Gene info: ID 4255

Gene: MGMT

GENE ID: 4255

Synonyms: -

Description: O-6-methylguanine-DNA methyltransferase

Gene type: protein-coding

Location: 10q26.3

dbXrefs: Ensembl:ENSG00000170430 MIM:156569 Vega:OTTHUMG00000019261 UniprotKB:P16455

RefSeq: NG_052673.1

Retrived from: PubMed|SNP Mapped

SNPs: 2 ANCO-SNPs

Phenotype: ND|AD

# Publications: 74

Sherlock p-value : 4.369e-2 (AD) 8.827e-1 (ND) (Frontal_Cortex)

Pascal p-value : 2.711e-1 (AD) 3.844e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs10829622	chr10:129721248 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs4751115	chr10:129712029 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg27041381	chr10:131357203	MGMT	Gene body	6.128e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TRAPPC6A	0.77
PMF1	0.766
ZNHIT1	0.765
TMEM134	0.764
PGLS	0.752
SWI5	0.752
NELFE	0.747
POLR2G	0.746
CHMP4A	0.74
NENF	0.738

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.498
OR4F5	-0.492
HTR1F	-0.273
ROS1	-0.244
DSC1	-0.244
MUC15	-0.242
HS6ST3	-0.241
CNTNAP5	-0.238
DLX3	-0.232
RAB39A	-0.231

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00151	L-Cysteine	Small Molecule	52-90-4	Approved\|Nutraceutical	Target
DB01593	Zinc	Small Molecule	7440-66-6	Approved\|Investigational	Target
DB02216	S-Methylcysteine	Small Molecule	1187-84-4	Experimental	Target
DB04531	Benzylcysteine	Small Molecule		Experimental	Target
DB11831	Dinitrochlorobenzene	Small Molecule	97-00-7	Investigational	Target

