Gene: MDM2

4193
ACTFS|HDMX|hdm2
MDM2 proto-oncogene
protein-coding
12q15
Ensembl:ENSG00000135679 MIM:164785 Vega:OTTHUMG00000142827 UniprotKB:Q00987
NG_016708.1
PubMed
ND|AD
47   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.716e-1 (AD)  6.381e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PGM30.868
UBXN40.861
RAB210.861
HOOK30.859
NUP540.854
CUL4A0.851
NUP430.851
MIER30.85
SAR1B0.85
COPB10.849

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.601
OR4F29-0.573
HMHB1-0.185
OR4F16-0.17
CMA1-0.16
MYZAP-0.14
STON1-GTF2A1L-0.139
EPPIN-0.137
SPRR2A-0.131
SPANXA2-0.127

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB02872Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]MethanoneSmall MoleculeExperimentalTarget
DB04144Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-MethanoneSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C02809810-hydroxycamptothecinMDM2 protein affects the susceptibility to 10-hydroxycamptothecin13130078
C0252051,10-phenanthroline"1,10-phenanthroline results in increased expression of MDM2 mRNA"19502547
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of MDM2 mRNA"26377693
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of MDM2 mRNA25596134
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MDM2 mRNA"23684557
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MDM2 protein"23684557
C0952841H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased expression of MDM2 protein"16288207
C0326681-nitropyrene1-nitropyrene results in increased expression of MDM2 mRNA10837373
C0326681-nitropyrene1-nitropyrene results in increased expression of MDM2 protein22044530
C0326681-nitropyrene1-nitropyrene results in increased expression of MDM2 protein modified form22044530
C0326681-nitropyrenenutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein]22044530
C0326681-nitropyrenenutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form]22044530
C0326681-nitropyreneTetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein]22044530
C0326681-nitropyreneTetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form]22044530
C0326681-nitropyreneTP53 affects the reaction [1-nitropyrene results in increased expression of MDM2 mRNA]10837373
C5411312,2',3,3',4,4',5-heptachlorobiphenyl"2,2',3,3',4,4',5-heptachlorobiphenyl results in increased phosphorylation of MDM2 protein"19751709
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased phosphorylation of MDM2 protein"19751709
C0329042,2',3,5',6-pentachlorobiphenyl"2,2',3,5',6-pentachlorobiphenyl results in increased phosphorylation of MDM2 protein"19751709
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MDM2 protein]25744307
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of MDM2 protein]28785074
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of MDM2 protein28785074
C4512192,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one"2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one results in increased expression of MDM2"21647879
C0104982,3,6,2',3',6'-hexachlorobiphenyl"2,3,6,2',3',6'-hexachlorobiphenyl results in increased phosphorylation of MDM2 protein"19751709
C0359762,4,2',4'-tetrachlorobiphenyl"2,4,2',4'-tetrachlorobiphenyl results in increased phosphorylation of MDM2 protein"19751709
C5411322,4,4',5-tetrachlorobiphenyl"2,4,4',5-tetrachlorobiphenyl results in increased phosphorylation of MDM2 protein"19751709
C0817662,4,4'-trichlorobiphenyl"2,4,4'-trichlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]"20840854
C0817662,4,4'-trichlorobiphenyl"2,4,4'-trichlorobiphenyl results in increased phosphorylation of MDM2 protein"19751709|2084085
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]"20840854
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of MDM2 protein"19751709|2084085
C0098282,4,5,2',5'-pentachlorobiphenyl"2,4,5,2',5'-pentachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]"20840854
C0098282,4,5,2',5'-pentachlorobiphenyl"2,4,5,2',5'-pentachlorobiphenyl results in increased phosphorylation of MDM2 protein"19751709|2084085
C0098282,4,5,2',5'-pentachlorobiphenyl"MDM2 mutant form inhibits the reaction [2,4,5,2',5'-pentachlorobiphenyl results in decreased phosphorylation of FOXO3 protein]"20840854
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MDM2 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased phosphorylation of MDM2 protein"19751709
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MDM2 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MDM2 protein"15635149
C5464602-amino-3-methyl-3H-imidazo(4,5-f)quinoline"2-amino-3-methyl-3H-imidazo(4,5-f)quinoline results in decreased expression of MDM2 mRNA"23810796
C0194992-nitrofluorene2-nitrofluorene results in increased expression of MDM2 mRNA14600272|1589037
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of MDM2 mRNA"12734338
C0163923,3'-diindolylmethane"3,3'-diindolylmethane analog results in decreased expression of MDM2 mRNA"26593444
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]"20840854
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of MDM2 protein"19751709|2084085
C0230353,4,5,3',4'-pentachlorobiphenyl"MDM2 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased phosphorylation of FOXO3 protein]"20840854
C0454213,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine"3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine results in increased expression of MDM2 mRNA"23810796
C5016343-(4-chlorophenyl)-3-(4-hydroxy-3,5-dimethoxybenzyloxy)-2-propyl-2,3-dihydroisoindol-1-one"3-(4-chlorophenyl)-3-(4-hydroxy-3,5-dimethoxybenzyloxy)-2-propyl-2,3-dihydroisoindol-1-one results in decreased activity of [MDM2 protein binds to TP53 protein]"21314128
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of MDM2 mRNA16788091
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MDM2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA"27188386
C5080854'-demethyldesoxypodophyllotoxin4'-demethyldesoxypodophyllotoxin analog results in increased cleavage of MDM2 protein25446499
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MDM2 mRNA14600272|1589037
C4718436-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine results in decreased expression of MDM2 protein15958644
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA"27188386
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in decreased expression of MDM2 protein"19936915
D000082AcetaminophenAcetaminophen results in decreased expression of MDM2 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of MDM2 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of MDM2 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of MDM2 mRNA26056430
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA]17585979
D000082AcetaminophenAcetaminophen promotes the reaction [MDM2 protein binds to TP53 protein]16330492
D000082AcetaminophenAcetaminophen results in decreased expression of MDM2 mRNA21807079
D000082AcetaminophenAcetaminophen results in increased expression of MDM2 mRNA17202762
D000082AcetaminophenAcetaminophen results in increased phosphorylation of MDM2 protein16330492
C106812adefovir dipivoxiladefovir dipivoxil results in increased expression of MDM2 mRNA25596134
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MDM2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MDM2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MDM2 mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MDM2 mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MDM2 mRNA14600272|1589037
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Oxygen deficiency results in increased expression of MDM2 mRNA]]19578757
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA]19578757
C067527aluminum maltolatealuminum maltolate results in increased expression of MDM2 mRNA15537749
C077990alvocidibalvocidib results in decreased expression of MDM2 mRNA12589031
C077990alvocidibalvocidib results in decreased expression of MDM2 protein12589031
D004999AmifostineAmifostine results in decreased expression of MDM2 mRNA14555708
D009762o-Aminoazotolueneo-Aminoazotoluene results in increased expression of MDM2 mRNA15346788
D006710HomocysteineHomocysteine results in decreased expression of MDM2 mRNA17326132
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of MDM2 mRNA12420312
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of MDM2 protein16483693
D000677AmsacrineMDM2 promoter SNP results in decreased susceptibility to Amsacrine17575151
D000732AndrostanolsAndrostanols inhibits the reaction [DDT results in increased expression of MDM2 mRNA]23684557
D001151ArsenicArsenic affects the methylation of MDM2 gene25304211
D001151ArsenicMDM2 SNP affects the susceptibility to Arsenic21982800
C006632arsenic trioxidearsenic trioxide results in decreased expression of MDM2 mRNA20458559
C006632arsenic trioxidearsenic trioxide results in increased expression of MDM2 mRNA20862710|2557460
C006632arsenic trioxidearsenic trioxide results in decreased expression of MDM2 mRNA21145380
C006632arsenic trioxidearsenic trioxide results in increased expression of MDM2 mRNA17487067
C006632arsenic trioxidepifithrin inhibits the reaction [arsenic trioxide results in increased expression of MDM2 mRNA]17487067
C015001arsenite[[[arsenite results in increased activity of PRKDC protein] which results in increased phosphorylation of and results in increased activity of MAPK9 protein] promotes the reaction [MAPK9 protein binds to TP53 protein]] inhibits the reaction [MDM2 results in increased degradation of and results in decreased stability of TP53 protein]22366412
D017636Asbestos, Amphibole"Asbestos, Amphibole results in decreased expression of MDM2 protein"20855422
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of MDM2 protein]21262251
D001241AspirinAspirin results in decreased expression of MDM2 mRNA20457246
D001374AzacitidineAzacitidine results in increased expression of MDM2 mRNA20823114
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MDM2 mRNA27858113
D001554BenzeneMDM2 gene polymorphism affects the reaction [CDKN2A gene polymorphism affects the susceptibility to Benzene]19596022
D001554BenzeneBenzene results in increased expression of MDM2 mRNA11896287|1534293
D001554BenzeneTRP53 protein affects the reaction [Benzene results in increased expression of MDM2 mRNA]11896287
