Gene: ARVCF

421
-
ARVCF, delta catenin family member
protein-coding
22q11.21
Ensembl:ENSG00000099889 MIM:602269 Vega:OTTHUMG00000030426 UniprotKB:O00192
NG_023326.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.179e-1 (AD)  8.792e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2238796chr22:20011550 (GRCh38.p7)C>A / C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18704527chr22:19962042ARVCF2.400e-15Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OBSL10.899
TAB10.874
PIGQ0.872
D2HGDH0.863
TRMT2A0.857
GALT0.857
MAPK120.855
SPPL2B0.855
GPC10.853
SCRN20.852

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.584
OR4F29-0.536
MTRNR2L6-0.416
MTRNR2L9-0.393
PPBP-0.368
MTRNR2L10-0.357
PABPC4L-0.352
CLEC2B-0.33
KCNJ15-0.328
KIAA0040-0.324

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ARVCF mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ARVCF mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ARVCF mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ARVCF mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ARVCF mRNA"25510870
D000082AcetaminophenAcetaminophen results in increased expression of ARVCF mRNA22230336|2906747
D000082AcetaminophenAcetaminophen affects the expression of ARVCF mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ARVCF mRNA21641981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ARVCF mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ARVCF mRNA19770486
D004958EstradiolEstradiol affects the expression of ARVCF mRNA22574217
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ARVCF gene20938992
D003471CuprizoneCuprizone results in increased expression of ARVCF mRNA26577399
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ARVCF mRNA27392435
D002945CisplatinCisplatin results in increased expression of ARVCF mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of ARVCF mRNA25016146
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ARVCF mRNA21658437
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARVCF mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ARVCF gene20938992
D017313FenretinideFenretinide results in increased expression of ARVCF mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ARVCF mRNA27392435
C008261lead acetatelead acetate results in decreased expression of ARVCF mRNA22609695
D008070Lipopolysaccharides[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased methylation of ARVCF gene21212295
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ARVCF gene20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ARVCF mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ARVCF mRNA"25554681
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ARVCF mRNA"25510870
C005556propionaldehydepropionaldehyde results in increased expression of ARVCF mRNA26079696
D011794QuercetinQuercetin results in decreased expression of ARVCF mRNA15309432
D012999SomanSoman results in decreased expression of ARVCF mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ARVCF mRNA21296121
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARVCF mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased methylation of ARVCF gene21212295
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ARVCF mRNA19770486
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ARVCF mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ARVCF mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of ARVCF mRNA28973697
D014635Valproic AcidValproic Acid results in increased methylation of ARVCF gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ARVCF gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19706687  
GO:0045296cadherin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007043cell-cell junction assembly-IBA21873635  
GO:0007155cell adhesion-TAS9126485  
GO:0007275multicellular organism development-IEA-  
GO:0009966regulation of signal transduction-IBA21873635  
GO:0016339calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules-IEA-  
GO:0098609cell-cell adhesion-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-TAS9126485  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IEA-  
GO:0005911cell-cell junction-IBA21873635  
GO:0005913cell-cell adherens junction-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal