Gene: MAP3K1

4214
MAPKKK1|MEKK|MEKK 1|MEKK1|SRXY6
mitogen-activated protein kinase kinase kinase 1
protein-coding
5q11.2
Ensembl:ENSG00000095015 MIM:600982 Vega:OTTHUMG00000059486 UniprotKB:Q13233
NG_031884.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.290e-2 (AD)  7.018e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2229882chr5:56872885 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC500.828
CARD80.795
FAM111A0.792
LIMA10.792
DISC10.781
CALCRL0.768
NEDD40.762
KDELC20.759
TMOD30.756
KLF30.753

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RHO-0.399
HAS1-0.392
MYADML2-0.389
SPEF1-0.388
BHLHA9-0.38
YBX2-0.38
CKMT1A-0.378
TGFBR3L-0.376
LRFN2-0.375
LRRC73-0.374

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB06061AZD-8330Small MoleculeInvestigationalTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MAP3K1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MAP3K1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MAP3K1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of MAP3K1 protein"22889935
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MAP3K1 mRNA"25510870
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [zinc chloride results in increased activity of MAP3K1 protein]11306679
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MAP3K1 mRNA"25510870
C0038982-anisidine2-anisidine results in decreased expression of MAP3K1 mRNA28089782
C5779422-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide results in decreased expression of MAP3K1 mRNA"26644586
C5850042-monochloropropanediol2-monochloropropanediol results in decreased expression of MAP3K1 mRNA28522335
C0354193,4-dihydroxybenzohydroxamic acid"3,4-dihydroxybenzohydroxamic acid inhibits the reaction [Lipopolysaccharides results in increased expression of MAP3K1 mRNA]"25843059
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of MAP3K1 mRNA]"23452621
C0264233,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one"3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one results in decreased expression of MAP3K1 mRNA"23811531
C0264233,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one"3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one results in decreased expression of MAP3K1 protein"23811531
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine results in increased expression of MAP3K1 mRNA14610520
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of MAP3K1 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of MAP3K1 mRNA17562736
D000086AcetazolamideAcetazolamide results in increased expression of MAP3K1 mRNA19274763
C000188alachloralachlor results in increased expression of MAP3K1 mRNA12419858
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of MAP3K1 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MAP3K1 mRNA16483693
D001151ArsenicArsenic affects the methylation of MAP3K1 gene25304211
D001152ArsenicalsArsenicals results in decreased methylation of MAP3K1 promoter23315758
C108637aspartyl-glutamyl-valyl-aspartalaspartyl-glutamyl-valyl-aspartal inhibits the reaction [Paclitaxel results in increased cleavage of MAP3K1 protein]11160861
C547126AZM551248AZM551248 results in decreased expression of MAP3K1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MAP3K1 protein16041517
D001564Benzo(a)pyreneNitrogen Oxides inhibits the reaction [Benzo(a)pyrene results in increased expression of MAP3K1 protein]16041517
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MAP3K1 mRNA"19150397
D004958Estradiol[Estradiol co-treated with IGF1R mutant form] results in increased expression of MAP3K1 mRNA23094148
C044887beta-methylcholinebeta-methylcholine affects the expression of MAP3K1 mRNA21179406
C095105bexarotenebexarotene results in increased expression of MAP3K1 mRNA16648578
C006780bisphenol Abisphenol A affects the expression of MAP3K1 mRNA20170705
C006780bisphenol Abisphenol A results in increased expression of MAP3K1 mRNA29275510
C006780bisphenol Abisphenol A results in decreased methylation of MAP3K1 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of MAP3K1 mRNA25181051
C028031cadmium acetatecadmium acetate affects the expression of MAP3K1 mRNA16249259
D002509CephaloridineCephaloridine results in increased expression of MAP3K1 mRNA18172885
D003024ClozapineClozapine results in increased expression of MAP3K1 mRNA15860345
D019327Copper SulfateCopper Sulfate results in increased expression of MAP3K1 mRNA19549813
C029892cupric chloridecupric chloride results in decreased expression of MAP3K1 mRNA19515434