D001554Benzene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of MDM2 mRNA17905399
C072019benzo(a)pyrene diolepoxide Ibenzo(a)pyrene diolepoxide I results in increased expression of MDM2 mRNA27694624
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MDM2 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of MDM2 mRNA26377693
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased phosphorylation of MDM2 protein26558467
D001564Benzo(a)pyrene"2,4,4'-trichlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]"20840854
D001564Benzo(a)pyrene"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]"20840854
D001564Benzo(a)pyrene"2,4,5,2',5'-pentachlorobiphenyl inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]"20840854
D001564Benzo(a)pyrene"3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]"20840854
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of MDM2 mRNA17690111
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [TP53 protein binds to MDM2 protein]15625077
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of and results in increased phosphorylation of MDM2 protein18096571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MDM2 mRNA10837373|1841887
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MDM2 protein22044530
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MDM2 protein modified form22044530
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased phosphorylation of MDM2 protein20840854|2574430
D001564Benzo(a)pyreneCadmium Chloride affects the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]25744307
D001564Benzo(a)pyreneMAPK3 mutant form inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]20840854
D001564Benzo(a)pyreneMDM2 mutant form promotes the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]20840854
D001564Benzo(a)pyreneSimvastatin promotes the reaction [Benzo(a)pyrene promotes the reaction [TP53 protein binds to MDM2 protein]]15625077
D001564Benzo(a)pyreneTP53 affects the reaction [Benzo(a)pyrene results in increased expression of MDM2 mRNA]10837373
D001564Benzo(a)pyreneU 0126 inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]20840854
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MDM2 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MDM2 mRNA18656336|1914693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MDM2 protein21467743
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of MDM2 mRNA"20382639|2623829
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]]17575151
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MDM2 mRNA20061341
D004958EstradiolEstradiol results in decreased expression of MDM2 mRNA24349563
D004958Estradiol[Estradiol co-treated with Parathion] results in increased expression of MDM2 mRNA17622325
D004958EstradiolEstradiol results in increased expression of MDM2 mRNA alternative form12168835
D004958EstradiolEstradiol results in increased expression of MDM2 protein12168835
D004958EstradiolEstradiol results in decreased phosphorylation of MDM2 protein22314386
D004958EstradiolEstradiol results in increased expression of MDM2 mRNA23684557
D004958EstradiolEstradiol results in increased expression of MDM2 protein23684557
C006780bisphenol Abisphenol A affects the expression of MDM2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of MDM2 mRNA29275510
C006780bisphenol Abisphenol A results in increased phosphorylation of MDM2 protein24831732
C006780bisphenol ACurcumin inhibits the reaction [bisphenol A results in increased phosphorylation of MDM2 protein]24831732
C006780bisphenol Abisphenol A results in increased expression of MDM2 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of MDM2 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of MDM2 mRNA26982218
D000069286BortezomibBortezomib affects the expression of MDM2 protein12393500
D000069286BortezomibBortezomib promotes the reaction [TP53 protein binds to MDM2 protein]12393500
D000069286BortezomibBortezomib results in increased cleavage of MDM2 protein12393500
D000069286Bortezomib[CASP8 protein results in increased activity of CASP3 protein] affects the reaction [Bortezomib results in increased cleavage of MDM2 protein]12393500
C023623brassinolidebrassinolide results in decreased expression of MDM2 protein20833159
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of MDM2 mRNA27509014
D002101Cacodylic Acid[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of MDM2 mRNA23192986
D002101Cacodylic AcidCacodylic Acid results in increased expression of MDM2 mRNA17481689
D002104CadmiumCadmium results in increased expression of MDM2 mRNA22666406
D002104CadmiumCadmium results in decreased expression of MDM2 mRNA21467746
C028031cadmium acetatecadmium acetate results in increased expression of MDM2 protein15450950
D019256Cadmium Chloride2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MDM2 protein]25744307
D019256Cadmium ChlorideCadmium Chloride affects the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]25744307
D019256Cadmium ChlorideCadmium Chloride affects the reaction [Etoposide results in increased phosphorylation of MDM2 protein]25744307
D019256Cadmium ChlorideCadmium Chloride affects the reaction [Fluorouracil results in increased phosphorylation of MDM2 protein]25744307
D019256Cadmium ChlorideCadmium Chloride results in increased phosphorylation of MDM2 protein25744307
D019256Cadmium ChlorideCadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in increased expression of MDM2 protein]12135628
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MDM2 mRNA11958953|2006134
D019256Cadmium ChlorideCadmium Chloride results in increased phosphorylation of MDM2 protein20525538|2231438
D019256Cadmium ChlorideMT1 affects the reaction [Cadmium Chloride results in increased expression of MDM2 mRNA]11958953
D019256Cadmium ChlorideMT2 affects the reaction [Cadmium Chloride results in increased expression of MDM2 mRNA]11958953
D019256Cadmium ChlorideCadmium Chloride affects the expression of MDM2 mRNA22110744
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MDM2 mRNA23405080
D002166CamptothecinCamptothecin results in increased expression of MDM2 protein17555331
D002211CapsaicinCapsaicin promotes the reaction [resveratrol results in decreased expression of MDM2 protein]19846903
D002211CapsaicinCapsaicin results in decreased expression of MDM2 protein19846903
D002211CapsaicinCapsaicin results in increased expression of MDM2 mRNA19502594
D002211Capsaicinresveratrol promotes the reaction [Capsaicin results in decreased expression of MDM2 protein]19846903
D002211CapsaicinTP53 affects the reaction [Capsaicin results in decreased expression of MDM2 protein]19846903
D002218CarbadoxCarbadox results in increased expression of MDM2 mRNA26558467
D002220CarbamazepineCarbamazepine affects the expression of MDM2 mRNA25979313
C006698carbendazimcarbendazim results in decreased expression of MDM2 mRNA26055223
C006698carbendazimcarbendazim results in increased expression of MDM2 mRNA25304545
D002259Carbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneCarbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of MDM2 mRNA16039398
D002392CatechinCatechin results in decreased expression of MDM2 mRNA23706674
D002699ChlorambucilChlorambucil results in increased expression of MDM2 mRNA17476690
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of MDM2 mRNA25596134
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of MDM2 mRNA26272509
D002737ChloropreneChloroprene results in increased expression of MDM2 mRNA23125180
D002746ChlorpromazineChlorpromazine results in increased expression of MDM2 mRNA25596134
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MDM2 gene20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MDM2 mRNA27858113
C059262cidofovircidofovir affects the expression of MDM2 mRNA25596134
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of MDM2 mRNA19000754
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA]17585979
D003035CobaltCobalt results in increased expression of MDM2 mRNA24068677
D003035CobaltTP53 protein affects the reaction [Cobalt results in increased expression of MDM2 mRNA]24068677
C018021cobaltous chloridecobaltous chloride results in increased expression of MDM2 protein19714248
C018021cobaltous chlorideMDM2 protein promotes the reaction [cobaltous chloride inhibits the reaction [HIPK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]]]19714248
C018021cobaltous chloridecobaltous chloride results in increased expression of MDM2 mRNA24386269
D003300CopperCopper results in increased expression of MDM2 mRNA16629173
C024015cryptolepinecryptolepine results in increased expression of MDM2 mRNA16120219
C024015cryptolepinecryptolepine results in increased expression of MDM2 protein16120219
D003474CurcuminCurcumin analog results in increased expression of MDM2 mRNA26409325
D003474CurcuminCurcumin inhibits the reaction [bisphenol A results in increased phosphorylation of MDM2 protein]24831732
D003474CurcuminCurcumin results in decreased expression of MDM2 mRNA17332326
D003474CurcuminCurcumin results in decreased expression of MDM2 protein17332326
D003474Curcumin[Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA17332326
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of MDM2 mRNA28414124
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of MDM2 protein28414124
D016572CyclosporineCyclosporine results in increased expression of MDM2 mRNA20106945|2556210
C089595cylindrospermopsincylindrospermopsin results in increased expression of MDM2 mRNA21607682
C093628cyproconazole[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of MDM2 mRNA29038839
C093628cyproconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of MDM2 mRNA29038839
D003634DDTAndrostanols inhibits the reaction [DDT results in increased expression of MDM2 mRNA]23684557
D003634DDTDDT results in increased expression of MDM2 mRNA23684557
D003634DDTDDT results in increased expression of MDM2 protein23684557
C014347decitabinedecitabine affects the expression of MDM2 mRNA17145863
D013759DronabinolDronabinol results in increased expression of MDM2 protein19819240
D003703DemecolcineDemecolcine results in increased expression of MDM2 mRNA23649840
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of MDM2 protein24415872
