Gene: ME1

4199
HUMNDME|MES
malic enzyme 1
protein-coding
6q14.2
Ensembl:ENSG00000065833 MIM:154250 Vega:OTTHUMG00000015111 UniprotKB:P48163
NC_000006.12
PubMed
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.021e-1 (AD)  9.721e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABI10.91
MARCH50.887
MUT0.878
HS2ST10.872
PAICS0.87
GLO10.869
SDHD0.866
ASPH0.859
C6orf620.856
ADH50.856

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.697
OR4F29-0.635
TRPV5-0.299
OR6C74-0.279
CETP-0.271
CTNNA3-0.263
FCRL1-0.25
TNFRSF13B-0.24
KLRK1-0.228
KEL-0.227

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB034612'-Monophosphoadenosine 5'-DiphosphoriboseSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of ME1 mRNA"18711122
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of ME1 mRNA"19162173
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of ME1 mRNA25596134
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ME1 mRNA"28903501
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of ME1 mRNA"21920950
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ME1 mRNA"19114083
C492600(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate"(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate affects the expression of ME1 mRNA"19176366
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ME1 mRNA"21346803
C0352082-amino-4,6-dinitrotoluene"2-amino-4,6-dinitrotoluene affects the expression of ME1 mRNA"26251320
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ME1 mRNA"20959002
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine results in increased expression of ME1 mRNA14610520
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of ME1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ME1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ME1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ME1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ME1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ME1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ME1 mRNA"27188386
C0297284-phenylenediamine4-phenylenediamine results in increased expression of ME1 mRNA16314067
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ME1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ME1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ME1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ME1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ME1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ME1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of ME1 mRNA15606129|1756273
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of ME1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ME1 mRNA]17585979
D000082AcetaminophenAcetaminophen results in increased expression of ME1 protein16538043|1668747
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA]22129741
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ME1 mRNA22129741
C096064acteinactein results in decreased expression of ME1 mRNA19527300
C016601afimoxifeneafimoxifene results in increased expression of ME1 mRNA19901195
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ME1 gene27153756
D000452AldrinAldrin results in increased expression of ME1 mRNA18579281
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of ME1 protein26597043
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of ME1 mRNA16631469
C040534alpha-hexachlorocyclohexanealpha-hexachlorocyclohexane results in increased expression of ME1 mRNA17785943
D000638AmiodaroneAmiodarone affects the expression of ME1 mRNA19483382
D000638AmiodaroneAmiodarone results in increased expression of ME1 protein16538043
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ME1 mRNA16483693
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in increased expression of ME1 mRNA28713220
C006632arsenic trioxidearsenic trioxide results in increased expression of ME1 mRNA15725085|1941714
C006632arsenic trioxideME1 protein results in decreased susceptibility to arsenic trioxide20707922
C547126AZM551248AZM551248 results in decreased expression of ME1 mRNA22323515
C051597Bandrowski's baseBandrowski's base results in increased expression of ME1 mRNA20566472
C044946benazeprilbenazepril results in increased expression of ME1 mRNA14871019
D001553BenzbromaroneBenzbromarone affects the expression of ME1 mRNA19483382
D001554BenzeneBenzene affects the expression of ME1 mRNA15878777
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of ME1 mRNA18711122
D019817Benzoic AcidBenzoic Acid results in increased expression of ME1 mRNA20566472
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ME1 mRNA22316170
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of ME1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ME1 mRNA20127859
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of ME1 mRNA"18711122
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of ME1 mRNA18711122
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of ME1 mRNA"18711122
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of ME1 mRNA18711122
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ME1 mRNA19619570
D004958EstradiolEstradiol results in increased expression of ME1 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of ME1 mRNA19484750
C095105bexarotenebexarotene results in increased expression of ME1 mRNA16648578|2329279
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in decreased expression of ME1 mRNA15912405
