Gene: MCM6

4175
MCG40308|Mis5|P105MCM
minichromosome maintenance complex component 6
protein-coding
2q21.3
Ensembl:ENSG00000076003 MIM:601806 Vega:OTTHUMG00000131739 UniprotKB:Q14566
NG_008958.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.810e-3 (AD)  8.765e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DIS30.861
ORC30.857
CDC230.852
RPA10.847
RRM10.845
ANO100.839
PMPCB0.839
GGNBP20.837
NUP1330.836
SRP540.835

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.5
OR4F29-0.468
MTRNR2L6-0.335
RERGL-0.328
MTRNR2L9-0.326
PTGDR2-0.323
MTRNR2L10-0.294
TTLL10-0.292
KLRK1-0.282
RNF223-0.264

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of MCM6 mRNA"26377693
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of MCM6 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MCM6 mRNA"22698814|2890350
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of MCM6 mRNA"20453058
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM6 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of MCM6 mRNA"25614096
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the expression of MCM6 mRNA14516785
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the expression of MCM6 protein14516785
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MCM6 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MCM6 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM6 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM6 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM6 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM6 mRNA"25510870
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MCM6 mRNA"16120219
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of MCM6 mRNA25088246
C0194992-nitrofluorene2-nitrofluorene results in increased expression of MCM6 mRNA15890375
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine results in increased expression of MCM6 mRNA14610520
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MCM6 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MCM6 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of MCM6 mRNA19191707
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MCM6 mRNA15890375
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MCM6 mRNA"27188386
C1217077,3'-dihydroxy-4'-methoxyisoflavone"7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of MCM6 mRNA"24455688
D000082AcetaminophenAcetaminophen affects the expression of MCM6 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MCM6 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MCM6 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MCM6 mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MCM6 mRNA15890375|2363061
C000188alachloralachlor results in increased expression of MCM6 mRNA12419858
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MCM6 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of MCM6 mRNA"22863853
C006632arsenic trioxidearsenic trioxide results in increased expression of MCM6 protein19364129
D001241AspirinAspirin results in decreased expression of MCM6 mRNA12800193
D001285AtropineAtropine results in increased expression of MCM6 mRNA17390078
D001285Atropine[Parathion co-treated with Atropine] results in increased expression of MCM6 mRNA17390078
C105832auraptenaurapten affects the expression of MCM6 mRNA23320178
D001379AzathioprineAzathioprine results in decreased expression of MCM6 mRNA22623647
C547126AZM551248AZM551248 results in increased expression of MCM6 mRNA22323515
D001507BeclomethasoneBeclomethasone results in decreased expression of MCM6 mRNA23656298
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of MCM6 mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of MCM6 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MCM6 mRNA16120219|2006483
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MCM6 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MCM6 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MCM6 mRNA"20382639
D004958Estradiol[Estradiol co-treated with Parathion] results in increased expression of MCM6 mRNA17622325
D004958EstradiolEstradiol results in increased expression of MCM6 mRNA16474171|1762232
D004958EstradiolEstradiol inhibits the reaction [Progesterone affects the localization of MCM6 protein]16966611
C006780bisphenol Abisphenol A affects the expression of MCM6 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of MCM6 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of MCM6 mRNA16474171
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of MCM6 gene28505145
C006780bisphenol Abisphenol A results in decreased expression of MCM6 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of MCM6 mRNA15336504
D002104CadmiumCadmium results in decreased expression of MCM6 mRNA23256528
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MCM6 mRNA19031917
D019256Cadmium Chloride[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of MCM6 mRNA19840844
D000074262Canola OilCanola Oil metabolite results in decreased expression of MCM6 mRNA27363782
D002220CarbamazepineCarbamazepine affects the expression of MCM6 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MCM6 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MCM6 mRNA27339419
D002509CephaloridineCephaloridine results in increased expression of MCM6 mRNA18500788
D002737ChloropreneChloroprene results in decreased expression of MCM6 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MCM6 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of MCM6 mRNA19320972
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of MCM6 mRNA20971185
D003300CopperCopper results in increased expression of MCM6 mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of MCM6 mRNA19549813
D003345CorticosteroneCorticosterone results in decreased expression of MCM6 mRNA15755911
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MCM6 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of MCM6 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of MCM6 mRNA19167446
C024015cryptolepinecryptolepine results in decreased expression of MCM6 mRNA16120219
C030973cupric oxidecupric oxide results in decreased expression of MCM6 mRNA22077320
D003471CuprizoneCuprizone results in increased expression of MCM6 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of MCM6 mRNA20106945|2163298
D000069439DasatinibDasatinib results in decreased expression of MCM6 mRNA20579391
