Gene info: ID 4163

Gene: MCC

GENE ID: 4163

Synonyms: MCC1

Description: MCC, WNT signaling pathway regulator

Gene type: protein-coding

Location: 5q22.2

dbXrefs: Ensembl:ENSG00000171444 MIM:159350 Vega:OTTHUMG00000128804 UniprotKB:P23508

RefSeq: NG_012265.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 14

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.652e-1 (AD) 9.552e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg08759041	chr5:112824614	MCC	Promoter	2.661e-4	Alcohol use disorders	26763658
cg01272202	chr5:112716899	MCC		2.730e-8	Maternal smoking in pregnancy	27040690
cg01272202	chr5:112716899	MCC		4.100e-10	Maternal smoking in pregnancy	27040690
cg01272202	chr5:112716899	MCC		4.100e-12	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
YAP1	0.894
S1PR1	0.889
ARHGAP31	0.885
ARHGEF26	0.883
SLC2A10	0.883
NOTCH2	0.877
PDLIM5	0.876
CDC14A	0.871
PPARA	0.856
SDC2	0.855

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GALNT14	-0.527
TMEFF2	-0.524
ADTRP	-0.515
NRG1	-0.515
CACNA1F	-0.515
DRD5	-0.503
CIDEA	-0.478
TRABD2A	-0.468
CYP26A1	-0.464
HAS1	-0.463

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of MCC mRNA"	21354444
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of MCC mRNA	28329830
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of MCC mRNA	19933214
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of MCC mRNA	21420995
C016601	afimoxifene	afimoxifene inhibits the reaction [Estrogens results in decreased expression of MCC mRNA]	21233418
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of MCC mRNA	24449571
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MCC mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MCC mRNA	19770486
D004958	Estradiol	Estradiol results in decreased expression of MCC mRNA	25210133
C006780	bisphenol A	bisphenol A results in decreased expression of MCC mRNA	25181051
D019256	Cadmium Chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MCC mRNA	12634122
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of MCC mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of MCC mRNA	27339419
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of MCC mRNA	26272509
D002737	Chloroprene	Chloroprene results in decreased expression of MCC mRNA	23125180
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MCC gene	20938992
C023600	chromic oxide	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MCC mRNA	12634122
C017133	chromous chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MCC mRNA	12634122
D003471	Cuprizone	Cuprizone results in decreased expression of MCC mRNA	26577399\|2752363
D016572	Cyclosporine	Cyclosporine results in decreased expression of MCC mRNA	27989131
D003907	Dexamethasone	Dexamethasone results in decreased expression of MCC mRNA	22733784
D019813	1,2-Dimethylhydrazine	"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of MCC mRNA"	27840820
C118739	entinostat	entinostat results in increased expression of MCC mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
D004967	Estrogens	afimoxifene inhibits the reaction [Estrogens results in decreased expression of MCC mRNA]	21233418
D004967	Estrogens	Estrogens results in decreased expression of MCC mRNA	21233418
C024565	ethylene dichloride	ethylene dichloride results in increased expression of MCC mRNA	28189721
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of MCC mRNA	23649840
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of MCC mRNA	28329830
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MCC gene	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of MCC mRNA	23649840
D017313	Fenretinide	Fenretinide results in increased expression of MCC mRNA	28973697
C544151	jinfukang	jinfukang results in decreased expression of MCC mRNA	27392435
C008261	lead acetate	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MCC mRNA	12634122
C045463	leflunomide	leflunomide results in increased expression of MCC mRNA	28988120
C042720	mercuric bromide	mercuric bromide results in increased expression of MCC mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
D008694	Methamphetamine	Methamphetamine results in increased expression of MCC mRNA	28341135
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MCC gene	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of MCC mRNA	23179753\|2627250
C004925	methylmercuric chloride	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of MCC mRNA	23649840
D015741	Metribolone	Metribolone results in increased expression of MCC mRNA	17010196
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of MCC mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of MCC mRNA"	25554681
C029938	nickel sulfate	nickel sulfate results in decreased expression of MCC mRNA	22714537
D010126	Ozone	Ozone results in decreased expression of MCC mRNA	28623178
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of MCC mRNA	26272509
D010634	Phenobarbital	Phenobarbital results in decreased expression of MCC mRNA	23091169
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of MCC mRNA	26272509
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of MCC mRNA	22714537
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of MCC mRNA	23608068
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of MCC mRNA	28903501
C045950	propiconazole	propiconazole results in decreased expression of MCC mRNA	21278054
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of MCC mRNA	25351596
D012906	Smoke	Smoke results in decreased expression of MCC mRNA	21095227
C017947	sodium arsenite	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MCC mRNA	12634122
C017947	sodium arsenite	sodium arsenite results in increased expression of MCC mRNA	17879257
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MCC mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MCC mRNA	26290441
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MCC mRNA	19465110\|1993321
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of MCC mRNA	24935251\|2627250
D014520	Urethane	Urethane results in decreased expression of MCC mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of MCC mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in increased methylation of MCC gene	29154799
C025643	vinclozolin	vinclozolin results in increased expression of MCC mRNA	23034163
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MCC mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of MCC mRNA	26272509