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of MGMT mRNA"	26377693
C530954	1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine	"MGMT protein affects the susceptibility to 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine"	25012050
C017139	1-(2-chloroethyl)-1-nitrosourea	MGMT protein results in decreased susceptibility to 1-(2-chloroethyl)-1-nitrosourea	1727384
C012277	1,2-diamino-4-nitrobenzene	"1,2-diamino-4-nitrobenzene results in increased expression of MGMT mRNA"	17070881
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of MGMT mRNA"	19162173
C582286	1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea	MGMT mutant form promotes the reaction [1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased phosphorylation of CHEK1 protein]	26208482
C582286	1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea	MGMT mutant form promotes the reaction [1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased phosphorylation of CHEK2 protein]	26208482
C025223	1,4-dioxane	"1,4-dioxane results in increased expression of MGMT mRNA"	22084566
C035314	1-nitropropane	1-nitropropane results in increased expression of MGMT mRNA	17070881
C044565	2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide	MGMT protein mutant form results in decreased susceptibility to [2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide co-treated with O(6)-benzylguanine]	12850483
C010914	2,4-diaminotoluene	"2,4-diaminotoluene affects the expression of MGMT mRNA"	22084566
C010914	2,4-diaminotoluene	"2,4-diaminotoluene results in increased expression of MGMT mRNA"	17070881
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of MGMT mRNA"	21346803
C025235	2,6-diaminotoluene	"2,6-diaminotoluene results in increased expression of MGMT mRNA"	17070881
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of MGMT mRNA"	21346803
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MGMT mRNA"	12706856\|1521517
C006593	2-anthramine	2-anthramine results in increased expression of MGMT mRNA	23038007
C014706	2-nitro-4-phenylenediamine	2-nitro-4-phenylenediamine results in decreased expression of MGMT mRNA	17070881
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of MGMT mRNA	14600272\|1589037
C016617	2-nitropropane	2-nitropropane results in increased expression of MGMT mRNA	17070881
C029536	2-oxothiazolidine-4-carboxylic acid	2-oxothiazolidine-4-carboxylic acid results in decreased activity of MGMT protein	16950796
C029536	2-oxothiazolidine-4-carboxylic acid	2-oxothiazolidine-4-carboxylic acid results in increased expression of and results in increased activity of MGMT protein	16950796
C029536	2-oxothiazolidine-4-carboxylic acid	2-oxothiazolidine-4-carboxylic acid results in increased expression of MGMT mRNA	16950796
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of MGMT mRNA"	25380136
C007542	4,4'-dipyridyl disulfide	"4,4'-dipyridyl disulfide binds to MGMT protein"	12974631
C583074	4,4'-hexafluorisopropylidene diphenol	"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MGMT protein modified form]"	28751236
C081510	4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone	MGMT protein affects the susceptibility to 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone	19601657
C028676	4-acetylaminofluorene	4-acetylaminofluorene results in increased expression of MGMT mRNA	17070881
C008651	4-nitrosodimethylaniline	4-nitrosodimethylaniline results in decreased expression of MGMT protein	15542103
C008651	4-nitrosodimethylaniline	4-nitrosodimethylaniline results in decreased expression of MGMT protein	15542103
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MGMT mRNA	14600272\|1589037
C105260	4-tert-octylphenol	4-tert-octylphenol results in decreased expression of MGMT mRNA	20965277
C524814	5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one	5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one results in increased expression of MGMT protein	28720507
D000082	Acetaminophen	Acetaminophen results in decreased expression of MGMT mRNA	29067470
D000082	Acetaminophen	Acetaminophen results in decreased expression of MGMT mRNA	12883083
D000082	Acetaminophen	Acetaminophen results in increased expression of MGMT mRNA	16751229
D000111	Acetylcysteine	Acetylcysteine results in decreased activity of MGMT protein	16950796
D000111	Acetylcysteine	Acetylcysteine results in increased expression of and results in increased activity of MGMT protein	16950796
D000111	Acetylcysteine	Acetylcysteine results in increased expression of MGMT mRNA	16950796
D000171	Acrolein	MGMT protein results in decreased susceptibility to Acrolein	17485251
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of MGMT protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of MGMT mRNA	22100608\|2715375
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of MGMT mRNA	14600272\|1589037
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in decreased methylation of MGMT promoter"	26410583
D000477	Alkylating Agents	MGMT protein results in decreased susceptibility to Alkylating Agents	15943786\|1607885
C041635	alpha-carotene	MGMT gene SNP affects the susceptibility to alpha-carotene	16014702
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MGMT mRNA	16483693
D018906	Antineoplastic Agents, Alkylating	"MGMT protein affects the susceptibility to Antineoplastic Agents, Alkylating"	15870861\|1603383
C000228	aristolochic acid I	[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of MGMT mRNA	23912714
C042310	aristolochic acid II	[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of MGMT mRNA	23912714
D001151	Arsenic	Arsenic affects the expression of MGMT mRNA	17450239
D001151	Arsenic	Arsenic affects the methylation of MGMT gene	25304211
C015001	arsenite	arsenite results in decreased expression of MGMT mRNA	18929588
C015001	arsenite	TRP53 protein affects the reaction [arsenite results in decreased expression of MGMT mRNA]	18929588
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [[kojic acid co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA]	18544905
D001374	Azacitidine	Azacitidine results in decreased methylation of MGMT protein	7511991
D001374	Azacitidine	Azacitidine results in increased expression of MGMT mRNA	12807730
C547126	AZM551248	AZM551248 results in decreased expression of MGMT mRNA	22323515
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MGMT mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MGMT mRNA	27858113
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of MGMT mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MGMT mRNA	20064835\|2569089
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MGMT mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to MGMT promoter]	19654925
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MGMT mRNA	22228805\|2261060
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tamoxifen results in increased degradation of MGMT protein]	17597106
D019207	beta Carotene	MGMT gene SNP affects the susceptibility to beta Carotene	16014702
D004958	Estradiol	Estradiol results in decreased expression of MGMT mRNA	20965277
D001629	Bezafibrate	Bezafibrate results in increased expression of MGMT mRNA	15447978
C522781	biflorin	biflorin affects the expression of MGMT mRNA	27079618
C006780	bisphenol A	[bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MGMT protein modified form]	28751236
C006780	bisphenol A	bisphenol A results in decreased expression of MGMT mRNA	20965277
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in increased expression of MGMT mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased expression of MGMT mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of MGMT gene	28505145
D000069286	Bortezomib	Bortezomib inhibits the reaction [Disulfiram results in increased degradation of MGMT protein]	24193513
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine inhibits the reaction [MGMT protein results in increased susceptibility to Mitomycin]	16039682
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in decreased activity of MGMT protein	16950796
D002087	Butyrates	Butyrates results in increased expression of MGMT mRNA	14674679
C584509	C646 compound	C646 compound results in increased expression of MGMT mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MGMT mRNA	12160620
D019256	Cadmium Chloride	MGMT gene SNP affects the susceptibility to Cadmium Chloride	25622337
C053400	cafestol	[cafestol co-treated with kahweol] results in increased activity of MGMT protein	12517412
C053400	cafestol	cafestol results in increased activity of MGMT protein	12517412
D002166	Camptothecin	Camptothecin results in decreased expression of MGMT mRNA	18492797
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of MGMT mRNA	17484886
D002330	Carmustine	MGMT protein mutant form results in decreased susceptibility to Carmustine	15053863
D002330	Carmustine	MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]	14617759
D002330	Carmustine	MGMT protein results in decreased susceptibility to Carmustine	15053863
D002330	Carmustine	Carmustine results in increased alkylation of MGMT protein	8823159
D002330	Carmustine	MGMT gene modified form affects the susceptibility to Carmustine	12684420
D002330	Carmustine	MGMT mRNA results in decreased susceptibility to Carmustine	16365179
D002330	Carmustine	MGMT mutant form results in increased susceptibility to Carmustine	26208482
