Gene info: ID 4153

Gene: MBL2

GENE ID: 4153

Description: mannose binding lectin 2

Gene type: protein-coding

Location: 10q21.1

dbXrefs: Ensembl:ENSG00000165471 MIM:154545 Vega:OTTHUMG00000150270 UniprotKB:P11226

RefSeq: NG_008196.1

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: CD|ND

# Publications: 10

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.801e-1 (AD) 2.789e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs1982266	chr10:52770876 (GRCh38.p7)	A>G	cocaine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR14J1	0.932
TRIM60	0.908
OR1I1	0.902
OR2H1	0.885
TDRD15	0.883
NLRP13	0.882
PCAT4	0.871
OR4K3	0.87
RNASE9	0.864
OR2J2	0.863

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HDDC3	-0.314
TMEM221	-0.288
MRPL46	-0.27
TIMM21	-0.258
KLHDC9	-0.256
CHCHD6	-0.255
TACO1	-0.252
C16orf95	-0.248
SMKR1	-0.247
RHEBL1	-0.246

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01818	O3-Sulfonylgalactose	Small Molecule		Experimental	Target
DB01979	Methyl alpha-D-mannoside	Small Molecule	25281-48-5	Experimental	Target
DB02837	O4-Sulfonylgalactose	Small Molecule		Experimental	Target
DB03194	beta-L-methyl-fucose	Small Molecule		Experimental	Target
DB03721	N-acetyl-alpha-neuraminic acid	Small Molecule		Experimental	Target
DB03879	alpha-L-methyl-fucose	Small Molecule		Experimental	Target
DB04426	Alpha-Methyl-N-Acetyl-D-Glucosamine	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of MBL2 mRNA"	19162173
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of MBL2 mRNA]"	19467301
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MBL2 mRNA"	19692669
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of MBL2 mRNA"	18648102
C020738	9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of MBL2 mRNA"	26238291
D000082	Acetaminophen	Acetaminophen affects the expression of MBL2 mRNA	17562736
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of MBL2 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MBL2 mRNA]	17585979
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of MBL2 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of MBL2 mRNA	22100608
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of MBL2 gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MBL2 mRNA	16483693
D003913	Dextroamphetamine	Dextroamphetamine results in decreased expression of MBL2 mRNA	16715494
D001280	Atrazine	Atrazine results in increased expression of MBL2 mRNA	25929836
D001379	Azathioprine	Azathioprine results in decreased expression of MBL2 mRNA	22623647
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MBL2 mRNA	20106945\|2163298
D019207	beta Carotene	MBL2 gene polymorphism affects the susceptibility to [Vitamin A co-treated with beta Carotene]	16960176
D004958	Estradiol	Estradiol results in decreased expression of MBL2 mRNA	20106945
C006780	bisphenol A	bisphenol A results in decreased expression of MBL2 mRNA	25181051
D000069286	Bortezomib	MBL2 gene SNP results in increased susceptibility to Bortezomib	20864405
D002065	Buspirone	Buspirone results in decreased expression of MBL2 mRNA	24136188
C026690	cerous chloride	[cerous chloride co-treated with lanthanum chloride] results in decreased expression of MBL2 mRNA	28954213
C026690	cerous chloride	cerous chloride results in decreased expression of MBL2 mRNA	28954213
D002793	Cholic Acids	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of MBL2 mRNA	27344345
D002793	Cholic Acids	[Cyclosporine co-treated with Cholic Acids] affects the expression of MBL2 mRNA	27344345
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of MBL2 mRNA	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of MBL2 mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MBL2 mRNA]	17585979
D002995	Clofibric Acid	Clofibric Acid affects the expression of MBL2 mRNA	17602206
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of MBL2 mRNA	24386269
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of MBL2 mRNA	19549813
C030123	coumarin	coumarin results in decreased expression of MBL2 mRNA	18480146
D016572	Cyclosporine	[Cyclosporine co-treated with Cholic Acids] affects the expression of MBL2 mRNA	27344345
D016572	Cyclosporine	Cyclosporine results in decreased expression of MBL2 mRNA	20106945\|2163298
D003907	Dexamethasone	Dexamethasone results in decreased expression of MBL2 mRNA	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of MBL2 mRNA]	20032058
D004041	Dietary Fats	"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of MBL2 mRNA]"	19467301
D004041	Dietary Fats	Dietary Fats results in decreased expression of MBL2 mRNA	18457598\|2501614
D004041	Dietary Fats	Dietary Fats results in increased expression of MBL2 mRNA	19467301
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of MBL2 mRNA	28085963
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of MBL2 mRNA	21607683
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of MBL2 mRNA	19638242
D004147	Dioxins	Dioxins affects the expression of MBL2 mRNA	20463971
D004726	Endosulfan	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of MBL2 mRNA	26159488
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of MBL2 mRNA	21607683
D005485	Flutamide	Flutamide results in decreased expression of MBL2 mRNA	24136188\|2479361
C039281	furan	furan results in decreased expression of MBL2 mRNA	25539665\|2619464
