Gene: MCAM

4162
CD146|MUC18
melanoma cell adhesion molecule
protein-coding
11q23.3
Ensembl:ENSG00000076706 MIM:155735 Vega:OTTHUMG00000166197 UniprotKB:P43121
NC_000011.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.915e-1 (AD)  2.472e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNASE10.758
PDE8A0.724
SHROOM40.719
MYO1E0.718
TMC70.715
PIK3C2B0.711
MICALL10.709
ICOSLG0.705
TRPM60.704
SH3D190.702

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.368
OR4F5-0.36
BRDT-0.265
KCNG1-0.241
WNT7B-0.233
NEUROD1-0.221
HTR3A-0.219
PPP1R3G-0.217
GPR83-0.215
WFDC13-0.21

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MCAM mRNA"19167446
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MCAM mRNA"23196670
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of MCAM mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCAM mRNA"27188386
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of MCAM mRNA21167638
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCAM mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of MCAM mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of MCAM mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MCAM mRNA21641981|2715375
D000447AldehydesAldehydes results in increased expression of MCAM mRNA25014914
D000638AmiodaroneAmiodarone results in increased expression of MCAM mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MCAM mRNA16483693
C015001arsenitearsenite results in increased methylation of MCAM promoter23974009
D001241AspirinAspirin results in increased expression of MCAM mRNA15456535
C547126AZM551248AZM551248 results in decreased expression of MCAM mRNA22323515
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MCAM mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MCAM mRNA27858113
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of MCAM mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MCAM mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MCAM mRNA22228805|2261060
D004958EstradiolEstradiol results in increased expression of MCAM mRNA19167446
D004958EstradiolEstradiol results in increased expression of MCAM mRNA20068009
C006780bisphenol Abisphenol A results in decreased expression of MCAM mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MCAM gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of MCAM mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of MCAM mRNA26079696
D002104CadmiumCadmium results in increased expression of MCAM mRNA22666406
C037123cadmium sulfatecadmium sulfate results in increased expression of MCAM mRNA19274763
D002220CarbamazepineCarbamazepine affects the expression of MCAM mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MCAM mRNA17273784
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MCAM protein17273784
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MCAM gene20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MCAM mRNA27858113
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of MCAM mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of MCAM mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MCAM mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of MCAM mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of MCAM mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of MCAM mRNA27989131
D000069439DasatinibDasatinib results in increased expression of MCAM mRNA20579391
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of MCAM mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of MCAM mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of MCAM mRNA]20032058
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MCAM mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MCAM mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of MCAM mRNA27392435
D002945CisplatinCisplatin results in decreased expression of MCAM mRNA27392435
D002945CisplatinCisplatin results in increased expression of MCAM mRNA25270620
D002945CisplatinCisplatin results in decreased expression of MCAM mRNA22023808
D004041Dietary FatsDietary Fats results in increased expression of MCAM mRNA18042831|2501614
D004221DisulfiramDisulfiram results in decreased expression of MCAM mRNA20530235
D004237DiuronDiuron results in decreased expression of MCAM mRNA25152437
D004237DiuronDiuron results in increased expression of MCAM mRNA21551480
C067311docetaxelMCAM protein results in decreased susceptibility to docetaxel22952755
D004317DoxorubicinMCAM protein results in decreased susceptibility to Doxorubicin22952755
C070609EMD 53998EMD 53998 analog results in decreased expression of MCAM mRNA24977338
C118739entinostatentinostat results in increased expression of MCAM mRNA27188386
D005047EtoposideEtoposide results in increased expression of MCAM mRNA25270620
D005419FlavonoidsFlavonoids results in increased expression of MCAM mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MCAM gene20938992
C069837fullerene C60fullerene C60 results in increased expression of MCAM mRNA19167457
C001277geldanamycingeldanamycin results in increased expression of MCAM mRNA26705709
D006534Heptachlor EpoxideHeptachlor Epoxide results in decreased expression of MCAM mRNA25270620