D003474CurcuminCurcumin inhibits the reaction [MAP3K1 protein results in increased expression of IVL mRNA]17148446
D003474CurcuminCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of MAP3K1 mRNA]23452621
D003474CurcuminCurcumin results in decreased expression of MAP3K1 mRNA15713895
C057862cyanoginosin LRcyanoginosin LR results in increased expression of MAP3K1 mRNA17654400
D016572CyclosporineCyclosporine results in decreased expression of MAP3K1 mRNA20106945
D003606DacarbazineMAP3K1 protein modified form results in decreased susceptibility to Dacarbazine15123733
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MAP3K1 mRNA]27941970
D016190CarboplatinCarboplatin results in decreased expression of MAP3K1 mRNA18172885
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MAP3K1 mRNA21266533
D002945CisplatinCisplatin results in increased expression of MAP3K1 mRNA26546572
D002945CisplatinCisplatin results in decreased expression of MAP3K1 mRNA18172885
D004008DiclofenacDiclofenac results in increased expression of MAP3K1 mRNA26934552
D004041Dietary FatsDietary Fats results in increased expression of MAP3K1 mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of MAP3K1 mRNA22467019
D002117CalcitriolCalcitriol results in increased expression of MAP3K1 mRNA26485663
D004610Ellagic AcidEllagic Acid results in decreased expression of MAP3K1 mRNA23811531
D004610Ellagic AcidEllagic Acid results in decreased expression of MAP3K1 protein23811531
C100264enniatinsenniatins results in decreased expression of MAP3K1 mRNA27163883
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MAP3K1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MAP3K1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MAP3K1 mRNA20170705
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of MAP3K1 mRNA12655037
D005485FlutamideFlutamide results in decreased expression of MAP3K1 mRNA24793618
D005557FormaldehydeFormaldehyde results in decreased expression of MAP3K1 mRNA20655997
D005620Freund's Adjuvant[Urethane co-treated with Freund's Adjuvant] results in increased expression of MAP3K1 mRNA12400877
C069837fullerene C60fullerene C60 results in increased expression of MAP3K1 mRNA19167457
C039281furanfuran results in decreased expression of MAP3K1 mRNA26194646
C039281furanfuran results in increased methylation of MAP3K1 gene22079235
C001277geldanamycingeldanamycin results in increased expression of MAP3K1 mRNA26705709
D019833GenisteinGenistein inhibits the reaction [Oxygen deficiency results in increased expression of MAP3K1 mRNA]23452621
D005839GentamicinsGentamicins results in increased expression of MAP3K1 mRNA22061828
D005947GlucoseGlucose results in increased expression of MAP3K1 mRNA24659233
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased expression of MAP3K1 mRNA]24659233
C568713GSK1210151AGSK1210151A results in decreased expression of MAP3K1 mRNA26644586
D006220HaloperidolHaloperidol results in increased expression of MAP3K1 mRNA15860345
D006533HeptachlorHeptachlor results in decreased expression of MAP3K1 protein9704902
D006581HexachlorobenzeneHexachlorobenzene affects the expression of MAP3K1 mRNA15159207
D006820Hyaluronic AcidHyaluronic Acid analog affects the localization of [MAP3K1 protein binds to CD44 protein]20159036
D006820Hyaluronic AcidHyaluronic Acid analog promotes the reaction [MAP3K1 protein binds to CD44 protein]20159036
D006820Hyaluronic AcidHyaluronic Acid analog results in increased phosphorylation of and results in increased activity of MAP3K1 protein20159036
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MAP3K1 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of MAP3K1 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of MAP3K1 protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TGFB1 protein results in increased expression of MAP3K1 mRNA]26644586
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MAP3K1 mRNA26644586
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in decreased expression of MAP3K1 mRNA"23090859
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of MAP3K1 mRNA"24972896
D008070Lipopolysaccharides"3,4-dihydroxybenzohydroxamic acid inhibits the reaction [Lipopolysaccharides results in increased expression of MAP3K1 mRNA]"25843059
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MAP3K1 mRNA25843059
C039798manganese sulfatemanganese sulfate results in decreased expression of MAP3K1 mRNA23714145
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MAP3K1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MAP3K1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MAP3K1 mRNA"25620056
