Gene: MEFV

4210
FMF|MEF|TRIM20
MEFV, pyrin innate immunity regulator
protein-coding
16p13.3
Ensembl:ENSG00000103313 MIM:608107 Vega:OTTHUMG00000129324 UniprotKB:O15553
NG_007871.1
PubMed
0   ANCO-SNPs
ND
10   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.717e-1 (AD)  6.133e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg08781710chr16:3301349MEFVGene body1.303e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HK30.701
NABP10.69
LILRA60.68
LILRA50.68
FFAR20.637
CR10.634
FRRS10.633
CSF2RB0.632
PSTPIP20.632
SLAMF80.628

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARSF-0.413
WFDC1-0.358
ASPDH-0.336
CRH-0.33
ACY3-0.323
ADRA2C-0.32
HAGHL-0.314
C1orf53-0.307
DLX1-0.301
MATK-0.3

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of MEFV mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MEFV gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of MEFV mRNA"23195993
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MEFV mRNA16483693
D001507BeclomethasoneMEFV mutant form results in increased susceptibility to Beclomethasone20828792
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of MEFV mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of MEFV mRNA26377693
C006780bisphenol Abisphenol A results in decreased expression of MEFV mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MEFV gene28505145
D003471CuprizoneCuprizone results in increased expression of MEFV mRNA27523638
C039281furanfuran results in increased expression of MEFV mRNA27387713
D006046GoldGold results in increased expression of MEFV mRNA25523186
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MEFV mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MEFV mRNA23086925|2675264
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MEFV mRNA25982114
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MEFV mRNA25613284
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of MEFV mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MEFV mRNA"25554681
D009532NickelNickel results in decreased expression of MEFV mRNA23195993
C025256nonylphenolnonylphenol results in decreased expression of MEFV mRNA22982499
C025589ochratoxin Aochratoxin A results in decreased methylation of MEFV gene26431795
D010936Plant ExtractsPlant Extracts results in increased expression of MEFV mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of MEFV mRNA24780913
D053260SootSoot results in increased expression of MEFV mRNA22461453|2655175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MEFV mRNA26377647
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MEFV mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of MEFV mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MEFV mRNA25447457
D014303TrinitrotolueneTrinitrotoluene affects the expression of MEFV mRNA21346803
D014635Valproic AcidValproic Acid results in increased methylation of MEFV gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IBA21873635  
GO:0003779actin binding-IDA11468188  
GO:0005515protein binding-IPI11498534  16785446  17964261  25006247  25127057  26347139  
GO:0008270zinc ion binding-NAS11115844  
GO:0042802identical protein binding-IPI17964261  22829933  25006247  
GO ID GO Term Qualifier Evidence PubMed
GO:0006954inflammatory response-IBA21873635  
GO:0006954inflammatory response-IDA11468188  
GO:0010508positive regulation of autophagy-IBA21873635  
GO:0010508positive regulation of autophagy-IDA26347139  
GO:0032691negative regulation of interleukin-1 beta production-IMP20041150  
GO:0032695negative regulation of interleukin-12 production-IMP20041150  
GO:0034341response to interferon-gamma-IBA21873635  
GO:0034341response to interferon-gamma-IDA26347139  
GO:0050728negative regulation of inflammatory response-IMP16403826  
GO:0071641negative regulation of macrophage inflammatory protein 1 alpha production-IMP20041150  
GO:1900016negative regulation of cytokine production involved in inflammatory response-IMP26347139  
GO:1900226negative regulation of NLRP3 inflammasome complex assembly-IMP26347139  
GO:2001056positive regulation of cysteine-type endopeptidase activity-IDA19158676  
GO ID GO Term Qualifier Evidence PubMed
GO:0001726ruffle-IEA-  
GO:0005634nucleus-IDA11115844  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA26347139  
GO:0005776autophagosome-IEA-  
GO:0005829cytosol-TAS-  
GO:0005874microtubule-IEA-  
GO:0005875microtubule associated complex-IBA21873635  
GO:0005875microtubule associated complex-IDA11468188  
GO:0030027lamellipodium-IEA-  
GO:0031410cytoplasmic vesicle-IEA-  
KEGG ID KEGG Term
hsa04621NOD-like receptor signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysTAS
R-HSA-622312InflammasomesTAS
R-HSA-844456The NLRP3 inflammasomeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26400644Relationship between periodontal destruction and gene mutations in patients with familial Mediterranean fever. (2016 Jul)Sezer UClin Rheumatol
27708899Serum lipid changes and insulin resistance in familial Mediterranean fever. (2014 Dec)Candan ZEur J Rheumatol
23794947Increased levels of macrophage migration inhibitory factor in patients with familial mediterranean Fever. (2013)Savran YInt J Med Sci
3730639Early lung function changes after short heavy exposure to chrysotile asbestos in non-smoking women. (1986 May-Jun)Rodriguez-Roisin RBull Eur Physiopathol Respir
2327637Carbon monoxide diffusing capacity, other indices of lung function, and respiratory symptoms in a general population sample. (1990 Apr)Viegi GAm Rev Respir Dis
3122567Can postoperative pulmonary complications after elective cholecystectomy be predicted? (1988 Jan)Poe RHAm J Med Sci
11316111The short-term repeatability of histamine bronchial testing in young males. The SUS study. (2001 Apr)Omland ORespir Med
10926342Airway obstruction and chronic exertional dyspnoea in patients with persistent bronchial asthma. (2000 Jul)Filippelli MRespir Med
7237734A pulmonary survey of grain handlers in the West of Scotland. (1981 Mar)Patel KRClin Allergy
11153034The shape of the maximum expiratory flow-volume curve reflects exposure in farming. (2000)Omland OAnn Agric Environ Med