Gene info: ID 4174

Gene: MCM5

GENE ID: 4174

Synonyms: CDC46|MGORS8|P1-CDC46

Description: minichromosome maintenance complex component 5

Gene type: protein-coding

Location: 22q12.3

dbXrefs: Ensembl:ENSG00000100297 MIM:602696 Vega:OTTHUMG00000150961 UniprotKB:P33992

RefSeq: NC_000022.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.457e-1 (AD) 9.740e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NPC2	0.832
PARP4	0.823
IRAK4	0.82
SFT2D2	0.812
EML3	0.808
MVP	0.806
SLC35D2	0.802
SPATA13	0.802
FAM114A1	0.801
AGTRAP	0.798

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ADRA1D	-0.498
FBLN7	-0.498
MARCH4	-0.496
ABCC12	-0.489
CALHM1	-0.482
OTUB2	-0.481
KCNK3	-0.475
KCNB2	-0.474
BEAN1	-0.472
OPRD1	-0.471

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MCM5 mRNA"	21354444\|2269881
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of MCM5 mRNA"	20453058
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM5 mRNA"	25510870
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of MCM5 mRNA"	25614096
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MCM5 mRNA"	19167446
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM5 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM5 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM5 mRNA"	25510870
C010914	2,4-diaminotoluene	"2,4-diaminotoluene results in increased expression of MCM5 mRNA"	20713471
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM5 mRNA"	25510870
C006551	2-amino-2-methyl-1-propanol	2-amino-2-methyl-1-propanol results in increased expression of MCM5 mRNA	25088246
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MCM5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MCM5 mRNA"	27188386
C121707	7,3'-dihydroxy-4'-methoxyisoflavone	"7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of MCM5 mRNA"	24455688
D000082	Acetaminophen	Acetaminophen affects the expression of MCM5 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of MCM5 mRNA	19770486
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of MCM5 mRNA	23630614
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of MCM5 mRNA	17023530
C103505	AM 251	AM 251 results in decreased expression of MCM5 mRNA	16500647
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of MCM5 mRNA"	22863853
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of MCM5 mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of MCM5 3' UTR	26771251
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of MCM5 mRNA	26705709
C006632	arsenic trioxide	arsenic trioxide results in increased expression of MCM5 mRNA	20458559
D001241	Aspirin	Aspirin results in decreased expression of MCM5 mRNA	12800193
D001280	Atrazine	Atrazine results in increased expression of MCM5 mRNA	25929836
D001280	Atrazine	Atrazine results in decreased expression of MCM5 mRNA	22378314
D001374	Azacitidine	[Azacitidine co-treated with Thalidomide] affects the expression of MCM5 mRNA	18720364
D001379	Azathioprine	Azathioprine results in decreased expression of MCM5 mRNA	22623647
D001507	Beclomethasone	Beclomethasone results in decreased expression of MCM5 mRNA	23656298
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of MCM5 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MCM5 mRNA	21632981
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MCM5 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MCM5 mRNA	20713471
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of MCM5 mRNA	25566086
D004958	Estradiol	EGF protein inhibits the reaction [Estradiol results in increased expression of MCM5 mRNA]	24758408
D004958	Estradiol	Estradiol results in increased expression of MCM5 mRNA	17268063\|1916744
D004958	Estradiol	Tamoxifen inhibits the reaction [Estradiol results in increased expression of MCM5 mRNA]	24758408
D004958	Estradiol	Estradiol affects the expression of MCM5 mRNA	15598610
C044887	beta-methylcholine	beta-methylcholine affects the expression of MCM5 mRNA	21179406
C006780	bisphenol A	bisphenol A results in increased expression of MCM5 mRNA	28159858
C006780	bisphenol A	bisphenol A affects the expression of MCM5 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of MCM5 mRNA	29027980
C006780	bisphenol A	bisphenol A results in decreased expression of MCM5 mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of MCM5 mRNA	17268063
C006780	bisphenol A	bisphenol A results in decreased expression of MCM5 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of MCM5 protein	24552547
C006780	bisphenol A	bisphenol A results in increased methylation of MCM5 gene	28505145
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in decreased expression of MCM5 mRNA	18958704
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide affects the expression of MCM5 mRNA	23410634
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of MCM5 mRNA	15336504
D020148	Butyric Acid	Butyric Acid results in decreased expression of MCM5 mRNA	12800193
D002104	Cadmium	Cadmium results in decreased expression of MCM5 mRNA	21297354
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of MCM5 mRNA	12760830
C037123	cadmium sulfate	cadmium sulfate affects the reaction [MTF1 affects the expression of MCM5 mRNA]	16221973
D000074262	Canola Oil	Canola Oil metabolite results in decreased expression of MCM5 mRNA	27363782
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of MCM5 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of MCM5 mRNA	27339419
D000068579	Celecoxib	Celecoxib results in increased expression of MCM5 mRNA	28201806
D002509	Cephaloridine	Cephaloridine results in increased expression of MCM5 mRNA	18500788
D002737	Chloroprene	Chloroprene results in decreased expression of MCM5 mRNA	23125180