C039281	furan	furan results in increased methylation of MBL2 gene	22079235
D005897	Glafenine	Glafenine results in decreased expression of MBL2 mRNA	24136188
C028521	lanthanum chloride	[cerous chloride co-treated with lanthanum chloride] results in decreased expression of MBL2 mRNA	28954213
C028521	lanthanum chloride	lanthanum chloride results in decreased expression of MBL2 mRNA	28954213
C045463	leflunomide	leflunomide results in increased expression of MBL2 mRNA	28988120
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MBL2 mRNA	24056979
D008070	Lipopolysaccharides	methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of MBL2 mRNA]	24056979
C008435	methyldithiocarbamate	methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of MBL2 mRNA]	24056979
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of MBL2 mRNA"	25620056
D015058	1-Naphthylisothiocyanate	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of MBL2 mRNA	27344345
C051752	nefazodone	nefazodone results in decreased expression of MBL2 mRNA	24136188
C022838	nickel chloride	nickel chloride affects the expression of MBL2 mRNA	22110744
C012655	nimesulide	nimesulide results in decreased expression of MBL2 mRNA	24136188
C016030	pantogab	pantogab results in decreased expression of MBL2 mRNA	17379144
C036567	perfluorodecanoic acid	perfluorodecanoic acid results in decreased expression of MBL2 mRNA	23567314
C522391	perfluorododecanoic acid	perfluorododecanoic acid results in decreased expression of MBL2 mRNA	23567314
C471071	perfluorohexanesulfonic acid	perfluorohexanesulfonic acid results in increased expression of MBL2 mRNA	23567314
C479228	perfluorohexanoic acid	perfluorohexanoic acid results in increased expression of MBL2 mRNA	23567314
C101815	perfluoro-n-heptanoic acid	perfluoro-n-heptanoic acid results in increased expression of MBL2 mRNA	23567314
C584865	perfluorononanoic acid	perfluorononanoic acid results in decreased expression of MBL2 mRNA	25543169
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in decreased expression of MBL2 mRNA	23602845
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of MBL2 mRNA	23567314
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of MBL2 mRNA	19429403\|2093613
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of MBL2 mRNA	18467677\|1942940
C023036	perfluorooctanoic acid	PPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of MBL2 mRNA]	18467677
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of MBL2 mRNA	19162173
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MBL2 mRNA	19710929
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MBL2 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of MBL2 mRNA	18467677
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in decreased expression of MBL2 mRNA]	18467677
C006253	pirinixic acid	pirinixic acid results in decreased expression of MBL2 mRNA	19162173
D011192	Potassium Dichromate	Potassium Dichromate affects the expression of MBL2 mRNA	23608068
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of MBL2 mRNA	27413110\|2890350
C089730	rosiglitazone	rosiglitazone results in increased expression of MBL2 mRNA	25572481
C089730	rosiglitazone	rosiglitazone results in decreased expression of MBL2 mRNA	21515302
D012715	Sesame Oil	Sesame Oil results in increased expression of MBL2 mRNA	29191790
C009277	sodium arsenate	sodium arsenate results in decreased expression of MBL2 mRNA	23922661
C017947	sodium arsenite	sodium arsenite affects the expression of MBL2 mRNA	29319823
C017947	sodium arsenite	sodium arsenite results in decreased expression of MBL2 mRNA	25270620
C016104	sodium bichromate	sodium bichromate results in decreased expression of MBL2 mRNA	24612858
C016104	sodium bichromate	sodium bichromate results in decreased expression of MBL2 mRNA	22155349
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of MBL2 protein	28918527
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of MBL2 mRNA]	20032058
D013749	Tetrachlorodibenzodioxin	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of MBL2 mRNA	26159488
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MBL2 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MBL2 mRNA	11489354\|2010694
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MBL2 mRNA	16120747\|2386450
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MBL2 mRNA	21215274\|2172422
D013755	Tetradecanoylphorbol Acetate	[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MBL2 mRNA	16979875
D013853	Thioacetamide	Thioacetamide results in decreased expression of MBL2 mRNA	23411599
C009495	titanium dioxide	titanium dioxide affects the expression of MBL2 mRNA	23557971
C057693	troglitazone	troglitazone results in increased expression of MBL2 mRNA	25572481
C057693	troglitazone	troglitazone results in decreased expression of MBL2 mRNA	21515302
D014520	Urethane	Urethane results in decreased expression of MBL2 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of MBL2 mRNA	29154799
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of MBL2 mRNA	26682919
D014801	Vitamin A	MBL2 gene polymorphism affects the susceptibility to [Vitamin A co-treated with beta Carotene]	16960176
D015032	Zinc	[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MBL2 mRNA	16979875