D013759DronabinolDronabinol results in decreased expression of MCM6 mRNA18454173
D003976DiazinonDiazinon affects the expression of MCM6 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MCM6 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MCM6 mRNA21266533
D002945CisplatinCisplatin results in increased phosphorylation of MCM6 protein22006019
C000944dicrotophosdicrotophos results in decreased expression of MCM6 mRNA28302478
D004041Dietary FatsDietary Fats affects the expression of MCM6 mRNA19680557
D004041Dietary FatsDietary Fats results in increased expression of MCM6 mRNA22609946
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of MCM6 mRNA15890375
D002117CalcitriolCalcitriol results in decreased expression of MCM6 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of MCM6 mRNA21592394
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of MCM6 mRNA15890375
D004317DoxorubicinDoxorubicin results in decreased expression of MCM6 mRNA16243910
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MCM6 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MCM6 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MCM6 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MCM6 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MCM6 mRNA17351261
D005047EtoposideEtoposide results in decreased expression of MCM6 mRNA16120219
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of MCM6 mRNA]15016801
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of MCM6 mRNA24657277
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MCM6 mRNA20938992
C039281furanfuran results in increased expression of MCM6 mRNA24183702
C039281furanfuran results in increased expression of MCM6 mRNA20124500|2553966
D019833GenisteinGenistein results in increased expression of MCM6 mRNA16474171
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of MCM6 gene28505145
C014026hexamethylene bisacetamidehexamethylene bisacetamide results in decreased expression of MCM6 mRNA26941288
D017313FenretinideFenretinide results in decreased expression of MCM6 mRNA28973697
D017313FenretinideFenretinide results in increased expression of MCM6 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MCM6 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MCM6 mRNA24796395
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MCM6 mRNA26941288
C410337K 7174K 7174 results in decreased expression of MCM6 mRNA24086573
D048628KetolidesKetolides analog results in increased expression of MCM6 mRNA24967691
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MCM6 mRNA27339419
D018021Lithium ChlorideLithium Chloride results in decreased expression of MCM6 mRNA17440966
D008701MethapyrileneMethapyrilene results in increased expression of MCM6 mRNA15890375
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MCM6 mRNA20938992
D008727MethotrexateDHFR protein mutant form inhibits the reaction [Methotrexate results in decreased expression of MCM6 mRNA]17519396
D008727MethotrexateMethotrexate results in decreased expression of MCM6 mRNA17519396
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of MCM6 mRNA24657277
D008727MethotrexateMethotrexate results in decreased expression of MCM6 mRNA24657277
D008748MethylcholanthreneMethylcholanthrene results in increased expression of MCM6 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MCM6 mRNA28001369
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of MCM6 mRNA19840844
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of MCM6 mRNA16026605
C008493methylselenic acidmethylselenic acid affects the expression of MCM6 mRNA14617803
C008493methylselenic acidmethylselenic acid results in decreased expression of MCM6 mRNA12517777
C523799MRK 003MRK 003 results in decreased expression of MCM6 protein19318552
D009151Mustard GasMustard Gas results in decreased expression of MCM6 mRNA25102026
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of MCM6 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MCM6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MCM6 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MCM6 mRNA"25554681
C461488N-benzylpiperazineN-benzylpiperazine results in increased expression of MCM6 mRNA26821219
C017096n-butoxyethanoln-butoxyethanol results in increased expression of MCM6 mRNA19812364
D009532NickelNickel results in increased expression of MCM6 mRNA25583101
C022838nickel chloridenickel chloride affects the expression of MCM6 mRNA22546817
C012655nimesulidenimesulide results in increased expression of MCM6 mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of MCM6 mRNA19716841
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of MCM6 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MCM6 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of MCM6 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of MCM6 mRNA26516004
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of MCM6 mRNA25658374
D010126OzoneOzone results in increased expression of MCM6 mRNA16716893
D000073878Palm OilPalm Oil affects the expression of MCM6 mRNA19680557
D010278Parathion[Estradiol co-treated with Parathion] results in increased expression of MCM6 mRNA17622325
D010278Parathion[Parathion co-treated with Atropine] results in increased expression of MCM6 mRNA17390078
D010278ParathionParathion results in increased expression of MCM6 mRNA17390078
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MCM6 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of MCM6 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of MCM6 mRNA18692542
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of MCM6 mRNA17097637
D010634PhenobarbitalPhenobarbital affects the expression of MCM6 mRNA19159669
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of MCM6 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of MCM6 mRNA19270015|1936314
D010634PhenobarbitalPhenobarbital results in increased expression of MCM6 mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MCM6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of MCM6 mRNA26272509
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of MCM6 mRNA15890375|2248451
C006253pirinixic acidpirinixic acid results in increased expression of MCM6 mRNA16985257|1795077
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of MCM6 mRNA]17950772
