Gene: MEN1

4221
MEAI|SCG2
menin 1
protein-coding
11q13.1
Ensembl:ENSG00000133895 MIM:613733 Vega:OTTHUMG00000045366 UniprotKB:O00255
NG_008929.1
PubMed
0   ANCO-SNPs
ND
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.562e-1 (AD)  1.750e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg22897141chr11:64577338MEN18.510e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
URGCP0.958
USP200.953
ZFYVE270.951
SIN3B0.95
TMUB20.949
LRSAM10.948
SH2B10.948
MAPK8IP30.947
CABIN10.945
ATG4B0.945

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.613
OR4F29-0.562
TFPI2-0.394
MTRNR2L9-0.39
RAI14-0.384
YES1-0.375
KLRB1-0.374
CD48-0.37
MBNL3-0.367
MTRNR2L6-0.365

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MEN1 mRNA"21346803
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of MEN1 mRNA12958071
C5830744,4'-hexafluorisopropylidene diphenol"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MEN1 protein modified form]"28751236
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of MEN1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MEN1 mRNA16483693
D001280AtrazineAtrazine results in increased expression of MEN1 mRNA25929836
D004958EstradiolMEN1 protein inhibits the reaction [Estradiol results in increased expression of FOS mRNA]15090535
C006780bisphenol Abisphenol A affects the expression of MEN1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of MEN1 mRNA25181051
C099555CD 437CD 437 results in decreased expression of MEN1 mRNA12958071
D004390ChlorpyrifosChlorpyrifos results in increased expression of MEN1 mRNA20691718
D016572CyclosporineCyclosporine results in decreased expression of MEN1 mRNA25562108
D017373Cyproterone Acetate[Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MEN1 protein modified form]28751236
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MEN1 mRNA17379624|2126653
D002945CisplatinCisplatin results in decreased expression of MEN1 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of MEN1 mRNA28302478
D004026DieldrinDieldrin affects the expression of MEN1 mRNA22546817
D004317DoxorubicinDoxorubicin affects the expression of MEN1 protein22615588
D004317DoxorubicinDoxorubicin results in decreased expression of MEN1 mRNA22615588
C070609EMD 53998EMD 53998 analog results in decreased expression of MEN1 mRNA24977338
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MEN1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MEN1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MEN1 mRNA17942748
D019833GenisteinMEN1 protein inhibits the reaction [Genistein results in increased expression of FOS mRNA]15090535
D005839GentamicinsGentamicins results in increased expression of MEN1 mRNA22061828
C010974glyphosateglyphosate results in increased expression of MEN1 mRNA26302742
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MEN1 mRNA25613284
C045463leflunomideleflunomide results in decreased expression of MEN1 mRNA28988120
C008493methylselenic acidmethylselenic acid affects the expression of MEN1 mRNA14617803
D015741Metribolone[Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MEN1 protein modified form]28751236
C022838nickel chloridenickel chloride affects the expression of MEN1 mRNA22546817
D017239PaclitaxelPaclitaxel results in increased expression of MEN1 mRNA15585946
C006253pirinixic acidpirinixic acid results in decreased expression of MEN1 mRNA20059764
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of MEN1 mRNA]20059764
D011794QuercetinMEN1 protein inhibits the reaction [Quercetin results in increased expression of FOS mRNA]15090535
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of MEN1 mRNA21427059
D012999SomanSoman results in decreased expression of MEN1 mRNA19281266
D013629TamoxifenMEN1 protein results in decreased susceptibility to Tamoxifen19847644
D013629TamoxifenTamoxifen inhibits the reaction [MEN1 protein binds to ESR1 protein]19847644
D013629TamoxifenTamoxifen affects the expression of MEN1 mRNA17555576
D013739TestosteroneTestosterone results in decreased expression of MEN1 mRNA19693291
C020806tetrabromobisphenol Atetrabromobisphenol A affects the expression of MEN1 mRNA18976794
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MEN1 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MEN1 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MEN1 mRNA25613284
D014635Valproic AcidValproic Acid results in increased methylation of MEN1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of MEN1 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of MEN1 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MEN1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of MEN1 mRNA22496781