C042577diallyl trisulfidediallyl trisulfide results in increased degradation of MDM2 protein23754639
D003976DiazinonDiazinon affects the expression of MDM2 mRNA22546817
D002945CisplatinCisplatin promotes the reaction [TP53 protein binds to MDM2 promoter]21552291
D002945CisplatinCisplatin promotes the reaction [TP53 protein results in increased expression of MDM2]21552291
D002945CisplatinCisplatin results in increased activity of and results in increased expression of MDM2 protein21624110
D002945CisplatinCisplatin results in increased expression of MDM2 mRNA24280081|2545074
D002945CisplatinCisplatin results in increased expression of MDM2 protein16797627
D002945Cisplatinnutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of MDM2 protein]21624110
D002945CisplatinTP53 affects the reaction [Cisplatin results in increased activity of and results in increased expression of MDM2 protein]21624110
D002945CisplatinTP53 affects the reaction [nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of MDM2 protein]]21624110
D002945Cisplatin[TP53 protein binds to MDM2 protein] which results in decreased susceptibility to Cisplatin21509038
D002945CisplatinCisplatin promotes the reaction [TRP53 protein results in increased expression of MDM2]21552291
D002945CisplatinCisplatin results in increased expression of MDM2 mRNA21151649|2428008
D002945CisplatinCisplatin results in increased expression of MDM2 mRNA24880025
D004008DiclofenacDiclofenac results in decreased expression of MDM2 mRNA17202759
D004026DieldrinDieldrin affects the expression of MDM2 mRNA22546817
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of MDM2 mRNA17854601|1910086
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of MDM2 protein18506893
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MDM2 mRNA]17854601
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of MDM2 protein11003613
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MDM2 mRNA18544905
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of MDM2 mRNA14555611|1545901
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of MDM2 protein14555611
D004054DiethylstilbestrolDiethylstilbestrol affects the mutagenesis of MDM2 gene7916985
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of MDM2 mRNA21041162
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of MDM2 mRNA15545218
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of MDM2 mRNA15890375
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA"23717041
D0151279,10-Dimethyl-1,2-benzanthracene"[epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA]"23717041
D0151279,10-Dimethyl-1,2-benzanthracene"[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA]"23717041
D0151279,10-Dimethyl-1,2-benzanthracene"theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA]"23717041
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of MDM2 mRNA14600272|1589037
C067311docetaxeldocetaxel results in increased expression of MDM2 protein16080190|1679762
D004317DoxorubicinDoxorubicin affects the expression of MDM2 mRNA25529476
D004317DoxorubicinDoxorubicin inhibits the reaction [TP53 protein binds to MDM2 protein]19351845
D004317DoxorubicinDoxorubicin results in increased activity of and results in increased expression of MDM2 protein21624110
D004317DoxorubicinDoxorubicin results in increased expression of MDM2 mRNA26317544
D004317DoxorubicinDoxorubicin results in increased expression of MDM2 protein14665630|1765308
D004317DoxorubicinDoxorubicin results in increased phosphorylation of MDM2 protein17935137
D004317DoxorubicinIFNA1 protein promotes the reaction [Doxorubicin results in increased expression of MDM2 protein]17959036
D004317DoxorubicinMDM2 protein inhibits the reaction [HIPK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]]19714248
D004317DoxorubicinMDM2 protein promotes the reaction [cobaltous chloride inhibits the reaction [HIPK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein]]]19714248
D004317DoxorubicinMDM2 protein results in decreased susceptibility to Doxorubicin26317544
D004317Doxorubicinnutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of MDM2 protein]21624110
D004317DoxorubicinSETD7 mutant form promotes the reaction [Doxorubicin results in increased expression of MDM2 mRNA]26317544
D004317DoxorubicinSETD7 mutant form promotes the reaction [Doxorubicin results in increased expression of MDM2 protein]26317544
D004317DoxorubicinTP53 affects the reaction [Doxorubicin results in increased activity of and results in increased expression of MDM2 protein]21624110
D004317DoxorubicinTP53 affects the reaction [nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of MDM2 protein]]21624110
D004317Doxorubicinwortmannin promotes the reaction [Doxorubicin results in increased phosphorylation of MDM2 protein]17935137
D004317DoxorubicinDoxorubicin results in increased expression of MDM2 mRNA14766674|1694905
D004317Doxorubicinpifithrin inhibits the reaction [Doxorubicin results in increased expression of MDM2 mRNA]14766674
D004317DoxorubicinDoxorubicin results in increased expression of MDM2 mRNA12187937|2725538
C509867E804 bisindoleE804 bisindole inhibits the reaction [Lipopolysaccharides results in increased expression of MDM2 mRNA]23107598
C509867E804 bisindoleE804 bisindole results in increased expression of MDM2 mRNA23107598
C034192ellipticineMDM2 promoter SNP results in decreased susceptibility to ellipticine17575151
C045651epigallocatechin gallate"[epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA]"23717041
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of MDM2 mRNA29038839
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of MDM2 mRNA29038839
C109476epoxiconazoleepoxiconazole results in increased expression of MDM2 mRNA29038839
C007366erythritol anhydrideerythritol anhydride inhibits the reaction [TP53 protein binds to MDM2 protein]20024960
D000431EthanolEthanol results in decreased expression of MDM2 mRNA22535522
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MDM2 mRNA17606305
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MDM2 mRNA alternative form12168835
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MDM2 protein12168835
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MDM2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MDM2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDM2 mRNA17942748
C002994ethylene dimethanesulfonateethylene dimethanesulfonate results in increased expression of MDM2 mRNA22711419
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MDM2 mRNA23649840
D005038EthylnitrosoureaEthylnitrosourea results in increased expression of MDM2 mRNA19100860
D005038EthylnitrosoureaEthylnitrosourea results in increased expression of MDM2 mRNA15954086
D005047Etoposidebenzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]]17575151
D005047EtoposideCadmium Chloride affects the reaction [Etoposide results in increased phosphorylation of MDM2 protein]25744307
D005047EtoposideEtoposide promotes the reaction [MDM2 protein binds to TOP2A protein]17575151
D005047EtoposideEtoposide results in decreased expression of MDM2 protein26259609
D005047EtoposideEtoposide results in increased expression of MDM2 mRNA16120219
D005047EtoposideEtoposide results in increased expression of MDM2 protein16120219|1809657
D005047EtoposideEtoposide results in increased phosphorylation of MDM2 protein17935137|2574430
D005047EtoposideMDM2 promoter SNP results in decreased susceptibility to Etoposide17575151
D005047Etoposidewortmannin promotes the reaction [Etoposide results in increased phosphorylation of MDM2 protein]17935137
D005047EtoposideEtoposide results in increased expression of MDM2 protein15459018
D005047EtoposideTetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased expression of MDM2 protein]15459018
C433928EUK-134EUK-134 inhibits the reaction [Hydrogen Peroxide results in decreased expression of MDM2 protein]25005833
C433928EUK-134EUK-134 inhibits the reaction [Vitamin K 3 results in decreased expression of MDM2 protein]25005833
D005273FenbendazoleFenbendazole results in increased expression of MDM2 mRNA23411599
D011345FenofibrateFenofibrate results in decreased expression of MDM2 mRNA25596134
C082360fipronilfipronil results in increased expression of MDM2 mRNA23962444
D005411Flame RetardantsFlame Retardants results in decreased expression of MDM2 mRNA19356805
D005411Flame RetardantsFlame Retardants results in increased expression of MDM2 mRNA26808241
D044950FlavanonesFlavanones results in increased phosphorylation of MDM2 protein21616090
C007738fluoranthene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of MDM2 mRNA17690111
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of MDM2 mRNA21607683
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of MDM2 mRNA19167416|2221319
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of MDM2 protein19167416
D0150732-Acetylaminofluorene[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of MDM2 protein11003613
D005437FlucytosineFlucytosine results in increased expression of MDM2 protein15592511
D005472FluorouracilCadmium Chloride affects the reaction [Fluorouracil results in increased phosphorylation of MDM2 protein]25744307
D005472Fluorouracil"Fluorouracil promotes the reaction [N(1),N(11)-diethylnorspermine results in increased expression of MDM2 protein]"15546879
D005472FluorouracilFluorouracil results in increased expression of MDM2 mRNA14665630|1655759
D005472FluorouracilFluorouracil results in increased expression of MDM2 protein14665630|1554687
D005472FluorouracilFluorouracil results in increased phosphorylation of MDM2 protein25744307
D005472Fluorouracil"TP53 protein promotes the reaction [Fluorouracil promotes the reaction [N(1),N(11)-diethylnorspermine results in increased expression of MDM2 protein]]"15546879
D005472FluorouracilTP53 protein promotes the reaction [Fluorouracil results in increased expression of MDM2 mRNA]17982676
D005472FluorouracilTP53 protein promotes the reaction [Fluorouracil results in increased expression of MDM2 protein]15546879
D005472FluorouracilFluorouracil results in increased expression of MDM2 mRNA16949053
D005485FlutamideFlutamide results in increased expression of MDM2 mRNA24136188
D005492Folic AcidFolic Acid affects the expression of MDM2 mRNA16361273
