Gene: MEST

4232
PEG1
mesoderm specific transcript
protein-coding
7q32.2
Ensembl:ENSG00000106484 MIM:601029 Vega:OTTHUMG00000156661 UniprotKB:Q5EB52
NG_009226.1
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.653e-1 (AD)  3.024e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg09003373chr7:130130995MESTPromoter1.109e-4Alcohol use disorders26763658
cg04819959chr7:130135065MESTPromoter2.824e-4Alcohol use disorders26763658
cg10249538chr7:130131829MESTPromoter3.858e-4Alcohol use disorders26763658
cg26275543chr7:130130383MESTPromoter6.102e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RPF20.833
TARS0.794
OSTC0.788
PUS30.786
PNO10.785
ALG20.784
MRPL180.784
EIF1AD0.783
HUS10.78
STIP10.78

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.499
OR4F29-0.434
P2RY14-0.3
SNX22-0.291
CTNNA3-0.29
SLC6A13-0.286
COX4I2-0.265
SLCO1A2-0.251
ANPEP-0.249
ITIH5-0.244

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MEST mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MEST mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MEST mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of MEST mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of MEST mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MEST gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MEST mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MEST mRNA24449571
C015001arsenitearsenite results in increased methylation of MEST promoter23974009
C015001arsenitearsenite results in decreased expression of MEST mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in decreased expression of MEST mRNA]18929588
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of MEST mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of MEST mRNA18164116
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of MEST mRNA26377693
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of MEST mRNA"20382639
D004958EstradiolEstradiol results in decreased expression of MEST mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of MEST mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of MEST mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of MEST mRNA18958704
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of MEST mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MEST mRNA19666079|2392115
C054133casticincasticin results in increased expression of MEST mRNA28444820
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of MEST mRNA25270620
C007095cobaltiprotoporphyrincobaltiprotoporphyrin affects the expression of MEST protein23497794
D019327Copper SulfateCopper Sulfate results in decreased expression of MEST mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of MEST mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of MEST mRNA19770486
D003907DexamethasoneDexamethasone results in increased expression of MEST mRNA25047013
C016366dibenzothiophenedibenzothiophene results in decreased expression of MEST mRNA23656968
D002945CisplatinCisplatin results in increased expression of MEST mRNA27392435
D002945CisplatinMEST protein affects the susceptibility to Cisplatin16217747
D004041Dietary FatsDietary Fats results in increased expression of MEST mRNA18042831|1903023
D004041Dietary FatsDiosgenin inhibits the reaction [Dietary Fats results in increased expression of MEST mRNA]26408789
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of MEST mRNA]19030233
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of MEST mRNA18164116
D004144DiosgeninDiosgenin inhibits the reaction [Dietary Fats results in increased expression of MEST mRNA]26408789
D004144DiosgeninDiosgenin results in decreased expression of MEST mRNA26408789
D004147DioxinsDioxins affects the expression of MEST mRNA20463971
D004317DoxorubicinMEST protein affects the susceptibility to Doxorubicin16217747
C118739entinostatentinostat results in decreased expression of MEST mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MEST mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MEST mRNA20227414
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MEST mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MEST mRNA23649840
D005492Folic Acid[Folic Acid co-treated with sodium arsenite] results in decreased methylation of MEST mRNA22959928
D005492Folic AcidFolic Acid results in decreased methylation of MEST mRNA22959928
D005557FormaldehydeFormaldehyde results in increased expression of MEST mRNA23649840
D017313FenretinideFenretinide results in decreased expression of MEST mRNA28973697
D017313FenretinideFenretinide results in increased expression of MEST mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MEST mRNA24796395
C008261lead acetatelead acetate results in decreased methylation of MEST gene25596546
C008261lead acetatelead acetate results in increased expression of MEST mRNA25596546
D015122MercaptopurineMercaptopurine results in decreased expression of MEST mRNA23358152
D008731MethoxychlorMethoxychlor results in increased methylation of MEST gene21062904
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MEST mRNA23458150
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of MEST protein26558463
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MEST mRNA23649840
D008942MitoxantroneMEST protein affects the susceptibility to Mitoxantrone16217747
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MEST mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MEST mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MEST mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MEST mRNA"25554681
C029938nickel sulfatenickel sulfate results in decreased expression of MEST mRNA16166746
D000073878Palm OilPalm Oil results in increased expression of MEST mRNA18042831
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of MEST mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of MEST mRNA19429403
C006253pirinixic acidpirinixic acid results in increased expression of MEST mRNA23811191
D010894PiroxicamPiroxicam results in decreased expression of MEST mRNA21858171
D011192Potassium DichromatePotassium Dichromate results in increased expression of MEST mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of MEST mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of MEST17510236
D011441PropylthiouracilPropylthiouracil results in increased expression of MEST mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of MEST mRNA27029645
C089032rimonabantrimonabant affects the expression of MEST mRNA19030233
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of MEST mRNA]19030233
C078903seocalcitolseocalcitol results in decreased expression of MEST mRNA12040012
D012834SilverSilver results in decreased expression of MEST mRNA27131904
C017947sodium arsenite[Folic Acid co-treated with sodium arsenite] results in decreased methylation of MEST mRNA22959928
D012999SomanSoman results in increased expression of MEST mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MEST mRNA12377990
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MEST mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MEST mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MEST mRNA26290441
C009495titanium dioxidetitanium dioxide results in increased expression of MEST mRNA23557971
D019772TopotecanMEST protein affects the susceptibility to Topotecan16217747
D014635Valproic AcidValproic Acid affects the expression of MEST mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MEST mRNA23179753|2800136
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MEST gene25560391
D001335Vehicle EmissionsVehicle Emissions analog results in increased expression of MEST mRNA15541757
C025643vinclozolinvinclozolin results in increased methylation of MEST gene19887539

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0016787hydrolase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007498mesoderm development-TAS9158153  
GO:0010883regulation of lipid storage-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-ISS-  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23116464Beckwith Wiedemann imprinting defect found in leucocyte but not buccal DNA in a child born small for gestational age. (2012 Nov 1)Murphy RBMC Med Genet
22677950Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. (2012 Jul)Liu YEpigenetics
24746205The expression of FOXL2 in pancreatic, hepatobiliary, and renal tumors with ovarian-type stroma. (2014 May)Westerhoff MHum Pathol