Gene: MAP3K3

4215
MAPKKK3|MEKK3
mitogen-activated protein kinase kinase kinase 3
protein-coding
17q23.3
Ensembl:ENSG00000198909 MIM:602539 Vega:OTTHUMG00000178905 UniprotKB:Q99759
NC_000017.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.352e-1 (AD)  2.109e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg22596016chr17:61711557MAP3K3Gene body4.810e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASXL10.886
FKBP150.884
PIAS30.864
TYK20.864
TTC170.863
TMEM430.863
MLXIP0.862
SETD50.86
ZZEF10.857
KDM2A0.854

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.546
OR4F29-0.53
HES5-0.268
REN-0.265
DIAPH3-0.261
SLC22A6-0.256
GSDMC-0.254
KLRC2-0.243
HPDL-0.242
BTBD17-0.236

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MAP3K3 mRNA"21346803
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of MAP3K3 mRNA20829426
C4771875-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole"5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole results in increased expression of MAP3K3 mRNA"22745752
D000082AcetaminophenAcetaminophen results in increased expression of MAP3K3 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of MAP3K3 mRNA17562736
C038491allyl sulfideallyl sulfide affects the expression of MAP3K3 protein21695758
D001152ArsenicalsArsenicals results in decreased expression of MAP3K3 mRNA24327377
D004958EstradiolEstradiol results in increased expression of MAP3K3 mRNA23094148
C006780bisphenol Abisphenol A results in decreased expression of MAP3K3 mRNA26364221
C006780bisphenol Abisphenol A affects the expression of MAP3K3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MAP3K3 gene28505145
C022777bufalinbufalin results in decreased expression of MAP3K3 protein23949904
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of MAP3K3 mRNA24317228
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of MAP3K3 mRNA23640034
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of MAP3K3 mRNA23914054
C014347decitabine[decitabine co-treated with Depsipeptides] results in increased expression of MAP3K3 mRNA17064661
C107676deguelindeguelin affects the expression of MAP3K3 protein25322282
D047630Depsipeptides[decitabine co-treated with Depsipeptides] results in increased expression of MAP3K3 mRNA17064661
D047630DepsipeptidesDepsipeptides results in increased expression of MAP3K3 mRNA17064661
C028009diallyl disulfidediallyl disulfide affects the expression of MAP3K3 protein21695758
C042577diallyl trisulfidediallyl trisulfide affects the expression of MAP3K3 protein21695758
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MAP3K3 mRNA21266533
C069837fullerene C60fullerene C60 results in increased expression of MAP3K3 mRNA19167457
D005839GentamicinsGentamicins results in increased expression of MAP3K3 mRNA22061828
D006820Hyaluronic AcidMAP3K3 protein promotes the reaction [TGFB2 protein results in increased abundance of Hyaluronic Acid]20633555
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MAP3K3 mRNA25613284
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of MAP3K3 mRNA25613284
C018091maduramicinmaduramicin results in increased expression of MAP3K3 mRNA29128925
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of MAP3K3 mRNA27188386
D008731MethoxychlorMethoxychlor affects the expression of MAP3K3 mRNA20829426
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MAP3K3 mRNA"20188158
C028007nickel monoxidenickel monoxide results in increased expression of MAP3K3 mRNA19167457
C507134ON 01910ON 01910 affects the expression of MAP3K3 mRNA22351695
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MAP3K3 mRNA25729387
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MAP3K3 mRNA17560707
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MAP3K3 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of MAP3K3 protein23955962
D011374ProgesteroneProgesterone results in increased expression of MAP3K3 mRNA23012394
D011794QuercetinQuercetin results in decreased expression of MAP3K3 protein23645742
C009166retinol acetateretinol acetate results in increased expression of MAP3K3 mRNA16772331
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of MAP3K3 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAP3K3 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MAP3K3 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of MAP3K3 mRNA27188386
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MAP3K3 mRNA25729387
D014241TrichloroethylenePPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of MAP3K3 mRNA]15363585
D014520UrethaneUrethane results in increased expression of MAP3K3 mRNA28818685
C025643vinclozolinvinclozolin results in decreased expression of MAP3K3 mRNA23034163
C111237vorinostatvorinostat results in decreased expression of MAP3K3 mRNA27188386
C111237vorinostatvorinostat results in increased expression of MAP3K3 mRNA22083351
D014873Water PollutantsWater Pollutants results in increased expression of MAP3K3 mRNA23591932

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IDA15001576  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004709MAP kinase kinase kinase activity-IEA-  
GO:0005515protein binding-IPI9452471  12392720  14743216  15001576  16407301  18308725  
25241761  25982527  27027284  
GO:0005524ATP binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS9006902  
GO:0000186activation of MAPKK activity-IEA-  
GO:0001568blood vessel development-IEA-  
GO:0007346regulation of mitotic cell cycle-IBA21873635  
GO:0023014signal transduction by protein phosphorylation-IBA21873635  
GO:0032147activation of protein kinase activity-IBA21873635  
GO:0035556intracellular signal transduction-IDA15001576  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IEP12761501  
GO:0046777protein autophosphorylation-IDA15001576  
GO:0070498interleukin-1-mediated signaling pathway-TAS-  
GO:0071864positive regulation of cell proliferation in bone marrow-IMP28640956  
GO:0090050positive regulation of cell migration involved in sprouting angiogenesis-IGI28640956  
GO:1900745positive regulation of p38MAPK cascade-IEA-  
GO:2000773negative regulation of cellular senescence-IMP28640956  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04912GnRH signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-446652Interleukin-1 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-9020702Interleukin-1 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17068819Discovery of deregulation of zinc homeostasis and its associated genes in esophageal squamous cell carcinoma using cDNA microarray. (2007 Jan 15)Kumar AInt J Cancer
23027623MAP kinase genes and colon and rectal cancer. (2012 Dec)Slattery MLCarcinogenesis