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MDM2 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of MDM2 mRNA18045764|2364984
D005557FormaldehydeFormaldehyde results in increased expression of MDM2 protein18045764
D005557FormaldehydeFormaldehyde results in increased expression of MDM2 mRNA18045764
D005557FormaldehydeFormaldehyde results in increased expression of MDM2 protein18045764
C007768formononetinformononetin results in increased expression of MDM2 protein28414026
D005620Freund's Adjuvant[Urethane co-treated with Freund's Adjuvant] results in increased expression of MDM2 mRNA12400877
C056933fumonisin B1fumonisin B1 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA]18206046
C056933fumonisin B1fumonisin B1 inhibits the reaction [AGT protein results in increased expression of MDM2 protein]18206046
C039281furanfuran results in increased expression of MDM2 mRNA22079235
D005665FurosemideFurosemide affects the expression of MDM2 mRNA17497460
D015774GanciclovirGanciclovir results in increased expression of MDM2 protein15592511
C001277geldanamycingeldanamycin results in increased expression of MDM2 mRNA26705709
C056507gemcitabinegemcitabine results in decreased expression of MDM2 mRNA20103597
C056507gemcitabinegemcitabine results in increased expression of MDM2 mRNA17039268
D019833GenisteinGenistein results in decreased expression of MDM2 mRNA21048042
D005839GentamicinsGentamicins results in increased expression of MDM2 mRNA22061828
C103280goniothalamingoniothalamin results in increased expression of MDM2 protein20498002
C425931GW 501516MDM2 protein inhibits the reaction [GW 501516 results in increased activity of PPARB protein]19103650
C500810GW8510GW8510 results in decreased phosphorylation of MDM2 protein22242153
C500810GW8510GW8510 results in increased expression of MDM2 mRNA22242153
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers results in increased expression of MDM2 mRNA26808241
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of MDM2 mRNA19356805
C070164homocastasteronehomocastasterone results in decreased expression of MDM2 protein20833159
D017313FenretinideFenretinide results in decreased expression of MDM2 mRNA16570282
D017313FenretinideFenretinide results in increased expression of MDM2 mRNA28973697
D006861Hydrogen PeroxideEUK-134 inhibits the reaction [Hydrogen Peroxide results in decreased expression of MDM2 protein]25005833
D006861Hydrogen Peroxide"Hydrogen Peroxide inhibits the reaction [N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of MDM2 protein]"25005833
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [TP53 protein binds to MDM2 promoter]21552291
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [TP53 protein results in increased expression of MDM2]21552291
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of MDM2 protein25005833
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [TRP53 protein results in increased expression of MDM2]21552291
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of and affects the localization of MDM2 protein14689451
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of MDM2 mRNA14689451|2752527
D006861Hydrogen PeroxideLuteolin promotes the reaction [Hydrogen Peroxide results in increased expression of MDM2 mRNA]27525270
D006861Hydrogen Peroxide[Quercetin co-treated with Hydrogen Peroxide] results in increased expression of MDM2 mRNA27525270
D006918HydroxyureaHydroxyurea results in increased expression of MDM2 mRNA18647660
D006918HydroxyureaHydroxyurea affects the expression of MDM2 protein16356682
D006918HydroxyureaHydroxyurea results in increased expression of MDM2 mRNA16356682
C411652IC 261IC 261 affects the expression of MDM2 protein16027726
D007069IfosfamideIfosfamide results in increased expression of MDM2 mRNA25596134
D007069IfosfamideMDM2 mRNA results in decreased susceptibility to Ifosfamide15736417
D007069IfosfamideMDM2 protein results in decreased susceptibility to Ifosfamide15736417
D007213IndomethacinIndomethacin results in decreased expression of MDM2 mRNA28201806
C051890irinotecanirinotecan metabolite results in increased expression of MDM2 mRNA15956246
C051890irinotecanirinotecan results in increased expression of MDM2 mRNA15956246
D007530IsofluraneIsoflurane results in decreased expression of MDM2 mRNA16978161
C544151jinfukangjinfukang results in decreased expression of MDM2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MDM2 mRNA23129625
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MDM2 protein23430699
C561695(+)-JQ1 compoundMDM2 protein results in decreased susceptibility to (+)-JQ1 compound23430699
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MDM2 protein23430699
C410337K 7174K 7174 results in increased expression of MDM2 mRNA24086573
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MDM2 mRNA18544905
C045463leflunomideleflunomide results in increased expression of MDM2 mRNA28988120
C038753leptomycin Bleptomycin B results in increased expression of MDM2 mRNA20803015
C015320leucomalachite greenleucomalachite green results in increased phosphorylation of MDM2 protein26558467
C533894LG 100815LG 100815 results in increased expression of MDM2 mRNA16951191
C018584linaloollinalool results in increased expression of MDM2 mRNA19922762
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MDM2 mRNA"18930950
D008070LipopolysaccharidesE804 bisindole inhibits the reaction [Lipopolysaccharides results in increased expression of MDM2 mRNA]23107598
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MDM2 mRNA10975854|2310759
C010480lupeollupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA]27235710
D047311LuteolinLuteolin promotes the reaction [Hydrogen Peroxide results in increased expression of MDM2 mRNA]27525270
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of MDM2 mRNA26378955
C013099mancozeblupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA]27235710
C013099mancozebmancozeb results in increased expression of MDM2 mRNA27235710
D008345Manganese[Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein25791630
D008345ManganeseManganese results in decreased expression of MDM2 protein25791630
D008345ManganesePPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein]25791630
C042720mercuric bromidemercuric bromide results in increased expression of MDM2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of MDM2 mRNA23202902
D008687MetforminMetformin results in increased expression of MDM2 mRNA25596134
D008701MethapyrileneMethapyrilene results in decreased expression of MDM2 mRNA22584684
D008701MethapyrileneMethapyrilene results in increased expression of MDM2 mRNA15890375|1861972
D008701MethapyrileneMethapyrilene results in increased phosphorylation of MDM2 protein26558467
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MDM2 gene20938992
D008727MethotrexateMethotrexate results in increased activity of and results in increased expression of MDM2 protein21624110
D008727MethotrexateMethotrexate results in increased expression of MDM2 mRNA21678067|2444957
D008727MethotrexateMethotrexate results in increased expression of MDM2 protein17637740
D008727Methotrexatenutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of MDM2 protein]21624110
D008727MethotrexateTP53 affects the reaction [Methotrexate results in increased activity of and results in increased expression of MDM2 protein]21624110
D008727MethotrexateTP53 affects the reaction [nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of MDM2 protein]]21624110
D008727MethotrexateMethotrexate affects the expression of MDM2 mRNA18502557
C042405methyl caffeatemethyl caffeate binds to MDM2 protein26415618
C005223methyleugenolmethyleugenol results in increased expression of MDM2 mRNA26011634
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MDM2 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MDM2 mRNA23202902
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of MDM2 mRNA20153410
C030957methylmercury II[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of MDM2 mRNA17905399
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MDM2 mRNA23649840
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MDM2 protein25078064
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of MDM2 mRNA12634122
D008769MethylnitronitrosoguanidineCadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in increased expression of MDM2 protein]12135628
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of MDM2 protein12135628
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of MDM2 mRNA28688903
C008480methylparaoxonmethylparaoxon results in increased expression of MDM2 mRNA18418871
D008743Methyl ParathionMethyl Parathion results in increased expression of MDM2 mRNA18418871
C574930MI-219MI-219 results in decreased activity of [MDM2 protein binds to TP53 protein]21314128
D015735MifepristoneMifepristone results in increased expression of MDM2 mRNA12605714
D016685MitomycinMitomycin results in increased expression of MDM2 protein18096571
D016685Mitomycin[Mitomycin results in increased stability of TP53 protein] which results in increased expression of MDM2 mRNA20536192
D016685MitomycinMitomycin results in increased expression of MDM2 mRNA25270620
D008942MitoxantroneMDM2 promoter SNP results in decreased susceptibility to Mitoxantrone17575151
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of MDM2 protein24706461
D016686Monocrotaline[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA21224054
C020300monomethylarsonic acid[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of MDM2 mRNA23192986
C020300monomethylarsonic acidmonomethylarsonic acid results in increased expression of MDM2 mRNA17481689
C437683motexafin gadoliniummotexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MDM2 mRNA]16357179
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of MDM2 mRNA16357179
D009151Mustard GasMustard Gas results in increased expression of MDM2 mRNA15674843|1895507
D009151Mustard GasMustard Gas affects the expression of MDM2 mRNA15651846
C059685N(1),N(11)-diethylnorspermine"Fluorouracil promotes the reaction [N(1),N(11)-diethylnorspermine results in increased expression of MDM2 protein]"15546879