C006780bisphenol Abisphenol A affects the expression of ME1 mRNA20170705
C006780bisphenol Abisphenol A results in increased expression of ME1 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ME1 mRNA28628672
C006780bisphenol Abisphenol A affects the methylation of ME1 promoter27334623
C006780bisphenol Abisphenol A affects the expression of ME1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of ME1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of ME1 mRNA27178563
D000069286BortezomibBortezomib results in increased expression of ME1 mRNA20977926
C017092bromopyruvatebromopyruvate results in decreased activity of ME1 protein7356971
D002065BuspironeBuspirone results in decreased expression of ME1 mRNA24136188
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ME1 mRNA12414654|1533650
C018475butyraldehydebutyraldehyde results in decreased expression of ME1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ME1 mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ME1 protein24527689
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ME1 mRNA25993096
C037123cadmium sulfatecadmium sulfate results in increased expression of ME1 mRNA12064557
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ME1 mRNA20360939
D002220CarbamazepineCarbamazepine affects the expression of ME1 mRNA25979313
D002220CarbamazepineCarbamazepine results in increased expression of ME1 mRNA17381134
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ME1 protein16538043
D002251Carbon Tetrachloride[Olive Oil analog co-treated with Carbon Tetrachloride] affects the expression of ME1 protein25303780
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of ME1 mRNA25596134
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of ME1 mRNA22659317
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ME1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of ME1 mRNA26272509
C020722cinnamyl alcoholcinnamyl alcohol results in increased expression of ME1 mRNA20566472
C503589cis-9, trans-11-conjugated linoleic acid"cis-9, trans-11-conjugated linoleic acid results in increased expression of ME1 mRNA"17217560
D004002Clodronic AcidClodronic Acid results in decreased expression of ME1 mRNA25596134
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of ME1 mRNA17585979
D002994ClofibrateClofibrate results in increased expression of ME1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ME1 mRNA]17585979
D002994ClofibrateClofibrate affects the expression of ME1 mRNA19483382
D002994ClofibrateClofibrate results in increased expression of ME1 mRNA12851107
D002994ClofibrateClofibrate results in increased expression of ME1 protein16470657
C018021cobaltous chloridecobaltous chloride results in increased expression of ME1 mRNA19320972|1937684
C018021cobaltous chloridecobaltous chloride results in increased expression of ME1 mRNA24386269
D009249NADPmalic acid binds to [ME1 protein binds to manganese chloride binds to NADP]7356971
D009249NADP[malic acid co-treated with manganese chloride co-treated with NADP] binds to and results in increased activity of ME1 protein7356971
D009249NADP[malic acid co-treated with manganese chloride co-treated with NADP] inhibits the reaction [Oxalic Acid binds to ME1 protein]7356971
D009249NADP[malic acid co-treated with manganese chloride] promotes the reaction [NADP binds to ME1 protein]7356971
D009249NADPNADP binds to ME1 protein7356971
D009249NADPNADP promotes the reaction [Oxalic Acid binds to ME1 protein]7356971
D009249NADP[Pyruvic Acid co-treated with manganese chloride] promotes the reaction [NADP binds to ME1 protein]7356971
D019327Copper SulfateCopper Sulfate results in increased expression of ME1 mRNA19549813
D003345CorticosteroneCorticosterone results in decreased expression of ME1 mRNA15755911
D016572CyclosporineCyclosporine results in increased expression of ME1 mRNA25596134
D016572CyclosporineCyclosporine results in increased expression of ME1 mRNA25596134
C004742daidzeindaidzein results in increased expression of ME1 mRNA16865672
C515055darinaparsindarinaparsin results in increased expression of ME1 mRNA19417148
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ME1 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of ME1 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of ME1 mRNA]20032058
C041517dibenzo(a,l)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of ME1 mRNA"18711122
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ME1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ME1 mRNA21266533|2174549
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of ME1 mRNA28962523
D002945CisplatinCisplatin results in decreased expression of ME1 mRNA25596134
D018119Stavudine[Stavudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ME1 mRNA11741158
D018119Stavudine[Stavudine co-treated with Lamivudine co-treated with Nelfinavir] results in decreased expression of ME1 mRNA11741158
D018119Stavudine[Stavudine co-treated with Lamivudine] results in increased expression of ME1 mRNA11741158
D018119StavudineStavudine results in increased expression of ME1 mRNA11741158
D019259LamivudineLamivudine results in increased expression of ME1 mRNA11741158
D019259Lamivudine[Stavudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ME1 mRNA11741158
D019259Lamivudine[Stavudine co-treated with Lamivudine co-treated with Nelfinavir] results in decreased expression of ME1 mRNA11741158