D002330	Carmustine	MGMT promoter modified form affects the susceptibility to Carmustine	19637364
D002330	Carmustine	MGMT protein affects the susceptibility to Carmustine	12394182\|1603383
D002330	Carmustine	[MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Carmustine	11792417
D002330	Carmustine	[MGMT protein mutant form co-treated with FECH protein] results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]	12950064
D002330	Carmustine	MGMT protein mutant form results in decreased susceptibility to Carmustine	20450874
D002330	Carmustine	MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]	11945064\|1247936
D002330	Carmustine	MGMT protein mutant form results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]	12036916\|1467012
D002330	Carmustine	MGMT protein results in decreased susceptibility to Carmustine	12479369\|1474274
D002330	Carmustine	MGMT protein results in decreased susceptibility to Carmustine analog	20654586
D002330	Carmustine	MGMT protein results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]	19415780
D002330	Carmustine	MGMT protein results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]	15319033
D002330	Carmustine	MGMT results in decreased susceptibility to Carmustine	9918549
D002330	Carmustine	[O(6)-benzyl-2'-deoxyguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine	14506174
D002330	Carmustine	[O(6)-benzylguanine co-treated with Carmustine] results in decreased activity of MGMT protein	16278409
D002330	Carmustine	O(6)-benzylguanine inhibits the reaction [MGMT protein mutant form results in decreased susceptibility to Carmustine]	20450874
D002330	Carmustine	[O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine	14506174\|1470727
D002330	Carmustine	[O(6)-benzyl-N-acetylguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine	12394182
D002330	Carmustine	[Tamoxifen results in increased degradation of MGMT protein] which results in increased susceptibility to Carmustine	17597106
D002330	Carmustine	Carmustine results in decreased activity of MGMT protein	16126841
D002330	Carmustine	MGMT protein affects the susceptibility to Carmustine	19844954
D002330	Carmustine	MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]	14707273
D002330	Carmustine	MGMT protein results in decreased susceptibility to Carmustine	15284838
D002330	Carmustine	MGMT protein results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]	19415780
D002330	Carmustine	[O(6)-benzylguanine results in decreased activity of MGMT protein] which affects the susceptibility to Carmustine	19844954
D002330	Carmustine	Carmustine results in decreased expression of MGMT protein	15104113
D002330	Carmustine	[MGMT protein mutant form co-treated with ABCB1 protein] results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]	16733832
D002330	Carmustine	[MGMT protein mutant form co-treated with ABCC1 protein] results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]	16733832
D002330	Carmustine	MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]	16733832
D002330	Carmustine	MGMT protein results in decreased susceptibility to Carmustine	16126841
D002330	Carmustine	MGMT protein results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]	15494421
D002330	Carmustine	MGMT results in decreased susceptibility to Carmustine	19048410
D002330	Carmustine	[O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine	21955333
D002713	Chlorine	[Ozone co-treated with Chlorine] results in decreased expression of MGMT mRNA	18636392
C004656	chloroacetaldehyde	MGMT protein results in decreased susceptibility to chloroacetaldehyde	17485251
D002725	Chloroform	Chloroform results in increased expression of MGMT mRNA	21813463
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MGMT mRNA	27858113
D002992	Clofenapate	Clofenapate results in increased expression of MGMT mRNA	12971794
D002994	Clofibrate	Clofibrate results in increased expression of MGMT mRNA	16081524
D002995	Clofibric Acid	Clofibric Acid results in decreased expression of MGMT mRNA	17602206
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MGMT mRNA	17602206
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of MGMT mRNA	19376846
D003077	Coke	Coke results in decreased expression of MGMT mRNA	23543013
D003077	Coke	Coke results in decreased expression of MGMT protein	23543013
D003077	Coke	Coke results in decreased methylation of MGMT promoter	23543013
D003077	Coke	Coke results in increased methylation of MGMT promoter	23543013
D003078	Colchicine	[MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Colchicine	11792417
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of and results in decreased activity of MGMT protein	24193513
D003300	Copper	Copper deficiency results in increased expression of MGMT mRNA	17418555
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in increased expression of MGMT mRNA	21878529
C029892	cupric chloride	[Disulfiram co-treated with cupric chloride] affects the expression of and affects the activity of MGMT protein	24193513
D003471	Cuprizone	Cuprizone results in increased expression of MGMT mRNA	26577399
D003474	Curcumin	Curcumin results in decreased activity of MGMT protein	16950796
D003474	Curcumin	Curcumin results in decreased expression of MGMT mRNA	17596214
D003474	Curcumin	Curcumin results in increased expression of and results in increased activity of MGMT protein	16950796
D003474	Curcumin	Curcumin results in increased expression of MGMT mRNA	16950796
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of MGMT mRNA	17403535
D003520	Cyclophosphamide	MGMT protein results in decreased susceptibility to Cyclophosphamide	15741301
D016572	Cyclosporine	Cyclosporine results in decreased expression of MGMT mRNA	20106945
C017160	cypermethrin	cypermethrin results in increased expression of MGMT mRNA	21142847
D003606	Dacarbazine	Dacarbazine results in decreased activity of MGMT protein	12494480
D003606	Dacarbazine	Dacarbazine results in decreased expression of MGMT protein	12494480
D003606	Dacarbazine	MGMT protein affects the susceptibility to Dacarbazine	14562026
D003606	Dacarbazine	MGMT protein results in decreased susceptibility to Dacarbazine	10751609\|1217018
D003606	Dacarbazine	MGMT gene mutant form results in increased susceptibility to Dacarbazine	11023546\|1501031
C014347	decitabine	[decitabine co-treated with trichostatin A] results in increased expression of MGMT mRNA	15657354
C014347	decitabine	decitabine promotes the reaction [HIST3H3 protein binds to MGMT promoter]	15657354
C014347	decitabine	decitabine promotes the reaction [HIST4H4 protein binds to MGMT promoter]	15657354
C014347	decitabine	decitabine results in decreased expression of MGMT protein	18021753
C014347	decitabine	decitabine results in decreased methylation of MGMT promoter	15703815
C014347	decitabine	decitabine results in increased expression of MGMT mRNA	15657354\|1570381
C107676	deguelin	deguelin results in decreased expression of MGMT mRNA	22227970
D003849	Deoxyguanosine	Deoxyguanosine analog results in decreased activity of MGMT protein	17880193
D003907	Dexamethasone	Dexamethasone promotes the reaction [MGMT protein results in decreased susceptibility to Nimustine]	15481722
D003907	Dexamethasone	Dexamethasone results in increased expression of MGMT mRNA	15481722
D003907	Dexamethasone	[Nimustine co-treated with Dexamethasone] results in increased expression of MGMT mRNA	15481722
D003907	Dexamethasone	Dexamethasone results in increased activity of MGMT protein	20308330
D003907	Dexamethasone	Dexamethasone results in increased expression of MGMT mRNA	20308330
D003907	Dexamethasone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of MGMT mRNA]	20308330
D016190	Carboplatin	Carboplatin results in decreased expression of MGMT mRNA	18172885
D003976	Diazinon	Diazinon results in increased methylation of MGMT gene	22964155
D015946	Ethylene Dibromide	Ethylene Dibromide binds to and results in decreased activity of MGMT protein	12151404
D015946	Ethylene Dibromide	Ethylene Dibromide binds to MGMT protein	17226938
D015946	Ethylene Dibromide	MGMT protein affects the metabolism of and results in increased activity of Ethylene Dibromide	14645247
D015946	Ethylene Dibromide	MGMT protein results in increased activity of and results in increased susceptibility to Ethylene Dibromide	10894884\|1215140
D015946	Ethylene Dibromide	MGMT protein results in increased susceptibility to Ethylene Dibromide	17226938
D002945	Cisplatin	Cisplatin results in decreased activity of MGMT protein	15015788\|2766459
D002945	Cisplatin	Cisplatin results in decreased expression of MGMT mRNA	15809756\|1604338
D002945	Cisplatin	Cisplatin results in decreased expression of MGMT protein	16043385
D002945	Cisplatin	MGMT protein results in decreased susceptibility to Cisplatin	16043385
D002945	Cisplatin	Cisplatin results in decreased activity of MGMT protein	15865103
D004006	Dichlorvos	Dichlorvos results in increased expression of MGMT mRNA	21813463
C014476	diethyl maleate	diethyl maleate results in decreased activity of MGMT protein	16950796
D004052	Diethylnitrosamine	Ascorbic Acid inhibits the reaction [[kojic acid co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA]	18544905
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MGMT mRNA	17602206
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of MGMT mRNA	11599795\|1760220
