Gene: MAP3K5

4217
ASK1|MAPKKK5|MEKK5
mitogen-activated protein kinase kinase kinase 5
protein-coding
6q23.3
Ensembl:ENSG00000197442 MIM:602448 Vega:OTTHUMG00000015647 UniprotKB:Q99683
NG_011965.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.807e-1 (AD)  5.369e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CADM10.894
SLC41A10.877
PRKCA0.873
ABI10.872
HS2ST10.87
ABLIM10.864
AHCYL20.863
HADH0.861
CPE0.859
PAICS0.857

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.654
OR4F29-0.598
OR6C74-0.321
CETP-0.32
FCRL1-0.286
CLEC6A-0.286
GADL1-0.285
CTNNA3-0.273
LY9-0.257
XCL2-0.248

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1053511-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene"MAP3K5 protein affects the reaction [1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene results in increased degradation of MCL1 protein]"19768117
C1053511-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene"MAP3K5 protein affects the reaction [1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene results in increased phosphorylation of MAPK8 protein]"19768117
C1053511-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene"MAP3K5 protein affects the susceptibility to 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene"19768117
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MAP3K5 protein"25639565
C5112952,2',4,4'-tetrabromodiphenyl ether"troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MAP3K5 protein]"25639565
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of MAP3K5 mRNA"21920950
C0259463-methyladenine3-methyladenine affects the susceptibility to MAP3K5 protein20929985
C0259463-methyladenine3-methyladenine inhibits the reaction [MAP3K5 protein results in decreased phosphorylation of MTOR protein]20929985
C0259463-methyladenine3-methyladenine promotes the reaction [MAP3K5 protein affects the localization of CYCS protein]20929985
C0259463-methyladenine3-methyladenine promotes the reaction [MAP3K5 protein results in increased activity of CASP3 protein]20929985
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K5 mRNA"27188386
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide results in increased expression of MAP3K5 mRNA23274565
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K5 mRNA"27188386
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Plant Extracts results in increased phosphorylation of MAP3K5 protein]"20206247
C5568018-phenyl-6a,7,8,9,9a,10-hexahydro-6H-isoindolo(5,6-g)quinoxaline-7,9-dione"8-phenyl-6a,7,8,9,9a,10-hexahydro-6H-isoindolo(5,6-g)quinoxaline-7,9-dione inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of MAP3K5 protein]"20946892
D000082AcetaminophenAcetaminophen results in decreased expression of MAP3K5 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen results in increased activity of MAP3K5 protein18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ACTG1 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of AK5 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ARIH1 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ARL4A mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ARL5B mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ARRDC5 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ASTN2 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of BCL2L14 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of BTC mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CASKIN1 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CCDC81 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CCL7 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CD3E mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CDS2 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CHIL3 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CHIL4 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CHKA mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CLASP1 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of COL3A1 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of COPG1 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CXCL5 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of DLX4 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of DNAH5 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of DNAJB4 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of DNAJB9 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of DPP6 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of EEA1 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of FOSL2 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of FOS mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of GAB2 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of GNAL mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of GZMM mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of HIST2H2BB mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of IFIT3 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of JUN mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of KDM3A mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of MAFF mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of MCL1 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of MX2 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of MYH3 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of NAIP6 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of NEDD9 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of NIPAL2 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of NSMCE2 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of