Gene info: ID 4160

Gene: MC4R

GENE ID: 4160

Synonyms: -

Description: melanocortin 4 receptor

Gene type: protein-coding

Location: 18q21.32

dbXrefs: Ensembl:ENSG00000166603 MIM:155541 Vega:OTTHUMG00000132766 UniprotKB:P32245

RefSeq: NG_016441.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 10

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.823e-1 (AD) 3.426e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RSPO3	0.726
MAGEE2	0.71
RAE1	0.705
NUDT10	0.7
TPX2	0.7
ARHGEF28	0.696
GRM1	0.696
TRIP13	0.695
OCRL	0.693
SLC7A3	0.693

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ASB4	-0.425
P2RY14	-0.424
PLA2G5	-0.4
RERGL	-0.399
ENDOU	-0.398
FZD10	-0.396
NKD1	-0.38
KLRB1	-0.379
MBNL3	-0.378
FOXL1	-0.374

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C471568	11-Mrp-14-Nal-18-Cys-22-Asp-beta-MSH(11-22)NH2	11-Mrp-14-Nal-18-Cys-22-Asp-beta-MSH(11-22)NH2 binds to and results in decreased activity of MC4R protein	16153779
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of MC4R mRNA"	25614096
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MC4R mRNA"	27291303
C075773	4-phenylbutyric acid	4-phenylbutyric acid results in increased expression of MC4R	23251400
D000242	Cyclic AMP	[POMC protein alternative form binds to MC4R protein] which results in increased abundance of Cyclic AMP	23251400
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MC4R mRNA	16483693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MC4R mRNA	22316170
C579663	BIM-22493	BIM-22493 binds to and results in increased activity of MC4R protein	23048186
C006780	bisphenol A	bisphenol A results in decreased expression of MC4R mRNA	22957036\|2518105
D002713	Chlorine	[Ozone co-treated with Chlorine] results in increased expression of MC4R mRNA	18636392
D019327	Copper Sulfate	Copper Sulfate results in increased expression of MC4R mRNA	23268349
D003471	Cuprizone	Cuprizone results in increased expression of MC4R mRNA	26577399
D004041	Dietary Fats	Dietary Fats results in decreased expression of MC4R mRNA	18721800
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of MC4R mRNA	26033743
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of MC4R mRNA	15620428
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of MC4R gene	16720677\|1714358
D005473	Fluoxetine	Fluoxetine results in decreased expression of MC4R mRNA	18359080
D005473	Fluoxetine	Fluoxetine results in decreased expression of MC4R protein	18359080
C030374	indole	indole analog binds to MC4R protein	11909711
D007854	Lead	Lead affects the expression of MC4R mRNA	28903495
C008261	lead acetate	lead acetate results in increased expression of MC4R mRNA	22641619
C579664	LY2112688	LY2112688 binds to and results in increased activity of MC4R protein	19092146
C579664	LY2112688	LY2112688 binds to and results in increased activity of MC4R protein	23048186
D008694	Methamphetamine	[Methamphetamine co-treated with SCH 23390] results in increased expression of MC4R mRNA	19564919
D008694	Methamphetamine	Methamphetamine results in increased expression of MC4R mRNA	19564919
D009020	Morphine	MC4R protein affects the susceptibility to Morphine	16153779
C027756	MSH, 4-Nle-7-Phe-alpha-	"MSH, 4-Nle-7-Phe-alpha- results in increased activity of MC4R protein"	17713970
C031721	naphthalene	naphthalene analog binds to MC4R protein	11909711
D010126	Ozone	[Ozone co-treated with Chlorine] results in increased expression of MC4R mRNA	18636392
D010852	Picrotoxin	Picrotoxin results in increased expression of MC4R mRNA	15170462
D059808	Polyphenols	Polyphenols results in decreased expression of MC4R mRNA	16293270
D011374	Progesterone	Progesterone results in decreased expression of MC4R mRNA	22238285
D011441	Propylthiouracil	Propylthiouracil results in increased expression of MC4R mRNA	24780913
C089730	rosiglitazone	rosiglitazone results in increased expression of MC4R mRNA	21515302
C534628	SCH 23390	[Methamphetamine co-treated with SCH 23390] results in increased expression of MC4R mRNA	19564919
C103272	SHU 9119	SHU 9119 binds to and results in decreased activity of MC4R protein	16153779
C501413	tesaglitazar	tesaglitazar results in increased expression of MC4R mRNA	21515302
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of MC4R mRNA	20399831
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MC4R mRNA	15977195
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of MC4R mRNA	15977195
C111237	vorinostat	vorinostat results in increased expression of MC4R mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004977	melanocortin receptor activity	-	TAS	8794897
GO:0004980	melanocyte-stimulating hormone receptor activity	-	IDA	14764818
GO:0004980	melanocyte-stimulating hormone receptor activity	-	IPI	19743876
GO:0005515	protein binding	-	IPI	19329486 19743876 21719532
GO:0017046	peptide hormone binding	-	IEA	-
GO:0031625	ubiquitin protein ligase binding	-	IPI	19737927
GO:0042923	neuropeptide binding	-	IMP	15927146