C029938nickel sulfatenickel sulfate results in decreased expression of MAP3K1 mRNA22714537
C029938nickel sulfateMAP3K1 protein affects the reaction [nickel sulfate results in increased phosphorylation of MAPK8 protein]18467339
C029938nickel sulfateMAP3K1 protein affects the susceptibility to nickel sulfate18467339
C029938nickel sulfate[MAP3K1 protein co-treated with MAP3K2 protein] affects the susceptibility to nickel sulfate18467339
D009589Nitrogen OxidesNitrogen Oxides inhibits the reaction [Benzo(a)pyrene results in increased expression of MAP3K1 protein]16041517
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MAP3K1 mRNA25729387
D010100Oxygen"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of MAP3K1 mRNA]"23452621
D010100OxygenCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of MAP3K1 mRNA]23452621
D010100OxygenGenistein inhibits the reaction [Oxygen deficiency results in increased expression of MAP3K1 mRNA]23452621
D010100OxygenOxygen deficiency results in increased expression of MAP3K1 mRNA23452621
D010100OxygenPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of MAP3K1 mRNA]23452621
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of MAP3K1 mRNA]23452621
D017239Paclitaxelaspartyl-glutamyl-valyl-aspartal inhibits the reaction [Paclitaxel results in increased cleavage of MAP3K1 protein]11160861
D017239PaclitaxelMAP3K1 protein affects the reaction [Paclitaxel results in increased activity of MAPK8 protein]11160861
D017239PaclitaxelMAP3K1 protein affects the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]11160861
D017239PaclitaxelPaclitaxel affects the localization of MAP3K1 protein11160861
D017239PaclitaxelPaclitaxel promotes the reaction [MAPK8 protein binds to MAP3K1 protein modified form]11160861
D017239PaclitaxelPaclitaxel results in increased cleavage of MAP3K1 protein11160861
D000073878Palm OilPalm Oil results in increased expression of MAP3K1 mRNA18042831
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MAP3K1 mRNA"25510870
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of MAP3K1 mRNA27614199
D010634PhenobarbitalPhenobarbital results in decreased expression of MAP3K1 mRNA19162173
D010936Plant ExtractsPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of MAP3K1 mRNA]23452621
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MAP3K1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MAP3K1 mRNA22079256
D011441PropylthiouracilPropylthiouracil results in increased expression of MAP3K1 mRNA24780913
C010313pseudocumenepseudocumene results in decreased expression of MAP3K1 protein17337753
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [MAP3K1 protein results in increased expression of ABCB1 mRNA]15604272
D011794QuercetinQuercetin results in increased expression of MAP3K1 mRNA23727915
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of MAP3K1 mRNA]23452621
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased expression of MAP3K1 mRNA]24659233
C488333Ro 65-7199Ro 65-7199 affects the expression of MAP3K1 mRNA14610520
D012834SilverSilver analog results in decreased expression of MAP3K1 mRNA24462830
D012834SilverSilver results in decreased expression of MAP3K1 mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of MAP3K1 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of MAP3K1 mRNA22714537
C016104sodium bichromatesodium bichromate results in decreased expression of MAP3K1 mRNA22155349
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in decreased expression of MAP3K1 mRNA12815608
D012969Sodium FluorideSodium Fluoride results in decreased expression of MAP3K1 mRNA27862939
C025462sulindac sulfidesulindac sulfide results in decreased expression of MAP3K1 mRNA12734198
D013629TamoxifenTamoxifen affects the expression of MAP3K1 mRNA17555576
C021751tanshinonetanshinone results in decreased expression of MAP3K1 mRNA15849732
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAP3K1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MAP3K1 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of MAP3K1 mRNA23411599
C402769tipifarnibtipifarnib results in increased expression of MAP3K1 mRNA16403772
C113106tocopheryloxybutyric acidtocopheryloxybutyric acid inhibits the reaction [Urethane results in increased phosphorylation of and results in increased activity of MAP3K1 protein]11062179
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MAP3K1 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of MAP3K1 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of MAP3K1 mRNA23724009