OBP2A mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of OLFR1273-PS mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of OLFR1339 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of OLFR905 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PCDH11X mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PCDH7 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PDCL2 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PDE4B mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PRRX1 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PVR mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of RNF207 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of RTP1 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of SCT mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of SLC25A2 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of SLFN3 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of SPZ1 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of STAT3 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of SYF2 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of TMEM54 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of TRP63 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of TSC22D2 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of TWSG1 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of USP31 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of USP6NL mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of WDFY3 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ZDHHC6 mRNA]18700144
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ZFAND2A mRNA]18700144
D000082AcetaminophenMAP3K5 protein promotes the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of MAPK8 protein]18700144
D000082AcetaminophenMAP3K5 protein promotes the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of MAPK9 protein]18700144
D000082AcetaminophenMAP3K5 protein results in increased susceptibility to Acetaminophen18700144
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP3K5 protein]18703135
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Quercetin results in decreased phosphorylation of and results in increased activity of MAP3K5 protein]20083342
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Rotenone inhibits the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]]16449798
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP3K5 protein]18703135
D000171AcroleinAcrolein results in increased expression of MAP3K5 protein17196791
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MAP3K5 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MAP3K5 mRNA27153756
C412373AG 1879AG 1879 inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAP3K5 protein]20181660
C030419andrographolideandrographolide inhibits the reaction [VEGFA protein results in increased phosphorylation of MAP3K5 protein]24814888
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MAP3K5 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of MAP3K5 mRNA"17331233
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Plant Extracts results in increased phosphorylation of MAP3K5 protein]20206247
D001280AtrazineAtrazine results in decreased expression of MAP3K5 mRNA25929836
C487081belinostatbelinostat results in decreased expression of MAP3K5 mRNA27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MAP3K5 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MAP3K5 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MAP3K5 mRNA"19150397
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MAP3K5 mRNA19619570
D004958EstradiolEstradiol results in increased expression of MAP3K5 mRNA19619570
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of MAP3K5 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of MAP3K5 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of MAP3K5 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of MAP3K5 mRNA25461909
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of MAP3K5 mRNA15336504
D002101Cacodylic AcidCacodylic Acid results in increased expression of MAP3K5 mRNA17441966
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP3K5 protein]18703135
D019256Cadmium ChlorideCadmium Chloride results in increased activity of MAP3K5 protein16337887
D019256Cadmium ChlorideCadmium Chloride results in increased phosphorylation of MAP3K5 protein18703135
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP3K5 protein]18703135
D019256Cadmium ChlorideCadmium Chloride results in increased phosphorylation of MAP3K5 protein18021293|1870313
C034939cadmium sulfidecadmium sulfide results in decreased expression of MAP3K5 mRNA27866839
D002166CamptothecinCamptothecin results in decreased expression of MAP3K5 mRNA17374387
C459604candoxincandoxin results in decreased expression of MAP3K5 mRNA16309724
D002518CeramidesCeramides analog affects the phosphorylation of and results in increased activity of MAP3K5 protein18270325
D017608Chromium CompoundsChromium Compounds results in increased activity of MAP3K5 protein19406221
C074702chromium hexavalent ionchromium hexavalent ion inhibits the reaction [TXN protein binds to MAP3K5 protein]19703554
D002922CiguatoxinsCiguatoxins affects the expression of MAP3K5 mRNA18353800
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of MAP3K5 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of MAP3K5 mRNA18579281
D003630DaunorubicinDaunorubicin results in decreased expression of MAP3K5 mRNA17374387
D003676DeferoxamineDeferoxamine inhibits the reaction [Plant Extracts results in increased phosphorylation of MAP3K5 protein]20206247
