decreased expression of MB mRNA	24768652\|2558310
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MB mRNA	27935865
C010615	Nonidet P-40	Nonidet P-40 inhibits the reaction [[MB protein modified form co-treated with Arachidonic Acid] results in increased metabolism of Oxygen]	2498331
C010615	Nonidet P-40	Nonidet P-40 inhibits the reaction [MB protein modified form results in increased oxidation of Arachidonic Acid]	2498331
D017830	Octoxynol	Octoxynol inhibits the reaction [[MB protein modified form co-treated with Arachidonic Acid] results in increased metabolism of Oxygen]	2498331
D017830	Octoxynol	Octoxynol inhibits the reaction [MB protein modified form results in increased oxidation of Arachidonic Acid]	2498331
D010100	Oxygen	[MB protein modified form co-treated with Arachidonic Acid] results in increased metabolism of Oxygen	2498331
D010100	Oxygen	Nonidet P-40 inhibits the reaction [[MB protein modified form co-treated with Arachidonic Acid] results in increased metabolism of Oxygen]	2498331
D010100	Oxygen	Octoxynol inhibits the reaction [[MB protein modified form co-treated with Arachidonic Acid] results in increased metabolism of Oxygen]	2498331
D010100	Oxygen	Polysorbates inhibits the reaction [[MB protein modified form co-treated with Arachidonic Acid] results in increased metabolism of Oxygen]	2498331
D010100	Oxygen	Sodium Dodecyl Sulfate inhibits the reaction [[MB protein modified form co-treated with Arachidonic Acid] results in increased metabolism of Oxygen]	2498331
D010100	Oxygen	MB protein affects the transport of Oxygen	10468637
D010126	Ozone	Ozone results in decreased expression of MB mRNA	12763052
D000073878	Palm Oil	Palm Oil results in increased expression of MB mRNA	18042831
D010634	Phenobarbital	Phenobarbital affects the expression of MB mRNA	23091169
C060836	pioglitazone	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MB mRNA	27935865
D059808	Polyphenols	Polyphenols results in decreased expression of MB mRNA	16293270
D011136	Polysorbates	Polysorbates inhibits the reaction [[MB protein modified form co-treated with Arachidonic Acid] results in increased metabolism of Oxygen]	2498331
D011136	Polysorbates	Polysorbates inhibits the reaction [MB protein modified form results in increased oxidation of Arachidonic Acid]	2498331
C051407	porphycene	porphycene analog binds to MB protein	17173408
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of MB mRNA	23608068
D011522	Protons	Protons promotes the reaction [MB protein modified form results in increased oxidation of Arachidonic Acid]	2498331
D011522	Protons	Protons promotes the reaction [[MB protein modified form results in increased oxidation of Arachidonic Acid] which results in increased chemical synthesis of Malondialdehyde]	2498331
C030984	pyrene	pyrene results in decreased expression of MB mRNA	23656968
D000068718	Rosuvastatin Calcium	Rosuvastatin Calcium affects the expression of MB protein	27815113
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in decreased expression of MB mRNA"	21514415
D017632	Asbestos, Serpentine	"SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in decreased expression of MB mRNA]"	21514415
D012834	Silver	Silver results in decreased expression of MB mRNA	19429238
D012838	Silymarin	Silymarin results in decreased expression of MB mRNA	22386810
C017947	sodium arsenite	[CARM1 mutant form co-treated with sodium arsenite] results in increased expression of MB mRNA	23699174
C017947	sodium arsenite	[PRMT1 mutant form co-treated with sodium arsenite] results in increased expression of MB mRNA	23699174
C017947	sodium arsenite	sodium arsenite affects the expression of MB mRNA	17450228
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate inhibits the reaction [[MB protein modified form co-treated with Arachidonic Acid] results in increased metabolism of Oxygen]	2498331