D019259Lamivudine[Stavudine co-treated with Lamivudine] results in increased expression of ME1 mRNA11741158
D019259Lamivudine[Zidovudine co-treated with Lamivudine] affects the expression of ME1 mRNA11741158
D019259Lamivudine[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ME1 mRNA11741158
D004041Dietary FatsDietary Fats results in increased expression of ME1 mRNA24709573
D004041Dietary Fatszerumbone inhibits the reaction [Dietary Fats results in increased expression of ME1 mRNA]24709573
D004041Dietary FatsDietary Fats results in increased expression of ME1 mRNA16357043|1845759
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of ME1 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of ME1 mRNA]19850644
C014476diethyl maleatediethyl maleate results in increased expression of ME1 mRNA25270620
D004052DiethylnitrosamineAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA]22129741
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ME1 mRNA20360939
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA20033131
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ME1 mRNA19638242
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ME1 mRNA22129741
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA22129741
D004052Diethylnitrosamineisoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA]20033131
D004052DiethylnitrosamineMelatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA]20033131
D004052Diethylnitrosamine[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA22687989
D004052Diethylnitrosamine[oxfendazole co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA18754104
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ME1 mRNA"22485181
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of ME1 mRNA20566472
D004178DiquatDiquat results in increased expression of ME1 mRNA16962985
D004221DisulfiramDisulfiram results in increased expression of ME1 mRNA20566472
C118739entinostatentinostat results in increased expression of ME1 mRNA27188386
D060754EquolEquol results in increased expression of ME1 mRNA16865672
D000431EthanolEthanol results in increased expression of ME1 mRNA19167417
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of ME1 mRNA17347304
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ME1 mRNA20170705|2686566
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ME1 mRNA20170705|2686566
D005001EthionineEthionine affects the expression of ME1 mRNA19483382
C024565ethylene dichlorideethylene dichloride results in decreased expression of ME1 mRNA28189721
D005054EugenolEugenol results in increased expression of ME1 mRNA20566472
D005228Fatty Acids, Essential"Fatty Acids, Essential deficiency results in increased expression of ME1 mRNA"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of ME1 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of ME1 mRNA]"23333450
C047360felbamatefelbamate results in increased expression of ME1 mRNA17381134
D011345FenofibrateFenofibrate results in increased expression of ME1 mRNA18565798
D011345FenofibrateFenofibrate results in increased expression of ME1 mRNA23063693
D011345FenofibrateNR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ME1 mRNA]23063693
D011345FenofibrateNR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ME1 mRNA]23063693
D011345FenofibratePPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ME1 mRNA]23063693
D011345FenofibrateFenofibrate affects the expression of ME1 mRNA20801182
D011345FenofibrateFenofibrate results in increased expression of ME1 mRNA25596134|2707170
D018120FinasterideFinasteride results in increased expression of ME1 mRNA24136188
C082360fipronilfipronil results in increased expression of ME1 mRNA23962444
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of ME1 mRNA17347304
C007738fluoranthene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of ME1 mRNA18711122
D005485FlutamideFlutamide results in increased expression of ME1 mRNA24136188
D005485FlutamideFlutamide results in increased expression of ME1 protein17311803
D005557FormaldehydeFormaldehyde results in decreased expression of ME1 mRNA23649840
C039281furanfuran results in decreased expression of ME1 mRNA26194646
C039281furanfuran results in increased expression of ME1 mRNA25539665
C106014geduningedunin results in increased expression of ME1 mRNA17010675
D019833GenisteinGenistein affects the expression of ME1 mRNA26865667
D019833GenisteinGenistein results in increased expression of ME1 mRNA16865672
D005897GlafenineGlafenine results in decreased expression of ME1 mRNA24136188
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of ME1 mRNA22634610
D005978GlutathioneGlutathione deficiency results in increased expression of ME1 mRNA15345336
C071834glycidamideglycidamide results in increased expression of ME1 mRNA17822822
C080043hexyl cinnamic aldehydehexyl cinnamic aldehyde results in increased expression of ME1 mRNA20566472
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of ME1 mRNA12414654
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of ME1 mRNA19376150
D007052IbuprofenIbuprofen results in increased expression of ME1 mRNA25596134
D007069IfosfamideIfosfamide results in decreased expression of ME1 mRNA25596134
D019469Indinavir[Stavudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ME1 mRNA11741158
D019469Indinavir[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ME1 mRNA11741158
