Gene: ART1

417
ART2|ARTC1|CD296|RT6
ADP-ribosyltransferase 1
protein-coding
11p15.4
Ensembl:ENSG00000129744 MIM:601625 Vega:OTTHUMG00000011845 UniprotKB:P52961
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.779e-1 (AD)  4.237e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLIC50.526
NEK50.499
ART50.448
ERVFRD-10.44
BCL2L150.437
KRTAP12-20.433
OR8A10.43
DENND2C0.424
HEG10.415
ZKSCAN30.411

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BOLA2B-0.186
PTGER1-0.182
MT1A-0.178
MAFF-0.176
MTFP1-0.176
GADD45A-0.174
UTF1-0.168
GADD45B-0.167
NXT1-0.167
PRSS41-0.167

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB018545-BromonicotinamideSmall Molecule28733-43-9ExperimentalTarget
ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ART1 mRNA"18648102
D020106AcrylamideAcrylamide results in decreased expression of ART1 mRNA28959563
D001374AzacitidineAzacitidine results in increased expression of ART1 mRNA20823114
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ART1 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of ART1 mRNA25181051
D003471CuprizoneCuprizone results in decreased expression of ART1 mRNA26577399|2752363
D003907DexamethasoneDexamethasone results in increased expression of ART1 mRNA22733784
D003907DexamethasoneDexamethasone results in increased expression of ART1 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of ART1 mRNA]20032058
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ART1 mRNA21266533
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of ART1 gene23968726
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ART1 mRNA27935865
C049032pinosylvinpinosylvin results in increased expression of ART1 mRNA23333577
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ART1 mRNA27935865
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of ART1 gene23968726
D011441PropylthiouracilPropylthiouracil results in decreased expression of ART1 mRNA24780913
D013629TamoxifenTamoxifen results in decreased expression of ART1 mRNA17555576
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of ART1 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ART1 mRNA22298810
C009495titanium dioxidetitanium dioxide results in decreased expression of ART1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ART1 mRNA20133372
D015032ZincZinc results in decreased expression of ART1 mRNA17074742
D019287Zinc SulfateZinc Sulfate results in decreased expression of ART1 mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003950NAD+ ADP-ribosyltransferase activity-IBA21873635  
GO:0003950NAD+ ADP-ribosyltransferase activity-IEA-  
GO:0003956NAD(P)+-protein-arginine ADP-ribosyltransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006471protein ADP-ribosylation-IBA21873635  
GO:0006471protein ADP-ribosylation-IEA-  
GO:0018120peptidyl-arginine ADP-ribosylation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IEA-  
GO:0031225anchored component of membrane-IEA-  
GO:0033017sarcoplasmic reticulum membrane-IEA-  
GO:0046658anchored component of plasma membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1461973DefensinsTAS
R-HSA-1462054Alpha-defensinsTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6803157Antimicrobial peptidesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16627471ADP-ribosyltransferase-specific modification of human neutrophil peptide-1. (2006 Jun 23)Paone GJ Biol Chem