Gene: MC3R

4159
BMIQ9|MC3|MC3-R|OB20|OQTL
melanocortin 3 receptor
protein-coding
20q13.2
Ensembl:ENSG00000124089 MIM:155540 Vega:OTTHUMG00000032785 UniprotKB:P41968
NG_012200.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.432e-1 (AD)  9.716e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24298684chr20:54823878MC3RPromoter1.139e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM216B0.491
SSTR40.484
RELN0.479
NDNF0.463
TOX30.459
PTHLH0.454
VIP0.447
CHRNA60.442
DLX20.441
HAPLN10.44

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HBA2-0.325
HBA1-0.3
HBB-0.284
NPIPB6-0.282
GNG8-0.28
S100A12-0.277
ANKRD23-0.27
AQP1-0.259
ALAS2-0.259
IL1R2-0.249

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of MC3R mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MC3R mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MC3R mRNA27195522
C006780bisphenol Abisphenol A results in decreased expression of MC3R mRNA22957036
D016572CyclosporineCyclosporine results in decreased expression of MC3R mRNA19770486
D004041Dietary FatsDietary Fats results in increased expression of MC3R mRNA25016146
D004791Enzyme InhibitorsEnzyme Inhibitors inhibits the reaction [Phenylpropanolamine results in increased expression of MC3R protein]24792324
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of MC3R gene16720677
C069837fullerene C60fullerene C60 results in decreased expression of MC3R mRNA19167457
C030374indoleindole analog binds to MC3R protein11909711
D009151Mustard GasMustard Gas results in increased expression of MC3R mRNA15674843
C031721naphthalenenaphthalene analog binds to MC3R protein11909711
D010665PhenylpropanolamineEnzyme Inhibitors inhibits the reaction [Phenylpropanolamine results in increased expression of MC3R protein]24792324
D010665PhenylpropanolaminePhenylpropanolamine results in increased expression of MC3R protein24792324
C005556propionaldehydepropionaldehyde results in decreased expression of MC3R mRNA26079696
C103272SHU 9119SHU 9119 binds to and results in decreased activity of MC3R protein16153779
D012834SilverSilver results in increased expression of MC3R mRNA27131904
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MC3R mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MC3R mRNA19770486
D014800VitalliumVitallium analog results in decreased expression of MC3R mRNA23825117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004977melanocortin receptor activity-TAS8175743  
GO:0004980melanocyte-stimulating hormone receptor activity-IPI19743876  
GO:0005515protein binding-IPI19329486  19743876  
GO:0017046peptide hormone binding-IEA-  
GO:0042923neuropeptide binding-IMP15927146  
GO ID GO Term Qualifier Evidence PubMed
GO:0002027regulation of heart rate-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-TAS8175743  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IDA19329486  19743876  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-TAS8175743  
GO:0008217regulation of blood pressure-IEA-  
GO:0032922circadian regulation of gene expression-ISS-  
GO:0042309homoiothermy-IEA-  
GO:0045475locomotor rhythm-IEA-  
GO:0055078sodium ion homeostasis-IEA-  
GO:0060259regulation of feeding behavior-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8463333  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15769990Genomewide linkage analysis of weight change in the Framingham Heart Study. (2005 Jun)Fox CSJ Clin Endocrinol Metab