C007262deoxynivalenolAG 1879 inhibits the reaction [deoxynivalenol results in increased phosphorylation of MAP3K5 protein]20181660
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of MAP3K5 protein20181660
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MAP3K5 mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of MAP3K5 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of MAP3K5 mRNA19561079|2739243
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of MAP3K5 mRNA26924002
D004041Dietary FatsSodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAP3K5 protein]26522834
D004041Dietary Fats[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAP3K5 protein26522834
D002117Calcitriol[Calcitriol promotes the reaction [TXNIP protein binds to TRN protein]] which results in increased activity of MAP3K5 protein10843682
D002117CalcitriolCalcitriol results in increased activity of MAP3K5 protein10843682
C024629dimethyl phthalatedimethyl phthalate affects the expression of MAP3K5 mRNA26924002
D004121Dimethyl SulfoxideDimethyl Sulfoxide inhibits the reaction [Thioacetamide results in increased activity of MAP3K5 protein]12370186
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in decreased activity of MAP3K5 protein12370186
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased phosphorylation of MAP3K5 protein21628959
D004229DithiothreitolDithiothreitol inhibits the reaction [NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]]18922898
D007980LevodopaLevodopa results in increased activity of MAP3K5 protein21815648
D007980LevodopaMAP3K5 protein affects the susceptibility to Levodopa21815648
D007980LevodopaMAP3K5 protein affects the susceptibility to [Levodopa results in increased activity of CASP3 protein]21815648
D004317DoxorubicinDoxorubicin results in increased expression of MAP3K5 protein25896364
D004317DoxorubicinPSMB10 protein inhibits the reaction [Doxorubicin results in increased expression of MAP3K5 protein]25896364
D004317DoxorubicinPSMB8 protein inhibits the reaction [Doxorubicin results in increased expression of MAP3K5 protein]25896364
D004317DoxorubicinPSMB9 protein inhibits the reaction [Doxorubicin results in increased expression of MAP3K5 protein]25896364
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of MAP3K5 mRNA"26539117
C098320efavirenzefavirenz metabolite results in increased phosphorylation of MAP3K5 protein21958719
C098320efavirenzefavirenz results in increased phosphorylation of MAP3K5 protein21958719
C118739entinostatentinostat results in increased expression of MAP3K5 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K5 mRNA"27188386
D000431EthanolALDH2 protein inhibits the reaction [Ethanol results in increased phosphorylation of MAP3K5 protein]19332462
D000431EthanolEthanol results in increased phosphorylation of MAP3K5 protein19332462
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of MAP3K5 mRNA23649840
D005047EtoposideEtoposide results in decreased expression of MAP3K5 mRNA17374387
D005054EugenolEugenol results in increased phosphorylation of MAP3K5 protein21628959
D005557FormaldehydeFormaldehyde results in decreased expression of MAP3K5 mRNA23416264
C039281furanfuran results in increased expression of MAP3K5 mRNA26194646
C546771gardiquimodgardiquimod results in increased expression of MAP3K5 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of MAP3K5 mRNA]28003376
C001277geldanamycingeldanamycin results in increased expression of MAP3K5 mRNA26705709
D005947GlucoseGlucose deficiency promotes the reaction [DAXX protein binds to MAP3K5 protein]14505347
D005947GlucoseGlucose results in increased expression of MAP3K5 protein16731828
D005947GlucoseGlucose results in increased phosphorylation of and results in increased activity of MAP3K5 protein16731828
D005947Glucose[Glucose promotes the reaction [TXNIP protein binds to TXN1 protein]] which results in increased activity of MAP3K5 protein26660634
D005947Glucose[[[[Glucose results in decreased expression of MIR17 mRNA] which results in increased expression of TXNIP mRNA] which results in increased expression of TXNIP protein] promotes the reaction [TXNIP protein binds to TXN1 protein]] which results in increased activity of MAP3K5 protein26660634
D005947GlucoseGlucose results in increased phosphorylation of and results in increased activity of MAP3K5 protein26660634
D005947GlucoseCAT protein inhibits the reaction [Glucose deficiency promotes the reaction [DAXX protein binds to MAP3K5 protein]]14505347
D005947Glucose[CAT protein promotes the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]] inhibits the reaction [Glucose deficiency results in increased activity of and results in increased phosphorylation of MAPK8 protein]14505347
D017313FenretinideFenretinide results in increased expression of MAP3K5 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased activity of MAP3K5 protein15629441
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of MAP3K5 protein16157298
C016517indole-3-carbinolindole-3-carbinol affects the expression of MAP3K5 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MAP3K5 mRNA25613284
C051890irinotecanirinotecan metabolite results in decreased expression of MAP3K5 mRNA15956246
C051890irinotecanirinotecan results in decreased expression of MAP3K5 mRNA15956246
D007545IsoproterenolIsoproterenol results in decreased expression of MAP3K5 mRNA21335049
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of MAP3K5 mRNA27392435
D007608Kainic AcidKainic Acid results in decreased expression of MAP3K5 mRNA17997037