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate inhibits the reaction [MB protein modified form results in increased oxidation of Arachidonic Acid]	2498331
C031618	sodium nitrate	sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of MB protein]	21251210
D053260	Soot	Soot results in decreased expression of MB mRNA	26551751
D013390	Succinylcholine	Succinylcholine results in increased secretion of MB protein	8217179
D013438	Sulfhydryl Compounds	Sulfhydryl Compounds inhibits the reaction [MB protein modified form results in increased oxidation of Arachidonic Acid]	2498331
D013438	Sulfhydryl Compounds	Sulfhydryl Compounds inhibits the reaction [[MB protein modified form results in increased oxidation of Arachidonic Acid] which results in increased chemical synthesis of Malondialdehyde]	2498331
D013629	Tamoxifen	Tamoxifen affects the expression of MB mRNA	17555576
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MB mRNA	18495758
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of MB mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MB mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MB mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MB mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MB mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of MB mRNA	17942748
C009438	tetrandrine	tetrandrine inhibits the reaction [Isoproterenol results in increased expression of MB]	20554997
D008625	Tiopronin	Tiopronin inhibits the reaction [[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Arachidonic Acid]	3199797
D008625	Tiopronin	Tiopronin inhibits the reaction [[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Uric Acid]	3199797
C009495	titanium dioxide	titanium dioxide results in decreased expression of MB mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of MB mRNA	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of MB protein	27793746
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of MB mRNA	27441981
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of MB protein	27441981
D014221	Triamcinolone	Triamcinolone results in increased secretion of MB protein	19628585
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MB mRNA"	26743178
D014520	Urethane	Urethane results in increased expression of MB mRNA	28818685
D014527	Uric Acid	Acetylcysteine inhibits the reaction [[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Uric Acid]	3199797
D014527	Uric Acid	Glutathione inhibits the reaction [[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Uric Acid]	3199797
D014527	Uric Acid	[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Uric Acid	3199797
D014527	Uric Acid	Tiopronin inhibits the reaction [[MB protein co-treated with Hydrogen Peroxide] results in increased oxidation of Uric Acid]	3199797
D014635	Valproic Acid	Valproic Acid results in decreased expression of MB mRNA	24935251\|2915479
C030106	very low density lipoprotein triglyceride	alpha-Tocopherol inhibits the reaction [MB modified form results in decreased secretion of very low density lipoprotein triglyceride]	17478120
C030106	very low density lipoprotein triglyceride	MB modified form results in decreased secretion of very low density lipoprotein triglyceride	17478120
D014810	Vitamin E	Vitamin E results in increased expression of MB mRNA	19244175

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005344	oxygen carrier activity	-	IEA	-
GO:0019825	oxygen binding	-	IEA	-
GO:0020037	heme binding	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001666	response to hypoxia	-	IEA	-
GO:0007507	heart development	-	IEA	-
GO:0009725	response to hormone	-	IEA	-
GO:0015671	oxygen transport	-	TAS	-
GO:0031444	slow-twitch skeletal muscle fiber contraction	-	IEA	-
GO:0042542	response to hydrogen peroxide	-	IEA	-
GO:0043353	enucleate erythrocyte differentiation	-	IEA	-