C016517indole-3-carbinolAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA]22129741
C016517indole-3-carbinolindole-3-carbinol affects the expression of ME1 mRNA21396975
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ME1 mRNA22129741
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA22129741
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ME1 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of ME1 mRNA18299717
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ME1 mRNA25613284
D007501IronIron deficiency results in increased expression of ME1 mRNA20368581
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ME1 mRNA28628672
C036643isoeugenolisoeugenol results in increased expression of ME1 mRNA20566472
D007529IsoflavonesIsoflavones results in increased expression of ME1 mRNA17374662
C016527isoquercitrinisoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA]20033131
D019344Lactic AcidLactic Acid results in increased expression of ME1 mRNA20566472
C008261lead acetatelead acetate results in increased expression of ME1 mRNA22839698
C045463leflunomideleflunomide results in increased expression of ME1 mRNA24136188
C095104LG 100268LG 100268 results in increased expression of ME1 mRNA16489205
C482199lipopolysaccharide, E coli O55-B5"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ME1 mRNA"20371263
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with resveratrol] results in decreased expression of ME1 mRNA26667767
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ME1 mRNA12388159
C030298malic acidmalic acid binds to [ME1 protein binds to manganese chloride binds to NADP]7356971
C030298malic acid[malic acid co-treated with manganese chloride co-treated with NADP] binds to and results in increased activity of ME1 protein7356971
C030298malic acid[malic acid co-treated with manganese chloride co-treated with NADP] inhibits the reaction [Oxalic Acid binds to ME1 protein]7356971
C030298malic acid[malic acid co-treated with manganese chloride] promotes the reaction [NADP binds to ME1 protein]7356971
C030298malic acidME1 protein results in decreased carboxylation of malic acid16865672
C025340manganese chloridemalic acid binds to [ME1 protein binds to manganese chloride binds to NADP]7356971
C025340manganese chloride[malic acid co-treated with manganese chloride co-treated with NADP] binds to and results in increased activity of ME1 protein7356971
C025340manganese chloride[malic acid co-treated with manganese chloride co-treated with NADP] inhibits the reaction [Oxalic Acid binds to ME1 protein]7356971
C025340manganese chloride[malic acid co-treated with manganese chloride] promotes the reaction [NADP binds to ME1 protein]7356971
C025340manganese chloride[Pyruvic Acid co-treated with manganese chloride] promotes the reaction [NADP binds to ME1 protein]7356971
D008550MelatoninMelatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA]20033131
C042720mercuric bromidemercuric bromide results in increased expression of ME1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ME1 mRNA"27188386
D008627Mercuric Chloride"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ME1 mRNA"27188386
D008687MetforminMetformin results in decreased expression of ME1 protein28576465
D008687MetforminMetformin results in increased expression of ME1 mRNA25596134
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ME1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ME1 mRNA"27188386
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of ME1 mRNA16525678
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ME1 mRNA24810058
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ME1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ME1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ME1 mRNA]"20230807
C033069methyl salicylatemethyl salicylate results in increased expression of ME1 mRNA20566472
C008493methylselenic acidmethylselenic acid results in increased expression of ME1 mRNA18548127
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of ME1 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ME1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ME1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ME1 mRNA"25620056
C051752nefazodonenefazodone results in increased expression of ME1 mRNA24136188
D019888NelfinavirNelfinavir results in decreased expression of ME1 mRNA11741158
D019888Nelfinavir[Stavudine co-treated with Lamivudine co-treated with Nelfinavir] results in decreased expression of ME1 mRNA11741158
C026385n-hexanen-hexane results in increased expression of ME1 mRNA20566472
C029938nickel sulfatenickel sulfate results in increased expression of ME1 mRNA16314067|2056647
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ME1 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ME1 mRNA]"20230807
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of ME1 mRNA17616710
C025589ochratoxin Aochratoxin A results in decreased expression of ME1 mRNA16251485
D000069463Olive Oil[Olive Oil analog co-treated with Carbon Tetrachloride] affects the expression of ME1 protein25303780
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 results in decreased expression of ME1 mRNA"23333450
D009853OmeprazoleOmeprazole affects the expression of ME1 mRNA19483382
D009853Omeprazole[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA22687989