C006253pirinixic acidpirinixic acid results in increased expression of MCM6 mRNA15890375|1916217
D010894PiroxicamPiroxicam results in decreased expression of MCM6 mRNA21858171
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of MCM6 mRNA16474171
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of MCM6 mRNA19162173
D011374ProgesteroneProgesterone results in decreased expression of MCM6 mRNA23012394
D011374ProgesteroneEstradiol inhibits the reaction [Progesterone affects the localization of MCM6 protein]16966611
D011374ProgesteroneProgesterone affects the localization of MCM6 protein16966611
D011374ProgesteroneProgesterone results in decreased expression of MCM6 mRNA16966611
D011374ProgesteroneProgesterone results in decreased expression of MCM6 mRNA20726854
C045950propiconazolepropiconazole results in increased expression of MCM6 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of MCM6 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of MCM6 mRNA23727915
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of MCM6 mRNA19167446
C059514resveratrolresveratrol results in decreased expression of MCM6 mRNA15767336
C059514resveratrolresveratrol results in decreased expression of MCM6 protein25505154
C488333Ro 65-7199Ro 65-7199 affects the expression of MCM6 mRNA14610520
D012402RotenoneRotenone results in increased expression of MCM6 mRNA19013527
D012835Silver NitrateSilver Nitrate results in increased expression of MCM6 mRNA22831968
C017947sodium arsenitesodium arsenite results in increased expression of MCM6 mRNA28595984
C016104sodium bichromatesodium bichromate affects the expression of MCM6 mRNA22110744
C016104sodium bichromatesodium bichromate results in increased expression of MCM6 mRNA25993096
D012999SomanSoman results in increased expression of MCM6 mRNA19281266
D053260SootSoot results in increased expression of MCM6 mRNA26551751
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of MCM6 mRNA"26680231
C013698tallowtallow affects the expression of MCM6 mRNA19680557
D013629TamoxifenTamoxifen results in increased expression of MCM6 protein17098229
D013629Tamoxifen[Tretinoin co-treated with Tamoxifen] results in increased expression of MCM6 protein17098229
D013629TamoxifenTamoxifen affects the expression of MCM6 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of MCM6 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of MCM6 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MCM6 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MCM6 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MCM6 mRNA16611356
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MCM6 mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MCM6 protein16548065
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MCM6 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of MCM6 mRNA22378314
D013893ThiramThiram results in decreased expression of MCM6 mRNA20530235
C009495titanium dioxidetitanium dioxide results in increased expression of MCM6 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MCM6 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MCM6 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of MCM6 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of MCM6 mRNA"19682533
D014212Tretinoin[Tretinoin co-treated with Tamoxifen] results in increased expression of MCM6 protein17098229
D014212TretinoinTretinoin results in increased expression of MCM6 protein17098229
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of MCM6 mRNA19042947
C001899triptolidetriptolide results in increased expression of MCM6 mRNA23639586
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MCM6 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of MCM6 mRNA19140230
D014415TunicamycinTunicamycin results in decreased expression of MCM6 mRNA22378314
D014520UrethaneUrethane results in decreased expression of MCM6 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of MCM6 mRNA28001369
D024483Vitamin K 3Vitamin K 3 affects the expression of MCM6 mRNA20044591
C088658zoledronic acidzoledronic acid results in decreased expression of MCM6 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003697single-stranded DNA binding-IEA-  
GO:0004003ATP-dependent DNA helicase activitycontributes_toIDA9305914  
GO:0005515protein binding-IPI11095689  12364596  15232106  16189514  16438930  16899510  
16902406  17296731  17955473  20202939  22190034  22540012  
23764002  24299456  25036637  25416956  26167883  26496610  
27107014  29426014  
GO:0005524ATP binding-NAS9286856  
GO:0042802identical protein binding-IPI15232106  16189514  
GO ID GO Term Qualifier Evidence PubMed
GO:0000082G1/S transition of mitotic cell cycle-TAS-  
GO:0006260DNA replication-NAS9286856  
GO:0006260DNA replication-TAS-  
GO:0006268DNA unwinding involved in DNA replication-IEA-  
GO:0006270DNA replication initiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000784nuclear chromosome, telomeric region-HDA19135898  
GO:0005634nucleus-IDA16899510  
GO:0005634nucleus-NAS9286856  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0042555MCM complex-IDA17296731  
KEGG ID KEGG Term
hsa03030DNA replication
hsa04110Cell cycle
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-176187Activation of ATR in response to replication stressTAS
R-HSA-176974Unwinding of DNAIEA
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-68867Assembly of the pre-replicative complexTAS
R-HSA-68874M/G1 TransitionTAS
R-HSA-68949Orc1 removal from chromatinTAS
R-HSA-68962Activation of the pre-replicative complexTAS
R-HSA-69002DNA Replication Pre-InitiationTAS
R-HSA-69052Switching of origins to a post-replicative stateTAS
R-HSA-69190DNA strand elongationIEA
R-HSA-69206G1/S TransitionTAS
R-HSA-69239Synthesis of DNATAS
R-HSA-69239Synthesis of DNAIEA
R-HSA-69242S PhaseTAS
R-HSA-69242S PhaseIEA
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69278Cell Cycle, MitoticIEA
R-HSA-69306DNA ReplicationTAS
R-HSA-69306DNA ReplicationIEA
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29151950MCMs expression in lung cancer: implication of prognostic significance. (2017)Liu YZJ Cancer
20447925Can lactase persistence genotype be used to reassess the relationship between renal cell carcinoma and milk drinking? Potentials and problems in the application of Mendelian randomization. (2010 May)Timpson NJCancer Epidemiol Biomarkers Prev