Gene: MCM2

4171
BM28|CCNL1|CDCL1|D3S3194|DFNA70|MITOTIN|cdc19
minichromosome maintenance complex component 2
protein-coding
3q21.3
Ensembl:ENSG00000073111 MIM:116945 Vega:OTTHUMG00000159637 UniprotKB:P49736
NG_050771.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.448e-1 (AD)  3.411e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02578470chr3:127320670MCM22.030e-9Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM161B0.846
WDR920.838
VPS33B0.834
MRPS270.834
MCM40.833
PARN0.83
RPA10.827
NIF3L10.824
C16orf580.823
ITFG20.822

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MTRNR2L6-0.467
MTRNR2L9-0.443
MTRNR2L10-0.427
OR4F5-0.424
OR4F29-0.392
TTLL10-0.389
MTRNR2L8-0.376
MTRNR2L2-0.365
RSPO1-0.344
PPBP-0.342

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of MCM2 mRNA"26377693
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased phosphorylation of MCM2 protein"27026707
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of MCM2 mRNA"23626729
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MCM2 mRNA"21354444|2269881
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of MCM2 mRNA"22101062
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM2 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MCM2 mRNA"19167446
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of MCM2 mRNA"17547211
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM2 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MCM2 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM2 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of MCM2 mRNA"20406850
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MCM2 mRNA"16120219
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MCM2 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of MCM2 mRNA"19561079
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to MCM2 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MCM2 protein]26598702
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MCM2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of MCM2 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of MCM2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MCM2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MCM2 mRNA22100608
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of MCM2 mRNA"22863853
C023650anilineaniline results in increased expression of MCM2 protein21070798
D000965AntimonyAntimony results in increased expression of MCM2 mRNA17547211
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in increased expression of MCM2 mRNA17547211
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MCM2 protein]26598702
C006632arsenic trioxidearsenic trioxide results in increased expression of MCM2 mRNA17530438|1754721
C006632arsenic trioxidearsenic trioxide results in increased expression of MCM2 protein25419056
D018053Arsenites[AS3MT protein results in increased susceptibility to Arsenites] which affects the expression of MCM2 mRNA19411561
D001379AzathioprineAzathioprine results in decreased expression of MCM2 mRNA22623647
D001507BeclomethasoneBeclomethasone results in decreased expression of MCM2 mRNA23656298
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of MCM2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MCM2 mRNA16120219|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MCM2 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to MCM2 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MCM2 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MCM2 mRNA"20382639
D001599BerberineBerberine inhibits the reaction [Dexamethasone results in increased expression of MCM2 mRNA]20462044
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in increased expression of MCM2 mRNA]24758408
D004958EstradiolEstradiol affects the phosphorylation of MCM2 protein27026707
D004958EstradiolEstradiol results in increased expression of MCM2 mRNA16474171|1726806
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of MCM2 mRNA]25210133
D004958EstradiolEstradiol affects the expression of MCM2 mRNA15598610
D004958EstradiolEstradiol results in increased expression of MCM2 mRNA25210133
D004958Estradiol[Progesterone co-treated with Estradiol] affects the localization of MCM2 protein16966611
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of MCM2 protein16966611
C044887beta-methylcholinebeta-methylcholine affects the expression of MCM2 mRNA21179406
C053541bicalutamidebicalutamide results in decreased expression of MCM2 mRNA15638997
C006780bisphenol Abisphenol A results in increased expression of MCM2 mRNA29027980
C006780bisphenol Abisphenol A results in decreased expression of MCM2 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of MCM2 mRNA16474171|1726806
C006780bisphenol Abisphenol A affects the methylation of MCM2 promoter27334623
C006780bisphenol Abisphenol A affects the expression of MCM2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of MCM2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MCM2 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MCM2 mRNA28628672
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of MCM2 mRNA18958704
C025703bleomycetinbleomycetin results in increased expression of MCM2 mRNA21040473
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of MCM2 mRNA15336504
D002104CadmiumCadmium results in increased expression of MCM2 mRNA17547211