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002024	diet induced thermogenesis	-	IEA	-
GO:0006112	energy reserve metabolic process	-	IEA	-
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	-	TAS	8794897
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	-	IDA	19329486 19743876
GO:0007631	feeding behavior	-	IEA	-
GO:0019222	regulation of metabolic process	-	IEA	-
GO:0030073	insulin secretion	-	IEA	-
GO:0032868	response to insulin	-	IEA	-
GO:0045780	positive regulation of bone resorption	-	IMP	16614075
GO:2000252	negative regulation of feeding behavior	-	IEA	-
GO:2000821	regulation of grooming behavior	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0016021	integral component of membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375276	Peptide ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-418555	G alpha (s) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28384342	Assessing gene-environment interaction effects of FTO, MC4R and lifestyle factors on obesity using an extreme phenotype sampling design: Results from the HUNT study. (2017)	Bjornland T	PLoS One
29113896	Neuroinflammation produced by heavy alcohol intake is due to loops of interactions between Toll-like 4 and TNF receptors, peroxisome proliferator-activated receptors and the central melanocortin system: A novel hypothesis and new therapeutic avenues. (2018 Jan)	Flores-Bastias O	Neuropharmacology
27701175	Evaluation of the Obesity Genes FTO and MC4R for Contribution to the Risk of Large Artery Atherosclerotic Stroke in a Chinese Population. (2016)	Song Z	Obes Facts
23054017	The joint effect of cigarette smoking and polymorphisms on LRP5, LEPR, near MC4R and SH2B1 genes on metabolic syndrome susceptibility in Taiwan. (2013 Jan)	Yang CW	Mol Biol Rep
29694503	Neonatal tobacco smoke reduces thermogenesis capacity in brown adipose tissue in adult rats. (2018)	Peixoto TC	Braz J Med Biol Res
23978819	Generalization of adiposity genetic loci to US Hispanic women. (2013 Aug 26)	Graff M	Nutr Diabetes
17587397	Genetic variation and decreased risk for obesity in the Atherosclerosis Risk in Communities Study. (2007 Jul)	Hart Sailors ML	Diabetes Obes Metab
26537541	Interaction of smoking and obesity susceptibility loci on adolescent BMI: The National Longitudinal Study of Adolescent to Adult Health. (2015 Nov 4)	Young KL	BMC Genet
26965781	Melanocortin-4 receptor rs17782313 polymorphisms are associated with serum triglycerides in older Chinese women. (2016)	Yang J	Asia Pac J Clin Nutr
26804193	Intra-cerebral and intra-nasal melanocortin-4 receptor antagonist blocks withdrawal hyperalgesia in alcohol-dependent rats. (2017 May)	Roltsch Hellard EA	Addict Biol