Gene: MC1R

4157
CMM5|MSH-R|SHEP2
melanocortin 1 receptor
protein-coding
16q24.3
Ensembl:ENSG00000258839 MIM:155555 Vega:OTTHUMG00000171163 UniprotKB:Q01726
NG_012026.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.322e-1 (AD)  6.957e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3212369chr16:89920352 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRSS530.767
LMBR1L0.748
MLXIP0.743
RANBP100.742
ZSWIM80.742
AOC20.738
DIDO10.731
STK11IP0.727
LENG80.723
QSOX20.722

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DIO2-0.358
HES5-0.327
HPDL-0.31
KCNJ16-0.31
ALDH1L1-AS2-0.291
TSPAN12-0.29
OR4F5-0.286
SLC22A6-0.281
DIAPH3-0.276
REN-0.274

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04931AfamelanotideSmall Molecule75921-69-6Approved|InvestigationalTarget
DB05479CZEN 002Small Molecule-InvestigationalTarget
ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of MC1R mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of MC1R mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MC1R mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MC1R mRNA21641981
C006632arsenic trioxidearsenic trioxide results in increased expression of MC1R mRNA20458559
D001280AtrazineAtrazine results in decreased expression of MC1R mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MC1R mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MC1R mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to MC1R promoter]19654925
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MC1R mRNA"20382639
C006780bisphenol Abisphenol A results in decreased expression of MC1R mRNA29275510
C006780bisphenol Abisphenol A results in decreased methylation of MC1R promoter27312807
C584509C646 compoundC646 compound results in increased expression of MC1R mRNA26191083
D002726Chlorogenic AcidChlorogenic Acid results in increased expression of MC1R mRNA20706672
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of MC1R mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MC1R mRNA]17585979
D003024ClozapineClozapine results in increased expression of MC1R mRNA17346280
C018021cobaltous chloridecobaltous chloride results in decreased expression of MC1R mRNA19376846
C472036dihydromyricetindihydromyricetin results in decreased expression of MC1R protein27586645
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of MC1R mRNA24834073
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of MC1R mRNA20706672
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of MC1R exon16300676
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of MC1R promoter16300676
C041877eumelaninMC1R protein results in increased chemical synthesis of eumelanin24975581
D011345FenofibrateFenofibrate results in decreased expression of MC1R mRNA23872139
D011345Fenofibrate[Fenofibrate results in decreased expression of MC1R mRNA] which results in decreased chemical synthesis of Melanins23872139
D019833GenisteinGenistein results in decreased expression of MC1R mRNA20706672
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of MC1R mRNA26846883
C492448ICG 001ICG 001 results in increased expression of MC1R mRNA26191083
C030374indoleindole analog binds to MC1R protein11909711
C011890kojic acidkojic acid results in decreased expression of MC1R protein27586645
D008543Melanins[Fenofibrate results in decreased expression of MC1R mRNA] which results in decreased chemical synthesis of Melanins23872139
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MC1R mRNA26011545
C031721naphthalenenaphthalene analog binds to MC1R protein11909711
C485800osajinosajin results in decreased expression of MC1R mRNA20706672
D052638Particulate MatterParticulate Matter results in decreased expression of MC1R mRNA24769257
D010456Peptides, Cyclic"Peptides, Cyclic binds to and results in decreased activity of MC1R protein"19996949
C016042phaeomelanin[ASIP protein binds to MC1R protein] which results in increased chemical synthesis of phaeomelanin21373989
C016042phaeomelaninMC1R gene mutant form results in increased chemical synthesis of phaeomelanin24975581
C016042phaeomelaninMC1R protein polymorphism affects the chemical synthesis of phaeomelanin22351934
D010634PhenobarbitalPhenobarbital affects the expression of MC1R mRNA19136022
C121565pifithrinpifithrin results in decreased expression of MC1R mRNA19098008
C006253pirinixic acidpirinixic acid affects the expression of MC1R mRNA19136022
C006253pirinixic acidpirinixic acid results in decreased expression of MC1R mRNA17950772
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of MC1R mRNA]17950772
D010936Plant ExtractsPlant Extracts results in decreased expression of MC1R mRNA24380755
D010936Plant ExtractsPlant Extracts results in decreased expression of MC1R protein24380755
C474837pomiferinpomiferin results in decreased expression of MC1R mRNA20706672
D011429PropolisPropolis results in decreased expression of MC1R mRNA20706672
C033607puerarinpuerarin results in decreased expression of MC1R mRNA20706672
C012526quercitrinquercitrin results in increased expression of MC1R mRNA25193878
C059514resveratrolresveratrol results in decreased expression of MC1R mRNA20706672
C529148rosavinrosavin results in decreased expression of MC1R mRNA20706672
D013440SulfidesSulfides binds to and results in decreased activity of MC1R protein19996949
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MC1R mRNA21570461
D014520UrethaneUrethane results in decreased expression of MC1R mRNA28818685
D024483Vitamin K 3Vitamin K 3 affects the expression of MC1R mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004977melanocortin receptor activity-TAS9571181  
GO:0004980melanocyte-stimulating hormone receptor activity-IPI19743876  
GO:0005515protein binding-IPI19329486  19743876  
GO:0008528G-protein coupled peptide receptor activity-TAS18292087  
GO:0031625ubiquitin protein ligase binding-IPI19737927  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-TAS9571181  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IDA19329486  19743876  
GO:0007275multicellular organism development-TAS7581459  
GO:0009650UV protection-TAS7581459  
GO:0010739positive regulation of protein kinase A signaling-ISS18292087  
GO:0032720negative regulation of tumor necrosis factor production-IMP10233018  
GO:0035556intracellular signal transduction-ISS18292087  
GO:0043473pigmentation-TAS18292087  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS18292087  
GO:0051897positive regulation of protein kinase B signaling-ISS18292087  
GO:0070914UV-damage excision repair-IDA18292087  
GO:0090037positive regulation of protein kinase C signaling-ISS18292087  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-IDA19452503  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9571181  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
hsa04916Melanogenesis
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21787368The determinants of periorbital skin ageing in participants of a melanoma case-control study in the U.K. (2011 Nov)Suppa MBr J Dermatol