C016517indole-3-carbinolindole-3-carbinol affects the expression of MCAM mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of MCAM mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of MCAM mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of MCAM mRNA27392435
C544151jinfukangjinfukang results in decreased expression of MCAM mRNA27392435
D008694MethamphetamineMethamphetamine results in decreased expression of MCAM mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MCAM gene20938992
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of MCAM mRNA12634122|1277377
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of MCAM mRNA25270620
D015735MifepristoneMifepristone results in decreased expression of MCAM mRNA25972201
D016685MitomycinMitomycin results in increased expression of MCAM mRNA25270620
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MCAM mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MCAM mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of MCAM mRNA20971185
D009966OrphenadrineOrphenadrine affects the expression of MCAM mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of MCAM mRNA25729387
D010100OxygenOxygen deficiency affects the expression of MCAM mRNA17193925
D000073878Palm OilPalm Oil results in increased expression of MCAM mRNA18042831
C046012pentanalpentanal results in increased expression of MCAM mRNA26079696
D010578PetroleumPetroleum affects the expression of MCAM mRNA25208076
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCAM mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MCAM mRNA26272509
D010758PhosphorusPhosphorus results in increased expression of MCAM mRNA17715259
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MCAM mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of MCAM mRNA23811191
D010894PiroxicamPiroxicam results in decreased expression of MCAM mRNA21858171
D011192Potassium DichromatePotassium Dichromate results in decreased expression of MCAM protein23718831
D011192Potassium DichromatePotassium Dichromate results in decreased expression of MCAM mRNA23608068
C024273profenofosprofenofos results in decreased expression of MCAM mRNA17569032
C005556propionaldehydepropionaldehyde results in increased expression of MCAM mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of MCAM mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of MCAM mRNA27029645
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of MCAM mRNA19167446
C059514resveratrolresveratrol results in increased expression of MCAM mRNA25888808
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of MCAM mRNA"24160326
D012834SilverSilver results in decreased expression of MCAM mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of MCAM mRNA22714537
C016104sodium bichromatesodium bichromate results in decreased expression of MCAM mRNA22561333
C016104sodium bichromatesodium bichromate results in increased expression of MCAM mRNA22561333
D018038Sodium SeleniteSodium Selenite results in decreased expression of MCAM mRNA18175754
D012999SomanSoman results in increased expression of MCAM mRNA19281266
D053260SootSoot results in increased expression of MCAM mRNA26551751
D016559TacrolimusTacrolimus results in decreased expression of MCAM mRNA25270620
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of MCAM mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MCAM mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MCAM mRNA26232522
D013893ThiramThiram results in decreased expression of MCAM mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MCAM mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MCAM mRNA28111298
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of MCAM mRNA25729387
C032910triadimefontriadimefon results in decreased expression of MCAM mRNA26705709
D014635Valproic AcidValproic Acid affects the expression of MCAM mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MCAM mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased methylation of MCAM gene29154799
D014635Valproic AcidValproic Acid results in increased expression of MCAM mRNA19136453
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MCAM gene25560391
D014800VitalliumVitallium analog results in decreased expression of MCAM mRNA23825117
D014810Vitamin EVitamin E results in increased expression of MCAM mRNA19244175
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of MCAM mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IDA23878390  
GO:0003094glomerular filtration-IEP20354148  
GO:0007155cell adhesion-IEA-  
GO:0009653anatomical structure morphogenesis-TAS8378324  
GO:0030335positive regulation of cell migration-IEA-  
GO:0061042vascular wound healing-IEP20354148  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005615extracellular space-IEA-  
GO:0005634nucleus-IEA-  
GO:0005886plasma membrane-NAS8378324  
GO:0005925focal adhesion-HDA21423176  
GO:0009897external side of plasma membrane-IDA20354148  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23435205Genome-wide methylation profiling and the PI3K-AKT pathway analysis associated with smoking in urothelial cell carcinoma. (2013 Apr 1)Brait MCell Cycle
27014752Altered Expression of Angiotensinogen and Mediators of Angiogenesis in Ileal Crohn's Disease. (2016 Mar)Hume GEJ Gastrointestin Liver Dis