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MCM2 mRNA17547211
D019256Cadmium Chloride[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of MCM2 mRNA19840844
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of MCM2 mRNA]16221973
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MCM2 mRNA27339419
D002509CephaloridineCephaloridine results in increased expression of MCM2 mRNA18500788
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MCM2 mRNA20938992
D002857ChromiumChromium results in increased expression of MCM2 mRNA17547211
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of MCM2 mRNA28472532
D003033Coal TarCoal Tar results in increased expression of MCM2 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of MCM2 mRNA19320972
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of MCM2 mRNA20971185
D003300CopperCopper results in increased expression of MCM2 mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of MCM2 mRNA19549813
C030123coumarincoumarin results in increased expression of MCM2 mRNA18480146
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MCM2 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of MCM2 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of MCM2 mRNA19167446
C024015cryptolepinecryptolepine results in decreased expression of MCM2 mRNA16120219
C029892cupric chloridecupric chloride results in increased expression of MCM2 mRNA19174923
C029892cupric chloridecupric chloride promotes the reaction [Disulfiram results in decreased expression of MCM2 mRNA]19789329
C030973cupric oxidecupric oxide results in decreased phosphorylation of MCM2 protein25470785
D003471CuprizoneCuprizone results in increased expression of MCM2 mRNA26577399
D003474CurcuminCurcumin results in decreased expression of MCM2 mRNA18299980
D016572CyclosporineCyclosporine affects the expression of MCM2 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of MCM2 mRNA20106945|2163298
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MCM2 mRNA28628672
D003907DexamethasoneBerberine inhibits the reaction [Dexamethasone results in increased expression of MCM2 mRNA]20462044
D003907DexamethasoneDexamethasone results in increased expression of MCM2 mRNA20462044
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MCM2 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MCM2 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of MCM2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of MCM2 mRNA16061661|2759478
D002945CisplatinCisplatin results in decreased expression of MCM2 mRNA21151649
D004026DieldrinDieldrin results in increased expression of MCM2 mRNA20438755
D004041Dietary FatsDietary Fats results in increased expression of MCM2 mRNA18457598
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of MCM2 mRNA17854601|2453584
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MCM2 mRNA]17854601
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of MCM2 mRNA19041683
D002117CalcitriolCalcitriol results in decreased expression of MCM2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of MCM2 mRNA21592394
D004221Disulfiramcupric chloride promotes the reaction [Disulfiram results in decreased expression of MCM2 mRNA]19789329
D004221DisulfiramDisulfiram results in decreased expression of MCM2 mRNA19789329
C067311docetaxel[zoledronic acid co-treated with docetaxel] results in decreased expression of MCM2 protein17562444
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of MCM2 mRNA26159488
D004967Estrogens[Malathion co-treated with Estrogens] results in increased expression of MCM2 mRNA18204794
D004967Estrogens[Parathion co-treated with Estrogens] results in increased expression of MCM2 mRNA18204794
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MCM2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MCM2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MCM2 mRNA17942748
D005031EthylenethioureaEthylenethiourea results in decreased expression of MCM2 mRNA18801409
D005031EthylenethioureaEthylenethiourea results in increased expression of MCM2 mRNA18801409
D005047EtoposideEtoposide results in decreased expression of MCM2 mRNA16120219
C540355fenamidonefenamidone results in increased expression of MCM2 mRNA27029645
D005472FluorouracilMCM2 protein affects the susceptibility to Fluorouracil15548681
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MCM2 mRNA20938992
C069837fullerene C60fullerene C60 results in increased expression of MCM2 mRNA19167457
C039281furanfuran results in increased expression of MCM2 mRNA20562052|2207923
D019833GenisteinGenistein affects the expression of MCM2 mRNA18214933
D019833GenisteinGenistein results in increased expression of MCM2 mRNA16474171
D005839GentamicinsGentamicins results in increased expression of MCM2 mRNA22061828
C014026hexamethylene bisacetamidehexamethylene bisacetamide results in decreased expression of MCM2 mRNA26941288
D017313FenretinideFenretinide results in increased expression of MCM2 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of MCM2 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MCM2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of MCM2 mRNA28628672
C544151jinfukangjinfukang results in increased expression of MCM2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MCM2 mRNA24796395
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MCM2 mRNA26941288
C410337K 7174K 7174 results in decreased expression of MCM2 mRNA24086573
