Gene: SMCP

4184
HSMCSGEN1|MCS|MCSP
sperm mitochondria associated cysteine rich protein
protein-coding
1q21.3
Ensembl:ENSG00000163206 MIM:601148 Vega:OTTHUMG00000012452 UniprotKB:P49901
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.264e-1 (AD)  9.768e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ENTHD10.609
GPR1010.601
SAG0.597
IRX60.594
DRD30.594
DGKK0.59
ZBED20.588
AMBN0.587
C6orf1320.576
MYO3A0.576

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC17A7-0.341
SYTL2-0.325
ELAVL4-0.325
SATB2-0.323
TBR1-0.318
QPCT-0.314
RFTN1-0.313
SLC17A6-0.307
FMN1-0.301
TRPV2-0.3

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SMCP mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SMCP mRNA24449571
D001280AtrazineAtrazine results in increased expression of SMCP mRNA22378314
C006780bisphenol Abisphenol A results in decreased expression of SMCP mRNA25181051
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of SMCP mRNA19395590
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of SMCP mRNA28962523
C004312glycidolglycidol results in decreased expression of SMCP mRNA24915197
C017461lead nitratelead nitrate results in decreased expression of SMCP mRNA21628963
D008694MethamphetamineMethamphetamine results in decreased expression of SMCP mRNA26307267
C006253pirinixic acidpirinixic acid results in increased expression of SMCP mRNA18301758
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of SMCP mRNA21334430
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SMCP mRNA19162173
D012969Sodium FluorideSodium Fluoride results in decreased expression of SMCP mRNA21340527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SMCP mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of SMCP mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SMCP mRNA25975270|2629044
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of SMCP mRNA28973375
C025643vinclozolinvinclozolin results in increased expression of SMCP mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI16189514  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0007341penetration of zona pellucida-ISS-  
GO:0030317flagellated sperm motility-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-ISS-  
GO:0005739mitochondrion-ISS-  
GO:0031966mitochondrial membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22409215Genetic and environmental risk factors for submucous cleft palate. (2012 Apr)Reiter REur J Oral Sci