C072105KN 93KN 93 inhibits the reaction [Phenylephrine results in increased activity of MAP3K5 protein]15629441
D008070LipopolysaccharidesMAP3K5 protein results in increased susceptibility to Lipopolysaccharides21449566
C018091maduramicinmaduramicin results in increased expression of MAP3K5 mRNA29128925
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of MAP3K5 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of MAP3K5 mRNA26378955
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K5 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride results in increased activity of MAP3K5 protein16337887
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of MAP3K5 mRNA19010555
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MAP3K5 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of MAP3K5 mRNA25234470
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased phosphorylation of MAP3K5 protein20946892
D0156551-Methyl-4-phenylpyridinium"8-phenyl-6a,7,8,9,9a,10-hexahydro-6H-isoindolo(5,6-g)quinoxaline-7,9-dione inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of MAP3K5 protein]"20946892
C571715mito-carboxy proxylmito-carboxy proxyl inhibits the reaction [troglitazone results in increased activity of MAP3K5 protein]17975114
C517284monomethyl phthalatemonomethyl phthalate affects the expression of MAP3K5 mRNA26924002
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of MAP3K5 mRNA"29244179
C064769N-acetylsphingosineN-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein18270325
C064769N-acetylsphingosineTXNIP affects the reaction [N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein]18270325
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MAP3K5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MAP3K5 mRNA"25554681
C005273naringeninnaringenin results in increased expression of MAP3K5 protein27838343
C498045NCX 4040Dithiothreitol inhibits the reaction [NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]]18922898
C498045NCX 4040NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]18922898
C498045NCX 4040[NCX 4040 results in increased oxidation of TXN1 protein] inhibits the reaction [TXN1 protein binds to MAP3K5 protein]18922898
C490266neoechinulin Aneoechinulin A inhibits the reaction [[APP protein binds to APP protein binds to APP protein] which results in increased phosphorylation of MAP3K5 protein]23261590
C017557nickel subsulfideMAP3K5 protein affects the susceptibility to nickel subsulfide20112989
C017557nickel subsulfidenickel subsulfide results in increased phosphorylation of and results in increased activity of MAP3K5 protein20112989
C029938nickel sulfatenickel sulfate results in increased expression of MAP3K5 mRNA22714537
D009599NitroprussideGHRL protein inhibits the reaction [Nitroprusside results in increased phosphorylation of and results in increased activity of MAP3K5 protein]17543279
D009599NitroprussideNitroprusside results in increased phosphorylation of and results in increased activity of MAP3K5 protein17543279
D009599NitroprussideQuercetin inhibits the reaction [GHRL protein inhibits the reaction [Nitroprusside results in increased expression of MAP3K5 protein]]17543279
C047330N-methylisoindigotinN-methylisoindigotin results in increased expression of MAP3K5 mRNA26887594
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of MAP3K5 mRNA20971185
C464660obeticholic acidobeticholic acid results in decreased expression of MAP3K5 mRNA27939613
D017239PaclitaxelMAP3K5 protein affects the reaction [Paclitaxel results in increased activity of CASP3 protein]10075725
D017239PaclitaxelMAP3K5 protein affects the reaction [Paclitaxel results in increased cleavage of PARP1 protein]10075725
C016030pantogabpantogab results in increased expression of MAP3K5 mRNA17379144
D010269Paraquat[Paraquat co-treated with MAP3K5 protein] results in increased degradation of SQSTM1 protein20929985
D010269Paraquat[Paraquat co-treated with MAP3K5 protein] results in increased expression of BECN1 protein20929985
D010269ParaquatParaquat promotes the reaction [MAP3K5 protein results in increased phosphorylation of ERN1 protein]20929985
D010269ParaquatParaquat results in increased phosphorylation of and results in increased activity of MAP3K5 protein19735704
D010269Paraquatsalubrinal affects the susceptibility to [Paraquat co-treated with MAP3K5 protein]20929985
D010269Paraquatsalubrinal inhibits the reaction [Paraquat results in increased phosphorylation of and results in increased activity of MAP3K5 protein]19735704
D010269Paraquatsalubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased degradation of SQSTM1 protein]20929985
D010269Paraquatsalubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased expression of BECN1 protein]20929985
D010269ParaquatMAP3K5 protein results in increased susceptibility to Paraquat20929985
D052638Particulate MatterParticulate Matter results in decreased expression of MAP3K5 mRNA17450221
D052638Particulate MatterParticulate Matter results in increased expression of MAP3K5 mRNA24769257
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of MAP3K5 mRNA26300304
D010634PhenobarbitalPhenobarbital results in increased expression of MAP3K5 mRNA19270015
C013192phenylacetaldehydephenylacetaldehyde results in increased phosphorylation of MAP3K5 protein21628959
D010656PhenylephrineCAMK2D protein promotes the reaction [Phenylephrine results in increased activity of MAP3K5 protein]15629441
D010656PhenylephrineKN 93 inhibits the reaction [Phenylephrine results in increased activity of MAP3K5 protein]15629441
