Gene: MDM4

4194
HDMX|MDMX|MRP1
MDM4, p53 regulator
protein-coding
1q32.1
Ensembl:ENSG00000198625 MIM:602704 Vega:OTTHUMG00000035877 UniprotKB:O15151
NG_029367.1
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.069e-1 (AD)  6.329e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRCH30.877
MAML10.861
PHACTR40.859
RBM280.856
CASP20.853
MSANTD20.85
MAP4K50.842
PAXBP10.84
TTC310.836
ZNF8410.834

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.456
OR4F29-0.443
CRH-0.309
KAZALD1-0.227
NEK2-0.221
PRSS56-0.218
GSG1-0.212
CYP1A1-0.202
VIP-0.201
HAPLN1-0.194

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in decreased expression of MDM4 mRNA"26377693
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MDM4 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MDM4 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MDM4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MDM4 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MDM4 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MDM4 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents affects the expression of MDM4 mRNA24449571
C058317arsenic disulfidearsenic disulfide results in decreased expression of MDM4 mRNA12890387
C006632arsenic trioxidearsenic trioxide results in decreased expression of MDM4 mRNA20458559
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of MDM4 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MDM4 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MDM4 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of MDM4 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MDM4 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased methylation of MDM4 promoter28329817
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of MDM4 mRNA]22228805
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MDM4 mRNA27858113
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MDM4 mRNA"20018196|2623829
D004958EstradiolEstradiol results in decreased expression of MDM4 mRNA20068009
C006780bisphenol Abisphenol A affects the expression of MDM4 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of MDM4 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of MDM4 mRNA26982218
C006780bisphenol Abisphenol A results in increased expression of MDM4 mRNA27571134|2909715
D000069287CapecitabineMDM4 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine]18678097
D002330Carmustine[Carmustine co-treated with MDM4 protein] results in increased expression of POLH protein20472715
D002330CarmustineMDM4 protein promotes the reaction [Carmustine affects the localization of H2AFX protein]20472715
D002330CarmustineMDM4 protein promotes the reaction [Carmustine results in increased expression of CDKN1A protein]20472715
D002330CarmustineMDM4 protein promotes the reaction [Carmustine results in increased expression of TP53 protein]20472715
D002330CarmustineMDM4 protein promotes the reaction [Carmustine results in increased phosphorylation of H2AFX protein]20472715
D002330CarmustineMDM4 protein results in decreased susceptibility to Carmustine20472715
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MDM4 mRNA27858113
C031180chrysenechrysene results in decreased expression of MDM4 mRNA26377693
D003033Coal TarCoal Tar results in decreased expression of MDM4 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in increased expression of MDM4 mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of MDM4 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of MDM4 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of MDM4 mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of MDM4 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of MDM4 mRNA20106945|2556210
C089595cylindrospermopsincylindrospermopsin results in increased expression of MDM4 mRNA24921660
D003630DaunorubicinDaunorubicin results in decreased expression of MDM4 mRNA12656675
C007262deoxynivalenoldeoxynivalenol results in increased expression of MDM4 mRNA22846391
D003976DiazinonDiazinon affects the expression of MDM4 mRNA22546817
D002945CisplatinCisplatin results in decreased expression of MDM4 mRNA27594783
D004026DieldrinDieldrin affects the expression of MDM4 mRNA22546817
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MDM4 mRNA18164116
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MDM4 mRNA16872691
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MDM4 mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MDM4 mRNA23649840
D005472FluorouracilMDM4 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine]18678097
C007768formononetinformononetin results in increased expression of MDM4 protein28414026
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of MDM4 protein24960055
C089796hexabromocyclododecanehexabromocyclododecane results in increased expression of MDM4 protein24960055
D007213IndomethacinIndomethacin results in decreased expression of MDM4 mRNA28201806
C544151jinfukangjinfukang results in decreased expression of MDM4 mRNA27392435
D007854LeadLead results in decreased expression of MDM4 mRNA19921347
C045463leflunomideleflunomide results in increased expression of MDM4 mRNA28988120
C038753leptomycin B[leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of MDM4 mRNA20803015
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of MDM4 mRNA18386188
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MDM4 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MDM4 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MDM4 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MDM4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MDM4 mRNA"25554681