D002746	Chlorpromazine	Chlorpromazine analog results in decreased expression of MCM5 mRNA	15924885
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of MCM5 mRNA	28472532
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of MCM5 mRNA	19320972\|1937684
C018021	cobaltous chloride	cobaltous chloride results in increased expression of MCM5 mRNA	24386269
D003300	Copper	Copper results in decreased expression of MCM5 mRNA	26293553
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of MCM5 mRNA	20971185
D003300	Copper	Copper affects the expression of MCM5 mRNA	23825565
D003300	Copper	Copper deficiency results in increased expression of MCM5 mRNA	26033743
C030123	coumarin	coumarin results in increased expression of MCM5 mRNA	18480146
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MCM5 mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of MCM5 mRNA	19167446
D003375	Coumestrol	Coumestrol results in increased expression of MCM5 mRNA	19167446
C029892	cupric chloride	cupric chloride promotes the reaction [Disulfiram results in decreased expression of MCM5 mRNA]	19789329
D003471	Cuprizone	Cuprizone results in increased expression of MCM5 mRNA	26577399
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of MCM5 mRNA	21041162
D016572	Cyclosporine	Cyclosporine results in decreased expression of MCM5 mRNA	20106945\|2163298
C014347	decitabine	decitabine affects the methylation of MCM5 gene	17630775
D003907	Dexamethasone	Dexamethasone results in decreased expression of MCM5 mRNA	21041162
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of MCM5 mRNA	17361019\|2126653
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of MCM5 mRNA	28962523
D002945	Cisplatin	Cisplatin results in increased expression of MCM5 mRNA	27594783
D002945	Cisplatin	Cisplatin results in decreased expression of MCM5 mRNA	22023808
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of MCM5 mRNA	17854601
D004052	Diethylnitrosamine	RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MCM5 mRNA]	17854601
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of MCM5 mRNA	19041683
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of MCM5 mRNA	21041162
D002117	Calcitriol	Calcitriol results in decreased expression of MCM5 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of MCM5 mRNA	21592394
D004147	Dioxins	Dioxins affects the expression of MCM5 mRNA	20463971
D004221	Disulfiram	cupric chloride promotes the reaction [Disulfiram results in decreased expression of MCM5 mRNA]	19789329
D004221	Disulfiram	Disulfiram results in decreased expression of MCM5 mRNA	19789329
D004726	Endosulfan	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of MCM5 mRNA	26159488
D005031	Ethylenethiourea	Ethylenethiourea results in increased expression of MCM5 mRNA	18801409
C082360	fipronil	fipronil results in increased methylation of MCM5 gene	28536466
C069837	fullerene C60	fullerene C60 results in increased expression of MCM5 mRNA	19167457
C039281	furan	furan results in increased expression of MCM5 mRNA	25539665
C004312	glycidol	glycidol results in increased expression of MCM5 mRNA	24915197
C014026	hexamethylene bisacetamide	hexamethylene bisacetamide results in decreased expression of MCM5 mRNA	26941288
D017313	Fenretinide	Fenretinide results in increased expression of MCM5 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of MCM5 mRNA	26846883
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of MCM5 mRNA	23410634
C492448	ICG 001	ICG 001 results in decreased expression of MCM5 mRNA	26191083
D007213	Indomethacin	Indomethacin results in increased expression of MCM5 mRNA	28201806
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MCM5 mRNA	25613284
C544151	jinfukang	jinfukang results in increased expression of MCM5 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of MCM5 mRNA	23086925\|2479639
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of MCM5 protein	26911376
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of MCM5 mRNA	26911376\|2694128
C410337	K 7174	K 7174 results in decreased expression of MCM5 mRNA	24086573
D018021	Lithium Chloride	Lithium Chloride results in decreased expression of MCM5 mRNA	17440966
D008345	Manganese	Manganese results in decreased expression of MCM5 mRNA	17175027
C025340	manganese chloride	manganese chloride results in decreased expression of MCM5 mRNA	17175027
D008713	Methimazole	Methimazole results in increased expression of MCM5 mRNA	17403546
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of MCM5 mRNA	20713471
C008493	methylselenic acid	methylselenic acid results in decreased expression of MCM5 mRNA	12517777
C059539	midostaurin	midostaurin results in decreased expression of MCM5 mRNA	20980353
D009151	Mustard Gas	Mustard Gas results in decreased expression of MCM5 mRNA	25102026
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of MCM5 mRNA"	15585362
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of MCM5 mRNA"	15585362
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of MCM5 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of MCM5 mRNA"	25554681
D009532	Nickel	Nickel results in increased expression of MCM5 mRNA	25583101
C022838	nickel chloride	nickel chloride results in increased expression of MCM5 mRNA	24612858
C022838	nickel chloride	nickel chloride affects the expression of MCM5 mRNA	22546817
C028007	nickel monoxide	nickel monoxide results in increased expression of MCM5 mRNA	19167457
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of MCM5 mRNA	20971185
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of MCM5 mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in decreased expression of MCM5 mRNA	17175027\|2651600