D007854LeadLead results in decreased expression of MCM2 mRNA19921347
C008261lead acetatelead acetate results in decreased expression of MCM2 mRNA21829687
D018021Lithium ChlorideLithium Chloride results in decreased expression of MCM2 mRNA17440966
D008294Malathion[Malathion co-treated with Estrogens] results in increased expression of MCM2 mRNA18204794
D008294MalathionMalathion results in increased expression of MCM2 mRNA18204794
D008628MercuryMercury results in increased expression of MCM2 mRNA17547211
D008713MethimazoleMethimazole results in increased expression of MCM2 mRNA17403546
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MCM2 mRNA20938992
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of MCM2 mRNA12634122
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of MCM2 mRNA19840844
C008493methylselenic acidmethylselenic acid affects the expression of MCM2 mRNA14617803
C059539midostaurinmidostaurin results in decreased expression of MCM2 mRNA20980353
D009151Mustard GasMustard Gas results in decreased expression of MCM2 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MCM2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MCM2 mRNA"25554681
D009532NickelNickel results in increased expression of MCM2 mRNA25583101
C022838nickel chloridenickel chloride results in decreased expression of MCM2 mRNA17312168
C028007nickel monoxidenickel monoxide results in increased expression of MCM2 mRNA19167457
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of MCM2 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MCM2 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of MCM2 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of MCM2 mRNA26516004
D010269ParaquatParaquat affects the expression of MCM2 mRNA26345256
D010278Parathion[Parathion co-treated with Estrogens] results in increased expression of MCM2 mRNA18204794
D010278ParathionParathion results in increased expression of MCM2 mRNA17390078
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM2 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of MCM2 mRNA23892564
C494474perchlorateperchlorate results in decreased expression of MCM2 mRNA17403546|1880140
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MCM2 mRNA23427857
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of MCM2 mRNA26678675
D010634PhenobarbitalPhenobarbital affects the expression of MCM2 mRNA19159669
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of MCM2 mRNA]19482888
D010634Phenobarbital[Phenobarbital co-treated with Pregnenolone Carbonitrile] results in increased expression of MCM2 mRNA23626729
D010634PhenobarbitalPhenobarbital results in increased expression of MCM2 mRNA19482888|2309116
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MCM2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of MCM2 mRNA26272509
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of MCM2 mRNA20813756
C006253pirinixic acid[pirinixic acid co-treated with Pregnenolone Carbonitrile] results in increased expression of MCM2 mRNA23626729
C006253pirinixic acidpirinixic acid results in increased expression of MCM2 mRNA17950772|1830175
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of MCM2 mRNA]17950772
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of MCM2 mRNA16474171
D011192Potassium DichromatePotassium Dichromate results in increased expression of MCM2 mRNA17547211
D011285Pregnenolone Carbonitrile"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of MCM2 mRNA"23626729
D011285Pregnenolone Carbonitrile[Phenobarbital co-treated with Pregnenolone Carbonitrile] results in increased expression of MCM2 mRNA23626729
D011285Pregnenolone Carbonitrile[pirinixic acid co-treated with Pregnenolone Carbonitrile] results in increased expression of MCM2 mRNA23626729
D011374ProgesteroneProgesterone results in decreased expression of MCM2 mRNA23012394
D011374Progesterone[Progesterone co-treated with Estradiol] affects the localization of MCM2 protein16966611
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of MCM2 protein16966611
D011374ProgesteroneProgesterone results in decreased expression of MCM2 mRNA16966611
C005556propionaldehydepropionaldehyde results in decreased expression of MCM2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of MCM2 mRNA24780913
D011441PropylthiouracilPropylthiouracil results in decreased expression of MCM2 mRNA17403546
C513428pyrachlostrobinpyrachlostrobin results in increased expression of MCM2 mRNA27029645
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [trichostatin A results in decreased expression of MCM2 protein]23770000
D011794QuercetinQuercetin results in decreased expression of MCM2 mRNA23727915
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of MCM2 mRNA19167446
D020123SirolimusSirolimus inhibits the reaction [IL2 protein results in increased expression of MCM2 mRNA]11355896
C009277sodium arsenatesodium arsenate results in decreased expression of MCM2 mRNA23922661
C017947sodium arsenitesodium arsenite results in decreased expression of MCM2 mRNA12760830
C017947sodium arsenitesodium arsenite results in increased expression of MCM2 mRNA28595984
C016104sodium bichromatesodium bichromate affects the expression of MCM2 mRNA22110744
C016104sodium bichromatesodium bichromate results in increased expression of MCM2 mRNA25993096
D012999SomanSoman results in increased expression of MCM2 mRNA19281266
