Gene: ART3

419
ARTC3
ADP-ribosyltransferase 3
protein-coding
4q21.1|4p15.1-p14
Ensembl:ENSG00000156219 MIM:603086 Vega:OTTHUMG00000130110 UniprotKB:Q13508
NC_000004.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.945e-1 (AD)  5.703e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SESN10.794
RBM480.789
FAM13A0.77
USP280.763
TIAM20.762
PLEKHA10.758
FLCN0.757
ZC3H80.757
PCID20.754
ARL4A0.752

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLRB1-0.45
TIGIT-0.42
LRAT-0.39
FZD10-0.372
IL2RB-0.37
TBX21-0.366
C9orf153-0.363
TSPAN12-0.362
KLRF1-0.358
RBP1-0.354

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of ART3 mRNA"26377693
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of ART3 mRNA"23829299
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ART3 mRNA16788091
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ART3 mRNA"18648102
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of ART3 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ART3 mRNA]17585979
D020106AcrylamideAcrylamide results in decreased expression of ART3 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ART3 mRNA16483693
D001151ArsenicArsenic affects the methylation of ART3 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ART3 mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ART3 mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ART3 mRNA]25566086
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of ART3 mRNA20660070
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of ART3 mRNA17404688
C006780bisphenol Abisphenol A results in increased expression of ART3 mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of ART3 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of ART3 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ART3 mRNA17484886
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of ART3 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ART3 mRNA]17585979
D016572CyclosporineCyclosporine results in decreased expression of ART3 mRNA20106945
D003907DexamethasoneDexamethasone results in increased expression of ART3 mRNA22733784
D004237DiuronDiuron results in decreased expression of ART3 mRNA25152437
D004237DiuronDiuron results in increased expression of ART3 mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ART3 mRNA17555576|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of ART3 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ART3 mRNA17108234
D017313FenretinideFenretinide results in decreased expression of ART3 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ART3 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ART3 mRNA24435446
D007649KetamineKetamine results in increased expression of ART3 mRNA20080153
C008261lead acetatelead acetate results in increased expression of ART3 mRNA22609695
D015122MercaptopurineMercaptopurine results in increased expression of ART3 mRNA23358152
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ART3 mRNA23519560
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ART3 mRNA"26251327
D009020MorphineMorphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in increased expression of ART3 protein]]23056601
D009020MorphineMorphine deficiency affects the reaction [Morphine results in increased expression of ART3 protein]23056601
D009020MorphineMorphine results in increased expression of ART3 protein23056601
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of ART3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of ART3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ART3 mRNA"25620056
D010269ParaquatParaquat results in increased expression of ART3 mRNA12595580
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ART3 mRNA22237054
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of ART3 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of ART3 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of ART3 mRNA20726854
D011441PropylthiouracilPropylthiouracil results in decreased expression of ART3 mRNA24780913
D012969Sodium FluorideSodium Fluoride results in increased expression of ART3 protein28918527
D012999SomanSoman results in decreased expression of ART3 mRNA19281266
D053260SootSoot results in decreased expression of ART3 mRNA26551751
D013629TamoxifenTamoxifen affects the expression of ART3 mRNA17555576
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of ART3 mRNA25172293
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of ART3 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ART3 mRNA23519560
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ART3 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of ART3 mRNA23557971
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of ART3 mRNA19042947
C057693troglitazonetroglitazone results in increased expression of ART3 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of ART3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of ART3 gene29154799
D014635Valproic AcidValproic Acid affects the expression of ART3 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ART3 gene25560391
D015032ZincZinc results in increased expression of ART3 mRNA17074742
D019287Zinc SulfateZinc Sulfate results in increased expression of ART3 mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003950NAD+ ADP-ribosyltransferase activity-IBA21873635  
GO:0003950NAD+ ADP-ribosyltransferase activity-TAS9119374  
GO:0003956NAD(P)+-protein-arginine ADP-ribosyltransferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006471protein ADP-ribosylation-IBA21873635  
GO:0006471protein ADP-ribosylation-IEA-  
GO:0018120peptidyl-arginine ADP-ribosylation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0031225anchored component of membrane-IEA-  
GO:0031226intrinsic component of plasma membrane-TAS9119374  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16627471ADP-ribosyltransferase-specific modification of human neutrophil peptide-1. (2006 Jun 23)Paone GJ Biol Chem