GO:0050873	brown fat cell differentiation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-382551	Transport of small molecules	TAS
R-HSA-8981607	Intracellular oxygen transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
7134815	Activity of creatine kinase isoenzymes in the serum after acute alcohol intake and in chronic alcoholism. (1982 Jun)	Kettunen P	Scand J Clin Lab Invest
28712188	A Novel Link Between Adipokines And Lipoprotein (A) To Contemplate Their Diagnostic Role In Patients With Stemi And Nstemi. (2017 Jan-Mar)	Rashid S	J Ayub Med Coll Abbottabad
27441981	Evaluation of globins expression in brain, heart, and lung in rats exposed to side stream cigarette smoke. (2017 Apr)	Tae B	Environ Toxicol
22096494	A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study. (2011)	Zuo L	PLoS One
21512282	The relationship between tenascin-C levels and the complexity of coronary lesion after myocardial infarction. (2011)	Celik A	J Atheroscler Thromb
20733118	Overexpression and activation of the alpha9-nicotinic receptor during tumorigenesis in human breast epithelial cells. (2010 Sep 8)	Lee CH	J Natl Cancer Inst
23866471	Is there any benefit of preoperative oral trimetazidine in coronary artery bypass graft? (2012 Dec)	Sher-i-Murtaza M	J Pak Med Assoc
25204042	Detection of CD34/CXCR4+ stem cells in peripheral blood of patients following acute myocardial infarction. (2014)	Abdallah KO	Egypt J Immunol
1478642	Structure and linkage of the D2 dopamine receptor and neural cell adhesion molecule genes on human chromosome 11q23. (1992 Dec)	Eubanks JH	Genomics
19921817	Combination treatment with luteolin and quercetin enhances antiproliferative effects in nicotine-treated MDA-MB-231 cells by down-regulating nicotinic acetylcholine receptors. (2010 Jan 13)	Shih YL	J Agric Food Chem
28506689	Genetic Factors Interact With Tobacco Smoke to Modify Risk for Inflammatory Bowel Disease in Humans and Mice. (2017 Aug)	Yadav P	Gastroenterology
21633901	Attenuation of the cardiac inflammatory changes and lipid anomalies by (-)-epigallocatechin-gallate in cigarette smoke-exposed rats. (2011 Aug)	Gokulakrisnan A	Mol Cell Biochem
18363851	Molecular analyses and identification of promising candidate genes for loci on mouse chromosome 1 affecting alcohol physical dependence and associated withdrawal. (2008 Jul)	Denmark DL	Genes Brain Behav
18363856	Mapping a locus for alcohol physical dependence and associated withdrawal to a 1.1 Mb interval of mouse chromosome 1 syntenic with human chromosome 1q23.2-23.3. (2008 Jul)	Kozell L	Genes Brain Behav
25186013	Enhanced breast cancer cell adherence to the lung endothelium via PAF acetylhydrolase inhibition: a potential mechanism for enhanced metastasis in smokers. (2014 Nov 15)	Kispert SE	Am J Physiol Cell Physiol
23926199	Genome-wide mutational signatures of aristolochic acid and its application as a screening tool. (2013 Aug 7)	Poon SL	Sci Transl Med
29272014	Relationship between the change in pacing threshold and the myocardial injury. (2017 Dec)	Huang GY	Eur Rev Med Pharmacol Sci
26517513	Disulfiram inhibits TGF-beta-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-kappaB/Snail pathway. (2015 Dec 1)	Han D	Oncotarget
29696937	The effects of atorvastatin on IL-6, CRP, blood lipid and myocardial protection of interventional therapy in patients with acute myocardial infarction. (2018 Apr 24)	Wang K	Minerva Med
28096806	A Systems Approach Implicates a Brain Mitochondrial Oxidative Homeostasis Co-expression Network in Genetic Vulnerability to Alcohol Withdrawal. (2016)	Walter NA	Front Genet
24996291	Protective effect of calpain inhibitor N-acetyl-L-leucyl-L-leucyl-L-norleucinal on acute alcohol consumption related cardiomyopathy. (2014 Oct)	Kartkaya K	Mol Biol Rep
25640319	The possible role of maternal bonding style and CHRNB2 gene polymorphisms in nicotine dependence and related depressive phenotype. (2015 Jun 3)	Csala I	Prog Neuropsychopharmacol Biol Psychiatry