D004052	Diethylnitrosamine	[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA	18253720
D004052	Diethylnitrosamine	[kojic acid co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA	18544905
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of MGMT mRNA	15890375
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in decreased expression of MGMT mRNA	27638505
D015127	9,10-Dimethyl-1,2-benzanthracene	"MGMT protein results in decreased susceptibility to [Methylnitrosourea co-treated with 9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate]"	12663516
D019813	1,2-Dimethylhydrazine	"1,2-Dimethylhydrazine results in increased expression of MGMT mRNA"	27840820
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of MGMT mRNA	14600272\|1589037
C007482	dimethyl sulfate	dimethyl sulfate results in increased alkylation of MGMT protein	8823159
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene binds to MGMT protein	12974631
D004221	Disulfiram	Bortezomib inhibits the reaction [Disulfiram results in increased degradation of MGMT protein]	24193513
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of and results in decreased activity of MGMT protein	24193513
D004221	Disulfiram	[Disulfiram co-treated with cupric chloride] affects the expression of and affects the activity of MGMT protein	24193513
D004221	Disulfiram	Disulfiram inhibits the reaction [O(6)-benzylguanine binds to MGMT protein]	24193513
D004221	Disulfiram	Disulfiram results in decreased expression of and results in decreased activity of MGMT protein	24193513
D004221	Disulfiram	Disulfiram results in increased degradation of MGMT protein	24193513
D004221	Disulfiram	Disulfiram results in decreased expression of and results in decreased activity of MGMT protein	24193513
D004221	Disulfiram	Disulfiram results in increased degradation of MGMT protein	24193513
D004221	Disulfiram	Disulfiram inhibits the reaction [O(6)-benzylguanine binds to MGMT protein]	24193513
D004221	Disulfiram	Disulfiram results in decreased activity of MGMT protein	24193513
D004317	Doxorubicin	MGMT promoter modified form results in decreased susceptibility to Doxorubicin	16356834
D004317	Doxorubicin	Doxorubicin results in increased expression of MGMT mRNA	22712078
D004391	Dust	Dust results in decreased expression of MGMT mRNA	17805423
D004642	Emodin	Emodin results in increased expression of MGMT mRNA	19549930
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased methylation of MGMT promoter	14633667
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of MGMT mRNA	14633667\|1570381
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased alkylation of MGMT protein	8823159
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased expression of MGMT mRNA	11599795\|1595408
D005047	Etoposide	[ABCB1 protein co-treated with MGMT protein mutant form] results in decreased susceptibility to Etoposide	16733832
D005047	Etoposide	[ABCC1 protein co-treated with MGMT protein mutant form] results in decreased susceptibility to Etoposide	16733832
D005047	Etoposide	Verapamil inhibits the reaction [[ABCB1 protein co-treated with MGMT protein mutant form] results in decreased susceptibility to Etoposide]	16733832
D005047	Etoposide	Verapamil inhibits the reaction [[ABCC1 protein co-treated with MGMT protein mutant form] results in decreased susceptibility to Etoposide]	16733832
D011345	Fenofibrate	[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA	18253720
D011345	Fenofibrate	Fenofibrate results in increased expression of MGMT mRNA	17264098
D018120	Finasteride	Finasteride results in increased expression of MGMT mRNA	24136188
D005395	Fish Oils	Fish Oils results in increased expression of MGMT mRNA	28659405
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in decreased expression of MGMT mRNA	22213190
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of MGMT mRNA	17070881
D005472	Fluorouracil	Fluorouracil results in decreased expression of MGMT mRNA	17487405
D005472	Fluorouracil	Fluorouracil results in decreased expression of MGMT protein	17487405
D005472	Fluorouracil	MGMT protein results in decreased susceptibility to Fluorouracil	17487405
D005472	Fluorouracil	O(6)-benzylguanine inhibits the reaction [MGMT protein results in decreased susceptibility to Fluorouracil]	17487405
D005492	Folic Acid	[Folic Acid co-treated with MTHFR gene SNP] affects the methylation of MGMT promoter	17301267
D004397	Fonofos	Fonofos results in increased methylation of MGMT promoter	22847954
C054368	fotemustine	MGMT protein results in decreased susceptibility to fotemustine	12970393\|1603968
C039281	furan	furan results in increased expression of MGMT mRNA	22507866\|2619464
D005707	Gallic Acid	Gallic Acid results in decreased expression of MGMT mRNA	21887735
C001277	geldanamycin	geldanamycin results in increased expression of and results in increased activity of MGMT protein	16950796
C056507	gemcitabine	gemcitabine results in decreased expression of MGMT mRNA	17039268
D019833	Genistein	Genistein results in increased expression of MGMT mRNA	15703815
D005897	Glafenine	Glafenine results in decreased expression of MGMT mRNA	24136188
D005938	Glucocorticoids	Glucocorticoids affects the expression of MGMT mRNA	20308330
D005978	Glutathione	Glutathione affects the reaction [MGMT protein results in increased susceptibility to Mitomycin]	16039682
C004312	glycidol	glycidol results in increased expression of MGMT mRNA	24915197
D006147	Guanine	Guanine analog results in decreased activity of MGMT protein	17880193\|1878371
D017313	Fenretinide	Fenretinide results in increased expression of and results in increased activity of MGMT protein	16950796
D017313	Fenretinide	Fenretinide results in increased expression of MGMT mRNA	16950796
D017313	Fenretinide	Fenretinide results in increased expression of MGMT protein	15059897
D006830	Hydralazine	Hydralazine results in decreased methylation of MGMT promoter	15862127
D006830	Hydralazine	Hydralazine results in increased expression of MGMT mRNA	15862127
D006843	Hydrocarbons, Chlorinated	"Hydrocarbons, Chlorinated results in decreased methylation of MGMT promoter"	25585924
D006918	Hydroxyurea	Hydroxyurea results in increased expression of MGMT mRNA	12929121
C492448	ICG 001	ICG 001 results in increased expression of MGMT mRNA	26191083
C051890	irinotecan	irinotecan metabolite results in decreased expression of MGMT mRNA	18492797
C051890	irinotecan	MGMT mRNA results in increased susceptibility to irinotecan	15239142
C544151	jinfukang	jinfukang results in increased expression of MGMT mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of MGMT mRNA	23086925
C053401	kahweol	[cafestol co-treated with kahweol] results in increased activity of MGMT protein	12517412
C011890	kojic acid	Ascorbic Acid inhibits the reaction [[kojic acid co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA]	18544905
C011890	kojic acid	[kojic acid co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA	18544905
C483604	laromustine	laromustine analog results in decreased activity of MGMT protein	14704831
C483604	laromustine	MGMT protein results in decreased susceptibility to laromustine analog	14685775\|2065458
C483604	laromustine	MGMT protein results in decreased susceptibility to laromustine analog	20654586
C495400	lime-piper betel quid	lime-piper betel quid results in increased methylation of MGMT promoter	25520135
C521206	lomeguatrib	lomeguatrib results in decreased activity of MGMT protein	16278661
D008130	Lomustine	MGMT mRNA results in decreased susceptibility to Lomustine	15448748
D008130	Lomustine	MGMT protein affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine]	16033832
C552857	lysomustine	MGMT protein mutant form results in decreased susceptibility to lysomustine	20450874
C025340	manganese chloride	manganese chloride results in increased methylation of MGMT gene	27913844
D008701	Methapyrilene	Methapyrilene results in increased expression of MGMT mRNA	15890375\|2181346
C014055	methyl iodide	methyl iodide results in increased alkylation of MGMT protein	8823159
C014055	methyl iodide	[methyl iodide results in increased alkylation of MGMT protein] which affects the folding of MGMT protein modified form	8823159
C008461	methyl isocyanate	methyl isocyanate results in decreased activity of MGMT protein	14685775
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of MGMT mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased alkylation of MGMT protein	8823159
D008741	Methyl Methanesulfonate	MGMT mutant form results in increased susceptibility to Methyl Methanesulfonate	26208482
D008741	Methyl Methanesulfonate	MGMT protein results in decreased susceptibility to Methyl Methanesulfonate	15833865
D008769	Methylnitronitrosoguanidine	MGMT protein results in decreased susceptibility to Methylnitronitrosoguanidine	16043385\|1727384
D008769	Methylnitronitrosoguanidine	MGMT protein results in decreased susceptibility to Methylnitronitrosoguanidine	15010311
D008770	Methylnitrosourea	Methylnitrosourea results in increased alkylation of MGMT protein	8823159
D008770	Methylnitrosourea	MGMT protein results in decreased susceptibility to Methylnitrosourea	15870882\|1750729
D008770	Methylnitrosourea	"MGMT protein results in decreased susceptibility to [Methylnitrosourea co-treated with 9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate]"	12663516
