Gene: RAB8A

4218
MEL|RAB8
RAB8A, member RAS oncogene family
protein-coding
19p13.11
Ensembl:ENSG00000167461 MIM:165040 Vega:OTTHUMG00000182238 UniprotKB:P61006
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.591e-1 (AD)  3.038e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NONO0.845
P4HB0.83
COPB20.828
CSNK1A10.826
GNS0.82
TOP10.819
STT3A0.819
COPB10.811
GALNT20.809
DCAF50.807

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.604
OR4F29-0.557
MTRNR2L6-0.23
CTNNA3-0.187
MTRNR2L9-0.186
RSPO1-0.185
MTRNR2L10-0.185
UGT2B11-0.184
HMHB1-0.179
C17orf112-0.174

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RAB8A mRNA"19167446
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of RAB8A mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of RAB8A mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of RAB8A mRNA27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RAB8A mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of RAB8A mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RAB8A mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of RAB8A mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of RAB8A protein28739533
C006780bisphenol Abisphenol A results in increased expression of RAB8A mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of RAB8A mRNA15336504
D020682Cefixime[RAB8A protein results in increased localization of SLC15A1 protein] which results in increased uptake of Cefixime19074526
D020682CefiximeRAB8A protein results in increased uptake of Cefixime19074526
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RAB8A mRNA"19167446
D003375CoumestrolCoumestrol results in increased expression of RAB8A mRNA19167446
D003474CurcuminCurcumin results in decreased expression of RAB8A mRNA21594647
D016572CyclosporineCyclosporine results in decreased expression of RAB8A mRNA20106945
D002945CisplatinRAB8A results in decreased susceptibility to Cisplatin21969054
D002945CisplatinTMEM205 promotes the reaction [RAB8A results in decreased susceptibility to Cisplatin]21969054
C000944dicrotophosdicrotophos results in increased expression of RAB8A mRNA28302478
D004051Diethylhexyl Phthalate[INS1 protein co-treated with Diethylhexyl Phthalate] results in decreased expression of RAB8A protein28526321
D004147DioxinsDioxins affects the expression of RAB8A mRNA20463971
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RAB8A mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RAB8A mRNA17942748
D005472FluorouracilFluorouracil results in decreased expression of RAB8A mRNA16709241
D004397FonofosFonofos results in increased methylation of RAB8A promoter22847954
C056507gemcitabinegemcitabine results in decreased expression of RAB8A mRNA17039268
D005839GentamicinsGentamicins results in increased expression of RAB8A mRNA22061828
D006220HaloperidolHaloperidol results in decreased expression of RAB8A mRNA15860345
C492448ICG 001ICG 001 results in increased expression of RAB8A mRNA26191083
D007854LeadLead affects the expression of RAB8A mRNA28903495
C027020methylglucosideRAB8A protein results in increased uptake of methylglucoside19074526
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of RAB8A mRNA"20188158
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [SNCA protein mutant form binds to RAB8A protein]"15099020
C016599mono-(2-ethylhexyl)phthalate[INS1 protein co-treated with mono-(2-ethylhexyl)phthalate] results in decreased expression of RAB8A protein28526321
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RAB8A mRNA"25554681
D010278ParathionParathion results in increased methylation of RAB8A promoter22847954
D010894PiroxicamPiroxicam results in increased expression of RAB8A mRNA21858171
C059514resveratrolresveratrol results in increased expression of RAB8A protein25505154
D012402RotenoneRotenone promotes the reaction [SNCA protein mutant form binds to RAB8A protein]15099020
D012715Sesame OilSesame Oil results in increased expression of RAB8A mRNA29191790
D012969Sodium FluorideSodium Fluoride results in increased expression of RAB8A protein27548804
C012568terbufosterbufos results in increased methylation of RAB8A promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RAB8A mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RAB8A mRNA17942748