D053260SootSoot results in increased expression of MCM2 mRNA22461453
C025462sulindac sulfidesulindac sulfide results in decreased expression of MCM2 mRNA16184548
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of MCM2 mRNA"26680231
D014284TriiodothyronineTriiodothyronine results in increased expression of MCM2 mRNA17403546
D013629TamoxifenTamoxifen affects the expression of MCM2 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of MCM2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of MCM2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MCM2 mRNA16714409
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of MCM2 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MCM2 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MCM2 mRNA20106945|2149626
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MCM2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MCM2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MCM2 mRNA16611356
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MCM2 mRNA15667827|2149626
D019284ThapsigarginThapsigargin results in decreased expression of MCM2 mRNA22378314
C009495titanium dioxidetitanium dioxide results in increased expression of MCM2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MCM2 mRNA28111298
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MCM2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of MCM2 mRNA25729387
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of MCM2 mRNA"17951470
D014212TretinoinTretinoin results in decreased expression of MCM2 mRNA18230668
D014212TretinoinTretinoin results in decreased expression of MCM2 mRNA16249480
C012589trichostatin Apyrazolanthrone inhibits the reaction [trichostatin A results in decreased expression of MCM2 protein]23770000
C012589trichostatin Atrichostatin A results in decreased expression of MCM2 mRNA23770000
C012589trichostatin Atrichostatin A results in decreased expression of MCM2 protein23770000
C012589trichostatin Atrichostatin A results in decreased expression of MCM2 mRNA15901671
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of MCM2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MCM2 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of MCM2 mRNA19140230
D014415TunicamycinTunicamycin results in decreased expression of MCM2 mRNA22378314
D014520UrethaneUrethane results in decreased expression of MCM2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of MCM2 mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of MCM2 mRNA15901671
C025643vinclozolinvinclozolin results in decreased expression of MCM2 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of MCM2 mRNA26682919
D015032ZincZinc deficiency results in increased expression of MCM2 mRNA22171008
C088658zoledronic acid[zoledronic acid co-treated with docetaxel] results in decreased expression of MCM2 protein17562444
C088658zoledronic acidzoledronic acid results in decreased expression of MCM2 protein17562444|2887133

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-TAS8175912  
GO:0003688DNA replication origin binding-IEA-  
GO:0004386helicase activity-IEA-  
GO:0005515protein binding-IPI11095689  12740381  15232106  15654075  16189514  16387653  
16899510  17296731  19805216  19819239  19862764  21044950  
21149733  22540012  23764002  24299456  25036637  25416956  
26167883  26496610  27173435  28191891  
GO:0005524ATP binding-IEA-  
GO:0019899enzyme binding-IEA-  
GO:0042393histone binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000082G1/S transition of mitotic cell cycle-TAS-  
GO:0006260DNA replication-TAS-  
GO:0006268DNA unwinding involved in DNA replication-IEA-  
GO:0006270DNA replication initiation-IMP16899510  
GO:0006334nucleosome assembly-IEA-  
GO:0006915apoptotic process-IMP26196677  
GO:0071353cellular response to interleukin-4-IEA-  
GO:0090102cochlea development-IMP26196677  
GO:1905775negative regulation of DNA helicase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000784nuclear chromosome, telomeric region-HDA19135898  
GO:0000785chromatin-IDA16899510  
GO:0005634nucleus-IDA16899510  21383955  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005664nuclear origin of replication recognition complex-IEA-  
GO:0005730nucleolusNOTIDA21383955  
GO:0005737cytoplasm-IDA26196677  
GO:0015630microtubule cytoskeleton-IDA-  
GO:0042555MCM complex-IDA17296731  
KEGG ID KEGG Term
hsa03030DNA replication
hsa04110Cell cycle
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-176187Activation of ATR in response to replication stressTAS
R-HSA-176974Unwinding of DNAIEA
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-68867Assembly of the pre-replicative complexTAS
R-HSA-68874M/G1 TransitionTAS
R-HSA-68949Orc1 removal from chromatinTAS
R-HSA-68962Activation of the pre-replicative complexTAS
R-HSA-69002DNA Replication Pre-InitiationTAS
R-HSA-69052Switching of origins to a post-replicative stateTAS
R-HSA-69190DNA strand elongationIEA
R-HSA-69206G1/S TransitionTAS
R-HSA-69239Synthesis of DNATAS
R-HSA-69239Synthesis of DNAIEA
R-HSA-69242S PhaseTAS
R-HSA-69242S PhaseIEA
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69278Cell Cycle, MitoticIEA
R-HSA-69306DNA ReplicationTAS
R-HSA-69306DNA ReplicationIEA
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29151950MCMs expression in lung cancer: implication of prognostic significance. (2017)Liu YZJ Cancer