Gene: MEOX2

4223
GAX|MOX2
mesenchyme homeobox 2
protein-coding
7p21.2
Ensembl:ENSG00000106511 MIM:600535 Vega:OTTHUMG00000152390 UniprotKB:P50222
NG_032988.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.309e-1 (AD)  7.122e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SHQ10.63
ZNF2300.598
NUDT50.588
MOSPD10.582
ZNF300.581
JAK20.581
USP450.58
DENND6A0.575
CYP2R10.575
SLC46A30.574

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLA2G5-0.381
HPSE2-0.367
WNT7B-0.366
MMD2-0.36
NKAIN3-0.355
DIO2-0.351
C10orf62-0.335
HES5-0.333
PIPOX-0.329
BTBD17-0.321

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MEOX2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MEOX2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MEOX2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of MEOX2 mRNA"20959002
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MEOX2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MEOX2 mRNA"25510870
C5850042-monochloropropanediol2-monochloropropanediol results in decreased expression of MEOX2 mRNA28522335
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MEOX2 mRNA"25380136
D000082AcetaminophenAcetaminophen affects the expression of MEOX2 mRNA25064622
D000082AcetaminophenAcetaminophen results in decreased expression of MEOX2 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MEOX2 gene27153756
C040534alpha-hexachlorocyclohexanealpha-hexachlorocyclohexane results in increased expression of MEOX2 mRNA17785943
D000638AmiodaroneAmiodarone affects the expression of MEOX2 mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MEOX2 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of MEOX2 mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MEOX2 mRNA24449571
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MEOX2 mRNA18164116
D004958EstradiolEstradiol results in increased expression of MEOX2 mRNA25878060
C006780bisphenol Abisphenol A affects the methylation of MEOX2 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of MEOX2 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of MEOX2 mRNA25181051
D002713ChlorineChlorine affects the expression of MEOX2 mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of MEOX2 mRNA18636392
D002737ChloropreneChloroprene results in decreased expression of MEOX2 mRNA23125180
D002746ChlorpromazineChlorpromazine affects the expression of MEOX2 mRNA25064622
D003471CuprizoneCuprizone results in decreased expression of MEOX2 mRNA26577399
D016572CyclosporineCyclosporine affects the expression of MEOX2 mRNA25064622
C014347decitabinedecitabine results in increased expression of MEOX2 mRNA27915011
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MEOX2 mRNA21266533
D004041Dietary FatsDietary Fats results in increased expression of MEOX2 mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MEOX2 mRNA18164116
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of MEOX2 mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of MEOX2 mRNA15591538
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of MEOX2 mRNA21658437
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of MEOX2 mRNA25380136
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of MEOX2 mRNA12655031
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MEOX2 mRNA25064622
C039281furanfuran results in decreased expression of MEOX2 mRNA25539665|2619464
C004312glycidolglycidol results in decreased expression of MEOX2 mRNA24915197
D001556LindaneLindane results in decreased expression of MEOX2 mRNA17785943
D008558MelphalanMelphalan results in decreased expression of MEOX2 mRNA22363485
D015122MercaptopurineMercaptopurine results in decreased expression of MEOX2 mRNA23358152
D008628MercuryMercury results in increased expression of MEOX2 mRNA16823088
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of MEOX2 mRNA24810058
D008917MirexMirex results in increased expression of MEOX2 mRNA23153324
D009151Mustard GasMustard Gas results in increased expression of MEOX2 mRNA15674843
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of MEOX2 mRNA25380136
D019829NevirapineNevirapine results in increased expression of MEOX2 mRNA23947594
D009532NickelNickel results in decreased expression of MEOX2 mRNA12540486
D010100OxygenOxygen deficiency results in decreased expression of MEOX2 mRNA26516004
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of MEOX2 mRNA18636392
D000073878Palm OilPalm Oil results in increased expression of MEOX2 mRNA18042831
D010269ParaquatParaquat affects the expression of MEOX2 mRNA25064622
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MEOX2 mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of MEOX2 mRNA26705709
D010634PhenobarbitalPhenobarbital results in increased expression of MEOX2 mRNA19162173
C006253pirinixic acidpirinixic acid results in increased expression of MEOX2 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of MEOX2 mRNA19162173
D059808PolyphenolsPolyphenols results in decreased expression of MEOX2 mRNA16293270
D011441PropylthiouracilPropylthiouracil results in increased expression of MEOX2 mRNA24780913
C116926rofecoxibrofecoxib results in decreased expression of MEOX2 mRNA17070997
C016104sodium bichromatesodium bichromate results in decreased expression of MEOX2 mRNA25993096
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in decreased expression of MEOX2 mRNA16214533
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MEOX2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MEOX2 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MEOX2 mRNA21215274
D013752TetracyclineTetracycline affects the expression of MEOX2 mRNA25064622
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MEOX2 mRNA16979875
D013853ThioacetamideThioacetamide affects the expression of MEOX2 mRNA25064622
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MEOX2 mRNA28111298
D014212TretinoinTretinoin results in increased expression of MEOX2 mRNA21934132
C011559tributyltintributyltin results in decreased expression of MEOX2 mRNA27614199
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of MEOX2 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of MEOX2 mRNA28973697
C406224valdecoxibvaldecoxib results in increased expression of MEOX2 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of MEOX2 mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of MEOX2 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of MEOX2 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MEOX2 gene25560391
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MEOX2 mRNA16979875

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA17074759  
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-IDA17074759  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA17074759  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IMP17074759  
GO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding-IDA17074759  
GO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding-IMP17074759  
GO:0003700DNA-binding transcription factor activity-IDA22206000  
GO:0005515protein binding-IPI11423130  16335786  25416956  25910212  27107014  
GO:0043565sequence-specific DNA binding-IDA9073066  
GO:0043565sequence-specific DNA binding-IMP22206000  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0001757somite specification-IEA-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007275multicellular organism development-TAS7713505  
GO:0007519skeletal muscle tissue development-IEA-  
GO:0008015blood circulation-TAS7713505  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA17074759  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP17074759  
GO:0060021roof of mouth development-IEA-  
GO:0060173limb development-IEA-  
GO:0061053somite development-IBA21873635  
GO:0070997neuron death-IMP22166940  
GO:0090051negative regulation of cell migration involved in sprouting angiogenesis-IGI20516212  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA22206000  
GO:0005737cytoplasm-IDA16335786  
GO:0016607nuclear speck-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26428460Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population. (2015 Oct 1)Yang WYBMC Genet