24902721	Catechol-O-methyltransferase gene methylation and substance use in adolescents: the TRAILS study. (2014 Sep)	van der Knaap LJ	Genes Brain Behav
2365797	[Clinical picture and background for progression of peripheral arteriosclerosis in Japanese patients with coronary artery disease]. (1990 Apr)	Takita T	Nihon Ika Daigaku Zasshi
25991709	Identification of candidate genes that underlie the QTL on chromosome 1 that mediates genetic differences in stress-ethanol interactions. (2015 Aug)	Cook MN	Physiol Genomics
18163977	A Systematic single nucleotide polymorphism screen to fine-map alcohol dependence genes on chromosome 7 identifies association with a novel susceptibility gene ACN9. (2008 Jun 1)	Dick DM	Biol Psychiatry
27989609	Limbic circuitry activation in ethanol withdrawal is regulated by a chromosome 1 locus. (2017 Feb)	Buck KJ	Alcohol
27437262	Gender Based Differences in Risk Factor Profile and Coronary Angiography of Patients Presenting with Acute Myocardial Infarction in North Indian Population. (2016 May)	Bajaj S	J Clin Diagn Res
18498660	Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study. (2008 May 22)	Laramie JM	BMC Med Genet
17405923	Strongly reduced number of parvalbumin-immunoreactive projection neurons in the mammillary bodies in schizophrenia: further evidence for limbic neuropathology. (2007 Jan)	Bernstein HG	Ann N Y Acad Sci
25802360	Cigarette smoke induces cell motility via platelet-activating factor accumulation in breast cancer cells: a potential mechanism for metastatic disease. (2015 Mar)	Kispert S	Physiol Rep
28932553	The relationship between apnoea hypopnoea index and Gensini score in patients with acute myocardial infarction undergoing emergency primary percutaneous coronary intervention. (2017 Aug)	Zhu CP	J Thorac Dis
528230	Human alveolar macrophages spontaneous reduction of BSPT salt. (1979 Nov)	Jaubert F	Histochemistry
3210108	Smoking during pregnancy and the perinatal cadmium burden. (1988)	Sikorski R	J Perinat Med
19759313	Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol. (2009 Sep 16)	Kozell LB	J Neurosci
14563341	Prognostic value and the changes of plasma levels of secretory type II phospholipase A2 in patients with coronary artery disease undergoing percutaneous coronary intervention. (2003 Oct)	Liu PY	Eur Heart J
23978819	Generalization of adiposity genetic loci to US Hispanic women. (2013 Aug 26)	Graff M	Nutr Diabetes
362734	[Isoenzymes, methodology and clinical significance (author's transl)]. (1978)	Bayer PM	Wien Klin Wochenschr Suppl
20548041	Incidence of cerebral microbleeds: a longitudinal study in a memory clinic population. (2010 Jun 15)	Goos JD	Neurology
15340673	Evaluation of systolic, diastolic, and pulse pressure as risk factors for severe coronary arteriosclerotic disease in women with unstable angina non-ST-elevation acute myocardial infarction. (2004 May)	Sousa JM	Arq Bras Cardiol
17624982	Variation in a bicarbonate co-transporter gene family member SLC4A7 is associated with propensity to addictions: a study using fine-mapping and three samples. (2007 Aug)	Ishiguro H	Addiction
29125109	Impact of Myocardial Bridge-mural Coronary Artery on Myocardial Functions. (2017 Oct 30)	Zhao XB	Zhongguo Yi Xue Ke Xue Yuan Xue Bao
1698239	Nicotine, acetylcholine and bombesin are trophic growth factors in neuroendocrine cell lines derived from experimental hamster lung tumors. (1990)	Schuller HM	Life Sci
8747752	The effects of NMDA receptor antagonists and nitric oxide synthase inhibitors on opioid tolerance and withdrawal. Medication development issues for opiate addiction. (1995 Dec)	Herman BH	Neuropsychopharmacology
17079463	Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity. (2006 Nov 1)	Chen D	Cancer Res
17204727	Secreted modular calcium-binding protein 2 haplotypes are associated with pulmonary function. (2007 Mar 15)	Wilk JB	Am J Respir Crit Care Med