C059685N(1),N(11)-diethylnorspermine"N(1),N(11)-diethylnorspermine results in increased expression of MDM2 protein"15546879
C059685N(1),N(11)-diethylnorspermine"TP53 protein promotes the reaction [Fluorouracil promotes the reaction [N(1),N(11)-diethylnorspermine results in increased expression of MDM2 protein]]"15546879
C059685N(1),N(11)-diethylnorspermine"TP53 protein promotes the reaction [N(1),N(11)-diethylnorspermine results in increased expression of MDM2 protein]"15546879
C554954N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochlorideN-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride results in increased expression of MDM2 mRNA28174063
C064769N-acetylsphingosineN-acetylsphingosine results in decreased expression of MDM2 mRNA18206046
C064769N-acetylsphingosineN-acetylsphingosine results in decreased expression of MDM2 protein18206046
C051752nefazodonenefazodone results in increased expression of MDM2 mRNA24136188
D009532NickelNickel results in increased expression of MDM2 mRNA24068677
D009532NickelTP53 protein affects the reaction [Nickel results in increased expression of MDM2 mRNA]24068677
C022838nickel chloridenickel chloride results in increased expression of MDM2 mRNA23566959|2855277
C022838nickel chlorideTP53 protein affects the reaction [nickel chloride results in increased expression of MDM2 mRNA]23566959
C022838nickel chloridenickel chloride affects the expression of MDM2 mRNA22546817
C012655nimesulidenimesulide results in increased expression of MDM2 mRNA24136188
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"Hydrogen Peroxide inhibits the reaction [N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of MDM2 protein]"25005833
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of MDM2 protein"25005833
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of MDM2 mRNA19716841
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of MDM2 protein14587038
C118989NSC 652287NSC 652287 results in increased expression of MDM2 mRNA21109480
C118989NSC 652287NSC 652287 results in increased expression of MDM2 protein21109480
C118989NSC 652287TP53 protein affects the reaction [NSC 652287 results in increased expression of MDM2 mRNA]21109480
C118989NSC 652287TP53 protein promotes the reaction [NSC 652287 results in increased expression of MDM2 protein]21109480
C482205nutlin 3nutlin 3 inhibits the reaction [TP53 protein binds to MDM2 protein]21509038|2226086
C482205nutlin 3[nutlin 3 inhibits the reaction [TP53 protein binds to MDM2 protein]] which results in increased activity of TP53 protein21509038
C482205nutlin 3nutlin 3 inhibits the reaction [TP73 binds to MDM2]20422343
C482205nutlin 3nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of MDM2 protein]21624110
C482205nutlin 3nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of MDM2 protein]21624110
C482205nutlin 3nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of MDM2 protein]21624110
C482205nutlin 3nutlin 3 results in increased activity of and results in increased expression of MDM2 protein21624110
C482205nutlin 3nutlin 3 results in increased expression of MDM2 mRNA21109480
C482205nutlin 3nutlin 3 results in increased expression of MDM2 protein16014563|1643968
C482205nutlin 3nutlin 3 results in increased expression of MDM2 protein modified form22044530
C482205nutlin 3nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein]22044530
C482205nutlin 3nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form]22044530
C482205nutlin 3TP53 affects the reaction [nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of MDM2 protein]]21624110
C482205nutlin 3TP53 affects the reaction [nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of MDM2 protein]]21624110
C482205nutlin 3TP53 affects the reaction [nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of MDM2 protein]]21624110
C482205nutlin 3TP53 affects the reaction [nutlin 3 results in increased activity of and results in increased expression of MDM2 protein]21624110
C482205nutlin 3TP53 protein affects the reaction [nutlin 3 results in increased expression of MDM2 protein]16439685
C482205nutlin 3TP53 protein promotes the reaction [nutlin 3 results in increased expression of MDM2 mRNA]21109480
C482205nutlin 3TP53 protein promotes the reaction [nutlin 3 results in increased expression of MDM2 protein]21109480
C482205nutlin 3nutlin 3 results in increased expression of MDM2 mRNA16949053
C482205nutlin 3nutlin 3 binds to and results in decreased activity of MDM2 protein16014563|2162411
C482205nutlin 3nutlin 3 binds to MDM2 protein22260869
C482205nutlin 3nutlin 3 inhibits the reaction [MDM2 protein binds to TP53 protein]16014563
C482205nutlin 3nutlin 3 inhibits the reaction [TP53 protein binds to MDM2 protein]22260869
C482205nutlin 3nutlin 3 results in decreased activity of MDM2 protein22044530
C482205nutlin 3nutlin 3 results in decreased activity of [MDM2 protein binds to TP53 protein]21314128
C042670N-vinyl-2-pyrrolidinone[N-vinyl-2-pyrrolidinone binds to N-vinyl-2-pyrrolidinone] which affects the expression of MDM2 mRNA22037397
C025589ochratoxin Aochratoxin A results in increased expression of MDM2 mRNA23358140
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of MDM2 mRNA"16951191
C475587olomoucine IIolomoucine II promotes the reaction [RPL11 protein binds to and results in decreased activity of MDM2 protein]16003486
C016340o,p'-DDT"o,p'-DDT affects the expression of MDM2 mRNA"18925944
D009942Organometallic CompoundsOrganometallic Compounds results in decreased expression of MDM2 protein17210701
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of MDM2 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of MDM2 mRNA25729387
C011030oxfendazoleoxfendazole results in decreased phosphorylation of MDM2 protein26558467
C011030oxfendazoleoxfendazole results in increased expression of MDM2 mRNA26558467
D010100Oxygenalpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Oxygen deficiency results in increased expression of MDM2 mRNA]]19578757
D010100OxygenOxygen deficiency results in increased expression of MDM2 mRNA19502547|1957875
D010100OxygenOxygen deficiency results in increased expression of MDM2 protein19578757|1971424
D010100OxygenTetrachlorodibenzodioxin promotes the reaction [Oxygen deficiency results in increased expression of MDM2 mRNA]19578757
D010100OxygenTetrachlorodibenzodioxin promotes the reaction [Oxygen deficiency results in increased expression of MDM2 protein]19578757
D017239PaclitaxelMDM2 protein results in decreased susceptibility to Paclitaxel13130078
D010269ParaquatParaquat results in increased expression of MDM2 mRNA20883675
D010269ParaquatGPX1 protein affects the reaction [Paraquat affects the expression of MDM2 mRNA]12654481
D010278Parathion[Estradiol co-treated with Parathion] results in increased expression of MDM2 mRNA17622325
D052638Particulate Matter[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of MDM2 protein28013216
D052638Particulate Matter[[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of MDM2 protein] which results in increased expression of TP53 protein28013216
D052638Particulate Matter[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of MDM2 protein28013216
C410127PCB 180PCB 180 results in decreased expression of MDM2 mRNA21703328
C073402PD 123319PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA]18206046
C073402PD 123319PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 protein]18206046
D010416PentachlorophenolPentachlorophenol results in increased expression of MDM2 mRNA23892564
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of MDM2 mRNA23602845
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MDM2 mRNA19162173
C011272perfosfamideperfosfamide results in increased expression of MDM218034189
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of MDM2 mRNA17097637
D010634PhenobarbitalPhenobarbital results in increased phosphorylation of MDM2 protein19751709
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of MDM2 mRNA]19482888
D010634PhenobarbitalNR1I3 protein promotes the reaction [Phenobarbital results in increased expression of MDM2 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of MDM2 mRNA19482888|2081699
D010634PhenobarbitalPhenobarbital results in increased expression of MDM2 mRNA25145657
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MDM2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MDM2 mRNA26272509
D010672Phenytoin[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA21224054
D010695PhlorhizinPhlorhizin results in decreased expression of MDM2 mRNA22538082
C030090phosphoramide mustardphosphoramide mustard results in increased expression of MDM2 mRNA26708502
C121565pifithrinpifithrin inhibits the reaction [Doxorubicin results in increased expression of MDM2 mRNA]14766674
C121565pifithrinpifithrin inhibits the reaction [Vehicle Emissions results in decreased expression of MDM2 protein]18940243
C121565pifithrinpifithrin inhibits the reaction [arsenic trioxide results in increased expression of MDM2 mRNA]17487067
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of MDM2 mRNA15890375|2248451
C006253pirinixic acidMDM2 protein affects the reaction [pirinixic acid results in increased activity of PPARA protein]19103650
C006253pirinixic acidMDM2 protein promotes the reaction [[pirinixic acid results in increased activity of PPARA protein] which results in increased expression of ACOX1 mRNA]19103650
C006253pirinixic acidMDM2 protein promotes the reaction [[pirinixic acid results in increased activity of PPARA protein] which results in increased expression of ANGPTL4 mRNA]19103650
C006253pirinixic acidMDM2 protein promotes the reaction [[pirinixic acid results in increased activity of PPARA protein] which results in increased expression of CYP4A1 mRNA]19103650
C006253pirinixic acidMDM2 protein promotes the reaction [[pirinixic acid results in increased activity of PPARA protein] which results in increased expression of EHHADH mRNA]19103650
C006253pirinixic acidMDM2 protein promotes the reaction [[pirinixic acid results in increased activity of PPARA protein] which results in increased expression of FABP1 mRNA]19103650
C006253pirinixic acidMDM2 protein promotes the reaction [pirinixic acid results in increased expression of PPARA protein]19103650