D009532NickelNickel results in decreased expression of MDM4 protein24068677
C022838nickel chloridenickel chloride results in decreased expression of MDM4 protein23566959
C022838nickel chloridenickel chloride affects the expression of MDM4 mRNA22546817
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of MDM4 mRNA20971185
C507134ON 01910ON 01910 affects the expression of MDM4 mRNA22351695
D009942Organometallic CompoundsOrganometallic Compounds results in decreased expression of MDM4 protein17210701
D010261ParaoxonParaoxon results in increased expression of MDM4 mRNA17223147
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of MDM4 mRNA18386188
D010634PhenobarbitalPhenobarbital affects the expression of MDM4 mRNA19159669
C006253pirinixic acidpirinixic acid results in decreased expression of MDM4 mRNA18445702
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls results in decreased expression of MDM4 protein24960055
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls results in increased expression of MDM4 protein24960055
D012428RutheniumRuthenium results in decreased expression of MDM4 protein17210701
D017975Ruthenium CompoundsRuthenium Compounds results in decreased expression of MDM4 protein17210701
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of MDM4 mRNA21427059
D013629TamoxifenTamoxifen results in decreased expression of MDM4 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MDM4 mRNA12377990
C009495titanium dioxidetitanium dioxide results in increased expression of MDM4 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MDM4 mRNA28065790
C012589trichostatin Atrichostatin A affects the expression of MDM4 mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MDM4 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of MDM4 mRNA22378314
D014520UrethaneUrethane results in decreased expression of MDM4 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MDM4 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of MDM4 mRNA23179753|2627250
D014635Valproic AcidValproic Acid analog results in increased expression of MDM4 mRNA21427059
D014635Valproic AcidValproic Acid results in decreased expression of MDM4 mRNA21427059
C025643vinclozolinvinclozolin results in decreased expression of MDM4 mRNA22570695|2303416
C025643vinclozolinvinclozolin results in increased expression of MDM4 mRNA20566332|2303416
C111237vorinostatvorinostat results in decreased expression of MDM4 mRNA27188386
D015032ZincZinc promotes the reaction [MDM2 protein binds to MDM4 protein]16965791
C088658zoledronic acidzoledronic acid results in increased expression of MDM4 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10469568  10608892  15604276  15916963  16227609  16510145  
16511560  16511572  17080083  17110929  17159902  17875722  
18356162  18566590  19255450  19521340  20515689  20705607  
21988832  22493164  22902369  24667498  25416956  25609649  
26871637  27107012  
GO:0008270zinc ion binding-TAS10608892  
GO:0019899enzyme binding-IPI19838211  
GO:0061630ubiquitin protein ligase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA9226370  
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-TAS-  
GO:0008283cell proliferation-IEP12101245  
GO:0008285negative regulation of cell proliferation-TAS9226370  
GO:0016567protein ubiquitination-IEA-  
GO:0016579protein deubiquitination-TAS-  
GO:0030330DNA damage response, signal transduction by p53 class mediator-IEP14660608  
GO:0042177negative regulation of protein catabolic process-IMP10608892  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0045023G0 to G1 transition-IEP12101245  
GO:0050821protein stabilization-IEP10608892  
GO:0065003protein-containing complex assembly-IDA10608892  
GO:0071157negative regulation of cell cycle arrest-IEA-  
GO:0071456cellular response to hypoxia-IEP20810912  
GO:1901796regulation of signal transduction by p53 class mediator-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005634nucleus-NAS9226370  
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
hsa04115p53 signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559585Oncogene Induced SenescenceTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-6804757Regulation of TP53 DegradationTAS
R-HSA-6804760Regulation of TP53 Activity through MethylationTAS
R-HSA-6806003Regulation of TP53 Expression and DegradationTAS
R-HSA-69541Stabilization of p53TAS
R-HSA-69563p53-Dependent G1 DNA Damage ResponseTAS
R-HSA-69580p53-Dependent G1/S DNA damage checkpointTAS
R-HSA-69615G1/S DNA Damage CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23724042Association of a genetic variation in a miR-191 binding site in MDM4 with risk of esophageal squamous cell carcinoma. (2013)Zhou LPLoS One
25882505Women who deliver twins are more likely to smoke and have high frequencies of specific SNPs: Results from a sample of African-American women who delivered preterm, low birth weight babies. (2015 Sep-Oct)Huang HAm J Hum Biol
27742919The associations between MDM4 gene polymorphisms and cancer risk. (2016 Aug 23)Wang MJOncotarget
21823114Modifying effect of MDM4 variants on risk of HPV16-associated squamous cell carcinoma of oropharynx. (2012 Mar 15)Yu HCancer
26274820A Regulatory MDM4 Genetic Variant Locating in the Binding Sequence of Multiple MicroRNAs Contributes to Susceptibility of Small Cell Lung Cancer. (2015)Gao FPLoS One