Gene: MDFI

4188
I-MF|I-mfa
MyoD family inhibitor
protein-coding
6p21.1
Ensembl:ENSG00000112559 MIM:604971 Vega:OTTHUMG00000014681 UniprotKB:Q99750
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.595e-1 (AD)  1.101e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14086013chr6:41604740MDFI3.020e-9Maternal smoking in pregnancy27040690
cg14086013chr6:41604740MDFI1.520e-9Maternal smoking in pregnancy27040690
cg14086013chr6:41604740MDFI2.340e-10Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB130.721
TMEM1020.686
RHOC0.684
S100A160.683
APOC10.682
CMTM30.675
TSPO0.665
VAMP50.664
EMP30.66
NTN10.655

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBXO40-0.576
ZNF385B-0.574
FMN1-0.559
PRSS16-0.555
MLIP-0.554
IPCEF1-0.55
DNAJC5G-0.548
TBR1-0.548
POU6F2-0.545
PTPN3-0.545

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of MDFI mRNA"23146750
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of MDFI mRNA"23146750
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of MDFI mRNA"23146750
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to MDFI protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MDFI protein]26598702
D000082AcetaminophenAcetaminophen results in increased expression of MDFI mRNA26690555
D020106AcrylamideAcrylamide results in decreased expression of MDFI mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MDFI mRNA22100608
D001104ArbutinArbutin results in decreased expression of MDFI mRNA17103032
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MDFI protein]26598702
C447119bazedoxifenebazedoxifene results in increased expression of MDFI mRNA19914376
C006780bisphenol Abisphenol A results in decreased expression of MDFI mRNA23146750
C006780bisphenol Abisphenol A results in increased expression of MDFI mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of MDFI mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of MDFI mRNA26079696
C018021cobaltous chloridecobaltous chloride results in decreased expression of MDFI mRNA19320972
D003471CuprizoneCuprizone results in decreased expression of MDFI mRNA26577399
D003907DexamethasoneDexamethasone results in decreased expression of MDFI mRNA25047013
D005472FluorouracilFluorouracil results in decreased expression of MDFI protein15352031
D005472FluorouracilMDFI protein affects the susceptibility to Fluorouracil15352031
C039281furanfuran results in increased expression of MDFI mRNA27387713
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MDFI mRNA24796395
C011890kojic acidkojic acid results in decreased expression of MDFI mRNA16595896
D007854LeadLead affects the expression of MDFI mRNA28903495
D008777MethyltestosteroneMethyltestosterone results in increased expression of MDFI mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MDFI mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MDFI mRNA"25554681
D009532NickelNickel results in increased expression of MDFI mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of MDFI mRNA16780908
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of MDFI mRNA23146750
C428725pyridabenpyridaben results in decreased expression of MDFI mRNA22563483
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MDFI mRNA26377647
D014635Valproic AcidValproic Acid affects the expression of MDFI mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MDFI mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of MDFI gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  17289077  19060904  19447967  21516116  23088713  
25416956  25910212  26871637  27107012  27107014  
GO:0008134transcription factor binding-IBA21873635  
GO:0042802identical protein binding-IPI16189514  25416956  27107012  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0009950dorsal/ventral axis specification-ISS-  
GO:0030178negative regulation of Wnt signaling pathway-ISS-  
GO:0042994cytoplasmic sequestering of transcription factor-TAS8797820  
GO:0043392negative regulation of DNA binding-ISS-  
GO:0048704embryonic skeletal system morphogenesis-IEA-  
GO:0060707trophoblast giant cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22083596Stool DNA testing for the detection of pancreatic cancer: assessment of methylation marker candidates. (2012 May 15)Kisiel JBCancer