Gene: MC4R

4160
-
melanocortin 4 receptor
protein-coding
18q21.32
Ensembl:ENSG00000166603 MIM:155541 Vega:OTTHUMG00000132766 UniprotKB:P32245
NG_016441.1
PubMed
ND|AD
10   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.823e-1 (AD)  3.426e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RSPO30.726
MAGEE20.71
RAE10.705
NUDT100.7
TPX20.7
ARHGEF280.696
GRM10.696
TRIP130.695
OCRL0.693
SLC7A30.693

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASB4-0.425
P2RY14-0.424
PLA2G5-0.4
RERGL-0.399
ENDOU-0.398
FZD10-0.396
NKD1-0.38
KLRB1-0.379
MBNL3-0.378
FOXL1-0.374

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C47156811-Mrp-14-Nal-18-Cys-22-Asp-beta-MSH(11-22)NH211-Mrp-14-Nal-18-Cys-22-Asp-beta-MSH(11-22)NH2 binds to and results in decreased activity of MC4R protein16153779
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of MC4R mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MC4R mRNA"27291303
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of MC4R23251400
D000242Cyclic AMP[POMC protein alternative form binds to MC4R protein] which results in increased abundance of Cyclic AMP23251400
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MC4R mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MC4R mRNA22316170
C579663BIM-22493BIM-22493 binds to and results in increased activity of MC4R protein23048186
C006780bisphenol Abisphenol A results in decreased expression of MC4R mRNA22957036|2518105
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of MC4R mRNA18636392
D019327Copper SulfateCopper Sulfate results in increased expression of MC4R mRNA23268349
D003471CuprizoneCuprizone results in increased expression of MC4R mRNA26577399
D004041Dietary FatsDietary Fats results in decreased expression of MC4R mRNA18721800
D019422Dietary SucroseDietary Sucrose results in increased expression of MC4R mRNA26033743
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of MC4R mRNA15620428
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of MC4R gene16720677|1714358
D005473FluoxetineFluoxetine results in decreased expression of MC4R mRNA18359080
D005473FluoxetineFluoxetine results in decreased expression of MC4R protein18359080
C030374indoleindole analog binds to MC4R protein11909711
D007854LeadLead affects the expression of MC4R mRNA28903495
C008261lead acetatelead acetate results in increased expression of MC4R mRNA22641619
C579664LY2112688LY2112688 binds to and results in increased activity of MC4R protein19092146
C579664LY2112688LY2112688 binds to and results in increased activity of MC4R protein23048186
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in increased expression of MC4R mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of MC4R mRNA19564919
D009020MorphineMC4R protein affects the susceptibility to Morphine16153779
C027756MSH, 4-Nle-7-Phe-alpha-"MSH, 4-Nle-7-Phe-alpha- results in increased activity of MC4R protein"17713970
C031721naphthalenenaphthalene analog binds to MC4R protein11909711
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of MC4R mRNA18636392
D010852PicrotoxinPicrotoxin results in increased expression of MC4R mRNA15170462
D059808PolyphenolsPolyphenols results in decreased expression of MC4R mRNA16293270
D011374ProgesteroneProgesterone results in decreased expression of MC4R mRNA22238285
D011441PropylthiouracilPropylthiouracil results in increased expression of MC4R mRNA24780913
C089730rosiglitazonerosiglitazone results in increased expression of MC4R mRNA21515302
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in increased expression of MC4R mRNA19564919
C103272SHU 9119SHU 9119 binds to and results in decreased activity of MC4R protein16153779
C501413tesaglitazartesaglitazar results in increased expression of MC4R mRNA21515302
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of MC4R mRNA20399831
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MC4R mRNA15977195
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of MC4R mRNA15977195
C111237vorinostatvorinostat results in increased expression of MC4R mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004977melanocortin receptor activity-TAS8794897  
GO:0004980melanocyte-stimulating hormone receptor activity-IDA14764818  
GO:0004980melanocyte-stimulating hormone receptor activity-IPI19743876  
GO:0005515protein binding-IPI19329486  19743876  21719532  
GO:0017046peptide hormone binding-IEA-  
GO:0031625ubiquitin protein ligase binding-IPI19737927  
GO:0042923neuropeptide binding-IMP15927146  
GO ID GO Term Qualifier Evidence PubMed
GO:0002024diet induced thermogenesis-IEA-  
GO:0006112energy reserve metabolic process-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway-TAS8794897  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IDA19329486  19743876  
GO:0007631feeding behavior-IEA-  
GO:0019222regulation of metabolic process-IEA-  
GO:0030073insulin secretion-IEA-  
GO:0032868response to insulin-IEA-  
GO:0045780positive regulation of bone resorption-IMP16614075  
GO:2000252negative regulation of feeding behavior-IEA-  
GO:2000821regulation of grooming behavior-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28384342Assessing gene-environment interaction effects of FTO, MC4R and lifestyle factors on obesity using an extreme phenotype sampling design: Results from the HUNT study. (2017)Bjornland TPLoS One
29113896Neuroinflammation produced by heavy alcohol intake is due to loops of interactions between Toll-like 4 and TNF receptors, peroxisome proliferator-activated receptors and the central melanocortin system: A novel hypothesis and new therapeutic avenues. (2018 Jan)Flores-Bastias ONeuropharmacology
27701175Evaluation of the Obesity Genes FTO and MC4R for Contribution to the Risk of Large Artery Atherosclerotic Stroke in a Chinese Population. (2016)Song ZObes Facts
23054017The joint effect of cigarette smoking and polymorphisms on LRP5, LEPR, near MC4R and SH2B1 genes on metabolic syndrome susceptibility in Taiwan. (2013 Jan)Yang CWMol Biol Rep
29694503Neonatal tobacco smoke reduces thermogenesis capacity in brown adipose tissue in adult rats. (2018)Peixoto TCBraz J Med Biol Res
23978819Generalization of adiposity genetic loci to US Hispanic women. (2013 Aug 26)Graff MNutr Diabetes
17587397Genetic variation and decreased risk for obesity in the Atherosclerosis Risk in Communities Study. (2007 Jul)Hart Sailors MLDiabetes Obes Metab
26537541Interaction of smoking and obesity susceptibility loci on adolescent BMI: The National Longitudinal Study of Adolescent to Adult Health. (2015 Nov 4)Young KLBMC Genet
26965781Melanocortin-4 receptor rs17782313 polymorphisms are associated with serum triglycerides in older Chinese women. (2016)Yang JAsia Pac J Clin Nutr
26804193Intra-cerebral and intra-nasal melanocortin-4 receptor antagonist blocks withdrawal hyperalgesia in alcohol-dependent rats. (2017 May)Roltsch Hellard EAAddict Biol