D010126	Ozone	[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of MCM5 mRNA	25658374
D010126	Ozone	Ozone results in increased expression of MCM5 mRNA	21543283
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM5 mRNA"	25510870
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of MCM5 mRNA	23892564
D010433	Pentylenetetrazole	Pentylenetetrazole affects the expression of MCM5 mRNA	21503142
C494474	perchlorate	perchlorate results in increased expression of MCM5 mRNA	17403546
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of MCM5 protein	26178269
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of MCM5 mRNA	23427857
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of MCM5 protein	26879310
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased expression of MCM5 mRNA	26678675
D010634	Phenobarbital	Phenobarbital affects the expression of MCM5 mRNA	19159669
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MCM5 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of MCM5 mRNA	19136022\|1948288
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MCM5 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of MCM5 mRNA	26272509
C049032	pinosylvin	pinosylvin results in decreased expression of MCM5 mRNA	23333577
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of MCM5 mRNA	22484513
C006253	pirinixic acid	[pirinixic acid co-treated with PPARA] results in increased expression of MCM5 mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in increased expression of MCM5 mRNA	17950772\|1830175
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of MCM5 mRNA]	17950772
C006253	pirinixic acid	pirinixic acid results in increased expression of MCM5 mRNA	19162173
D010894	Piroxicam	Piroxicam results in increased expression of MCM5 mRNA	21858171
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of MCM5 mRNA	22698814
D011374	Progesterone	Progesterone results in decreased expression of MCM5 mRNA	21795739
D011374	Progesterone	Progesterone affects the expression of MCM5 mRNA	17251523
D011374	Progesterone	Progesterone results in decreased expression of MCM5 mRNA	16966611
C045950	propiconazole	propiconazole results in increased expression of MCM5 mRNA	21278054
C005556	propionaldehyde	propionaldehyde results in decreased expression of MCM5 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in increased expression of MCM5 mRNA	24780913
D011441	Propylthiouracil	Propylthiouracil results in increased expression of MCM5 mRNA	17403546
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of MCM5 mRNA	19167446
D012643	Selenium	Selenium results in increased expression of MCM5 mRNA	19244175
C017947	sodium arsenite	sodium arsenite affects the methylation of MCM5 gene	28589171
C017947	sodium arsenite	sodium arsenite results in decreased expression of MCM5 mRNA	20371982
C017947	sodium arsenite	sodium arsenite results in increased expression of MCM5 mRNA	28595984
C016104	sodium bichromate	sodium bichromate affects the expression of MCM5 mRNA	22110744
C016104	sodium bichromate	sodium bichromate results in increased expression of MCM5 mRNA	25993096
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Estradiol results in increased expression of MCM5 mRNA]	24758408
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of MCM5 mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of MCM5 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MCM5 mRNA	16714409
D013749	Tetrachlorodibenzodioxin	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of MCM5 mRNA	26159488
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MCM5 mRNA	22574217
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MCM5 mRNA	12377990
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MCM5 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MCM5 mRNA	15591033
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MCM5 mRNA	19770486
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MCM5 mRNA	25613284
D013792	Thalidomide	[Azacitidine co-treated with Thalidomide] affects the expression of MCM5 mRNA	18720364
D019284	Thapsigargin	Thapsigargin results in decreased expression of MCM5 mRNA	22378314
C009495	titanium dioxide	titanium dioxide results in increased expression of MCM5 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of MCM5 mRNA	20133372
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of MCM5 mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of MCM5 mRNA	16249480
D014241	Trichloroethylene	Trichloroethylene results in increased expression of MCM5 mRNA	25549359
C012589	trichostatin A	trichostatin A affects the expression of MCM5 mRNA	28542535
C012589	trichostatin A	trichostatin A results in decreased expression of MCM5 mRNA	23770000
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of MCM5 mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MCM5 mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of MCM5 mRNA	19140230
D014415	Tunicamycin	Tunicamycin results in decreased expression of MCM5 mRNA	22378314
D014520	Urethane	Urethane results in decreased expression of MCM5 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of MCM5 mRNA	25979313
D014640	Vancomycin	Vancomycin results in decreased expression of MCM5 mRNA	18930951
C025643	vinclozolin	vinclozolin results in increased methylation of MCM5 promoter	22570695
C029297	vinylidene chloride	vinylidene chloride results in increased expression of MCM5 mRNA	26682919
D014800	Vitallium	Vitallium analog results in decreased expression of MCM5 mRNA	23825117
D024483	Vitamin K 3	Vitamin K 3 affects the expression of MCM5 mRNA	20044591\|2341063