C006253pirinixic acidpirinixic acid promotes the reaction [MDM2 protein binds to PPARA protein]19103650
C006253pirinixic acidpirinixic acid promotes the reaction [[PPARA protein binds to MDM2 protein] which binds to ACOX1 promoter]19103650
C006253pirinixic acidpirinixic acid promotes the reaction [[PPARA protein binds to MDM2 protein] which binds to DBI promoter]19103650
C006253pirinixic acidpirinixic acid results in increased expression of MDM2 mRNA15890375|1916217
D010936Plant ExtractsPlant Extracts affects the expression of MDM2 mRNA12878215
D010936Plant ExtractsPlant Extracts results in increased expression of MDM2 mRNA23557933
C043435polylactic acid-polyglycolic acid copolymer"[epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA]"23717041
C043435polylactic acid-polyglycolic acid copolymer"[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA]"23717041
D011192Potassium DichromateAscorbic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of MDM2 protein]21262251
D011192Potassium DichromatePotassium Dichromate results in decreased expression of MDM2 protein21262251
D011205Povidone[Silver co-treated with Povidone] affects the expression of MDM2 protein27387714
D011205Povidone[Silver co-treated with Povidone] results in decreased expression of MDM2 mRNA27387714
D017035PravastatinPravastatin results in increased phosphorylation of MDM2 protein15625077
D017035Pravastatin[Pravastatin results in increased phosphorylation of MDM2 protein] which results in increased degradation of TP53 protein15625077
D017035PravastatinSirolimus inhibits the reaction [Pravastatin results in increased phosphorylation of MDM2 protein]15625077
D017035PravastatinU 0126 inhibits the reaction [Pravastatin results in increased phosphorylation of MDM2 protein]15625077
D017035PravastatinPravastatin results in increased expression of MDM2 protein15625077
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of MDM2 mRNA19162173
C045362prochloraz[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of MDM2 mRNA29038839
C035988procymidoneprocymidone results in decreased expression of MDM2 mRNA15686871
D011374ProgesteroneProgesterone results in increased expression of MDM2 mRNA23012394
D011398PromethazinePromethazine results in increased phosphorylation of MDM2 protein26558467
C005556propionaldehydepropionaldehyde results in increased expression of MDM2 mRNA26079696
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of MDM2 mRNA"21152443
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of MDM2 mRNA"21152443
C010423pyrithione zincpyrithione zinc results in increased expression of MDM2 mRNA21424779
D011794QuercetinQuercetin results in decreased expression of MDM2 protein21933852
D011794QuercetinQuercetin results in decreased phosphorylation of and results in decreased expression of MDM2 protein17973296
D011794QuercetinQuercetin results in increased expression of MDM2 mRNA21632981|2372791
D011794Quercetin[Quercetin co-treated with Hydrogen Peroxide] results in increased expression of MDM2 mRNA27525270
D017382Reactive Oxygen Species[[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of MDM2 protein27634759
C059514resveratrolCapsaicin promotes the reaction [resveratrol results in decreased expression of MDM2 protein]19846903
C059514resveratrolEGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]15542774
C059514resveratrolresveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]15542774
C059514resveratrolresveratrol promotes the reaction [Capsaicin results in decreased expression of MDM2 protein]19846903
C059514resveratrolresveratrol results in decreased expression of MDM2 mRNA16998810|2087809
C059514resveratrolresveratrol results in decreased expression of MDM2 protein19846903
C059514resveratrolresveratrol results in increased expression of MDM2 mRNA15280659|1576733
C059514resveratrolStaurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]]15542774
C059514resveratrolTP53 affects the reaction [resveratrol results in decreased expression of MDM2 protein]19846903
C059514resveratrolresveratrol affects the expression of MDM2 protein16369916
C059514resveratrolresveratrol results in increased expression of MDM2 mRNA16081268|1636991
C059514resveratrolresveratrol results in increased expression of MDM2 protein11245472
C059514resveratrol[resveratrol results in increased phosphorylation of TRP53 protein] inhibits the reaction [TRP53 protein binds to MDM2 protein]11245472
D012293Rifampin[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA21224054
C089730rosiglitazonerosiglitazone results in increased expression of MDM2 mRNA25596134
D012428RutheniumRuthenium results in decreased expression of MDM2 protein17210701
D017975Ruthenium CompoundsRuthenium Compounds results in decreased expression of MDM2 protein17210701
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of MDM2 mRNA"16678137
D012822Silicon DioxideSilicon Dioxide results in increased expression of MDM2 mRNA19073995
D012834Silver[Silver co-treated with Povidone] affects the expression of MDM2 protein27387714
D012834Silver[Silver co-treated with Povidone] results in decreased expression of MDM2 mRNA27387714
D012834SilverSilver results in decreased expression of MDM2 mRNA26014281
D019821SimvastatinSimvastatin promotes the reaction [Benzo(a)pyrene promotes the reaction [TP53 protein binds to MDM2 protein]]15625077
D019821SimvastatinSimvastatin results in increased phosphorylation of MDM2 protein15625077
D020123SirolimusEIF4E protein inhibits the reaction [Sirolimus results in decreased expression of MDM2 protein]19560264
D020123SirolimusSirolimus inhibits the reaction [Pravastatin results in increased phosphorylation of MDM2 protein]15625077
D020123SirolimusSirolimus promotes the reaction [TP73 protein binds to MDM2 promoter]21245298
D020123SirolimusSirolimus results in decreased expression of MDM2 protein19560264
C009277sodium arsenatesodium arsenate results in decreased expression of MDM2 mRNA24349563
C009277sodium arsenatesodium arsenate results in increased expression of MDM2 mRNA23922661
C009277sodium arsenatesodium arsenate results in increased expression of MDM2 mRNA11353140
C017947sodium arsenite2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of MDM2 protein]28785074
C017947sodium arseniteMAPK1 protein promotes the reaction [sodium arsenite results in increased expression of MDM2 protein]28785074
C017947sodium arsenitesodium arsenite affects the expression of MDM2 mRNA29319823
C017947sodium arsenite[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of MDM2 mRNA23192986
C017947sodium arsenitesodium arsenite results in increased expression of MDM2 mRNA12016162|2878507
C017947sodium arsenitesodium arsenite results in increased expression of MDM2 protein11813266|1901088
C017947sodium arsenitesodium arsenite results in increased expression of MDM2 protein alternative form29319823
C017947sodium arseniteTP53 protein mutant form inhibits the reaction [sodium arsenite results in increased expression of MDM2 mRNA]28785074
C017947sodium arseniteTP53 protein promotes the reaction [sodium arsenite results in increased expression of MDM2 protein]20375080
C017947sodium arsenitesodium arsenite results in decreased expression of MDM2 protein16166651
C017947sodium arsenitesodium arsenite results in increased expression of MDM2 mRNA11353140|2047794
C016104sodium bichromatesodium bichromate affects the expression of MDM2 mRNA11960910|2211074
C016104sodium bichromatesodium bichromate results in increased expression of MDM2 mRNA25993096
D018038Sodium SeleniteSodium Selenite results in increased expression of MDM2 mRNA24383545
C471405sorafenibsorafenib results in increased expression of MDM2 mRNA26409325
D019311StaurosporineStaurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]]15542774
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of MDM2 mRNA26378955
D013605T-2 ToxinT-2 Toxin results in increased expression of MDM2 mRNA26141394
D013629TamoxifenTamoxifen affects the expression of MDM2 mRNA17555576
C112765tanespimycintanespimycin results in increased degradation of MDM2 protein17157164
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]14514686
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in increased expression of MDM2 mRNA15885361
C508490TDP 521252TDP 521252 inhibits the reaction [MDM2 protein binds to TP53 protein]16432175
C508490TDP 521252TDP 521252 results in increased expression of MDM2 mRNA16432175
C508490TDP 521252TDP 521252 results in increased expression of MDM2 protein16432175
C508491TDP 665759TDP 665759 inhibits the reaction [MDM2 protein binds to TP53 protein]16432175
D013739TestosteroneTestosterone results in decreased expression of MDM2 mRNA20403060
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of MDM2 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MDM2 protein22015590
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MDM2 mRNA24349563
D013749Tetrachlorodibenzodioxinalpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Oxygen deficiency results in increased expression of MDM2 mRNA]]19578757
D013749Tetrachlorodibenzodioxinalpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA]19578757
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [Oxygen deficiency results in increased expression of MDM2 mRNA]19578757
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [Oxygen deficiency results in increased expression of MDM2 protein]19578757
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MDM2 mRNA16039398
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein]22044530
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form]22044530
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MDM2 mRNA19578757
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased phosphorylation of MDM2 protein19751709
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MDM2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MDM2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MDM2 mRNA12167310|2104116
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased expression of MDM2 protein]15459018
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased degradation of MDM2 protein15459018
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of and results in increased phosphorylation of and results in increased activity of MDM2 protein15459018
