Gene info: ID 4172

Gene: MCM3

GENE ID: 4172

Synonyms: HCC5|P1-MCM3|P1.h|RLFB

Description: minichromosome maintenance complex component 3

Gene type: protein-coding

Location: 6p12.2

dbXrefs: Ensembl:ENSG00000112118 MIM:602693 Vega:OTTHUMG00000014844 UniprotKB:P25205

RefSeq: NC_000006.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.328e-1 (AD) 1.039e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
EIF3D	0.831
DDX39B	0.798
APH1A	0.793
TINF2	0.793
EIF3F	0.792
RNPEP	0.788
DAZAP2	0.785
NUP43	0.785
PCYT1A	0.778
CHD4	0.778

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.634
OR4F29	-0.625
EPPIN	-0.197
RAX2	-0.185
MOGAT2	-0.175
HS3ST6	-0.172
OR2T10	-0.159
SERPINA11	-0.154
PRAMEF8	-0.144
MMP23B	-0.142

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of MCM3 mRNA"	26377693
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of MCM3 mRNA"	23626729
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MCM3 mRNA"	22698814\|2890350
C495626	14-deoxy-11,12-didehydroandrographolide	"14-deoxy-11,12-didehydroandrographolide results in decreased expression of MCM3 mRNA"	22101062
C025223	1,4-dioxane	"1,4-dioxane results in increased expression of MCM3 protein"	20025956
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of MCM3 mRNA"	20453058
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM3 mRNA"	25510870
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of MCM3 mRNA"	25614096
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MCM3 mRNA"	19167446
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM3 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM3 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM3 mRNA"	25510870
C010914	2,4-diaminotoluene	"2,4-diaminotoluene results in increased expression of MCM3 mRNA"	20713471
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM3 mRNA"	25510870
C006551	2-amino-2-methyl-1-propanol	2-amino-2-methyl-1-propanol results in increased expression of MCM3 mRNA	25088246
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of MCM3 mRNA"	19561079
D000082	Acetaminophen	Acetaminophen results in increased expression of MCM3 mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of MCM3 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of MCM3 protein	20025956
D020106	Acrylamide	Acrylamide results in increased expression of MCM3 protein	20025956
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of MCM3 mRNA	21641981
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of MCM3 mRNA	22100608
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of MCM3 mRNA	19770486
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of MCM3 mRNA	23630614
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in decreased expression of MCM3 mRNA"	23195993
C103505	AM 251	AM 251 results in decreased expression of MCM3 mRNA	16500647
D000616	Aminoglutethimide	Aminoglutethimide results in decreased expression of MCM3 protein	26102013
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of MCM3 mRNA"	22863853
C105832	aurapten	aurapten affects the expression of MCM3 mRNA	23320178
D001379	Azathioprine	Azathioprine results in decreased expression of MCM3 mRNA	22623647
C547126	AZM551248	AZM551248 results in increased expression of MCM3 mRNA	22323515
D001507	Beclomethasone	Beclomethasone results in decreased expression of MCM3 mRNA	23656298
C487081	belinostat	belinostat results in decreased expression of MCM3 mRNA	19606018
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of MCM3 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MCM3 mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MCM3 mRNA	20064835
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MCM3 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MCM3 mRNA	20713471
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MCM3 mRNA"	20382639
D004958	Estradiol	Estradiol results in increased expression of MCM3 mRNA	19167446\|2004911
D004958	Estradiol	Estradiol affects the localization of MCM3 protein	16966611
D004958	Estradiol	Estradiol promotes the reaction [Progesterone affects the localization of MCM3 protein]	16966611
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in decreased expression of MCM3 protein	16966611
D001622	Betaine	Betaine results in decreased expression of MCM3 mRNA	26391144
C006780	bisphenol A	bisphenol A results in decreased expression of MCM3 mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of MCM3 mRNA	22494775
C006780	bisphenol A	bisphenol A results in decreased expression of MCM3 mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in decreased expression of MCM3 mRNA	18958704
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in decreased phosphorylation of MCM3 protein	22174045
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene results in increased expression of MCM3 mRNA	19000923
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide affects the expression of MCM3 mRNA	23410634
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of MCM3 mRNA	15336504
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of MCM3 mRNA	17961207
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of MCM3 mRNA	19031917
