Gene: MDH1

4190
HEL-S-32|MDH-s|MDHA|MGC:1375|MOR2
malate dehydrogenase 1
protein-coding
2p15
Ensembl:ENSG00000014641 MIM:154200 Vega:OTTHUMG00000129512 UniprotKB:P40925
NC_000002.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.761e-1 (AD)  3.209e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP6V1B20.981
PCMT10.981
RTN30.98
SCG50.98
ATP6V1D0.979
ATP6V1E10.978
RTN10.978
VDAC30.978
SERPINI10.976
GOT20.975

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.626
OR4F29-0.582
CSAG1-0.436
TFPI2-0.435
CNN2-0.428
MAGEA12-0.427
RAI14-0.426
KCNJ15-0.424
RUNX3-0.423
MTRNR2L6-0.418

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of MDH1 mRNA"19162173
C0364231-aminomethylphosphonic acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of MDH1 mRNA"20566314
C0668412,3,7,8-tetrabromodibenzo-4-dioxin"2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of MDH1 protein"27604104
C0112692,5-hexanedione"2,5-hexanedione results in increased expression of MDH1 protein"19033394
C0158022,6-dichloro-4-nitrophenol"2,6-dichloro-4-nitrophenol results in decreased expression of MDH1 mRNA"11227219
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of MDH1 mRNA"20406850
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MDH1 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDH1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDH1 mRNA"27188386
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to MDH1 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MDH1 protein]26598702
C0293704-toluidine4-toluidine results in increased expression of MDH1 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDH1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDH1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MDH1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of MDH1 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of MDH1 protein22939915
D000082Acetaminophendioscin inhibits the reaction [Acetaminophen results in decreased expression of MDH1 protein]22939915
D000082AcetaminophenAcetaminophen results in increased expression of MDH1 mRNA15084756
C043377acetochlor"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of MDH1 mRNA"20566314
D020106AcrylamideAcrylamide results in increased expression of MDH1 mRNA28959563
D016604Aflatoxin B1[sulforafan co-treated with Aflatoxin B1] affects the expression of MDH1 mRNA25450479
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of MDH1 protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of MDH1 protein26597043
C061621alpha-naphthyl isocyanatealpha-naphthyl isocyanate affects the expression of MDH1 protein16099942
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MDH1 mRNA16483693
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MDH1 protein]26598702
D001280AtrazineAtrazine results in increased expression of MDH1 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of MDH1 mRNA22323515
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MDH1 mRNA18164116
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of MDH1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MDH1 mRNA22228805
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of MDH1 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of MDH1 mRNA25047013
C006780bisphenol Abisphenol A results in decreased expression of MDH1 protein24909818
C006780bisphenol Abisphenol A results in increased expression of MDH1 protein24909818
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of MDH1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of MDH1 mRNA26982218
C006780bisphenol Abisphenol A results in increased expression of MDH1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of MDH1 mRNA22079614
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MDH1 protein21667247
D002211CapsaicinCapsaicin inhibits the reaction [Dietary Fats results in decreased expression of MDH1 protein]20359164
C100187chloropicrinchloropicrin results in increased expression of MDH1 mRNA26352163
C041167chromium nitratechromium nitrate results in increased expression of MDH1 protein22144121
D002922CiguatoxinsCiguatoxins affects the expression of MDH1 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of MDH1 protein16470657
D002995Clofibric AcidClofibric Acid affects the expression of MDH1 mRNA17602206
D003042CocaineCocaine results in decreased expression of MDH1 mRNA12629581
D003300CopperCopper results in decreased expression of MDH1 protein23882024
D003300CopperCopper results in decreased expression of MDH1 mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of MDH1 mRNA19549813
D016578Crack CocaineCrack Cocaine results in increased expression of MDH1 mRNA12629581
C029892cupric chloridecupric chloride results in decreased expression of MDH1 protein22030410
C030973cupric oxidecupric oxide analog results in decreased expression of MDH1 protein23882024
D016572CyclosporineCyclosporine results in decreased expression of MDH1 mRNA20106945|2116390