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	14743216 17353931 18591935 19555689 21900206 21988832 23455922 24824780 26496610 28330616
GO:0038023	signaling receptor activity	-	TAS	1848370

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007165	signal transduction	-	TAS	1848370
GO:0010633	negative regulation of epithelial cell migration	-	IMP	19555689
GO:0016055	Wnt signaling pathway	-	IEA	-
GO:0045184	establishment of protein localization	-	IDA	18591935
GO:0050680	negative regulation of epithelial cell proliferation	-	IDA	18591935
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	IDA	18591935
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	IMP	24824780

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	18591935 24824780
GO:0005654	nucleoplasm	-	IDA	-
GO:0005737	cytoplasm	-	IDA	18591935 24824780
GO:0005829	cytosol	-	IDA	-
GO:0005886	plasma membrane	-	IDA	19555689
GO:0030027	lamellipodium	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26298258	Levels and predictors of persistent organic pollutants in an adult population from four Spanish regions. (2015 Dec 15)	Fernandez-Rodriguez M	Sci Total Environ
28177498	Effects of Switching to the Menthol Tobacco Heating System 2.2, Smoking Abstinence, or Continued Cigarette Smoking on Clinically Relevant Risk Markers: A Randomized, Controlled, Open-Label, Multicenter Study in Sequential Confinement and Ambulatory Settings (Part 2). (2018 Jan 5)	Ludicke F	Nicotine Tob Res
19232498	Chronic inflammatory status in patients with coronary artery ectasia. (2009 Apr)	Li JJ	Cytokine
24302675	The bitter taste receptor T2R38 is an independent risk factor for chronic rhinosinusitis requiring sinus surgery. (2014 Jan)	Adappa ND	Int Forum Allergy Rhinol
24307008	Young "healthy" smokers have functional and inflammatory changes in the nasal and the lower airways. (2014 May)	Nicola ML	Chest
28874823	Role of Smad3 and p38 Signalling in Cigarette Smoke-induced CFTR and BK dysfunction in Primary Human Bronchial Airway Epithelial Cells. (2017 Sep 5)	Sailland J	Sci Rep
26521141	Roflumilast partially reverses smoke-induced mucociliary dysfunction. (2015 Oct 31)	Schmid A	Respir Res
25389352	Nasal Mucociliary Clearance in Subjects With COPD After Smoking Cessation. (2015 Mar)	Ito JT	Respir Care
28177489	Effects of Switching to the Tobacco Heating System 2.2 Menthol, Smoking Abstinence, or Continued Cigarette Smoking on Biomarkers of Exposure: A Randomized, Controlled, Open-Label, Multicenter Study in Sequential Confinement and Ambulatory Settings (Part 1). (2018 Jan 5)	Ludicke F	Nicotine Tob Res
26528246	Mucociliary dysfunction in HIV and smoked substance abuse. (2015)	Chinnapaiyan S	Front Microbiol
7557283	[Etiology of colorectal cancer]. (1994 Oct-Dec)	Matos Villalobos M	G E N
29789655	Cigarette smoke promotes HIV infection of primary bronchial epithelium and additively suppresses CFTR function. (2018 May 22)	Chinnapaiyan S	Sci Rep
26462765	Effect of a single 1200 Mg dose of Mucinex(R) on mucociliary and cough clearance during an acute respiratory tract infection. (2015 Nov)	Bennett WD	Respir Med
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