D002110	Caffeine	Caffeine results in increased expression of MCM3 protein	20025956
D002220	Carbamazepine	Carbamazepine affects the expression of MCM3 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of MCM3 mRNA	27339419
D002509	Cephaloridine	Cephaloridine results in increased expression of MCM3 mRNA	18500788
D002746	Chlorpromazine	Chlorpromazine analog results in decreased expression of MCM3 mRNA	15924885
D019826	Cholic Acid	Cholic Acid results in increased expression of MCM3 protein	20025956
C018021	cobaltous chloride	cobaltous chloride results in increased expression of MCM3 mRNA	24612858
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of MCM3 mRNA	19320972\|1937684
D003300	Copper	Copper results in decreased expression of MCM3 mRNA	26293553
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of MCM3 mRNA	20971185
D003300	Copper	Copper results in increased expression of MCM3 mRNA	22465980
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of MCM3 mRNA	19549813
D003345	Corticosterone	Corticosterone results in decreased expression of MCM3 mRNA	15755911
C030123	coumarin	coumarin results in increased expression of MCM3 mRNA	18480146
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MCM3 mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of MCM3 mRNA	19167446
D003375	Coumestrol	Coumestrol results in increased expression of MCM3 mRNA	19167446
C029892	cupric chloride	cupric chloride results in decreased expression of MCM3 mRNA	24650576
D003471	Cuprizone	Cuprizone results in increased expression of MCM3 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of MCM3 mRNA	20106945\|2163298
D013759	Dronabinol	Dronabinol results in decreased expression of MCM3 mRNA	18454173
D016264	Dextran Sulfate	Dextran Sulfate results in increased expression of MCM3 protein	20025956
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of MCM3 mRNA	17361019\|2126653
D002945	Cisplatin	Cisplatin results in increased expression of MCM3 mRNA	27594783
D002945	Cisplatin	Cisplatin results in decreased expression of MCM3 mRNA	22023808
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of MCM3 mRNA	17854601
D004052	Diethylnitrosamine	RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MCM3 mRNA]	17854601
D000875	Anthralin	Anthralin results in increased expression of MCM3 protein	20025956
D002117	Calcitriol	Calcitriol results in decreased expression of MCM3 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of MCM3 mRNA	21592394
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of MCM3 protein"	20025956
D004147	Dioxins	Dioxins affects the expression of MCM3 mRNA	20463971
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MCM3 protein	23301498
C024555	ferric chloride	ferric chloride results in increased expression of MCM3 protein	20025956
C020326	ferric nitrilotriacetate	ferric nitrilotriacetate results in increased expression of MCM3 mRNA	23208426
C029451	ferrous chloride	ferrous chloride results in increased expression of MCM3 protein	20025956
D005472	Fluorouracil	Fluorouracil results in decreased expression of MCM3 mRNA	16709241
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in decreased expression of MCM3 mRNA]	15016801
C039281	furan	furan results in increased expression of MCM3 mRNA	25539665
C014026	hexamethylene bisacetamide	hexamethylene bisacetamide results in decreased expression of MCM3 mRNA	26941288
D017313	Fenretinide	Fenretinide results in increased expression of MCM3 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of MCM3 mRNA	23410634
C492448	ICG 001	ICG 001 results in decreased expression of MCM3 mRNA	26191083
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MCM3 mRNA	25613284
C544151	jinfukang	jinfukang results in increased expression of MCM3 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of MCM3 mRNA	24796395
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of MCM3 mRNA	26941288
D007649	Ketamine	Ketamine results in decreased expression of MCM3 mRNA	20080153
D007854	Lead	Lead affects the expression of MCM3 mRNA	28903495
D007854	Lead	Lead results in decreased expression of MCM3 mRNA	19921347
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of MCM3 mRNA	20713471
C008493	methylselenic acid	methylselenic acid results in decreased expression of MCM3 mRNA	12517777
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of MCM3 mRNA	29191790
C011309	mezerein	mezerein results in increased expression of MCM3 mRNA	19000923
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of MCM3 mRNA	20024957
D009151	Mustard Gas	Mustard Gas results in decreased expression of MCM3 mRNA	25102026
D009151	Mustard Gas	Mustard Gas results in increased phosphorylation of MCM3 protein	19845377
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of MCM3 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of MCM3 mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of MCM3 mRNA	23195993
C022838	nickel chloride	nickel chloride results in increased expression of MCM3 mRNA	24612858
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of MCM3 mRNA	20971185
C025589	ochratoxin A	ochratoxin A results in increased expression of MCM3 mRNA	23208426
