Gene: MECP2

4204
AUTSX3|MRX16|MRX79|MRXS13|MRXSL|PPMX|RS|RTS|RTT
methyl-CpG binding protein 2
protein-coding
Xq28
Ensembl:ENSG00000169057 MIM:300005 Vega:OTTHUMG00000024229 UniprotKB:P51608
NG_007107.2
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
USP220.963
PRRC2B0.95
LARP10.949
IP6K10.949
TAF60.949
PDPK10.949
WIPF20.947
XPO70.947
HTT0.946
ATP2A20.945

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.614
OR4F29-0.568
TFPI2-0.401
CSAG1-0.391
MYL3-0.384
IL18RAP-0.363
KLRB1-0.362
CST7-0.359
SLAMF6-0.351
KLRF1-0.35

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"[2,2',4,4'-tetrabromodiphenyl ether co-treated with MECP2 gene polymorphism] results in increased expression of DNMT3A mRNA"22343140
C5112952,2',4,4'-tetrabromodiphenyl ether"MECP2 affects the susceptibility to 2,2',4,4'-tetrabromodiphenyl ether"22343140
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MECP2 mRNA"27291303
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MECP2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MECP2 mRNA"27188386
C0757734-phenylbutyric acid[4-phenylbutyric acid affects the acetylation of MECP2 protein] which affects the expression of TUBB3 protein18497984
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MECP2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of MECP2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MECP2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MECP2 mRNA19770486
D006710HomocysteineHomocysteine inhibits the reaction [MECP2 protein binds to CCNA1 promoter]17698632
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MECP2 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of MECP2 mRNA25929836
D001374AzacitidineAzacitidine inhibits the reaction [MECP2 protein binds to CCNA1 promoter]17698632
D001554BenzeneBenzene results in increased expression of MECP2 mRNA19162166
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MECP2 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MECP2 mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ethanol results in increased degradation of MECP2 protein]23395981
D004958Estradiol[Estradiol co-treated with sodium arsenite] results in decreased expression of MECP2 mRNA22952798
D004958EstradiolEstradiol results in decreased expression of MECP2 mRNA22952798
D004958Estradiol[Testosterone co-treated with Estradiol] results in decreased expression of MECP2 mRNA22109888
D001640BicucullineMECP2 protein affects the reaction [Bicuculline results in decreased expression of GRIA2 protein]22262897
D001640BicucullineBicuculline promotes the reaction [MECP2 protein binds to GRIA2 promoter]22262897
D001640BicucullineBicuculline results in increased expression of MECP2 mRNA22262897
D001640BicucullineBicuculline results in increased phosphorylation of MECP2 protein22262897
D001640BicucullineMECP2 protein affects the reaction [Bicuculline results in decreased expression of GRIA2 protein]22262897
C006780bisphenol Abisphenol A results in decreased expression of MECP2 mRNA27120497
C006780bisphenol Abisphenol A promotes the reaction [MECP2 protein binds to SLC12A5 promoter]23440186
C006780bisphenol Abisphenol A results in increased expression of MECP2 mRNA23535407
C006780bisphenol Abisphenol A promotes the reaction [MECP2 protein binds to SLC12A5 promoter]23440186
C006780bisphenol Abisphenol A results in increased expression of MECP2 mRNA23440186|2518105
C006780bisphenol Abisphenol A results in increased expression of MECP2 protein23440186
D001761BleomycinMECP2 protein affects the susceptibility to Bleomycin21435439
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of MECP2 mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of MECP2 mRNA26079696
D002087ButyratesButyrates inhibits the reaction [MECP2 protein binds to CCNA1 promoter]17698632
D002087ButyratesButyrates results in decreased expression of MECP2 mRNA16042588
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MECP2 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MECP2 mRNA27350269
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MECP2 protein22056649|2735026
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of MECP2 mRNA18636392
D003042CocaineMECP2 mRNA inhibits the reaction [Cocaine results in increased expression of MIR132 protein]20711185