23322787	Heritability and preliminary genome-wide linkage analysis of arsenic metabolites in urine. (2013 Mar)	Tellez-Plaza M	Environ Health Perspect
19921103	Impact of distal embolization on myocardial perfusion and survival among patients undergoing primary angioplasty with glycoprotein IIb-IIIa inhibitors: insights from the EGYPT cooperation. (2010 Jul)	De Luca G	J Thromb Thrombolysis
24879575	Utility of salivary biomarkers for demonstrating acute myocardial infarction. (2014 Jul)	Miller CS	J Dent Res
23144326	Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. (2012 Dec 15)	Kim DK	Am J Respir Crit Care Med
24157158	Free triiodothyronine level indicates the degree of myocardial injury in patients with acute ST-elevation myocardial infarction. (2013 Oct)	Wang WY	Chin Med J (Engl)
28208842	Assessment of Serum VASPIN Levels among Type 2 Diabetes Mellitus Patients with or without Acute Coronary Syndrome. (2016 Dec)	Sathyaseelan AJ	J Clin Diagn Res
24358215	Neurobiological signatures of alcohol dependence revealed by protein profiling. (2013)	Gorini G	PLoS One
19562039	Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array. (2009 Jun 29)	Sober S	PLoS One
23363671	[Prognostic value of circulating catestatin levels for in-hospital heart failure in patients with acute myocardial infarction]. (2012 Nov)	Ji L	Zhonghua Xin Xue Guan Bing Za Zhi
6851084	Changes in serum myoglobin, total creatine kinase, lactate dehydrogenase and creatine kinase MB levels in runners. (1983 Jun)	Munjal DD	Clin Biochem
26407342	A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism. (2015)	Loukola A	PLoS Genet
29799009	Whole-genome sequencing reveals genomic signatures associated with the inflammatory microenvironments in Chinese NSCLC patients. (2018 May 24)	Wang C	Nat Commun
28726720	TGF-beta-Dependent Growth Arrest and Cell Migration in Benign and Malignant Breast Epithelial Cells Are Antagonistically Controlled by Rac1 and Rac1b. (2017 Jul 20)	Melzer C	Int J Mol Sci
10771023	Interaction of tobacco-specific toxicants with the neuronal alpha(7) nicotinic acetylcholine receptor and its associated mitogenic signal transduction pathway: potential role in lung carcinogenesis and pediatric lung disorders. (2000 Mar 30)	Schuller HM	Eur J Pharmacol
19124843	Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q. (2009 May)	Ober C	J Lipid Res
27977510	A comprehensive contribution of genes for aryl hydrocarbon receptor signaling pathway to hypertension susceptibility. (2017 Feb)	Polonikov AV	Pharmacogenet Genomics
27743853	Comparison of Various Strategies for the Prognosis and Outcomes of Ischaemic Dilated Cardiomyopathy in Smokers: Complete Revascularisation and Smoking Cessation Produces a Superior Outcome. (2017 May)	Wang J	Heart Lung Circ
20979877	[Effect of duration of clopidogrel use on clinical follow-up outcomes in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention]. (2010 Jun 22)	Wang CH	Zhonghua Yi Xue Za Zhi
29195920	Loss of Lypd6 leads to reduced anxiety-like behaviour and enhanced responses to nicotine. (2018 Mar 2)	Arvaniti M	Prog Neuropsychopharmacol Biol Psychiatry
6686846	Variation of serum myoglobin levels in normal individuals. With reference to the use of myoglobin measurements for the detection of women carrying genes for the X-linked muscular dystrophies. (1983 Dec)	Nicholson LV	J Neurol Sci
29655949	Incidence and predictors of 6months mortality after an acute heart failure event in rural Uganda: The Mbarara Heart Failure Registry (MAHFER). (2018 Aug 1)	Abeya FC	Int J Cardiol
28927238	Factor V Leiden is associated with increased sperm count. (2017 Nov 1)	van Mens TE	Hum Reprod
21423427	Determination of Methylated CpG Sites in the Promoter Region of Catechol-O-Methyltransferase (COMT) and their Involvement in the Etiology of Tobacco Smoking. (2010)	Xu Q	Front Psychiatry