D019815Oxalic Acid[malic acid co-treated with manganese chloride co-treated with NADP] inhibits the reaction [Oxalic Acid binds to ME1 protein]7356971
D019815Oxalic AcidNADP promotes the reaction [Oxalic Acid binds to ME1 protein]7356971
D019815Oxalic AcidOxalic Acid binds to ME1 protein7356971
C011030oxfendazole[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA20033131
C011030oxfendazoleisoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA]20033131
C011030oxfendazoleMelatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA]20033131
C011030oxfendazole[oxfendazole co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA18754104
D010100OxygenOxygen deficiency affects the expression of ME1 mRNA25596134
D010126OzoneOzone results in decreased expression of ME1 mRNA16183385
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of ME1 mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ME1 mRNA18565798
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ME1 mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased activity of ME1 protein18063289
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ME1 mRNA18063289|1916217
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of ME1 mRNA18281256
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ME1 mRNA22154759
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ME1 mRNA17681415|2215475
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of ME1 mRNA17383973
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ME1 mRNA16221955|1916217
D010634PhenobarbitalPhenobarbital results in increased expression of ME1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of ME1 mRNA17381134|1916217
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ME1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ME1 mRNA26272509
D010672PhenytoinPhenytoin results in increased expression of ME1 mRNA17381134
D010795Phthalic AcidsPhthalic Acids results in decreased expression of ME1 mRNA15728792
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of ME1 mRNA18544911|2248451
D010882Piperonyl ButoxideTriterpenes promotes the reaction [Piperonyl Butoxide results in increased expression of ME1 mRNA]18544911
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ME1 mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of ME1 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of ME1 mRNA15777286|1635704
C006253pirinixic acidpirinixic acid results in increased expression of ME1 protein15226431
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of ME1 mRNA]15777286|1648920
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of ME1 mRNA]20059764
C006253pirinixic acidpirinixic acid affects the expression of ME1 mRNA19483382
C006253pirinixic acidpirinixic acid results in increased expression of ME1 mRNA16489205|1916217
D010936Plant ExtractsPlant Extracts results in increased expression of ME1 mRNA23557933
D028321Plant PreparationsPlant Preparations results in increased expression of ME1 mRNA26945725
D059808PolyphenolsPolyphenols results in decreased expression of ME1 mRNA16293270
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ME1 mRNA19162173|2265931
C035988procymidoneprocymidone results in decreased expression of ME1 mRNA15686871
D0198402-Propanol2-Propanol results in increased expression of ME1 mRNA20566472
D011441PropylthiouracilPropylthiouracil affects the expression of ME1 mRNA19483382
D011441PropylthiouracilPropylthiouracil results in decreased expression of ME1 mRNA24780913
D011718PyrazinamidePyrazinamide results in increased expression of ME1 mRNA27071702
D019289Pyruvic Acid[Pyruvic Acid co-treated with manganese chloride] promotes the reaction [NADP binds to ME1 protein]7356971
C052785rebamipiderebamipide results in increased expression of ME1 mRNA18299717
C059514resveratrol[Lipopolysaccharides co-treated with resveratrol] results in decreased expression of ME1 mRNA26667767
D015474IsotretinoinIsotretinoin results in decreased expression of ME1 mRNA20436886
C488333Ro 65-7199Ro 65-7199 results in increased expression of ME1 mRNA14610520
C089730rosiglitazonerosiglitazone results in decreased expression of ME1 mRNA17361034
C089730rosiglitazonerosiglitazone results in increased expression of ME1 mRNA19201733|2559613
D019258SaquinavirSaquinavir results in decreased expression of ME1 mRNA11741158
D012643SeleniumSelenium results in decreased expression of ME1 mRNA19244175
C017947sodium arsenitesodium arsenite results in increased expression of ME1 mRNA25493608|2871322
C017947sodium arsenitesodium arsenite results in increased expression of ME1 mRNA25270620
C016104sodium bichromatesodium bichromate results in decreased expression of ME1 mRNA24612858
C016104sodium bichromatesodium bichromate results in decreased expression of ME1 mRNA25993096
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in increased expression of ME1 mRNA20566472
C016766sulforafansulforafan results in increased expression of ME1 mRNA26833863
D013467Sulindac"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ME1 mRNA"20371263
C446685systhanesysthane affects the expression of ME1 mRNA17383973
D014284TriiodothyronineTriiodothyronine results in increased expression of ME1 mRNA15953391
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of ME1 mRNA]21079772
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of ME1 mRNA]20032058