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of MGMT mRNA	20965277
D008770	Methylnitrosourea	MGMT protein affects the reaction [Methylnitrosourea results in increased activity of CASP3 protein]	13679151
D008770	Methylnitrosourea	MGMT protein inhibits the reaction [TRP53 gene mutant form results in increased susceptibility to Methylnitrosourea]	11536039
D008770	Methylnitrosourea	MGMT protein results in decreased susceptibility to Methylnitrosourea	11276365\|1153603
D008770	Methylnitrosourea	MLH1 affects the reaction [MGMT protein affects the reaction [Methylnitrosourea results in increased activity of CASP3 protein]]	13679151
D008770	Methylnitrosourea	MLH1 protein promotes the reaction [MGMT protein results in decreased susceptibility to Methylnitrosourea]	13679151
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of MGMT mRNA	28688903
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of MGMT mRNA	24810058
D015741	Metribolone	[Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MGMT protein modified form]	28751236
D008825	Miconazole	Miconazole results in decreased expression of MGMT mRNA	22262564
D015735	Mifepristone	Mifepristone inhibits the reaction [Dexamethasone results in increased expression of MGMT mRNA]	20308330
D016685	Mitomycin	Buthionine Sulfoximine inhibits the reaction [MGMT protein results in increased susceptibility to Mitomycin]	16039682
D016685	Mitomycin	Glutathione affects the reaction [MGMT protein results in increased susceptibility to Mitomycin]	16039682
D016685	Mitomycin	MGMT protein results in increased susceptibility to Mitomycin	16039682
C040369	mitozolomide	MGMT protein affects the susceptibility to mitozolomide	10880022
C040369	mitozolomide	MGMT protein results in decreased susceptibility to mitozolomide	10022554\|1035581
C040369	mitozolomide	MGMT results in decreased susceptibility to mitozolomide	9918549
C051263	N'-(2-chloroethyl)-N-(2-(methylsulfonyl)ethyl)-N'-nitrosourea	MGMT protein affects the susceptibility to N'-(2-chloroethyl)-N-(2-(methylsulfonyl)ethyl)-N'-nitrosourea	12394182
C051263	N'-(2-chloroethyl)-N-(2-(methylsulfonyl)ethyl)-N'-nitrosourea	[O(6)-benzyl-N-acetylguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to N'-(2-chloroethyl)-N-(2-(methylsulfonyl)ethyl)-N'-nitrosourea	12394182
C554954	N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride	N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride results in increased expression of MGMT mRNA	28174063
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of MGMT mRNA"	25554681
D015376	Nimustine	Dexamethasone promotes the reaction [MGMT protein results in decreased susceptibility to Nimustine]	15481722
D015376	Nimustine	MGMT protein results in decreased susceptibility to Nimustine	15809756
D015376	Nimustine	[Nimustine co-treated with Dexamethasone] results in increased expression of MGMT mRNA	15481722
D015376	Nimustine	Nimustine results in increased expression of MGMT mRNA	15481722
D015376	Nimustine	[O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to Nimustine	12014639
D015376	Nimustine	MGMT gene mutant form results in increased susceptibility to Nimustine	11023546
D009588	Nitrogen Mustard Compounds	MGMT protein affects the reaction [Nitrogen Mustard Compounds results in increased expression of H2AFX protein]	27342729
D009588	Nitrogen Mustard Compounds	MGMT protein affects the reaction [Nitrogen Mustard Compounds results in increased expression of SPRTN protein]	27342729
D009588	Nitrogen Mustard Compounds	Nitrogen Mustard Compounds results in decreased expression of MGMT mRNA	27342729
D009602	Nitrosamines	Nitrosamines results in increased methylation of MGMT promoter	25520135
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of MGMT mRNA	17616710
D009607	Nitrosourea Compounds	MGMT affects the susceptibility to [Procarbazine co-treated with Vincristine co-treated with Nitrosourea Compounds]	16936459
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of MGMT mRNA	19716841
C403290	O(6)-(4-bromothenyl)guanine	MGMT protein mutant form results in decreased susceptibility to [O(6)-(4-bromothenyl)guanine co-treated with temozolomide]	16075413
C403290	O(6)-(4-bromothenyl)guanine	O(6)-(4-bromothenyl)guanine inhibits the reaction [MGMT protein results in decreased susceptibility to temozolomide]	15486188
C403290	O(6)-(4-bromothenyl)guanine	O(6)-(4-bromothenyl)guanine results in decreased activity of MGMT protein	15486188\|1583153
C088636	O(6)-benzyl-2'-deoxyguanosine	[O(6)-benzyl-2'-deoxyguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine	14506174
C088636	O(6)-benzyl-2'-deoxyguanosine	[O(6)-benzyl-2'-deoxyguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to temozolomide	14506174
C064976	O(6)-benzylguanine	MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]	14617759
C064976	O(6)-benzylguanine	Disulfiram inhibits the reaction [O(6)-benzylguanine binds to MGMT protein]	24193513
C064976	O(6)-benzylguanine	[MGMT protein mutant form co-treated with FECH protein] results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]	12950064
C064976	O(6)-benzylguanine	MGMT protein mutant form results in decreased susceptibility to [2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide co-treated with O(6)-benzylguanine]	12850483
C064976	O(6)-benzylguanine	MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]	11945064\|1247936
C064976	O(6)-benzylguanine	MGMT protein mutant form results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]	12036916\|1467012
C064976	O(6)-benzylguanine	MGMT protein mutant form results in decreased susceptibility to [O(6)-benzylguanine co-treated with temozolomide]	15319033\|1643217
C064976	O(6)-benzylguanine	MGMT protein results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]	19415780
C064976	O(6)-benzylguanine	MGMT protein results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]	15319033
C064976	O(6)-benzylguanine	MGMT protein results in decreased susceptibility to [O(6)-benzylguanine co-treated with temozolomide]	15319033
C064976	O(6)-benzylguanine	O(6)-benzylguanine analog affects the metabolism of MGMT protein	18783719
C064976	O(6)-benzylguanine	O(6)-benzylguanine analog results in decreased activity of MGMT protein	15993610\|1878371
C064976	O(6)-benzylguanine	O(6)-benzylguanine binds to MGMT protein	24193513
C064976	O(6)-benzylguanine	[O(6)-benzylguanine co-treated with Carmustine] results in decreased activity of MGMT protein	16278409
C064976	O(6)-benzylguanine	O(6)-benzylguanine inhibits the reaction [MGMT protein mutant form results in decreased susceptibility to Carmustine]	20450874
C064976	O(6)-benzylguanine	O(6)-benzylguanine inhibits the reaction [MGMT protein results in decreased susceptibility to Fluorouracil]	17487405
C064976	O(6)-benzylguanine	O(6)-benzylguanine results in decreased activity of MGMT protein	12014639\|1253881
C064976	O(6)-benzylguanine	[O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine	14506174\|1470727
C064976	O(6)-benzylguanine	[O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to Nimustine	12014639
C064976	O(6)-benzylguanine	[O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to temozolomide	12538819\|1450617
C064976	O(6)-benzylguanine	O(6)-benzylguanine results in decreased expression of and results in decreased activity of MGMT protein	24193513
C064976	O(6)-benzylguanine	O(6)-benzylguanine results in increased alkylation of MGMT protein	8823159
C064976	O(6)-benzylguanine	[O(6)-benzylguanine results in increased alkylation of MGMT protein] which affects the folding of MGMT protein modified form	8823159
C064976	O(6)-benzylguanine	MGMT protein affects the susceptibility to [temozolomide co-treated with O(6)-benzylguanine]	19509470
C064976	O(6)-benzylguanine	MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]	14707273
C064976	O(6)-benzylguanine	MGMT protein mutant form results in decreased susceptibility to O(6)-benzylguanine	12842427
C064976	O(6)-benzylguanine	MGMT protein results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]	19415780
C064976	O(6)-benzylguanine	O(6)-benzylguanine analog affects the metabolism of MGMT protein	18783719
C064976	O(6)-benzylguanine	O(6)-benzylguanine results in decreased activity of MGMT protein	10753191\|1501031
C064976	O(6)-benzylguanine	[O(6)-benzylguanine results in decreased activity of MGMT protein] which affects the susceptibility to Carmustine	19844954
C064976	O(6)-benzylguanine	Disulfiram inhibits the reaction [O(6)-benzylguanine binds to MGMT protein]	24193513
C064976	O(6)-benzylguanine	O(6)-benzylguanine binds to MGMT protein	24193513
C064976	O(6)-benzylguanine	[MGMT protein mutant form co-treated with ABCB1 protein] results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]	16733832
C064976	O(6)-benzylguanine	[MGMT protein mutant form co-treated with ABCC1 protein] results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]	16733832
C064976	O(6)-benzylguanine	MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]	16733832
C064976	O(6)-benzylguanine	MGMT protein results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]	15494421
C064976	O(6)-benzylguanine	MGMT protein results in decreased susceptibility to [O(6)-benzylguanine co-treated with temozolomide]	15494421
C064976	O(6)-benzylguanine	MGMT results in decreased susceptibility to O(6)-benzylguanine	19048410
C064976	O(6)-benzylguanine	O(6)-benzylguanine results in decreased activity of MGMT protein	11751525\|2195533