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of MCM3 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of MCM3 mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in decreased expression of MCM3 mRNA	26516004
C010272	palytoxin	palytoxin results in increased expression of MCM3 protein	20025956
D010278	Parathion	Parathion results in increased expression of MCM3 mRNA	17390078
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM3 mRNA"	25510870
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of MCM3 mRNA	23892564
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of MCM3 mRNA	23427857
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of MCM3 protein	26879310
C031181	phenanthrene	phenanthrene results in increased expression of MCM3 mRNA	19457238
D010634	Phenobarbital	Phenobarbital affects the expression of MCM3 mRNA	19159669
D010634	Phenobarbital	Phenobarbital affects the expression of MCM3 mRNA	19136022
D010634	Phenobarbital	Phenobarbital results in increased expression of MCM3 mRNA	19136022\|2309116
C006253	pirinixic acid	pirinixic acid affects the expression of MCM3 mRNA	19136022
C006253	pirinixic acid	pirinixic acid results in increased expression of MCM3 mRNA	17950772\|1830175
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of MCM3 mRNA]	17950772
D010894	Piroxicam	Piroxicam results in decreased expression of MCM3 mRNA	21858171
D011285	Pregnenolone Carbonitrile	"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of MCM3 mRNA"	23626729
D011374	Progesterone	Estradiol promotes the reaction [Progesterone affects the localization of MCM3 protein]	16966611
D011374	Progesterone	Progesterone affects the localization of MCM3 protein	16966611
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in decreased expression of MCM3 protein	16966611
D011374	Progesterone	Progesterone results in decreased expression of MCM3 mRNA	16966611
D011441	Propylthiouracil	Propylthiouracil results in increased expression of MCM3 mRNA	24780913
D011794	Quercetin	Quercetin results in decreased expression of MCM3 mRNA	23727915
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of MCM3 mRNA	19167446
D012439	Saccharin	Saccharin results in increased expression of MCM3 mRNA	19000923
D012834	Silver	Silver results in decreased expression of MCM3 mRNA	26014281
D012835	Silver Nitrate	Silver Nitrate analog results in decreased expression of MCM3 mRNA	22831968
C017947	sodium arsenite	sodium arsenite results in increased expression of MCM3 mRNA	28595984
C016104	sodium bichromate	sodium bichromate affects the expression of MCM3 mRNA	22110744
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of MCM3 protein	28918527
D012977	Sodium Nitrite	Sodium Nitrite results in increased expression of MCM3 protein	20025956
C013690	styrene oxide	styrene oxide results in increased expression of MCM3 protein	20025956
D013412	Sulfadimethoxine	Sulfadimethoxine results in increased expression of MCM3 mRNA	19000923
D000952	Antigens, Polyomavirus Transforming	"Antigens, Polyomavirus Transforming results in increased expression of MCM3 mRNA"	26680231
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of MCM3 mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of MCM3 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MCM3 mRNA	18495758
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MCM3 mRNA	22574217
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MCM3 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MCM3 mRNA	19770486
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of MCM3 mRNA	19000923
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MCM3 mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in decreased expression of MCM3 mRNA	22378314
D013853	Thioacetamide	Thioacetamide results in increased expression of MCM3 mRNA	23411599
C009495	titanium dioxide	titanium dioxide results in increased expression of MCM3 mRNA	23557971
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of MCM3 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of MCM3 mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of MCM3 mRNA	16054129
D014212	Tretinoin	Tretinoin results in increased expression of MCM3 protein	20025956
C012589	trichostatin A	trichostatin A results in decreased expression of MCM3 mRNA	19606018\|2377000
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of MCM3 mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MCM3 mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of MCM3 mRNA	19140230
D014415	Tunicamycin	Tunicamycin results in decreased expression of MCM3 mRNA	22378314
D014520	Urethane	Urethane results in decreased expression of MCM3 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of MCM3 mRNA	21427059
D014635	Valproic Acid	Valproic Acid results in increased expression of MCM3 mRNA	21427059
D014638	Vanadates	Vanadates results in increased expression of MCM3 mRNA	19000923
C029297	vinylidene chloride	vinylidene chloride results in increased expression of MCM3 mRNA	26682919
D024483	Vitamin K 3	Vitamin K 3 affects the expression of MCM3 mRNA	20044591\|2341063
C016837	zinc chloride	zinc chloride results in increased expression of MCM3 mRNA	19000923

