Gene: MFAP4

4239
-
microfibril associated protein 4
protein-coding
17p11.2
Ensembl:ENSG00000166482 MIM:600596 Vega:OTTHUMG00000059585 UniprotKB:P55083
NG_027952.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.304e-1 (AD)  4.436e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLN0.76
MGP0.756
OGN0.751
PDE3A0.746
TBX180.745
TRABD2B0.738
COL8A10.737
ACTA20.725
MYL90.723
MYH110.722

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RHO-0.396
XKR7-0.373
KCNB2-0.37
CALHM1-0.362
BCL11A-0.362
LIN28B-0.362
MARCH11-0.354
GALNT14-0.351
RDH12-0.347
ABCC12-0.343

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of MFAP4 mRNA20566314
C0166141-nitronaphthalene1-nitronaphthalene metabolite binds to MFAP4 protein16453347
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MFAP4 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MFAP4 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MFAP4 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MFAP4 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MFAP4 mRNA"25510870
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of MFAP4 mRNA"23994337
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MFAP4 mRNA"25380136
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of MFAP4 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MFAP4 mRNA]17585979
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MFAP4 mRNA24449571
D001104ArbutinArbutin results in decreased expression of MFAP4 mRNA17103032
D001280AtrazineAtrazine results in increased expression of MFAP4 mRNA22378314
C547126AZM551248AZM551248 results in increased expression of MFAP4 mRNA22323515
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MFAP4 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MFAP4 mRNA27858113
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of MFAP4 mRNA23994337
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of MFAP4 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MFAP4 mRNA26001963
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MFAP4 mRNA27858113
D004958EstradiolEstradiol results in increased expression of MFAP4 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of MFAP4 mRNA25912373
C006780bisphenol Abisphenol A results in increased expression of MFAP4 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MFAP4 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of MFAP4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MFAP4 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MFAP4 mRNA28628672
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MFAP4 mRNA24982889
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MFAP4 mRNA24982889
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MFAP4 mRNA25993096
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MFAP4 mRNA27858113
C031180chrysenechrysene results in increased expression of MFAP4 mRNA26377693
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of MFAP4 mRNA17585979
D002994ClofibrateClofibrate results in increased expression of MFAP4 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MFAP4 mRNA]17585979
D003471CuprizoneCuprizone results in increased expression of MFAP4 mRNA26577399
D003561CytarabineCytarabine results in decreased expression of MFAP4 mRNA21198554
D000069439DasatinibDasatinib results in increased expression of MFAP4 mRNA20579391
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MFAP4 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MFAP4 mRNA28628672
C016366dibenzothiophenedibenzothiophene results in increased expression of MFAP4 mRNA23656968
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MFAP4 mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of MFAP4 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of MFAP4 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of MFAP4 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of MFAP4 mRNA18042831
C014476diethyl maleatediethyl maleate results in decreased expression of MFAP4 mRNA21161181
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of MFAP4 mRNA22129741
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of MFAP4 mRNA21658437
D002117CalcitriolCalcitriol results in decreased expression of MFAP4 mRNA26485663
D004237DiuronDiuron results in decreased expression of MFAP4 mRNA25152437
D004237DiuronDiuron results in increased expression of MFAP4 mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MFAP4 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MFAP4 mRNA17942748
C069837fullerene C60fullerene C60 results in increased expression of MFAP4 mRNA19167457
C039281furanfuran results in increased expression of MFAP4 mRNA27387713
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of MFAP4 mRNA20566314
D017313FenretinideFenretinide results in decreased expression of MFAP4 mRNA28973697
D017313FenretinideFenretinide results in increased expression of MFAP4 mRNA28973697
C016517indole-3-carbinolindole-3-carbinol affects the expression of MFAP4 mRNA21396975
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of MFAP4 mRNA22129741
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MFAP4 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MFAP4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MFAP4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MFAP4 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of MFAP4 mRNA27392435
C011890kojic acidkojic acid results in decreased expression of MFAP4 mRNA16595896
D008727MethotrexateMethotrexate results in decreased expression of MFAP4 mRNA17400583
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of MFAP4 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MFAP4 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MFAP4 mRNA"25620056
C031721naphthalenenaphthalene metabolite binds to MFAP4 protein16453347
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of MFAP4 mRNA25380136
D009532NickelNickel results in decreased expression of MFAP4 mRNA25583101
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MFAP4 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of MFAP4 mRNA27935865
D000073878Palm OilPalm Oil results in increased expression of MFAP4 mRNA18042831
D052638Particulate MatterParticulate Matter results in increased methylation of MFAP4 gene28495853
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MFAP4 mRNA"25510870
D010656PhenylephrinePhenylephrine results in decreased expression of MFAP4 mRNA18158353
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MFAP4 mRNA27935865
D011374ProgesteroneProgesterone results in decreased expression of MFAP4 mRNA23012394
D011374ProgesteroneProgesterone results in increased expression of MFAP4 mRNA21540246
D011441PropylthiouracilPropylthiouracil results in increased expression of MFAP4 mRNA24780913
D015474IsotretinoinIsotretinoin results in increased expression of MFAP4 mRNA20436886
D012524SarinSarin results in decreased expression of MFAP4 mRNA19522546
D012524SarinSarin results in increased expression of MFAP4 mRNA19522546
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MFAP4 mRNA25895662
D012834SilverSilver analog results in increased expression of MFAP4 mRNA24974767
C017947sodium arsenitesodium arsenite results in decreased expression of MFAP4 protein21925251
D012999SomanSoman results in increased expression of MFAP4 mRNA19281266
C016766sulforafansulforafan results in decreased expression of MFAP4 mRNA26833863
D013739TestosteroneTestosterone results in decreased expression of MFAP4 mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MFAP4 mRNA20055451
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MFAP4 mRNA21296121
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MFAP4 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MFAP4 mRNA15328365|2399433
D019284ThapsigarginThapsigargin results in increased expression of MFAP4 mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MFAP4 mRNA28065790
D014212TretinoinTretinoin results in decreased expression of MFAP4 mRNA23724009
D017973Tungsten CompoundsTungsten Compounds results in decreased expression of MFAP4 mRNA28666766
D014415TunicamycinTunicamycin results in increased expression of MFAP4 mRNA22378314
D017974Uranium CompoundsUranium Compounds results in increased expression of MFAP4 mRNA19654044
D014635Valproic AcidValproic Acid affects the expression of MFAP4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MFAP4 mRNA19101580|2915479
D014635Valproic AcidValproic Acid results in increased expression of MFAP4 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MFAP4 gene28495853
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of MFAP4 mRNA19165385
C025643vinclozolinvinclozolin affects the expression of MFAP4 mRNA19015723
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of MFAP4 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI22355679  26601954  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0009650UV protection-IDA22355679  
GO:0010712regulation of collagen metabolic process-IDA22355679  
GO:0048251elastic fiber assembly-IDA22355679  
GO:0071493cellular response to UV-B-IDA22355679  
GO:0097435supramolecular fiber organization-IDA22355679  
GO ID GO Term Qualifier Evidence PubMed
GO:0001527microfibril-IDA22355679  
GO:0001527microfibril-NAS7633408  
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-IDA22355679  
GO:0005576extracellular region-TAS-  
GO:0031012extracellular matrix-IDA26601954  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:0071953elastic fiber-IDA10424889  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1566948Elastic fibre formationTAS
R-HSA-2129379Molecules associated with elastic fibresTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24324779Enzyme-linked immunosorbent assay characterization of basal variation and heritability of systemic microfibrillar-associated protein 4. (2013)Saekmose SGPLoS One