D010656PhenylephrinePhenylephrine results in increased activity of MAP3K5 protein15629441
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K5 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MAP3K5 mRNA26272509
C005435phenylmethylpyrazolonephenylmethylpyrazolone results in decreased activity of MAP3K5 protein15824197
C006253pirinixic acidpirinixic acid results in increased expression of MAP3K5 mRNA18445702
D010936Plant Extracts"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Plant Extracts results in increased phosphorylation of MAP3K5 protein]"20206247
D010936Plant ExtractsAscorbic Acid inhibits the reaction [Plant Extracts results in increased phosphorylation of MAP3K5 protein]20206247
D010936Plant ExtractsDeferoxamine inhibits the reaction [Plant Extracts results in increased phosphorylation of MAP3K5 protein]20206247
D010936Plant ExtractsPlant Extracts results in increased expression of MAP3K5 mRNA23557933
D010936Plant ExtractsPlant Extracts results in increased phosphorylation of MAP3K5 protein20206247
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of MAP3K5 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of MAP3K5 mRNA28903501
D011441PropylthiouracilPropylthiouracil results in decreased expression of MAP3K5 mRNA24780913
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of MAP3K5 mRNA]28003376
D011794QuercetinAcetylcysteine inhibits the reaction [Quercetin results in decreased phosphorylation of and results in increased activity of MAP3K5 protein]20083342
D011794QuercetinQuercetin results in decreased phosphorylation of and results in increased activity of MAP3K5 protein20083342
D011794QuercetinQuercetin inhibits the reaction [GHRL protein inhibits the reaction [Nitroprusside results in increased expression of MAP3K5 protein]]17543279
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAP3K5 mRNA19059307
D017382Reactive Oxygen SpeciesReactive Oxygen Species affects the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]16449798
C059514resveratrolresveratrol results in increased activity of MAP3K5 protein15217905
C059514resveratrolresveratrol inhibits the reaction [Streptozocin results in increased expression of MAP3K5 protein]26499206
C059514resveratrolMAP3K5 protein promotes the reaction [resveratrol results in increased activity of MAPK8 protein]15217905
C059514resveratrolMAP3K5 protein promotes the reaction [resveratrol results in increased expression of FASLG]15217905
C059514resveratrolMAP3K5 protein results in increased susceptibility to resveratrol15217905
D012402RotenoneAcetylcysteine inhibits the reaction [Rotenone inhibits the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]]16449798
D012402RotenoneRotenone inhibits the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]16449798
C496827salubrinalsalubrinal affects the susceptibility to MAP3K5 protein20929985
C496827salubrinalsalubrinal affects the susceptibility to [Paraquat co-treated with MAP3K5 protein]20929985
C496827salubrinalsalubrinal inhibits the reaction [MAP3K5 protein affects the localization of CYCS protein]20929985
C496827salubrinalsalubrinal inhibits the reaction [MAP3K5 protein results in increased activity of CASP3 protein]20929985
C496827salubrinalsalubrinal inhibits the reaction [Paraquat results in increased phosphorylation of and results in increased activity of MAP3K5 protein]19735704
C496827salubrinalsalubrinal promotes the reaction [MAP3K5 protein results in increased degradation of SQSTM1 protein]20929985
C496827salubrinalsalubrinal promotes the reaction [MAP3K5 protein results in increased expression of BECN1 protein]20929985
C496827salubrinalsalubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased degradation of SQSTM1 protein]20929985
C496827salubrinalsalubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased expression of BECN1 protein]20929985
D012643SeleniumSelenium results in decreased expression of MAP3K5 mRNA19244175
C009250sevofluranesevoflurane results in increased phosphorylation of MAP3K5 protein18349187
C017947sodium arsenitesodium arsenite results in increased activity of MAP3K5 protein16337887
C017947sodium arsenitesodium arsenite results in increased expression of MAP3K5 mRNA22714537
C016104sodium bichromatesodium bichromate results in decreased expression of MAP3K5 mRNA22155349
C016104sodium bichromatesodium bichromate results in increased expression of MAP3K5 mRNA22155349
D018038Sodium SeleniteSodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAP3K5 protein]26522834
D013311StreptozocinSodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAP3K5 protein]26522834
D013311Streptozocin[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAP3K5 protein26522834
D013311StreptozocinStreptozocin promotes the reaction [MAP3K5 protein results in increased expression of SERPINE1 protein]16731828
D013311Streptozocinresveratrol inhibits the reaction [Streptozocin results in increased expression of MAP3K5 protein]26499206
D013311StreptozocinStreptozocin results in increased expression of MAP3K5 protein26499206
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of MAP3K5 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of MAP3K5 mRNA26378955
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of MAP3K5 mRNA19059307
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MAP3K5 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAP3K5 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MAP3K5 mRNA19619570
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of MAP3K5 mRNA25975270