C064976	O(6)-benzylguanine	[O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine	21955333
C090349	O(6)-benzyl-N-acetylguanosine	O(6)-benzyl-N-acetylguanosine results in decreased activity of MGMT protein	12394182
C090349	O(6)-benzyl-N-acetylguanosine	[O(6)-benzyl-N-acetylguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine	12394182
C090349	O(6)-benzyl-N-acetylguanosine	[O(6)-benzyl-N-acetylguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to N'-(2-chloroethyl)-N-(2-(methylsulfonyl)ethyl)-N'-nitrosourea	12394182
C025589	ochratoxin A	ochratoxin A results in increased expression of MGMT mRNA	23358140
C026209	oltipraz	oltipraz results in increased expression of and results in increased activity of MGMT protein	16950796
C026209	oltipraz	oltipraz results in increased expression of MGMT mRNA	16950796
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of MGMT mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of MGMT mRNA	25729387
D010126	Ozone	[Ozone co-treated with Chlorine] results in decreased expression of MGMT mRNA	18636392
D017239	Paclitaxel	Paclitaxel results in increased expression of MGMT mRNA	12929121
D010278	Parathion	Parathion results in increased methylation of MGMT promoter	22847954
C011272	perfosfamide	perfosfamide results in decreased expression of MGMT mRNA	11754170
D010575	Pesticides	Pesticides results in decreased methylation of MGMT promoter	25585924
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of MGMT mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of MGMT mRNA	19482888
D010672	Phenytoin	Phenytoin results in increased methylation of MGMT promoter	15949900
C030090	phosphoramide mustard	phosphoramide mustard results in increased expression of MGMT mRNA	26708502
D010862	Pilocarpine	Pilocarpine results in increased expression of MGMT mRNA	17971868
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of MGMT mRNA	15890375
C006253	pirinixic acid	pirinixic acid results in increased expression of MGMT mRNA	15890375\|1916217
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the methylation of MGMT promoter	25585924
D011084	Polycyclic Aromatic Hydrocarbons	Polycyclic Aromatic Hydrocarbons results in decreased methylation of MGMT promoter	23543013
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of MGMT mRNA	18332044
D011223	Praziquantel	Praziquantel results in increased expression of MGMT mRNA	21813463
D011344	Procarbazine	MGMT affects the susceptibility to [Procarbazine co-treated with Vincristine co-treated with Nitrosourea Compounds]	16936459
D011344	Procarbazine	MGMT protein affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine]	16033832
D011441	Propylthiouracil	Propylthiouracil results in increased expression of MGMT mRNA	24780913
D011886	Radon	Radon results in increased methylation of MGMT promoter	16902270
C059514	resveratrol	resveratrol results in increased expression of and results in increased activity of MGMT protein	16950796
C440975	silybin	silybin results in increased expression of and results in increased activity of MGMT protein	16950796
D012838	Silymarin	Silymarin results in decreased activity of MGMT protein	16950796
D012838	Silymarin	Silymarin results in increased expression of and results in increased activity of MGMT protein	16950796
D012838	Silymarin	Silymarin results in increased expression of MGMT mRNA	16950796
D012906	Smoke	Smoke analog affects the expression of MGMT	23174910
D012906	Smoke	Smoke analog affects the methylation of MGMT promoter	23174910
C017947	sodium arsenite	sodium arsenite results in decreased expression of MGMT mRNA	12760830\|2587980
C017947	sodium arsenite	sodium arsenite results in increased expression of MGMT mRNA	11241755
C016104	sodium bichromate	sodium bichromate results in increased expression of MGMT mRNA	25993096
D013311	Streptozocin	MGMT protein results in decreased susceptibility to Streptozocin	16039682
C016766	sulforafan	sulforafan results in increased expression of and results in increased activity of MGMT protein	16950796
D013629	Tamoxifen	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tamoxifen results in increased degradation of MGMT protein]	17597106
D013629	Tamoxifen	Tamoxifen inhibits the reaction [ESR1 protein binds to MGMT protein]	23665804
D013629	Tamoxifen	Tamoxifen results in decreased activity of MGMT protein	17597106
D013629	Tamoxifen	Tamoxifen results in decreased expression of MGMT protein	17597106
D013629	Tamoxifen	Tamoxifen results in increased degradation of MGMT protein	17597106
D013629	Tamoxifen	[Tamoxifen results in increased degradation of MGMT protein] which results in increased susceptibility to Carmustine	17597106
D013629	Tamoxifen	Tamoxifen results in decreased expression of MGMT mRNA	20965277
C047246	temozolomide	MGMT mRNA results in decreased susceptibility to temozolomide	16365179
C047246	temozolomide	MGMT promoter modified form affects the susceptibility to temozolomide	15297393\|2016708
C047246	temozolomide	MGMT protein affects the reaction [BCL2L1 protein affects the susceptibility to temozolomide]	16405512
C047246	temozolomide	MGMT protein affects the susceptibility to temozolomide	15865885\|1843078
C047246	temozolomide	MGMT protein mutant form results in decreased susceptibility to [O(6)-(4-bromothenyl)guanine co-treated with temozolomide]	16075413
C047246	temozolomide	MGMT protein mutant form results in decreased susceptibility to [O(6)-benzylguanine co-treated with temozolomide]	15319033\|1643217
C047246	temozolomide	MGMT protein promotes the reaction [IL24 protein results in increased susceptibility to temozolomide]	19056673
C047246	temozolomide	MGMT protein results in decreased susceptibility to [O(6)-benzylguanine co-treated with temozolomide]	15319033
C047246	temozolomide	MGMT protein results in decreased susceptibility to temozolomide	15758010\|1581465
C047246	temozolomide	MGMT results in decreased susceptibility to temozolomide	9918549
C047246	temozolomide	O(6)-(4-bromothenyl)guanine inhibits the reaction [MGMT protein results in decreased susceptibility to temozolomide]	15486188
C047246	temozolomide	[O(6)-benzyl-2'-deoxyguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to temozolomide	14506174
C047246	temozolomide	[O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to temozolomide	12538819\|1450617
C047246	temozolomide	temozolomide results in decreased activity of MGMT protein	19056673
C047246	temozolomide	MGMT protein affects the susceptibility to [temozolomide co-treated with O(6)-benzylguanine]	19509470
C047246	temozolomide	MGMT protein inhibits the reaction [temozolomide results in increased mutagenesis of HPRT1 gene]	17116724
C047246	temozolomide	temozolomide results in decreased activity of MGMT protein	10753191
C047246	temozolomide	MGMT protein results in decreased susceptibility to [O(6)-benzylguanine co-treated with temozolomide]	15494421
C047246	temozolomide	temozolomide results in decreased activity of MGMT protein	17024124
C012568	terbufos	terbufos results in increased methylation of MGMT promoter	22847954
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in increased expression of MGMT mRNA	26496021
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MGMT mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	"MGMT protein results in decreased susceptibility to [Methylnitrosourea co-treated with 9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate]"	12663516
D013849	Thimerosal	Thimerosal results in decreased expression of MGMT mRNA	27188386
D013853	Thioacetamide	Thioacetamide results in increased expression of MGMT mRNA	22084566
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased methylation of MGMT promoter	25214829
D019772	Topotecan	Topotecan results in decreased expression of MGMT mRNA	18492797
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of MGMT mRNA	25729387
D014226	Triazenes	Triazenes analog results in decreased activity of MGMT protein	15615536
C012589	trichostatin A	[decitabine co-treated with trichostatin A] results in increased expression of MGMT mRNA	15657354
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of MGMT mRNA	29024780
D014635	Valproic Acid	Valproic Acid affects the expression of MGMT mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of MGMT promoter	26410583
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of MGMT gene	25560391
D014700	Verapamil	Verapamil inhibits the reaction [[ABCB1 protein co-treated with MGMT protein mutant form] results in decreased susceptibility to Etoposide]	16733832
D014700	Verapamil	Verapamil inhibits the reaction [[ABCC1 protein co-treated with MGMT protein mutant form] results in decreased susceptibility to Etoposide]	16733832
D014750	Vincristine	MGMT affects the susceptibility to [Procarbazine co-treated with Vincristine co-treated with Nitrosourea Compounds]	16936459
D014750	Vincristine	MGMT protein affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine]	16033832
D014750	Vincristine	[MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Vincristine	11792417
D014752	Vinyl Chloride	Vinyl Chloride results in decreased expression of MGMT protein	15256147
D015032	Zinc	Zinc binds to and results in increased activity of and results in increased stability of MGMT protein	12549918
D015032	Zinc	Zinc binds to and results in increased activity of MGMT protein	12974631

