Gene: MDK

4192
ARAP|MK|NEGF2
midkine
protein-coding
11p11.2
Ensembl:ENSG00000110492 MIM:162096 Vega:OTTHUMG00000150315 UniprotKB:P21741
NC_000011.10
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.937e-2 (AD)  5.848e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1orf540.782
HMGB20.752
NECAP20.751
SLC2A4RG0.742
MOV100.72
ZNF4420.719
TAPBPL0.718
ERBB20.715
ADAMTSL40.714
RAB340.714

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AGMAT-0.401
LRRC38-0.399
ABCC12-0.386
CACNA1S-0.383
CALHM1-0.372
OTOA-0.366
PLEKHD1-0.363
OPRD1-0.361
COL24A1-0.357
PHOSPHO1-0.356

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4327471,1-dimethylbutyl-1-deoxy-Delta(9)-THC"1,1-dimethylbutyl-1-deoxy-Delta(9)-THC results in decreased expression of MDK mRNA"15313899
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MDK mRNA"15215175
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of MDK mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of MDK mRNA]28655636
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of MDK protein"25670856
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MDK mRNA22100608
C103303alitretinoinalitretinoin results in increased expression of MDK mRNA14502603
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MDK mRNA16483693
D000661AmphetamineAmphetamine inhibits the reaction [MDK gene mutant form results in decreased expression of ATP5D protein]23459167
D000661AmphetamineAmphetamine inhibits the reaction [MDK gene mutant form results in decreased expression of ENO2 protein]23459167
D000661AmphetamineAmphetamine inhibits the reaction [MDK gene mutant form results in decreased expression of FAH protein]23459167
D000661AmphetamineAmphetamine promotes the reaction [MDK gene mutant form results in decreased expression of ATP5A1 protein]23459167
D000661AmphetamineAmphetamine promotes the reaction [MDK gene mutant form results in increased expression of ALAD protein]23459167
D000661AmphetamineMDK gene mutant form inhibits the reaction [Amphetamine results in increased expression of RAN protein]23459167
D000661AmphetamineMDK gene mutant form promotes the reaction [Amphetamine results in decreased expression of ALDH1A1 protein]23459167
D000661AmphetamineMDK gene mutant form results in decreased susceptibility to Amphetamine23459167
D000661Amphetamine[MDK gene mutant form results in decreased susceptibility to Amphetamine] which results in increased expression of and results in increased phosphorylation of ERP29 protein23459167
D000661Amphetamine[MDK gene mutant form results in decreased susceptibility to Amphetamine] which results in increased expression of CCT2 protein23459167
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MDK mRNA24449571
C015001arsenitearsenite results in increased methylation of MDK promoter23974009
D001205Ascorbic AcidAscorbic Acid results in increased expression of MDK mRNA15372504
D001280AtrazineAtrazine results in increased expression of MDK mRNA22378314
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of MDK mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MDK mRNA20106945
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of MDK mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MDK mRNA22228805
D004958EstradiolEstradiol affects the expression of MDK mRNA22574217
C053541bicalutamidebicalutamide results in increased expression of MDK mRNA15638997
C006780bisphenol Abisphenol A affects the expression of MDK mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of MDK mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of MDK gene28505145
D002330CarmustineCarmustine results in decreased expression of MDK mRNA15980968
D004390ChlorpyrifosChlorpyrifos affects the expression of MDK mRNA26775027
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MDK mRNA20938992
D002809Chondroitin SulfatesChondroitin Sulfates analog binds to MDK protein12221095
D002809Chondroitin Sulfates[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK protein15385557
D002809Chondroitin Sulfates[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK protein14699094
D003471CuprizoneCuprizone results in increased expression of MDK mRNA26577399|2752363
D003513CycloheximideCycloheximide promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of MDK mRNA]11007951
D016572CyclosporineCyclosporine results in decreased expression of MDK mRNA25562108
D003561CytarabineCytarabine results in decreased expression of MDK mRNA21198554
D013759DronabinolMDK inhibits the reaction [Dronabinol results in decreased phosphorylation of AKT1 protein]21233844
D013759DronabinolMDK inhibits the reaction [Dronabinol results in decreased phosphorylation of NUPR1 protein]21233844
D013759DronabinolMDK inhibits the reaction [Dronabinol results in increased expression of NUPR1 mRNA]21233844
D013759DronabinolMDK inhibits the reaction [Dronabinol results in increased expression of TRIB3 mRNA]21233844
D013759DronabinolMDK results in decreased susceptibility to Dronabinol21233844
D003871Dermatan Sulfate[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK protein15385557
D003871Dermatan Sulfate[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK protein14699094
D003907DexamethasoneDexamethasone results in decreased expression of MDK mRNA25047013
D003907DexamethasoneDexamethasone results in increased expression of MDK mRNA21041162
D003976DiazinonDiazinon results in increased methylation of MDK gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MDK mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of MDK mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MDK mRNA27392435
D004026DieldrinDieldrin affects the expression of MDK mRNA22546817
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of MDK mRNA25242112
D004317DoxorubicinMDK mRNA results in decreased susceptibility to Doxorubicin16322897
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MDK mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of MDK mRNA16174780
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDK mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of MDK mRNA16174780|1755790
D015025ZearalenoneZearalenone results in decreased expression of MDK mRNA19371625
C540355fenamidonefenamidone results in increased expression of MDK mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MDK mRNA20938992
D005665FurosemideFurosemide results in increased expression of MDK mRNA16526316
C419708gefitinibgefitinib inhibits the reaction [TGFA protein results in increased expression of MDK mRNA]18424623
D019833GenisteinGenistein results in decreased expression of MDK mRNA19371625
D005947GlucoseGlucose results in increased expression of MDK protein17607302
D006072GossypolGossypol results in decreased expression of MDK mRNA19825521
D006072Gossypolzoledronic acid promotes the reaction [Gossypol results in decreased expression of MDK mRNA]19825521
D017313FenretinideFenretinide results in increased expression of MDK mRNA16671099
D017313FenretinideFenretinide results in increased expression of MDK mRNA28973697
C492448ICG 001ICG 001 results in increased expression of MDK mRNA26191083
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MDK mRNA27392435
C544151jinfukangjinfukang results in increased expression of MDK mRNA27392435
C008261lead acetatelead acetate results in decreased expression of MDK mRNA21864555
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MDK mRNA20938992
D008777MethyltestosteroneMethyltestosterone results in decreased expression of MDK mRNA29191790
D016685MitomycinMDK protein affects the susceptibility to Mitomycin16217747
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of MDK mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MDK mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MDK mRNA"25554681
C022838nickel chloridenickel chloride affects the expression of MDK mRNA22546817
C029938nickel sulfatenickel sulfate results in decreased expression of MDK mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of MDK mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of MDK mRNA17914565
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of MDK mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of MDK mRNA28655636
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of MDK mRNA18692542
D010672PhenytoinPhenytoin results in increased expression of MDK mRNA14741686
D010795Phthalic AcidsPhthalic Acids results in increased expression of MDK mRNA15728792
D010894PiroxicamPiroxicam results in increased expression of MDK mRNA21858171
D011374ProgesteroneProgesterone results in decreased expression of MDK mRNA23018184
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in decreased expression of MDK mRNA12660332
D011692Puromycin AminonucleosideTretinoin inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of MDK mRNA]12660332
D011794QuercetinQuercetin results in increased expression of MDK mRNA21632981
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of MDK mRNA19244175
D012643SeleniumSelenium results in increased expression of MDK mRNA19244175
C078903seocalcitolseocalcitol results in decreased expression of MDK mRNA12040012
D012715Sesame OilSesame Oil results in increased expression of MDK mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MDK mRNA25895662
D018038Sodium SeleniteSodium Selenite results in increased expression of MDK mRNA18175754
C061133tamibarotenetamibarotene results in increased expression of MDK mRNA17229644
D013629TamoxifenTamoxifen affects the expression of MDK mRNA17555576
D013749TetrachlorodibenzodioxinCycloheximide promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of MDK mRNA]11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MDK mRNA11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MDK mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDK mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to MDK promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MDK mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MDK mRNA21215274
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of MDK mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of MDK mRNA25729387
D019772TopotecanTopotecan results in increased expression of MDK mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of MDK mRNA"19682533
D014212TretinoinTretinoin results in increased expression of MDK mRNA17138961|2372400
D014212TretinoinTretinoin results in increased expression of MDK mRNA16604517
D014212TretinoinTretinoin inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of MDK mRNA]12660332
C011559tributyltintributyltin results in increased expression of MDK mRNA27614199
D014241TrichloroethyleneTrichloroethylene results in increased expression of MDK mRNA14565619
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MDK mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of MDK mRNA19140230
D014635Valproic AcidValproic Acid results in increased methylation of MDK gene29154799
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of MDK mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of MDK mRNA28655636
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of MDK mRNA19244175
D014810Vitamin EVitamin E results in increased expression of MDK mRNA19244175
C088658zoledronic acidzoledronic acid promotes the reaction [Gossypol results in decreased expression of MDK mRNA]19825521