D003042CocaineMECP2 mRNA inhibits the reaction [Cocaine results in increased expression of MIR212 protein]20711185
D003042CocaineCocaine inhibits the reaction [MECP2 protein binds to BDNF promoter]24358339
D003042CocaineCocaine affects the reaction [MECP2 protein affects the expression of BDNF protein]20711185
D003042CocaineCocaine affects the reaction [MECP2 protein binds to and results in decreased activity of BDNF promoter]20810894
D003042CocaineCocaine results in increased expression of MECP2 protein16670375|2071118
D019327Copper SulfateCopper Sulfate results in increased expression of MECP2 mRNA19549813
D003474CurcuminCurcumin results in decreased expression of MECP2 protein23593078
C014347decitabine[decitabine co-treated with trichostatin A] results in decreased expression of MECP2 mRNA17891453
C014347decitabinedecitabine inhibits the reaction [PDGFB protein results in increased expression of MECP2 mRNA]22056649
C000944dicrotophosdicrotophos results in increased expression of MECP2 mRNA28302478
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of MECP2 mRNA25280772
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MECP2 mRNA18164116
D004147DioxinsDioxins affects the expression of MECP2 mRNA20463971
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MECP2 protein23301498
D000431Ethanolbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ethanol results in increased degradation of MECP2 protein]23395981
D000431EthanolEthanol results in decreased expression of MECP2 protein23395981|2354414
D000431EthanolEthanol results in increased degradation of MECP2 protein23395981
D000431EthanolEthanol results in increased expression of MECP2 mRNA23395981
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MECP2 mRNA29097150
D005038EthylnitrosoureaEthylnitrosourea results in increased expression of MECP221154115
D005419FlavonoidsFlavonoids results in decreased expression of MECP2 mRNA18035473
D005473FluoxetineFluoxetine results in increased expression of MECP2 mRNA16670375
D005473FluoxetineFluoxetine results in increased expression of MECP2 mRNA alternative form16670375
D005473FluoxetineFluoxetine results in increased expression of MECP2 protein16670375
D005557FormaldehydeFormaldehyde results in increased expression of MECP2 mRNA12679049
C069837fullerene C60fullerene C60 results in decreased expression of MECP2 mRNA19167457
D019833GenisteinGenistein results in decreased expression of MECP2 protein23593078
D019833GenisteinGenistein results in increased expression of MECP2 mRNA15256057
D005839GentamicinsGentamicins results in increased expression of MECP2 protein mutant form19190538
D017313FenretinideFenretinide results in increased expression of MECP2 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MECP2 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MECP2 mRNA23086925
D007854LeadLead affects the splicing of MECP2 mRNA28903495
D007854LeadLead results in decreased expression of MECP2 mRNA22272629
D007854LeadLead results in decreased expression of MECP2 protein22272629
D007854LeadLead results in decreased expression of MECP2 mRNA27239543
D007854LeadLead results in decreased expression of MECP2 protein27239543
D007854Lead[Lead results in decreased expression of BDNF protein] which results in decreased phosphorylation of and results in decreased expression of MECP2 protein22345308
C008261lead acetatelead acetate results in decreased expression of MECP2 protein21891863
C008261lead acetatelead acetate affects the expression of MECP2 mRNA22160880
C008261lead acetatelead acetate results in decreased expression of MECP2 protein23246732
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of MECP2 mRNA"24972896
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of MECP2 mRNA21641980
D008555MelittenMelitten results in decreased expression of MECP2 mRNA26189965
D008555MelittenMelitten results in decreased expression of MECP2 protein26189965
D008715MethionineMethionine promotes the reaction [MECP2 binds to GAD1 promoter]16113080
D008715MethionineMethionine promotes the reaction [MECP2 binds to RELN promoter]16113080
C004925methylmercuric chloridemethylmercuric chloride inhibits the reaction [MECP2 protein binds to MMP9 promoter]28526320