D0150842,4-Dichlorophenoxyacetic Acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of MDH1 mRNA"20566314
D003840Deoxycholic Acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of MDH1 mRNA16556975
D064791Desoxycorticosterone Acetate"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of MDH1 mRNA"22228705
D003907DexamethasoneDexamethasone results in increased expression of MDH1 mRNA25047013
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MDH1 mRNA21266533
D002945CisplatinCisplatin results in increased expression of MDH1 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of MDH1 mRNA28302478
D004041Dietary FatsCapsaicin inhibits the reaction [Dietary Fats results in decreased expression of MDH1 protein]20359164
D004041Dietary FatsDietary Fats results in decreased expression of MDH1 protein20359164
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of MDH1 protein28934723
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with HRAS protein] results in increased activity of MDH1 protein12499697
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MDH1 mRNA18164116
C039060dihydroartemisinindihydroartemisinin analog binds to MDH1 protein26340163
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of MDH1 mRNA27638505
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of MDH1 mRNA"22485181
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of MDH1 mRNA25380136
C051904dinophysistoxin 1dinophysistoxin 1 results in decreased expression of MDH1 mRNA28939011
C019357dioscindioscin inhibits the reaction [Acetaminophen results in decreased expression of MDH1 protein]22939915
D004726EndosulfanEndosulfan results in decreased activity of MDH1 protein14575683|2331326
D004726EndosulfanTriiodothyronine inhibits the reaction [Endosulfan results in decreased activity of MDH1 protein]2331326
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MDH1 protein23301498
D000431EthanolEthanol results in increased expression of MDH1 protein23702218
D005419FlavonoidsFlavonoids results in decreased expression of MDH1 mRNA18035473
D005485FlutamideFlutamide results in increased expression of MDH1 mRNA19299419|2152539
D005485FlutamideFlutamide results in increased expression of MDH1 protein17311803
D005557FormaldehydeFormaldehyde results in decreased expression of MDH1 mRNA20655997
C039281furanfuran binds to MDH1 protein22240984
C040029gabapentin[gabapentin co-treated with Pentylenetetrazole] affects the expression of MDH1 mRNA21503142
D005839GentamicinsGentamicins results in increased expression of MDH1 mRNA22061828
C030691gluconic acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of MDH1 mRNA16556975
D005947GlucoseGlucose deficiency results in increased expression of MDH1 mRNA26811028
D005947GlucoseGlucose results in increased expression of MDH1 mRNA24349266
D006540Herbicides"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of MDH1 mRNA"20566314
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of MDH1 protein18951874
C492448ICG 001ICG 001 results in increased expression of MDH1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MDH1 mRNA25613284
C410337K 7174K 7174 results in decreased expression of MDH1 mRNA24086573
D007657Ketone BodiesKetone Bodies results in increased expression of MDH1 mRNA16807920
C029891lead chloridelead chloride results in decreased expression of MDH1 protein22030410
C045463leflunomideleflunomide results in decreased expression of MDH1 mRNA24136188
C052901lemongrass oillemongrass oil affects the expression of MDH1 mRNA25976427
C030298malic acidmalic acid deficiency results in increased expression of MDH1 mRNA26811028
D008345ManganeseManganese results in decreased activity of MDH1 protein17040939
C008340mecoprop"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of MDH1 mRNA"20566314
C054487menthofuranmenthofuran metabolite binds to MDH1 protein23106769
D008767Methylmercury Compounds[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of MDH1 mRNA20020106
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MDH1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MDH1 mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of MDH1 mRNA25380136
C461488N-benzylpiperazineN-benzylpiperazine results in decreased expression of MDH1 mRNA26821219
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of MDH1 protein19716841
C464660obeticholic acidobeticholic acid results in increased expression of MDH1 mRNA27939613
D062907Oxaloacetic AcidOxaloacetic Acid results in increased expression of MDH1 protein26811028
D010100OxygenOxygen deficiency results in decreased expression of MDH1 protein25937538
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of MDH1 protein25616259
D010433Pentylenetetrazole[gabapentin co-treated with Pentylenetetrazole] affects the expression of MDH1 mRNA21503142
C522391perfluorododecanoic acidperfluorododecanoic acid results in increased expression of MDH1 protein26168851