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004252	serine-type endopeptidase activity	-	TAS	-
GO:0005102	signaling receptor binding	-	IPI	11549596
GO:0005509	calcium ion binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	11485744 21054788 25579818
GO:0005537	mannose binding	-	IBA	21873635
GO:0005537	mannose binding	-	IDA	23544079
GO:0005537	mannose binding	-	NAS	11549596
GO:0005537	mannose binding	-	TAS	2477488
GO:0030246	carbohydrate binding	-	IBA	21873635
GO:0048306	calcium-dependent protein binding	-	IPI	12421953 18596036

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001867	complement activation, lectin pathway	-	IBA	21873635
GO:0001867	complement activation, lectin pathway	-	IDA	15148336
GO:0001867	complement activation, lectin pathway	-	IPI	11549596
GO:0001867	complement activation, lectin pathway	-	TAS	-
GO:0003429	growth plate cartilage chondrocyte morphogenesis	-	IBA	21873635
GO:0006508	proteolysis	-	IEA	-
GO:0006953	acute-phase response	-	TAS	2477488
GO:0006956	complement activation	-	TAS	-
GO:0006958	complement activation, classical pathway	-	IEA	-
GO:0006979	response to oxidative stress	-	NAS	11549596
GO:0008228	opsonization	-	TAS	2477488
GO:0042742	defense response to bacterium	-	TAS	2477488
GO:0044130	negative regulation of growth of symbiont in host	-	IDA	15148336
GO:0045087	innate immune response	-	IDA	23544079
GO:0048525	negative regulation of viral process	-	IDA	23544079
GO:0050766	positive regulation of phagocytosis	-	IEA	-
GO:0050830	defense response to Gram-positive bacterium	-	IDA	15148336
GO:0051873	killing by host of symbiont cells	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005581	collagen trimer	-	IEA	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IDA	23544079
GO:0009986	cell surface	-	TAS	2477488

KEGG ID	KEGG Term
hsa04145	Phagosome
hsa04610	Complement and coagulation cascades
hsa05150	Staphylococcus aureus infection

Reactome ID	Reactome Term	Evidence
R-HSA-166658	Complement cascade	TAS
R-HSA-166662	Lectin pathway of complement activation	TAS
R-HSA-166663	Initial triggering of complement	TAS
R-HSA-166786	Creation of C4 and C2 activators	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28189510	Evaluation of TNF-alpha gene (G308A) and MBL2 gene codon 54 polymorphisms in Turkish patients with tuberculosis. (2017 Nov - Dec)	Ceylan E	J Infect Public Health
15592292	Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth. (2004 Dec)	Annells MF	Am J Obstet Gynecol
27351742	A Case-Control Study on the Risk Factors for Meningococcal Disease among Children in Greece. (2016)	Hadjichristodoulou C	PLoS One
24264011	Smoking and polymorphisms of genes encoding mannose-binding lectin and surfactant protein-D in patients with rheumatoid arthritis. (2014 Mar)	Kristiansen M	Rheumatol Int
16721783	Mannose-binding lectin-2 genetic variation and stomach cancer risk. (2006 Oct 15)	Baccarelli A	Int J Cancer
21496252	Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers. (2011 Apr 15)	Saevarsdottir S	Arthritis Res Ther
17848669	Lung cancer survival and functional polymorphisms in MBL2, an innate-immunity gene. (2007 Sep 19)	Pine SR	J Natl Cancer Inst
20923744	Genetic, biochemical, and environmental factors associated with pregnancy outcomes in newborns from the Czech Republic. (2011 Feb)	Rossner P Jr	Environ Health Perspect
18782274	Gene-environment interaction between MBL2 genotype and smoking, and the risk of gram-positive bacteraemia. (2008 Oct)	Huttunen R	Scand J Immunol
20038440	Smoking status interacts with the association between mannose-binding lectin serum levels and gene polymorphism and the carriage of oropharyngeal bacteria. (2010 Mar)	Jounio U	Hum Immunol