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased phosphorylation of MDM2 protein15459018
C056068theaflavin"[theaflavin co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA]"23717041
C056068theaflavin"theaflavin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MDM2 mRNA]"23717041
D013853ThioacetamideThioacetamide results in increased expression of MDM2 mRNA18619722|2265951
D013853ThioacetamideThioacetamide results in increased phosphorylation of MDM2 protein26558467
D013893ThiramThiram results in increased expression of MDM2 mRNA20530235
C009495titanium dioxidetitanium dioxide results in increased expression of MDM2 mRNA21067279
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MDM2 mRNA27404394|2806579
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MDM2 mRNA27865774
D014028Tobacco Smoke PollutionCAVIN1 protein affects the reaction [Tobacco Smoke Pollution promotes the reaction [MDM2 protein binds to CAV1 protein]]21705337
D014028Tobacco Smoke PollutionTobacco Smoke Pollution promotes the reaction [MDM2 protein binds to CAV1 protein]21705337
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of MDM2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of MDM2 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of MDM2 mRNA"19682533
D014241TrichloroethyleneTrichloroethylene affects the expression of MDM2 mRNA21135412
D014241Trichloroethylene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of MDM2 mRNA17905399
C012589trichostatin Atrichostatin A affects the expression of MDM2 mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MDM2 mRNA"26179874
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MDM2 mRNA"18930950
C113580U 0126U 0126 inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MDM2 protein]20840854
C113580U 0126U 0126 inhibits the reaction [Pravastatin results in increased phosphorylation of MDM2 protein]15625077
D014520Urethane[Urethane co-treated with Freund's Adjuvant] results in increased expression of MDM2 mRNA12400877
D014580Ursodeoxycholic AcidMDM2 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased ubiquitination of TP53 protein]20807506
D014580Ursodeoxycholic AcidMDM2 mutant form inhibits the reaction [Ursodeoxycholic Acid affects the localization of TP53 protein]17881359
D014580Ursodeoxycholic AcidNR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]]15222754
D014580Ursodeoxycholic AcidNR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]]15222754
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]14514686|1522275
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid promotes the reaction [TP53 protein binds to MDM2 protein]17881359
D014580Ursodeoxycholic Acid[Ursodeoxycholic Acid promotes the reaction [TP53 protein binds to MDM2 protein]] which results in increased degradation of TP53 protein17881359
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of MDM2 mRNA15885361
C406224valdecoxibvaldecoxib results in increased expression of MDM2 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of MDM2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MDM2 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of MDM2 mRNA23179753
D001335Vehicle Emissions[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of MDM2 protein28013216
D001335Vehicle Emissions[[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of MDM2 protein] which results in increased expression of TP53 protein28013216
D001335Vehicle Emissions[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of MDM2 protein28013216
D001335Vehicle Emissionspifithrin inhibits the reaction [Vehicle Emissions results in decreased expression of MDM2 protein]18940243
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of MDM2 protein18940243
D014750VincristineVincristine results in decreased expression of MDM2 mRNA16001973
D014750VincristineVincristine results in increased expression of MDM2 mRNA23649840
D014752Vinyl ChlorideMDM2 polymorphism affects the susceptibility to Vinyl Chloride24464562
D009536NiacinamideNiacinamide results in increased expression of MDM2 mRNA16998810
D024483Vitamin K 3EUK-134 inhibits the reaction [Vitamin K 3 results in decreased expression of MDM2 protein]25005833
D024483Vitamin K 3Vitamin K 3 results in decreased expression of MDM2 protein25005833
C111237vorinostatvorinostat results in decreased expression of MDM2 mRNA27188386
C009687wortmanninwortmannin promotes the reaction [Doxorubicin results in increased phosphorylation of MDM2 protein]17935137
C009687wortmanninwortmannin promotes the reaction [Etoposide results in increased phosphorylation of MDM2 protein]17935137
D015215ZidovudineZidovudine results in increased expression of MDM2 protein16797627
D015032ZincZinc affects the expression of MDM2 protein16636310
D015032ZincZinc binds to and results in increased folding of MDM2 protein16965791
D015032ZincZinc promotes the reaction [MDM2 protein binds to MDM2 protein]16965791
D015032ZincZinc promotes the reaction [MDM2 protein binds to MDM4 protein]16965791
D015032ZincZinc results in increased ubiquitination of MDM2 protein16965791
D019345Zinc Acetatemotexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MDM2 mRNA]16357179
D019345Zinc AcetateZinc Acetate results in increased expression of MDM2 mRNA16357179

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002039p53 binding-IPI9529249  15053879  20173098  25417702  
GO:0004842ubiquitin-protein transferase activity-IDA9450543  
GO:0004842ubiquitin-protein transferase activity-IMP20173098  
GO:0005515protein binding-IPI7791904  8875929  9271120  9529249  10196247  10608892  
11178989  11588219  12740913  12915590  14704432  15144954  
15195100  15313915  15314173  15364927  15527798  15604276  
15848166  15862297  15878855  15916963  16023600  16173922  
16212962  16374512  16402859  16432196  16474402  16845383  
17006543  17080083  17110929  17139261  17159902  17170761  
17237821  17268548  17290220  17310983  17347673  17373842  
17438265  17470788  17875722  17909018  17936559  17984062  
18172499  18191226  18309296  18316739  18332867  18485870  
18548200  18560357  18566590  18583933  18952844  19015526  
19098711  19166840  19166854  19218448  19234109  19249676  
19255450  19369353  19372219  19411066  19483087  19656744  
19713960  19833129  19879840  20173098  20181722  20195357  
20591429  20598683  20708156  20713054  20856200  20871633  
21132010  21170087  21333377  21399665  21460856  21726810  
21857681  21988832  22056774  22085928  22103682  22124327  
22493164  22510990  22575647  22653443  22659184  22819825  
22869143  22902369  22975381  23092970  23260144  23397142  
23507139  23776060  24207125  24667498  25241761  
GO:00080975S rRNA binding-IDA24120868  
GO:0008270zinc ion binding-IDA10722742  
GO:0016874ligase activity-IDA17142452  
GO:0019789SUMO transferase activity-EXP21900752  
GO:0019899enzyme binding-IPI15577914  17290220  18566590  20173098  
GO:0019904protein domain specific binding-IPI16479015  
GO:0031625ubiquitin protein ligase binding-IPI18382127  
GO:0033612receptor serine/threonine kinase binding-IEA-  
GO:0042802identical protein binding-IPI17159902  17936559  22493164  
GO:0042975peroxisome proliferator activated receptor binding-IEA-  
GO:0043021ribonucleoprotein complex binding-IDA24120868  
GO:0047485protein N-terminus binding-IPI11718560  
GO:0061630ubiquitin protein ligase activity-IDA15314173  17310983  
GO:0061630ubiquitin protein ligase activity-IMP16479015  18560357  19372219  
GO:0061630ubiquitin protein ligase activity-TAS-  
GO:0061663NEDD8 ligase activity-IMP18560357  
GO:0097110scaffold protein binding-IEA-  
GO:0097718disordered domain specific binding-IPI12630860  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA9271120  17310983  
GO:0001568blood vessel development-IEA-  
GO:0001974blood vessel remodeling-IEA-  
GO:0002027regulation of heart rate-IEA-  
GO:0003181atrioventricular valve morphogenesis-IEA-  
GO:0003203endocardial cushion morphogenesis-IEA-  
GO:0003281ventricular septum development-IEA-  
GO:0003283atrial septum development-IEA-  
GO:0006511ubiquitin-dependent protein catabolic process-IDA11278372  15314173  16173922  17310983  
GO:0006511ubiquitin-dependent protein catabolic process-IGI17237821  
GO:0006511ubiquitin-dependent protein catabolic process-IMP16479015  18560357  24506068  
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-IMP21726810  
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-TAS-  
GO:0007089traversing start control point of mitotic cell cycle-IEA-  
GO:0008284positive regulation of cell proliferation-TAS7791904  
GO:0010039response to iron ion-IEA-  
GO:0010628positive regulation of gene expression-IEA-  
GO:0010955negative regulation of protein processing-IEA-  
GO:0010977negative regulation of neuron projection development-IEA-  
GO:0016032viral process-IEA-  
GO:0016567protein ubiquitination-IDA9450543  15878855  19656744  20153724  
GO:0016579protein deubiquitination-TAS-  
GO:0016925protein sumoylation-IEA-  
GO:0018205peptidyl-lysine modification-IMP19372219  
GO:0031648protein destabilization-IDA9529249  10360174  15314173  
GO:0031648protein destabilization-IMP16479015  18560357  
GO:0032026response to magnesium ion-IEA-  
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process-IDA11278372  
GO:0034504protein localization to nucleus-IDA10360174  
GO:0036369transcription factor catabolic process-TAS20181722  
GO:0042176regulation of protein catabolic process-IDA9153395  
GO:0042220response to cocaine-IEA-  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IEA-  
GO:0043278response to morphine-IEA-  
GO:0043518negative regulation of DNA damage response, signal transduction by p53 class mediator-IDA9529249  10360174  
GO:0045184establishment of protein localization-IDA10360174  
GO:0045472response to ether-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IDA9271120  
GO:0045892negative regulation of transcription, DNA-templated-IMP16479015  25417702  
GO:0045931positive regulation of mitotic cell cycle-IMP17290220  
GO:0046677response to antibiotic-IEP20810912  
GO:0046827positive regulation of protein export from nucleus-IEA-  
GO:0048545response to steroid hormone-IEA-  
GO:0051603proteolysis involved in cellular protein catabolic process-IMP25417702  