C011559tributyltintributyltin results in decreased expression of MAP3K1 mRNA27614199
C113580U 0126U 0126 results in decreased activity of MAP3K1 protein15010209
C022884undecaneundecane results in decreased expression of MAP3K1 protein17337753
D014520UrethaneUrethane results in decreased expression of MAP3K1 mRNA28818685
D014520Urethanetocopheryloxybutyric acid inhibits the reaction [Urethane results in increased phosphorylation of and results in increased activity of MAP3K1 protein]11062179
D014520Urethane[Urethane co-treated with Freund's Adjuvant] results in increased expression of MAP3K1 mRNA12400877
D014520UrethaneUrethane results in increased phosphorylation of and results in increased activity of MAP3K1 protein11062179
D014520UrethaneVitamin E inhibits the reaction [Urethane results in increased phosphorylation of and results in increased activity of MAP3K1 protein]11062179
D014635Valproic AcidValproic Acid affects the expression of MAP3K1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MAP3K1 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of MAP3K1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MAP3K1 gene25560391
D014750VincristineVincristine results in decreased expression of MAP3K1 mRNA23649840
D014810Vitamin EVitamin E inhibits the reaction [Urethane results in increased phosphorylation of and results in increased activity of MAP3K1 protein]11062179
D015032ZincZinc results in decreased expression of MAP3K1 mRNA17074742
C016837zinc chloride2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [zinc chloride results in increased activity of MAP3K1 protein]11306679
C016837zinc chloridePIK3CG protein affects the reaction [zinc chloride results in increased activity of MAP3K1 protein]11306679
C016837zinc chloridezinc chloride results in increased activity of MAP3K1 protein11306679
D019287Zinc SulfateZinc Sulfate results in decreased expression of MAP3K1 mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IDA15001576  
GO:0004672protein kinase activity-TAS-  
GO:0004674protein serine/threonine kinase activity-EXP7997270  9639556  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004709MAP kinase kinase kinase activity-NAS9808624  
GO:0005515protein binding-IPI9452471  9808624  11784851  14743216  16636664  16810323  
16888650  17620599  19270716  20940704  25241761  
GO:0005524ATP binding-IEA-  
GO:0008270zinc ion binding-IEA-  
GO:0019901protein kinase binding-IPI17906693  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IEA-  
GO:0000186activation of MAPKK activity-IEA-  
GO:0002755MyD88-dependent toll-like receptor signaling pathway-TAS-  
GO:0006468protein phosphorylation-NAS9808624  
GO:0007346regulation of mitotic cell cycle-IBA21873635  
GO:0023014signal transduction by protein phosphorylation-IBA21873635  
GO:0032147activation of protein kinase activity-IBA21873635  
GO:0038095Fc-epsilon receptor signaling pathway-TAS-  
GO:0071260cellular response to mechanical stimulus-IEP19593445  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04120Ubiquitin mediated proteolysis
hsa04622RIG-I-like receptor signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04912GnRH signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166058MyD88:Mal cascade initiated on plasma membraneTAS
R-HSA-168138Toll Like Receptor 9 (TLR9) CascadeTAS
R-HSA-168142Toll Like Receptor 10 (TLR10) CascadeTAS
R-HSA-168176Toll Like Receptor 5 (TLR5) CascadeTAS
R-HSA-168179Toll Like Receptor TLR1:TLR2 CascadeTAS
R-HSA-168181Toll Like Receptor 7/8 (TLR7/8) CascadeTAS
R-HSA-168188Toll Like Receptor TLR6:TLR2 CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaIEA
R-HSA-181438Toll Like Receptor 2 (TLR2) CascadeTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingIEA
R-HSA-2871796FCERI mediated MAPK activationTAS
R-HSA-2871796FCERI mediated MAPK activationIEA
R-HSA-933542TRAF6 mediated NF-kB activationTAS
R-HSA-933542TRAF6 mediated NF-kB activationIEA
R-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationTAS
R-HSA-975155MyD88 dependent cascade initiated on endosomeTAS
R-HSA-975871MyD88 cascade initiated on plasma membraneTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24993294Diet and lifestyle factors interact with MAPK genes to influence survival: the Breast Cancer Health Disparities Study. (2014 Sep)Slattery MLCancer Causes Control
23027623MAP kinase genes and colon and rectal cancer. (2012 Dec)Slattery MLCarcinogenesis
21791674Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium. (2011 Aug 17)Campa DJ Natl Cancer Inst