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003688	DNA replication origin binding	-	IEA	-
GO:0004386	helicase activity	-	IEA	-
GO:0005515	protein binding	-	IPI	12364596 15232106 16899510 17296731 19150984 19862764 21149733 22540012 23764002 24299456 25036637
GO:0005524	ATP binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000082	G1/S transition of mitotic cell cycle	-	TAS	-
GO:0006260	DNA replication	-	TAS	-
GO:0006270	DNA replication initiation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000784	nuclear chromosome, telomeric region	-	HDA	19135898
GO:0005634	nucleus	-	TAS	8751386
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005829	cytosol	-	IEA	-
GO:0016020	membrane	-	HDA	19946888
GO:0042555	MCM complex	-	IDA	17296731

KEGG ID	KEGG Term
hsa03030	DNA replication
hsa04110	Cell cycle

Reactome ID	Reactome Term	Evidence
R-HSA-1640170	Cell Cycle	TAS
R-HSA-1640170	Cell Cycle	IEA
R-HSA-176187	Activation of ATR in response to replication stress	TAS
R-HSA-176974	Unwinding of DNA	IEA
R-HSA-453279	Mitotic G1-G1/S phases	TAS
R-HSA-68867	Assembly of the pre-replicative complex	TAS
R-HSA-68874	M/G1 Transition	TAS
R-HSA-68949	Orc1 removal from chromatin	TAS
R-HSA-68962	Activation of the pre-replicative complex	TAS
R-HSA-69002	DNA Replication Pre-Initiation	TAS
R-HSA-69052	Switching of origins to a post-replicative state	TAS
R-HSA-69190	DNA strand elongation	IEA
R-HSA-69206	G1/S Transition	TAS
R-HSA-69239	Synthesis of DNA	TAS
R-HSA-69239	Synthesis of DNA	IEA
R-HSA-69242	S Phase	TAS
R-HSA-69242	S Phase	IEA
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-69278	Cell Cycle, Mitotic	IEA
R-HSA-69306	DNA Replication	TAS
R-HSA-69306	DNA Replication	IEA
R-HSA-69481	G2/M Checkpoints	TAS
R-HSA-69620	Cell Cycle Checkpoints	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29151950	MCMs expression in lung cancer: implication of prognostic significance. (2017)	Liu YZ	J Cancer