GO:0051865protein autoubiquitination-IMP16479015  17237821  
GO:0060411cardiac septum morphogenesis-IEA-  
GO:0065003protein-containing complex assembly-IDA10608892  12915590  
GO:0070301cellular response to hydrogen peroxide-IEA-  
GO:0071157negative regulation of cell cycle arrest-IDA9529249  
GO:0071301cellular response to vitamin B1-IEA-  
GO:0071312cellular response to alkaloid-IEA-  
GO:0071363cellular response to growth factor stimulus-IEA-  
GO:0071375cellular response to peptide hormone stimulus-IEA-  
GO:0071391cellular response to estrogen stimulus-IEA-  
GO:0071456cellular response to hypoxia-IEP20810912  
GO:0071480cellular response to gamma radiation-IDA16213212  
GO:0071494cellular response to UV-C-IEA-  
GO:0072717cellular response to actinomycin D-IDA15314173  
GO:1901796regulation of signal transduction by p53 class mediator-TAS-  
GO:1901797negative regulation of signal transduction by p53 class mediator-IDA16173922  
GO:1902254negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator-IMP17310983  
GO:1904404response to formaldehyde-IEA-  
GO:1904707positive regulation of vascular smooth muscle cell proliferation-IEA-  
GO:1904754positive regulation of vascular associated smooth muscle cell migration-IEA-  
GO:1990000amyloid fibril formation-IMP12630860  
GO:1990785response to water-immersion restraint stress-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA10360174  
GO:0005634nucleus-IMP15314173  21726810  
GO:0005654nucleoplasm-IDA10707090  12915590  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA10707090  22869143  
GO:0005730nucleolus-IMP11718560  
GO:0005737cytoplasm-IMP15314173  21726810  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0016604nuclear bodycolocalizes_withIDA10360174  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0032991protein-containing complex-IDA9529249  17310983  
GO:0032991protein-containing complex-IMP11718560  15314173  16479015  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa04120Ubiquitin mediated proteolysis
hsa04144Endocytosis
hsa05200Pathways in cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05219Bladder cancer
hsa05220Chronic myeloid leukemia
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1643685DiseaseTAS
R-HSA-198323AKT phosphorylates targets in the cytosolTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559585Oncogene Induced SenescenceTAS
R-HSA-2990846SUMOylationTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-3232118SUMOylation of transcription factorsTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-399719Trafficking of AMPA receptorsTAS
R-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticityTAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5674400Constitutive Signaling by AKT1 E17K in CancerTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-6804757Regulation of TP53 DegradationTAS
R-HSA-6804760Regulation of TP53 Activity through MethylationTAS
R-HSA-6806003Regulation of TP53 Expression and DegradationTAS
R-HSA-69541Stabilization of p53TAS
R-HSA-69563p53-Dependent G1 DNA Damage ResponseTAS
R-HSA-69580p53-Dependent G1/S DNA damage checkpointTAS
R-HSA-69615G1/S DNA Damage CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8941858Regulation of RUNX3 expression and activityTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006925Intracellular signaling by second messengersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25054017Single-nucleotide polymorphism (c.309T>G) in the MDM2 gene and lung cancer risk. (2014 Sep)Enokida YBiomed Rep
19521721Accelerated decline in lung function in cigarette smokers is associated with TP53/MDM2 polymorphisms. (2009 Oct)Hancox RJHum Genet
19492228Cigarette smoking, MDM2 SNP309, gene-environment interactions, and lung cancer risk: a meta-analysis. (2009)Bai JJ Toxicol Environ Health A
19305381P21 Cip1/WAF1 expression is strongly associated with HPV-positive tonsillar carcinoma and a favorable prognosis. (2009 May)Hafkamp HCMod Pathol
15714438Alternative splicing of MDM2 mRNA in lung carcinomas and lung cell lines. (2005 Jul)Weng MWEnviron Mol Mutagen
23837945Association of p53 and MDM2 polymorphisms with risk of human papillomavirus (HPV)-related esophageal squamous cell carcinoma (ESCC). (2013 Oct)Yang JCancer Epidemiol
18398041MDM2 SNP309 is associated with endometrial cancer risk. (2008 Apr)Terry KCancer Epidemiol Biomarkers Prev
26476535Interaction between p53 codon 72 and MDM2 309T>G polymorphisms and the risk of hepatocellular carcinoma. (2016 Mar)Qiu MTumour Biol
20219101Effect of MDM2 SNP309 and p53 codon 72 polymorphisms on lung cancer risk and survival among non-smoking Chinese women in Singapore. (2010 Mar 10)Chua HWBMC Cancer
22541966Incorporating single-nucleotide polymorphisms into the Lyman model to improve prediction of radiation pneumonitis. (2013 Jan 1)Tucker SLInt J Radiat Oncol Biol Phys
28781817Association between MDM2-SNP309 and p53R72P polymorphisms and the risk of bladder cancer in the Mongolian population. (2017 Sep)Avirmed SMol Clin Oncol
27565936Autoantibodies against tumor-associated antigens in the early detection of lung cancer. (2016 Sep)Dai LLung Cancer
12845670Alterations of RB1, p53 and Wnt pathways in hepatocellular carcinomas associated with hepatitis C, hepatitis B and alcoholic liver cirrhosis. (2003 Sep 1)Edamoto YInt J Cancer
17957785Genetic polymorphisms of MDM2, cumulative cigarette smoking and nonsmall cell lung cancer risk. (2008 Feb 15)Liu GInt J Cancer
24435975p53 signaling pathway polymorphisms associated to recurrent pregnancy loss. (2014 Mar)Fraga LRMol Biol Rep
26273341Mouse double minute-2 homolog (MDM2)-rs2279744 polymorphism associated with lung cancer risk in a Northeastern Chinese population. (2015 Jan)Wang XThorac Cancer
18433484Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene. (2008 Apr 23)Mittelstrass KBMC Cancer
9762452Proliferative activity and loss of function of tumour suppressor genes as 'biomarkers' in diagnosis and prognosis of benign and preneoplastic oral lesions and oral squamous cell carcinoma. (1998 Aug)Girod SCBr J Oral Maxillofac Surg
25218545Interaction between TP63 and MDM2 genes and the risk of recurrent pregnancy loss. (2014 Nov)Fraga LREur J Obstet Gynecol Reprod Biol
9846966Alterations of the p16-pRb pathway and the chromosome locus 9p21-22 in non-small-cell lung carcinomas: relationship with p53 and MDM2 protein expression. (1998 Dec)Gorgoulis VGAm J Pathol
22912557Human papilloma virus 16 E6 oncoprotein associated with p53 inactivation in colorectal cancer. (2012 Aug 14)Chen THWorld J Gastroenterol
16230424The role of P53 and MDM2 polymorphisms in the risk of esophageal squamous cell carcinoma. (2005 Oct 15)Hong YCancer Res
24175836P53 Arg72Pro and MDM2 SNP309 polymorphisms cooperate to increase lung adenocarcinoma risk in Chinese female non-smokers: a case control study. (2013)Ren YWAsian Pac J Cancer Prev
28315337p53 Signaling Pathway Polymorphisms Associated With Emphysematous Changes in Patients With COPD. (2017 Jul)Mizuno SChest
22844496Association of MDM2 SNP309 variation with lung cancer risk: evidence from 7196 cases and 8456 controls. (2012)Zhuo WPLoS One
16287156Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer. (2006 Jan)Zhang XHum Mutat
26224627Murine Double-Minute 2 Homolog Single Nucleotide Polymorphisms 285 and 309 in Cervical Carcinogenesis. (2015 Aug)Roszak AMol Diagn Ther
27542180A Graphical Model of Smoking-Induced Global Instability in Lung Cancer. (2018 Jan-Feb)Wang YIEEE/ACM Trans Comput Biol Bioinform
19383811p53 Arg72Pro and MDM2 T309G polymorphisms, histology, and esophageal cancer prognosis. (2009 May 1)Cescon DWClin Cancer Res
16675470MDM2 gene promoter polymorphisms and risk of lung cancer: a case-control analysis. (2006 Oct)Li GCarcinogenesis
23448401Significance of CD133 expression in esophageal squamous cell carcinoma. (2013 Mar 1)Okamoto HWorld J Surg Oncol
29777315The MDM2 rs937283 A > G variant significantly increases the risk of lung and gastric cancer in Chinese population. (2018 May 18)Chen BInt J Clin Oncol
26320449MDM2 and TP53 Polymorphisms as Predictive Markers for Head and Neck Cancer in Northeast Indian Population: Effect of Gene-Gene and Gene-Environment Interactions. (2015)Bhowmik AAsian Pac J Cancer Prev
25987086MDM2 (RS769412) G>A Polymorphism in Cigarette Smokers: a Clue for the Susceptibility to Smoking and Lung Cancer Risk. (2015)Ahmad DAsian Pac J Cancer Prev
24173110Association between single nucleotide polymorphisms in the p53 pathway and response to radiotherapy in patients with nasopharyngeal carcinoma. (2014 Jan)Xie XOncol Rep
18559624MDM2 promoter polymorphism and pancreatic cancer risk and prognosis. (2008 Jun 15)Asomaning KClin Cancer Res
23170107MDM2 SNP309 polymorphism is associated with lung cancer risk in women: A meta-analysis using METAGEN. (2012 Oct)He WExp Ther Med
22336889Association of genetic polymorphisms in MDM2, PTEN and P53 with risk of esophageal squamous cell carcinoma. (2012 Apr)Ma JJ Hum Genet
25594032PICT1 expression is a poor prognostic factor in non-small cell lung cancer. (2014)Okamura KOncoscience
18618574Association of p53 codon 72 polymorphism and MDM2 SNP309 with clinical outcome of advanced nonsmall cell lung cancer. (2008 Aug 15)Han JYCancer
20447891MDM2 promoter polymorphism is associated with increased susceptibility to hepatocellular carcinoma in Turkish population. (2010 Aug)Akkiz HCancer Epidemiol
28210120Single nucleotide polymorphisms as susceptibility, prognostic, and therapeutic markers of nonsmall cell lung cancer. (2012)Zienolddiny SLung Cancer (Auckl)
8600505Analysis of the K-ras and p53 pathways in X-ray-induced lung tumors in the rat. (1996 Apr)Belinsky SARadiat Res
21268124MDM2 SNP309 contributes to non-small cell lung cancer survival in Chinese. (2011 Jun)Dong JMol Carcinog
24040073SNP (-617C>A) in ARE-like loci of the NRF2 gene: a new biomarker for prognosis of lung adenocarcinoma in Japanese non-smoking women. (2013)Okano YPLoS One
10607740P53 point mutations in initial superficial bladder cancer occur only in tumors from current or recent cigarette smokers. (2000 Jan)LaRue HCarcinogenesis
8666362p53 and MDM2 immunostaining in pulmonary blastomas and bronchogenic carcinomas. (1996 Jun)Pacinda SJHum Pathol