D016685MitomycinMitomycin results in increased expression of MECP2 protein27032448
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MECP2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MECP2 mRNA"25554681
C017558nickel sulfidenickel sulfide promotes the reaction [MECP2 protein binds to MIR152 promoter]23125218
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of MECP2 mRNA18636392
D010269ParaquatParaquat results in increased expression of MECP2 mRNA21371552
D052638Particulate MatterParticulate Matter affects the methylation of MECP2 promoter28153600
D052638Particulate MatterParticulate Matter results in increased expression of MECP2 mRNA28153600
D010634PhenobarbitalPhenobarbital results in decreased expression of MECP2 mRNA28495587
D011189Potassium ChloridePotassium Chloride affects the localization of MECP2 protein14593183
D011189Potassium ChloridePotassium Chloride inhibits the reaction [MECP2 protein binds to BDNF promoter]14593183
C023617pregna-4,17-diene-3,16-dione"pregna-4,17-diene-3,16-dione results in decreased expression of MECP2 protein"23593078
C009131pyrimidin-2-one beta-ribofuranosidepyrimidin-2-one beta-ribofuranoside results in decreased expression of MECP2 protein19459041
C059514resveratrolresveratrol results in decreased expression of MECP2 protein23593078
C009277sodium arsenatesodium arsenate results in increased expression of MECP2 mRNA21795629
C017947sodium arsenite[Estradiol co-treated with sodium arsenite] results in decreased expression of MECP2 mRNA22952798
C017947sodium arsenitesodium arsenite affects the expression of MECP2 mRNA22952798
C017947sodium arsenitesodium arsenite results in increased expression of MECP2 mRNA19822182
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of MECP2 mRNA21641980
D013739Testosterone[Testosterone co-treated with Estradiol] results in decreased expression of MECP2 mRNA22109888
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MECP2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MECP2 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MECP2 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MECP2 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MECP2 mRNA28065790
C012589trichostatin A[decitabine co-treated with trichostatin A] results in decreased expression of MECP2 mRNA17891453
C012589trichostatin Atrichostatin A inhibits the reaction [MECP2 protein binds to CCNA1 promoter]17698632
D014260TriclosanTriclosan results in decreased expression of MECP2 mRNA26970259
D014260TriclosanTriclosan results in decreased expression of MECP2 protein26970259
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MECP2 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MECP2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MECP2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MECP2 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased methylation of MECP2 gene29154799
D014635Valproic AcidValproic Acid inhibits the reaction [MECP2 binds to GAD1 promoter]16113080
D014635Valproic AcidValproic Acid inhibits the reaction [MECP2 binds to RELN promoter]16113080
C009684withaferin Awithaferin A results in decreased expression of MECP2 protein23593078
C049109zolpidemzolpidem promotes the reaction [MECP2 protein binds to BDNF promoter]24367698

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0003677DNA binding-IBA21873635  
GO:0003677DNA binding-TAS9620804  
GO:0003682chromatin binding-IEA-  
GO:0003714transcription corepressor activity-TAS10773092  
GO:0003723RNA binding-HDA22658674  
GO:0003729mRNA binding-IEA-  
GO:0005515protein binding-IPI15696166  19820693  23770565  25609649  
GO:0008134transcription factor binding-IEA-  
GO:0008327methyl-CpG binding-IBA21873635  
GO:0010385double-stranded methylated DNA binding-IBA21873635  
GO:0010385double-stranded methylated DNA binding-IMP17296936  
GO:0019904protein domain specific binding-IPI11441023  
GO:0035197siRNA binding-IEA-  
GO:0047485protein N-terminus binding-IPI11441023  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-TAS9620804  
GO:0001662behavioral fear response-IEA-  
GO:0001666response to hypoxia-IEA-  
GO:0001964startle response-IEA-  
GO:0001976neurological system process involved in regulation of systemic arterial blood pressure-IEA-  