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003677	DNA binding	-	IEA	-
GO:0004386	helicase activity	-	IEA	-
GO:0005515	protein binding	-	IPI	12364596 15232106 16899510 17296731 19150984 19862764 22540012 24299456 25036637 26167883 26496610 29395061
GO:0005524	ATP binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000082	G1/S transition of mitotic cell cycle	-	TAS	-
GO:0006260	DNA replication	-	TAS	-
GO:0006270	DNA replication initiation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000784	nuclear chromosome, telomeric region	-	HDA	19135898
GO:0005634	nucleus	-	IDA	20531406 21383955
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005658	alpha DNA polymerase:primase complex	-	TAS	1549468
GO:0005730	nucleolus	NOT	IDA	21383955
GO:0005813	centrosome	-	IDA	-
GO:0016020	membrane	-	HDA	19946888
GO:0042555	MCM complex	-	IDA	17296731
GO:0048471	perinuclear region of cytoplasm	-	IDA	20531406

KEGG ID	KEGG Term
hsa03030	DNA replication
hsa04110	Cell cycle

Reactome ID	Reactome Term	Evidence
R-HSA-1640170	Cell Cycle	TAS
R-HSA-1640170	Cell Cycle	IEA
R-HSA-176187	Activation of ATR in response to replication stress	TAS
R-HSA-176974	Unwinding of DNA	IEA
R-HSA-453279	Mitotic G1-G1/S phases	TAS
R-HSA-68867	Assembly of the pre-replicative complex	TAS
R-HSA-68874	M/G1 Transition	TAS
R-HSA-68949	Orc1 removal from chromatin	TAS
R-HSA-68962	Activation of the pre-replicative complex	TAS
R-HSA-69002	DNA Replication Pre-Initiation	TAS
R-HSA-69052	Switching of origins to a post-replicative state	TAS
R-HSA-69190	DNA strand elongation	IEA
R-HSA-69206	G1/S Transition	TAS
R-HSA-69239	Synthesis of DNA	TAS
R-HSA-69239	Synthesis of DNA	IEA
R-HSA-69242	S Phase	TAS
R-HSA-69242	S Phase	IEA
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-69278	Cell Cycle, Mitotic	IEA
R-HSA-69306	DNA Replication	TAS
R-HSA-69306	DNA Replication	IEA
R-HSA-69481	G2/M Checkpoints	TAS
R-HSA-69620	Cell Cycle Checkpoints	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29034276	Evaluation of the Ki-67 and MCM3 Expression in Cytologic Smear of Oral Squamous Cell Carcinoma. (2017 Sep)	Rezazadeh F	J Dent (Shiraz)
28832714	Ki-67 protein predicts survival in oral squamous carcinoma cells: an immunohistochemical study. (2017 Aug 21)	Lopes VKM	Braz Oral Res