Gene: ART4

420
ARTC4|CD297|DO|DOK1
ADP-ribosyltransferase 4 (Dombrock blood group)
protein-coding
12p12.3
Ensembl:ENSG00000111339 MIM:110600 Vega:OTTHUMG00000168738 UniprotKB:Q93070
NG_007477.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.780e-1 (AD)  7.662e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
INMT0.774
COL8A10.758
TRABD2B0.751
ALX40.741
SLC22A20.736
FOXD20.731
SLC13A40.729
BMX0.728
PKHD1L10.727
GATA60.725

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.321
NDP-0.304
BAIAP2L2-0.304
HAGHL-0.304
CLDND2-0.286
MARCH11-0.283
CCDC24-0.278
TMEM191C-0.276
KCNIP3-0.276
MYADML2-0.273

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of ART4 mRNA"26377693
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ART4 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ART4 mRNA"25614096
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ART4 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ART4 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ART4 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ART4 mRNA"25510870
D000082AcetaminophenAcetaminophen results in decreased expression of ART4 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of ART4 mRNA17562736
D000111AcetylcysteineAcetylcysteine results in decreased expression of ART4 mRNA16084531
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ART4 protein20106945
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ART4 mRNA21298039
D001151ArsenicArsenic affects the methylation of ART4 gene25304211
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of ART4 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ART4 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ART4 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of ART4 mRNA20106945|2163298
C006780bisphenol Abisphenol A results in decreased expression of ART4 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ART4 mRNA20938992
D003300CopperCopper deficiency results in increased expression of ART4 mRNA26033743
D016572CyclosporineCyclosporine results in decreased expression of ART4 mRNA20106945|2556210
D003561CytarabineCytarabine results in decreased expression of ART4 mRNA21198554
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ART4 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ART4 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of ART4 mRNA28302478
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of ART4 mRNA16084531
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ART4 mRNA20938992
D017313FenretinideFenretinide results in increased expression of ART4 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of ART4 mRNA17183730
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ART4 mRNA20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ART4 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ART4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ART4 mRNA"25620056
C017096n-butoxyethanoln-butoxyethanol results in increased expression of ART4 mRNA19812364
C028007nickel monoxidenickel monoxide results in decreased expression of ART4 mRNA19167457
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ART4 mRNA"25510870
D010433PentylenetetrazolePentylenetetrazole affects the expression of ART4 mRNA21503142
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ART4 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of ART4 mRNA20813756
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ART4 mRNA23608068
C005556propionaldehydepropionaldehyde results in decreased expression of ART4 mRNA26079696
D011794QuercetinQuercetin results in decreased expression of ART4 mRNA21632981
C089730rosiglitazonerosiglitazone results in increased expression of ART4 mRNA23166672
D018038Sodium SeleniteSodium Selenite results in decreased expression of ART4 mRNA18175754
C075117squalestatin 1squalestatin 1 results in increased expression of ART4 mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of ART4 mRNA27225895
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ART4 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ART4 mRNA15328365
D014520UrethaneUrethane results in decreased expression of ART4 mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of ART4 mRNA17183730
D014635Valproic AcidValproic Acid results in decreased expression of ART4 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ART4 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003950NAD+ ADP-ribosyltransferase activity-IBA21873635  
GO:0003956NAD(P)+-protein-arginine ADP-ribosyltransferase activity-NAS9119374  
GO ID GO Term Qualifier Evidence PubMed
GO:0006471protein ADP-ribosylation-IBA21873635  
GO:0006471protein ADP-ribosylation-NAS9119374  
GO:0006525arginine metabolic process-NAS11001920  
GO:0018120peptidyl-arginine ADP-ribosylation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-NAS9119374  
GO:0031225anchored component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16627471ADP-ribosyltransferase-specific modification of human neutrophil peptide-1. (2006 Jun 23)Paone GJ Biol Chem