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000400four-way junction DNA binding-IDA15331604  
GO:0000403Y-form DNA binding-IBA21873635  
GO:0000403Y-form DNA binding-IDA15331604  
GO:0003682chromatin binding-IBA21873635  
GO:0003690double-stranded DNA binding-IBA21873635  
GO:0003690double-stranded DNA binding-IDA15331604  
GO:0005515protein binding-IPI9989505  11500056  11526476  12509449  12874027  14508515  
14992727  15199122  16951149  20484083  20969866  23784080  
GO:0018024histone-lysine N-methyltransferase activityCONTRIBUTES_TOIBA21873635  
GO:0018024histone-lysine N-methyltransferase activitycontributes_toIDA14992727  
GO:0030674protein binding, bridging-IDA20484083  
GO:0044212transcription regulatory region DNA binding-IBA21873635  
GO:0044212transcription regulatory region DNA binding-IDA20484083  
GO:0047485protein N-terminus binding-IPI11526476  
GO:0070412R-SMAD binding-IPI11274402  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA9989505  12837246  23784080  
GO:0000165MAPK cascade-IDA12226747  
GO:0000278mitotic cell cycle-IEA-  
GO:0001933negative regulation of protein phosphorylation-IDA12226747  
GO:0002076osteoblast development-IGI15563473  
GO:0003309type B pancreatic cell differentiation-IEA-  
GO:0006281DNA repair-NAS12874027  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006974cellular response to DNA damage stimulus-IDA16690369  
GO:0007420brain development-IEA-  
GO:0008285negative regulation of cell proliferation-IBA21873635  
GO:0008285negative regulation of cell proliferation-IDA15331604  
GO:0009411response to UV-IDA16690369  
GO:0010332response to gamma radiation-IDA12874027  
GO:0010812negative regulation of cell-substrate adhesion-IEA-  
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathway-IMP11274402  
GO:0032092positive regulation of protein binding-IDA20484083  
GO:0032925regulation of activin receptor signaling pathway-IEA-  
GO:0034968histone lysine methylation-IEA-  
GO:0043433negative regulation of DNA-binding transcription factor activity-IDA11526476  12226747  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0045668negative regulation of osteoblast differentiation-IGI15563473  
GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity-IMP15640349  
GO:0045786negative regulation of cell cycle-IBA21873635  
GO:0045786negative regulation of cell cycle-IDA15331604  
GO:0045892negative regulation of transcription, DNA-templated-IDA12226747  
GO:0045944positive regulation of transcription by RNA polymerase II-TAS-  
GO:0046329negative regulation of JNK cascade-IDA12226747  
GO:0046697decidualization-IEA-  
GO:0050680negative regulation of epithelial cell proliferation-IEA-  
GO:0051974negative regulation of telomerase activity-IMP12837246  
GO:0061469regulation of type B pancreatic cell proliferation-IEA-  
GO:0071333cellular response to glucose stimulus-IEA-  
GO:0071375cellular response to peptide hormone stimulus-IEA-  
GO:0071559response to transforming growth factor beta-IEA-  
GO:1902807negative regulation of cell cycle G1/S phase transition-IEA-  
GO:1904837beta-catenin-TCF complex assembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000784nuclear chromosome, telomeric region-ISS-  
GO:0000785chromatin-IBA21873635  
GO:0000785chromatin-IDA12874027  
GO:0000790nuclear chromatin-IDA12837246  
GO:0005634nucleus-IDA9465067  14508515  15199122  15640349  17500065  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA11500056  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005829cytosol-IDA14508515  
GO:0005829cytosol-TAS-  
GO:0016363nuclear matrix-IDA12874027  
GO:0032154cleavage furrow-IDA14508515  
GO:0032991protein-containing complex-IDA15199122  
GO:0035097histone methyltransferase complex-IBA21873635  
GO:0035097histone methyltransferase complex-IDA17500065  
GO:0035097histone methyltransferase complex-IPI14992727  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-201722Formation of the beta-catenin:TCF transactivating complexTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerTAS
R-HSA-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionTAS
R-HSA-3769402Deactivation of the beta-catenin transactivating complexTAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5626467RHO GTPases activate IQGAPsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8957275Post-translational protein phosphorylationTAS
R-HSA-9006936Signaling by TGF-beta family membersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27311764Clinical Features, Treatments, and Outcomes of Patients with Thymic Carcinoids and Multiple Endocrine Neoplasia Type 1 Syndrome at MD Anderson Cancer Center. (2016 Aug)Christakis IHorm Cancer
9064485Clinicopathologic studies of thymic carcinoids in multiple endocrine neoplasia type 1. (1997 Jan)Teh BTMedicine (Baltimore)
17848844Atypical thymic carcinoid in multiple endocrine neoplasia type 1 syndrome. (2007 Jul-Aug)Vidal AJ Endocrinol Invest
28940393Clinical features and prognosis of thymic neuroendocrine tumours associated with multiple endocrine neoplasia type 1: A single-centre study, systematic review and meta-analysis. (2017 Dec)Ye LClin Endocrinol (Oxf)
22690831Thymic neuroendocrine tumour in multiple endocrine neoplasia type 1: female patients are not rare exceptions. (2013 Feb)Sakurai AClin Endocrinol (Oxf)
23050049Genetic and lifestyle influence on telomere length and subsequent risk of colon cancer in a case control study. (2012)Pellatt AJInt J Mol Epidemiol Genet
22080849Natural history of gastro-entero-pancreatic and thoracic neuroendocrine tumors. Data from a large prospective and retrospective Italian epidemiological study: the NET management study. (2012 Oct)Faggiano AJ Endocrinol Invest
23319214Thymic carcinomas: clinicopathologic study of 37 cases from a single institution. (2013 Mar)Thomas de Montpreville VVirchows Arch