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008083growth factor activity-IBA21873635  
GO:0008083growth factor activity-NAS1639750  
GO:0008201heparin binding-IDA9384573  
GO ID GO Term Qualifier Evidence PubMed
GO:0001662behavioral fear response-IEA-  
GO:0007165signal transduction-NAS7835084  
GO:0007219Notch signaling pathway-TAS-  
GO:0007399nervous system development-NAS9384573  
GO:0007614short-term memory-IEA-  
GO:0009611response to wounding-ISS-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0016477cell migration-IEA-  
GO:0021542dentate gyrus development-IEA-  
GO:0021681cerebellar granular layer development-IEA-  
GO:0021987cerebral cortex development-IEA-  
GO:0030154cell differentiation-NAS1639750  
GO:0030325adrenal gland development-ISS-  
GO:0030421defecation-IEA-  
GO:0042493response to drug-IEA-  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IEA-  
GO:0050795regulation of behavior-IEA-  
GO:0051384response to glucocorticoid-IEA-  
GO:0051781positive regulation of cell division-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005737cytoplasm-IEA-  
GO:0042995cell projection-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-157118Signaling by NOTCHTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1980145Signaling by NOTCH2TAS
R-HSA-2979096NOTCH2 Activation and Transmission of Signal to the NucleusTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25888331A segregation index combining phenotypic (clinical characteristics) and genotypic (gene expression) biomarkers from a urine sample to triage out patients presenting with hematuria who have a low probability of urothelial carcinoma. (2015 Mar 27)Kavalieris LBMC Urol
18657127Impact of alcohol abuse on protein expression of midkine and excitatory amino acid transporter 1 in the human prefrontal cortex. (2008 Oct)Flatscher-Bader TAlcohol Clin Exp Res