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ME1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ME1 mRNA17555868|1961957
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ME1 mRNA24680724|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ME1 mRNA16054898|1846511
D013752TetracyclineTetracycline results in increased expression of ME1 protein16538043
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ME1 mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of ME1 mRNA19483382
C009495titanium dioxidetitanium dioxide results in decreased expression of ME1 mRNA23557971
C423915TO-901317NR1H2 gene mutant form inhibits the reaction [TO-901317 results in increased expression of ME1 mRNA]23063693|2333345
C423915TO-901317NR1H3 gene mutant form inhibits the reaction [TO-901317 results in increased expression of ME1 mRNA]23063693|2333345
C423915TO-901317TO-901317 results in increased expression of ME1 mRNA23063693|2333345
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ME1 mRNA22363418
C052342topiramatetopiramate results in decreased expression of ME1 mRNA16979414
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in increased expression of ME1 mRNA"17217560
D014212TretinoinTretinoin results in increased expression of ME1 mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in increased expression of ME1 mRNA25549359
D014241TrichloroethyleneTrichloroethylene results in increased expression of ME1 mRNA19448997
D014241TrichloroethyleneTrichloroethylene results in increased methylation of ME1 gene27618143
C012589trichostatin Atrichostatin A results in increased expression of ME1 mRNA24935251|2627250
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of ME1 mRNA17982090
C050414tripterinetripterine results in increased expression of ME1 mRNA17010675
D014315TriterpenesTriterpenes promotes the reaction [Piperonyl Butoxide results in increased expression of ME1 mRNA]18544911
C057693troglitazonetroglitazone results in increased expression of ME1 mRNA25596134
C057693troglitazonetroglitazone results in increased expression of ME1 protein21315101
C080163trovafloxacintrovafloxacin results in decreased expression of ME1 mRNA24136188
C406224valdecoxibvaldecoxib results in increased expression of ME1 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ME1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ME1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ME1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of ME1 mRNA17292431|1796380
D014635Valproic AcidValproic Acid results in increased expression of ME1 mRNA17381134
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ME1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of ME1 mRNA22570695
D014752Vinyl ChlorideVinyl Chloride results in increased expression of ME1 mRNA18579281
C029297vinylidene chloridevinylidene chloride results in decreased expression of ME1 mRNA26682919
D014807Vitamin DVitamin D affects the expression of ME1 mRNA20368581
D024483Vitamin K 3Vitamin K 3 results in increased expression of ME1 mRNA12414654
C403304zerumbonezerumbone inhibits the reaction [Dietary Fats results in increased expression of ME1 mRNA]24709573
D015215Zidovudine[Zidovudine co-treated with Lamivudine] affects the expression of ME1 mRNA11741158
D015215Zidovudine[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ME1 mRNA11741158
D015215ZidovudineZidovudine results in decreased expression of ME1 mRNA11741158
C088658zoledronic acidzoledronic acid results in increased expression of ME1 mRNA24714768|2559613

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004470malic enzyme activity-IBA21873635  
GO:0004470malic enzyme activity-IDA7622060  8187880  
GO:0004470malic enzyme activity-IMP23334421  
GO:0004471malate dehydrogenase (decarboxylating) (NAD+) activity-IEA-  
GO:0004473malate dehydrogenase (decarboxylating) (NADP+) activity-IBA21873635  
GO:0004473malate dehydrogenase (decarboxylating) (NADP+) activity-IDA8187880  
GO:0004473malate dehydrogenase (decarboxylating) (NADP+) activity-ISS-  
GO:0004473malate dehydrogenase (decarboxylating) (NADP+) activity-TAS-  
GO:0008948oxaloacetate decarboxylase activity-IEA-  
GO:0009055electron transfer activity-TAS7622060  
GO:0030145manganese ion binding-IDA7622060  
GO:0043531ADP binding-TAS7622060  
GO:0050661NADP binding-TAS7622060  
GO:0051287NAD binding-TAS7622060  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-NAS8187880  
GO:0006090pyruvate metabolic process-IBA21873635  
GO:0006090pyruvate metabolic process-TAS-  
GO:0006108malate metabolic process-IBA21873635  
GO:0006108malate metabolic process-IDA7622060  8187880  
GO:0006741NADP biosynthetic process-TAS8187880  
GO:0009725response to hormone-ISS-  
GO:0009743response to carbohydrate-TAS8187880  
GO:0019216regulation of lipid metabolic process-TAS-  
GO:0022900electron transport chain-IEA-  
GO:0051262protein tetramerization-IEA-  
GO:1902031regulation of NADP metabolic process-IMP23334421  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005829cytosol-ISS-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00620Pyruvate metabolism
hsa01100Metabolic pathways
hsa03320PPAR signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-70268Pyruvate metabolismTAS
R-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29483230Cocaine Exposure Increases Blood Pressure and Aortic Stiffness via the miR-30c-5p-Malic Enzyme 1-Reactive Oxygen Species Pathway. (2018 Apr)Zhu WHypertension