GO:0002087regulation of respiratory gaseous exchange by neurological system process-IEA-  
GO:0006020inositol metabolic process-IEA-  
GO:0006122mitochondrial electron transport, ubiquinol to cytochrome c-IEA-  
GO:0006342chromatin silencing-IEA-  
GO:0006349regulation of gene expression by genetic imprinting-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006541glutamine metabolic process-IEA-  
GO:0006576cellular biogenic amine metabolic process-IEA-  
GO:0007052mitotic spindle organization-IMP25527496  
GO:0007416synapse assembly-IEA-  
GO:0007585respiratory gaseous exchange-IEA-  
GO:0007616long-term memory-IEA-  
GO:0007626locomotory behavior-IBA21873635  
GO:0008104protein localization-IEA-  
GO:0008211glucocorticoid metabolic process-IEA-  
GO:0008284positive regulation of cell proliferation-IMP25527496  
GO:0008344adult locomotory behavior-IEA-  
GO:0008542visual learning-IEA-  
GO:0009314response to radiation-IBA21873635  
GO:0009405pathogenesis-IEA-  
GO:0009791post-embryonic development-IEA-  
GO:0010629negative regulation of gene expression-IDA23960241  
GO:0010971positive regulation of G2/M transition of mitotic cell cycle-IMP25527496  
GO:0016358dendrite development-IEA-  
GO:0016525negative regulation of angiogenesis-IMP23960241  
GO:0016571histone methylation-IEA-  
GO:0016573histone acetylation-IEA-  
GO:0019230proprioception-IEA-  
GO:0019233sensory perception of pain-IEA-  
GO:0021549cerebellum development-IEA-  
GO:0021591ventricular system development-IEA-  
GO:0031061negative regulation of histone methylation-IEA-  
GO:0032048cardiolipin metabolic process-IEA-  
GO:0035067negative regulation of histone acetylation-IEA-  
GO:0035176social behavior-IEA-  
GO:0042551neuron maturation-IEA-  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0043537negative regulation of blood vessel endothelial cell migration-IDA23960241  
GO:0045892negative regulation of transcription, DNA-templated-IDA11441023  
GO:0045893positive regulation of transcription, DNA-templated-IEA-  
GO:0046470phosphatidylcholine metabolic process-IEA-  
GO:0050432catecholamine secretion-IEA-  
GO:0051151negative regulation of smooth muscle cell differentiation-IEA-  
GO:0051965positive regulation of synapse assembly-IEA-  
GO:0060079excitatory postsynaptic potential-IEA-  
GO:0060291long-term synaptic potentiation-IEA-  
GO:0090063positive regulation of microtubule nucleation-IMP25527496  
GO:1900114positive regulation of histone H3-K9 trimethylation-IEA-  
GO:1905643positive regulation of DNA methylation-IDA23960241  
GO:2000820negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000785chromatin-IBA21873635  
GO:0000792heterochromatin-IBA21873635  
GO:0000792heterochromatin-IDA11441023  
GO:0000930gamma-tubulin complexcolocalizes_withIMP25527496  
GO:0005615extracellular space-HDA22664934  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA11441023  21782149  
GO:0005739mitochondrion-IEA-  
GO:0005813centrosomecolocalizes_withIMP25527496  
GO:0005829cytosol-IBA21873635  
GO:0098794postsynapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26482727Cigarette smoke induces proteasomal-mediated degradation of DNA methyltransferases and methyl CpG-/CpG domain-binding proteins in embryonic orofacial cells. (2015 Dec)Mukhopadhyay PReprod Toxicol
27213019MeCP2 and the enigmatic organization of brain chromatin. Implications for depression and cocaine addiction. (2016)Ausio JClin Epigenetics
25661292Perinatal nicotine exposure suppresses PPARgamma epigenetically in lung alveolar interstitial fibroblasts. (2015 Apr)Gong MMol Genet Metab
23717324MicroRNAs and Drug Addiction. (2013)Bali PFront Genet
25392083Elevation of BDNF exon I-specific transcripts in the frontal cortex and midbrain of rat during spontaneous morphine withdrawal is accompanied by enhanced pCreb1 occupancy at the corresponding promoter. (2015 Jan)Peregud DINeurochem Res
24990928MeCP2 repression of G9a in regulation of pain and morphine reward. (2014 Jul 2)Zhang ZJ Neurosci
20711185MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212. (2010 Sep)Im HINat Neurosci
23382145Cracking the molecular code of cocaine addiction. (2011)Ahmed SHILAR J
23448145MeCP2 regulates ethanol sensitivity and intake. (2014 Sep)Repunte-Canonigo VAddict Biol