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003677	DNA binding	-	IEA	-
GO:0003908	methylated-DNA-[protein]-cysteine S-methyltransferase activity	-	IEA	-
GO:0005509	calcium ion binding	-	IEA	-
GO:0008168	methyltransferase activity	-	TAS	2188979
GO:0009008	DNA-methyltransferase activity	-	TAS	2405387

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006266	DNA ligation	-	TAS	2188979
GO:0006306	DNA methylation	-	IEA	-
GO:0006307	DNA dealkylation involved in DNA repair	-	TAS	-
GO:0034599	cellular response to oxidative stress	-	IEA	-
GO:0043066	negative regulation of apoptotic process	-	IDA	24147153
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	-	IEA	-
GO:0045471	response to ethanol	-	IEA	-
GO:0051593	response to folic acid	-	IEA	-
GO:0060644	mammary gland epithelial cell differentiation	-	IEA	-
GO:0071407	cellular response to organic cyclic compound	-	IEA	-
GO:0071479	cellular response to ionizing radiation	-	IEA	-
GO:2000781	positive regulation of double-strand break repair	-	IDA	24147153

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	TAS	2188979
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0016020	membrane	-	HDA	19946888

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-5657655	MGMT-mediated DNA damage reversal	TAS
R-HSA-73894	DNA Repair	TAS
R-HSA-73942	DNA Damage Reversal	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21575478	[Role of heterogeneous nuclear ribonucleoprotein A2/B1 protein in the pathogenesis of non-small cell lung cancer]. (2011 Feb)	Shi Y	Zhonghua Zhong Liu Za Zhi
20979814	[The expression of O6-methylguanine DNA methyltransferase and p53 in non-small cell lung cancer and the association with the prognosis]. (2010 Jun)	Liu Y	Zhonghua Jie He He Hu Xi Za Zhi
28421310	Comparison of Selected Protein Levels in Tumour and Surgical Margin in a Group of Patients with Oral Cavity Cancer. (2017 Aug)	Strzelczyk JK	Biochem Genet
15831994	DNA hypermethylation of tumor-related genes in gastric carcinoma. (2005 Apr)	Hong SH	J Korean Med Sci
16007001	The L84F and the I143V polymorphisms in the O6-methylguanine-DNA-methyltransferase (MGMT) gene increase human sensitivity to the genotoxic effects of the tobacco-specific nitrosamine carcinogen NNK. (2005 Aug)	Hill CE	Pharmacogenet Genomics
20451846	Loss expression of O6-methylguanine DNA methyltransferase by promoter hypermethylation and its relationship to betel quid chewing in oral squamous cell carcinoma. (2010 Jun)	Huang SH	Oral Surg Oral Med Oral Pathol Oral Radiol Endod
17285579	Aberrant promoter methylation in pleural fluid DNA for diagnosis of malignant pleural effusion. (2007 May 15)	Katayama H	Int J Cancer
16533425	Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients. (2006 Jan)	Liu Y	Neoplasia
26688266	DNA methylation is differentially associated with environmental cadmium exposure based on sex and smoking status. (2016 Feb)	Virani S	Chemosphere
21146512	Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake. (2011 Apr)	Lambert MP	J Hepatol
17158087	Polymorphisms of phase II xenobiotic-metabolizing and DNA repair genes and in vitro N-ethyl-N-nitrosourea-induced O6-ethylguanine levels in human lymphocytes. (2007 Mar 5)	Jiao L	Mutat Res
11956099	Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers. (2002 Apr 15)	Belinsky SA	Cancer Res
24376999	Analysis of O6-methylguanine-DNA methyltransferase methylation status in sporadic colon polyps. (2012)	Kycler W	Rep Pract Oncol Radiother
28371614	Hypermutations in gliomas: a potential immunotherapy target. (2017 Feb)	Finocchiaro G	Discov Med
20682983	MGMT activity in mucosal epithelium and squamous cell carcinoma of the head and neck. (2010 Jul)	Jacob R	Anticancer Res
15885889	Exon 3 polymorphisms and haplotypes of O6-methylguanine-DNA methyltransferase and risk of bladder cancer in southern China: a case-control analysis. (2005 Sep 8)	Li C	Cancer Lett
27494112	Expression profiles of MGMT, p16, and APC genes in tumor and matching surgical margin from patients with oral squamous cell carcinoma. (2016)	Strzelczyk JK	Acta Biochim Pol
12455028	Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer. (2003 Jan 10)	Toyooka S	Int J Cancer
23047041	Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide. (2012 Oct)	Triscott J	Oncotarget
22217548	Similar DNA methylation pattern in lung tumours from smokers and never-smokers with second-hand tobacco smoke exposure. (2012 Jul)	Scesnaite A	Mutagenesis
29258097	Clinical Significance of O-6-Methylguanine-DNA-Methyltransferase Promoter Methylation in Patients with Esophageal Carcinoma: A Systematic Meta-Analysis. (2018)	Zhang Y	Dig Dis
19902366	Genetic variation in DNA repair genes and prostate cancer risk: results from a population-based study. (2010 Feb)	Agalliu I	Cancer Causes Control
11479891	Molecular genetics of small cell lung carcinoma. (2001 Apr)	Wistuba II	Semin Oncol
12104047	Smoking-related increase of O(6)-methylguanine-DNA methyltransferase expression in squamous cell carcinoma of the esophagus. (2002 Oct 8)	Nozoe T	Cancer Lett
17285603	Genetic variants in MGMT and risk of lung cancer in Southeastern Chinese: a haplotype-based analysis. (2007 May)	Hu Z	Hum Mutat
15635575	Aberrant promoter hypermethylation of multiple genes in head and neck squamous cell carcinoma. (2005 Jan-Feb)	Puri SK	Am J Otolaryngol
18712569	Association of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation with p53 mutation occurrence in non-small cell lung cancer with different histology, gender, and smoking status. (2008 Nov)	Wu JY	Ann Surg Oncol
19302287	Methylation of estrogen receptor 1 in colorectal adenomas is not age-dependent, but is correlated with K-ras mutation. (2009 Jun)	Horii J	Cancer Sci
10207610	Activity of O6-methylguanine DNA methyltransferase in mononuclear blood cells of formaldehyde-exposed medical students. (1999 Feb)	Schlink K	Arch Toxicol
21288129	Determination of O(6)-methylguanine DNA methyltransferase promoter methylation in non-small cell lung cancer. (2011 May)	Ekim M	Genet Test Mol Biomarkers
23278137	The expression of O(6) -methylguanine-DNA methyltransferase in human oral keratinocytes stimulated with arecoline. (2013 Sep)	Lee SS	J Oral Pathol Med
22757675	Cigarette smoke-induced failure of apoptosis resulting in enhanced neoplastic transformation in human bronchial epithelial cells. (2012)	Du H	J Toxicol Environ Health A
