Gene: CD46

4179
AHUS2|MCP|MIC10|TLX|TRA2.10
CD46 molecule
protein-coding
1q32.2
Ensembl:ENSG00000117335 MIM:120920 Vega:OTTHUMG00000036397 UniprotKB:P15529
NG_009296.1
PubMed
0   ANCO-SNPs
ND
2   
3.017e-2 (AD)  4.816e-1 (ND)   (Frontal_Cortex)
1.022e-1 (AD)  6.075e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PICALM0.867
PRPF4B0.865
UBXN40.86
FAM76B0.859
ELF20.857
BTAF10.854
SF3B10.851
SENP60.846
SMCHD10.846
SMC50.844

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.551
OR4F29-0.549
HES5-0.25
PLA2G5-0.227
ARSF-0.213
WNT7B-0.189
BTBD17-0.184
RLBP1-0.17
LCN1-0.169
FTH1P18-0.165

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0065932-anthramine2-anthramine results in increased expression of CD46 mRNA23038007
C5575053',4'-dimethoxy-alpha-naphthoflavone"[3',4'-dimethoxy-alpha-naphthoflavone results in increased activity of AHR protein] inhibits the reaction [IL1B protein results in increased expression of CD46 mRNA]"22553215
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CD46 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CD46 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of CD46 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of CD46 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CD46 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CD46 mRNA16483693
C547126AZM551248AZM551248 results in decreased expression of CD46 mRNA22323515
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CD46 mRNA"20018196
C006780bisphenol Abisphenol A results in increased methylation of CD46 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of CD46 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CD46 mRNA15336504
C028031cadmium acetatecadmium acetate results in decreased expression of CD46 mRNA18155341
D002211CapsaicinCapsaicin results in increased expression of CD46 mRNA16278290
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CD46 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of CD46 mRNA19320972
D003300Copper[Disulfiram binds to Copper] which results in increased expression of CD46 mRNA24690739
D019327Copper SulfateCopper Sulfate results in decreased expression of CD46 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of CD46 mRNA25562108
D002945CisplatinCisplatin results in increased expression of CD46 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of CD46 mRNA28302478
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CD46 mRNA17602206
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of CD46 mRNA24690739
D004391DustDust results in decreased expression of CD46 mRNA17805423
D005485FlutamideFlutamide results in increased expression of CD46 mRNA24793618
C039281furanfuran results in increased expression of CD46 mRNA25539665
C016517indole-3-carbinolindole-3-carbinol affects the expression of CD46 mRNA21396975
D022542Measles-Mumps-Rubella VaccineCD46 gene results in increased susceptibility to Measles-Mumps-Rubella Vaccine25344690
D009532NickelNickel affects the expression of CD46 mRNA14575637
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of CD46 mRNA]14575637
D009538NicotineNicotine results in increased expression of CD46 mRNA16949557
D017239PaclitaxelCD46 mRNA results in increased susceptibility to Paclitaxel16322897
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CD46 mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CD46 protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CD46 mRNA19162173
C006253pirinixic acidpirinixic acid results in increased expression of CD46 mRNA19162173
D010936Plant ExtractsPlant Extracts results in increased expression of CD46 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of CD46 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of CD46 mRNA21632981
C078903seocalcitolseocalcitol results in increased expression of CD46 mRNA12040012
D012460SulfasalazineSulfasalazine results in decreased expression of CD46 mRNA15625186
C025462sulindac sulfidesulindac sulfide results in decreased expression of CD46 mRNA16184548
C009495titanium dioxidetitanium dioxide results in increased expression of CD46 mRNA19695317
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of CD46 mRNA]14575637
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CD46 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CD46 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CD46 mRNA23179753|2627250
C111237vorinostatvorinostat results in decreased expression of CD46 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0005515protein binding-IPI23086448  
GO:0038023signaling receptor activity-TAS8402913  
GO:0045296cadherin binding-IPI23086448  
GO ID GO Term Qualifier Evidence PubMed
GO:0002250adaptive immune response-IC12540904  
GO:0002456T cell mediated immunity-IMP23086448  
GO:0006958complement activation, classical pathway-IEA-  
GO:0007165signal transduction-IEA-  
GO:0007338single fertilization-IEA-  
GO:0008593regulation of Notch signaling pathway-IDA23086448  
GO:0010628positive regulation of gene expression-IMP23086448  
GO:0010629negative regulation of gene expression-IDA23086448  
GO:0030449regulation of complement activation-TAS-  
GO:0032613interleukin-10 production-IDA23086448  
GO:0032733positive regulation of interleukin-10 production-IDA12540904  
GO:0035581sequestering of extracellular ligand from receptor-IDA23086448  
GO:0042102positive regulation of T cell proliferation-IDA12540904  
GO:0043382positive regulation of memory T cell differentiation-IDA12540904  
GO:0045087innate immune response-IEA-  
GO:0045591positive regulation of regulatory T cell differentiation-IDA12540904  
GO:0046718viral entry into host cell-IEA-  
GO:0071636positive regulation of transforming growth factor beta production-IDA12540904  
GO ID GO Term Qualifier Evidence PubMed
GO:0002079inner acrosomal membrane-IEA-  
GO:0005886plasma membrane-IDA20534589  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS1711570  
GO:0005925focal adhesion-HDA21423176  
GO:0009986cell surface-IDA23086448  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
Reactome ID Reactome Term Evidence
R-HSA-166658Complement cascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24440594Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells. (2014 May)Wang LFree Radic Biol Med
21573156CD46 protects against chronic obstructive pulmonary disease. (2011 May 6)Grumelli SPLoS One