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of MAP3K5 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MAP3K5 mRNA25613284
D013853ThioacetamideDimethyl Sulfoxide inhibits the reaction [Thioacetamide results in increased activity of MAP3K5 protein]12370186
D013853ThioacetamideThioacetamide results in increased activity of MAP3K5 protein12370186
D013853ThioacetamideThioacetamide results in increased expression of MAP3K5 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of MAP3K5 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MAP3K5 mRNA28111298
D014212TretinoinTretinoin results in increased expression of MAP3K5 mRNA21934132|2372400
D014212TretinoinTretinoin results in decreased expression of MAP3K5 mRNA22498432
C012589trichostatin Atrichostatin A results in increased expression of MAP3K5 mRNA24935251
C057693troglitazonemito-carboxy proxyl inhibits the reaction [troglitazone results in increased activity of MAP3K5 protein]17975114
C057693troglitazonetroglitazone results in increased activity of MAP3K5 protein17975114
C005865troxerutin"troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MAP3K5 protein]"25639565
D014415TunicamycinTunicamycin results in increased phosphorylation of and results in increased activity of MAP3K5 protein19735704
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MAP3K5 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MAP3K5 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MAP3K5 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of MAP3K5 mRNA17292431
D014752Vinyl ChlorideVinyl Chloride results in decreased expression of MAP3K5 mRNA18579281
D014810Vitamin EVitamin E results in decreased expression of MAP3K5 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IDA17210579  
GO:0004672protein kinase activity-IBA21873635  
GO:0004672protein kinase activity-IDA11096076  21771788  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004709MAP kinase kinase kinase activity-IDA17210579  
GO:0005515protein binding-IPI9743501  11003656  11154276  11298454  11495919  12556535  
12813029  14761963  15023544  15983381  16049941  16449798  
16636664  16648474  17210579  17389591  19590015  19782076  
19805025  21496457  21771788  22609355  25241761  25852190  
GO:0005524ATP binding-IDA17210579  
GO:0019901protein kinase binding-IEA-  
GO:0019903protein phosphatase binding-IPI11959862  20674765  
GO:0019904protein domain specific binding-IPI11096076  
GO:0042802identical protein binding-IPI9743501  17937911  19805025  
GO:0042803protein homodimerization activity-IDA11920685  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IDA17210579  21771788  
GO:0000186activation of MAPKK activity-IBA21873635  
GO:0000186activation of MAPKK activity-IDA11959862  
GO:0002931response to ischemia-IEA-  
GO:0006468protein phosphorylation-IDA11096076  15983381  
GO:0007254JNK cascade-IDA21771788  
GO:0007257activation of JUN kinase activity-TAS8974401  
GO:0008631intrinsic apoptotic signaling pathway in response to oxidative stress-IBA21873635  
GO:0008631intrinsic apoptotic signaling pathway in response to oxidative stress-IDA21771788  
GO:0010666positive regulation of cardiac muscle cell apoptotic process-IEA-  
GO:0016032viral process-IEA-  
GO:0034198cellular response to amino acid starvation-IDA11096076  
GO:0034976response to endoplasmic reticulum stress-IMP23000344  
GO:0038066p38MAPK cascade-IEA-  
GO:0042060wound healing-IEA-  
GO:0043065positive regulation of apoptotic process-IDA21771788  
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process-IDA20674765  
GO:0043507positive regulation of JUN kinase activity-IMP23000344  
GO:0045087innate immune response-IEA-  
GO:0045663positive regulation of myoblast differentiation-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IDA11096076  
GO:0046330positive regulation of JNK cascade-ISS-  
GO:0051403stress-activated MAPK cascade-IDA11096076  
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress-ISS-  
GO:0070301cellular response to hydrogen peroxide-IDA20674765  
GO:0071356cellular response to tumor necrosis factor-IEA-  
GO:0072577endothelial cell apoptotic process-IEA-  
GO:0097190apoptotic signaling pathway-TAS8974401  
GO:0097300programmed necrotic cell death-IEA-  
GO:1900745positive regulation of p38MAPK cascade-IEA-  
GO:1901216positive regulation of neuron death-IGI15983381  
GO:1901216positive regulation of neuron death-ISS-  
GO:1902170cellular response to reactive nitrogen species-IEA-  
GO:1904707positive regulation of vascular smooth muscle cell proliferation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0009897external side of plasma membrane-IEA-  
GO:0032991protein-containing complex-IMP11096076  
GO:1902911protein kinase complex-IDA15983381  
GO:1990604IRE1-TRAF2-ASK1 complex-IDA12050113  23000344  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04141Protein processing in endoplasmic reticulum
hsa04722Neurotrophin signaling pathway
hsa05014Amyotrophic lateral sclerosis (ALS)
Reactome ID Reactome Term Evidence
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2262752Cellular responses to stressIEA
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559580Oxidative Stress Induced SenescenceIEA
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559583Cellular SenescenceIEA
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-8953897Cellular responses to external stimuliIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29762635An Epigenome-Wide Association Study (EWAS) of Obesity-Related Traits. (2018 May 14)Dhana KAm J Epidemiol