D013792ThalidomideThalidomide results in decreased expression of RAB8A mRNA26006729
D014212TretinoinTretinoin results in increased expression of RAB8A mRNA16054129
D014635Valproic AcidValproic Acid results in increased expression of RAB8A mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of RAB8A mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IBA21873635  
GO:0003924GTPase activity-IDA17646400  
GO:0005515protein binding-IPI15837803  16541104  16902405  17646400  18329369  19864458  
20308558  20388642  20643351  21273506  21378754  22011575  
22159412  22543976  22854040  26258637  26824392  27103069  
27173435  
GO:0005525GTP binding-IDA20937701  
GO:0017137Rab GTPase binding-ISS-  
GO:0019003GDP binding-IDA20937701  
GO:0019901protein kinase binding-IEA-  
GO:0031489myosin V binding-IPI24006491  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IBA21873635  
GO:0006904vesicle docking involved in exocytosis-IBA21873635  
GO:0006904vesicle docking involved in exocytosis-IDA17574030  
GO:0006914autophagy-IEA-  
GO:0007409axonogenesis-ISS-  
GO:0009306protein secretion-IBA21873635  
GO:0010506regulation of autophagy-IMP27103069  
GO:0017157regulation of exocytosis-IBA21873635  
GO:0032482Rab protein signal transduction-IBA21873635  
GO:0032869cellular response to insulin stimulus-IBA21873635  
GO:0032869cellular response to insulin stimulus-ISS-  
GO:0043687post-translational protein modification-TAS-  
GO:0048169regulation of long-term neuronal synaptic plasticity-IEA-  
GO:0048210Golgi vesicle fusion to target membrane-IBA21873635  
GO:0048210Golgi vesicle fusion to target membrane-IDA17574030  
GO:0051223regulation of protein transport-IEA-  
GO:0060271cilium assembly-IDA17574030  
GO:0060271cilium assembly-IMP17646400  21844891  
GO:0072659protein localization to plasma membrane-IBA21873635  
GO:0072659protein localization to plasma membrane-ISS-  
GO:0098969neurotransmitter receptor transport to postsynaptic membrane-IBA21873635  
GO:0098969neurotransmitter receptor transport to postsynaptic membrane-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005768endosome-IBA21873635  
GO:0005813centrosome-IDA24421332  
GO:0005814centriole-IEA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005929cilium-IDA17646400  24421332  
GO:0005929ciliumcolocalizes_withIDA21844891  
GO:0012505endomembrane system-IBA21873635  
GO:0014069postsynaptic density-IEA-  
GO:0030140trans-Golgi network transport vesicle-IBA21873635  
GO:0030140trans-Golgi network transport vesicle-IEA-  
GO:0030496midbody-IDA22159412  
GO:0030667secretory granule membrane-IBA21873635  
GO:0030670phagocytic vesicle membrane-IEA-  
GO:0032588trans-Golgi network membrane-TAS-  
GO:0036064ciliary basal body-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0043197dendritic spine-IBA21873635  
GO:0043197dendritic spine-IEA-  
GO:0045335phagocytic vesicle-IDA21255211  
GO:0055038recycling endosome membrane-IDA19864458  21951725  
GO:0055038recycling endosome membrane-TAS-  
GO:0070062extracellular exosome-HDA19056867  20458337  
GO:0097546ciliary base-IEA-  
GO:0097730non-motile cilium-IDA17574030  24648492  
KEGG ID KEGG Term
hsa04972Pancreatic secretion
Reactome ID Reactome Term Evidence
R-HSA-1445148Translocation of GLUT4 to the plasma membraneIEA
R-HSA-1640170Cell CycleTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-199991Membrane TraffickingIEA
R-HSA-199991Membrane TraffickingTAS
R-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5620912Anchoring of the basal body to the plasma membraneTAS
R-HSA-5620916VxPx cargo-targeting to ciliumTAS
R-HSA-5620920Cargo trafficking to the periciliary membraneTAS
R-HSA-5653656Vesicle-mediated transportIEA
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-8854214TBC/RABGAPsTAS
R-HSA-8873719RAB geranylgeranylationTAS
R-HSA-8876198RAB GEFs exchange GTP for GDP on RABsTAS
R-HSA-9007101Rab regulation of traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24419231Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: a gene- and pathway-based interaction analysis of GWAS data. (2014 May)Tang HCarcinogenesis