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of MDH1 mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of MDH1 protein26178269
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of MDH1 mRNA19429403
D010634PhenobarbitalPhenobarbital results in increased expression of MDH1 mRNA19162173
D011078Polychlorinated Biphenyls[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of MDH1 mRNA20020106
D011189Potassium Chloride"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of MDH1 mRNA"22228705
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of MDH1 protein22144121
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of MDH1 mRNA19162173
D011794QuercetinQuercetin results in decreased expression of MDH1 protein19207037
D015474IsotretinoinIsotretinoin results in decreased expression of MDH1 mRNA20436886
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of MDH1 protein25895662
D012834SilverSilver results in decreased expression of MDH1 mRNA27131904
D019821SimvastatinSimvastatin results in decreased expression of MDH1 protein20217863
C080703SK&F 83959SK&F 83959 results in decreased expression of MDH1 protein25852303
C016104sodium bichromatesodium bichromate results in decreased expression of MDH1 mRNA25993096
D017673Sodium Chloride, Dietary"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of MDH1 mRNA"22228705
D018038Sodium SeleniteSodium Selenite results in increased expression of MDH1 mRNA18175754
D013311StreptozocinStreptozocin results in increased expression of MDH1 protein21136691
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in increased expression of MDH1 protein]21136691
C016766sulforafan[sulforafan co-treated with Aflatoxin B1] affects the expression of MDH1 mRNA25450479
D014284TriiodothyronineTriiodothyronine inhibits the reaction [Endosulfan results in decreased activity of MDH1 protein]2331326
D013605T-2 ToxinT-2 Toxin affects the expression of MDH1 protein26141394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MDH1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MDH1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MDH1 mRNA21215274|2172422
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MDH1 mRNA19490992
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MDH1 mRNA25613284
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of MDH1 protein18951874
C009495titanium dioxidetitanium dioxide affects the expression of MDH1 mRNA17656681
C009495titanium dioxidetitanium dioxide results in decreased expression of MDH1 mRNA23557971
D014118Toxins, Biological"Toxins, Biological affects the expression of MDH1 mRNA"19682533
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDH1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of MDH1 mRNA24935251
D014266TrientineTrientine inhibits the reaction [Streptozocin results in increased expression of MDH1 protein]21136691
C112106UAB 30UAB 30 analog results in increased expression of MDH1 mRNA23292798
C406224valdecoxibvaldecoxib results in decreased expression of MDH1 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDH1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MDH1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of MDH1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of MDH1 mRNA19101580|2317975
D014635Valproic AcidValproic Acid affects the expression of MDH1 mRNA17292431
D014640VancomycinVancomycin results in increased expression of MDH1 mRNA18930951
C025643vinclozolinvinclozolin results in increased expression of MDH1 mRNA23034163
D019820Xanthine[Xanthine co-treated with XDH protein] results in decreased expression of MDH1 protein19464573

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004470malic enzyme activity-TAS8786100  
GO:0005515protein binding-IPI21044950  
GO:0030060L-malate dehydrogenase activity-IBA21873635  
GO:0030060L-malate dehydrogenase activity-TAS-  
GO:0047860diiodophenylpyruvate reductase activity-IEA-  
GO:0051287NAD binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006094gluconeogenesis-TAS-  
GO:0006099tricarboxylic acid cycle-IBA21873635  
GO:0006107oxaloacetate metabolic process-IBA21873635  
GO:0006108malate metabolic process-IBA21873635  
GO:0006734NADH metabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA22664934  
GO:0005739mitochondrion-IBA21873635  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0043209myelin sheath-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa00020Citrate cycle (TCA cycle)
hsa00620Pyruvate metabolism
hsa00630Glyoxylate and dicarboxylate metabolism
hsa01100Metabolic pathways
hsa04964Proximal tubule bicarbonate reclamation
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-70263GluconeogenesisTAS
R-HSA-70326Glucose metabolismTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26988295The influence of chronic nicotine treatment on proteins expressed in the mouse hippocampus and cortex. (2016 Jun 5)Matsuura KEur J Pharmacol