29362385	A systematic review and meta-analysis: Association between MGMT hypermethylation and the clinicopathological characteristics of non-small-cell lung carcinoma. (2018 Jan 23)	Chen L	Sci Rep
19861513	Association between lifestyle factors and CpG island methylation in a cancer-free population. (2009 Nov)	Brait M	Cancer Epidemiol Biomarkers Prev
25520135	Promoter methylation of MGMT gene in serum of patients with esophageal squamous cell carcinoma in North East India. (2014)	Das M	Asian Pac J Cancer Prev
26410583	Associations between DNA methylation in DNA damage response-related genes and cytokinesis-block micronucleus cytome index in diesel engine exhaust-exposed workers. (2016 Aug)	Zhang X	Arch Toxicol
16284370	DNA repair polymorphisms and risk of colorectal adenomatous or hyperplastic polyps. (2005 Nov)	Bigler J	Cancer Epidemiol Biomarkers Prev
21708177	O(6)-methylguanine-DNA methyltransferase (MGMT): impact on cancer risk in response to tobacco smoke. (2012 Aug 1)	Christmann M	Mutat Res
28592103	[Association of etheno-DNA adduct and DNA methylation level among workers exposed to diesel engine exhaust]. (2017 Jun 6)	Shen ML	Zhonghua Yu Fang Yi Xue Za Zhi
23665414	Topographical study of O(6)-alkylguanine DNA alkyltransferase repair activity and N7-methylguanine levels in resected lung tissue. (2013 Jul 5)	Crosbie PA	Chem Biol Interact
16777993	Polymorphisms in O6-methylguanine DNA methyltransferase and endometrial cancer risk. (2006 Nov)	Han J	Carcinogenesis
11297252	Aberrant methylation during cervical carcinogenesis. (2001 Mar)	Virmani AK	Clin Cancer Res
11856482	Inactivation of O6-methylguanine-DNA methyltransferase in human lung adenocarcinoma relates to high-grade histology and worse prognosis among smokers. (2002 Feb)	Hayashi H	Jpn J Cancer Res
19506903	RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China. (2009 Dec)	Lin Q	J Cancer Res Clin Oncol
16517062	Loss of expression of DNA repair enzyme MGMT in oral leukoplakia and early oral squamous cell carcinoma. A prognostic tool? (2007 Jan 8)	Rodriguez MJ	Cancer Lett
15709192	Identification of epigenetic aberrant promoter methylation in serum DNA is useful for early detection of lung cancer. (2005 Feb 1)	Fujiwara K	Clin Cancer Res
9683184	Smoking-related increase of O6-methylguanine-DNA methyltransferase expression in human lung carcinomas. (1998 Jul)	Mattern J	Carcinogenesis
19596925	O6-Methylguanine-DNA methyltransferase hypermethylation modulated by 17beta-estradiol in lung cancer cells. (2009 Jul)	Lai JC	Anticancer Res
23788902	Cytological examination of pleural cavity lavage accompanied by the study of gene promoter hypermethylation of p16 and O6-methylguanine-DNA-methyltransferase genes in diagnostics of non-small cell lung cancer metastatic changes into pleura. (2012)	Kaczmarczyk G	Contemp Oncol (Pozn)
27110300	The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma. (2016)	Ma K	Clin Epigenetics
11196170	Aberrant promoter methylation of multiple genes in non-small cell lung cancers. (2001 Jan 1)	Zochbauer-Muller S	Cancer Res
25754026	Meta-analyses of gene methylation and smoking behavior in non-small cell lung cancer patients. (2015 Mar 10)	Huang T	Sci Rep
18386788	Polymorphisms in MGMT and DNA repair genes and the risk of esophageal adenocarcinoma. (2008 Jul 1)	Doecke J	Int J Cancer
27042875	Cigarette Smoking, BPDE-DNA Adducts, and Aberrant Promoter Methylations of Tumor Suppressor Genes (TSGs) in NSCLC from Chinese Population. (2016)	Jin Y	Cancer Invest
16014702	MGMT genotype modulates the associations between cigarette smoking, dietary antioxidants and breast cancer risk. (2005 Dec)	Shen J	Carcinogenesis
7926865	O6-methylguanine-DNA methyltransferase activity in the human lung persists with advancing age. (1994)	Nakatsuru Y	Gerontology
28404957	Gene methylation as a powerful biomarker for detection and screening of non-small cell lung cancer in blood. (2017 May 9)	Wang BH	Oncotarget
25813726	Gene promoter methylation and DNA repair capacity in monozygotic twins with discordant smoking habits. (2015 Feb)	Ottini L	Mutat Res Genet Toxicol Environ Mutagen
19807915	Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylation. (2009 Oct 6)	Taioli E	BMC Cancer
16844323	Selected polymorphisms of DNA repair genes and risk of pancreatic cancer. (2006)	Jiao L	Cancer Detect Prev
18006925	DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study. (2007 Nov)	Stern MC	Cancer Epidemiol Biomarkers Prev
23573237	Kras gene mutation and RASSF1A, FHIT and MGMT gene promoter hypermethylation: indicators of tumor staging and metastasis in adenocarcinomatous sporadic colorectal cancer in Indian population. (2013)	Sinha R	PLoS One
21078381	Frequent gene hypermethylation in laryngeal cancer cell lines and the resistance to demethylation induction by plant polyphenols. (2011 Feb)	Paluszczak J	Toxicol In Vitro
19079989	[Correlation of aberrant methylation of MGMT gene to MTHFR C677T genetic polymorphisms in esophageal squamous cell carcinoma]. (2008 Dec)	Xue HC	Ai Zheng
28468586	Alteration in the expression of MGMT and RUNX3 due to non-CpG promoter methylation and their correlation with different risk factors in esophageal cancer patients. (2017 May)	Saikia S	Tumour Biol
24084248	The GSTM1null (deletion) and MGMT84 rs12917 (Phe/Phe) haplotype are associated with bulky DNA adduct levels in human leukocytes. (2013 Dec 12)	Molina E	Mutat Res
18632757	Aberrant promoter hypermethylation in serum DNA from patients with silicosis. (2008 Sep)	Umemura S	Carcinogenesis
16052427	Molecular epidemiology of non-small cell lung cancer. (2005 Jun)	Liu G	Semin Respir Crit Care Med
16788379	Polymorphisms in O6-methylguanine DNA methyltransferase and breast cancer risk. (2006 Jul)	Han J	Pharmacogenet Genomics
20572039	Relation between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomas. (2010 Oct 1)	Paun BC	Cancer
25443735	The anti-cancer actions of O6-methylguanine-DNA-methyltransferase in relation to colon polyps. (2014 Dec)	Kycler W	Pharmacol Rep
11221887	Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients. (2001 Feb 1)	Rosas SL	Cancer Res
16038584	Influence of polymorphisms in DNA repair genes XPD, XRCC1 and MGMT on DNA damage induced by gamma radiation and its repair in lymphocytes in vitro. (2005 Aug)	Rzeszowska-Wolny J	Radiat Res
18349282	DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients. (2008 Mar)	Feng Q	Cancer Epidemiol Biomarkers Prev