Gene: MGMT

4255
-
O-6-methylguanine-DNA methyltransferase
protein-coding
10q26.3
Ensembl:ENSG00000170430 MIM:156569 Vega:OTTHUMG00000019261 UniprotKB:P16455
NG_052673.1
PubMed|SNP Mapped
ND|AD
74   
4.369e-2 (AD)  8.827e-1 (ND)   (Frontal_Cortex)
2.711e-1 (AD)  3.844e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10829622chr10:129721248 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4751115chr10:129712029 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg27041381chr10:131357203MGMTGene body6.128e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRAPPC6A0.77
PMF10.766
ZNHIT10.765
TMEM1340.764
PGLS0.752
SWI50.752
NELFE0.747
POLR2G0.746
CHMP4A0.74
NENF0.738

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.498
OR4F5-0.492
HTR1F-0.273
ROS1-0.244
DSC1-0.244
MUC15-0.242
HS6ST3-0.241
CNTNAP5-0.238
DLX3-0.232
RAB39A-0.231

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00151L-CysteineSmall Molecule52-90-4Approved|NutraceuticalTarget
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB02216S-MethylcysteineSmall Molecule1187-84-4ExperimentalTarget
DB04531BenzylcysteineSmall MoleculeExperimentalTarget
DB11831DinitrochlorobenzeneSmall Molecule97-00-7InvestigationalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of MGMT mRNA"26377693
C5309541,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine"MGMT protein affects the susceptibility to 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine"25012050
C0171391-(2-chloroethyl)-1-nitrosoureaMGMT protein results in decreased susceptibility to 1-(2-chloroethyl)-1-nitrosourea1727384
C0122771,2-diamino-4-nitrobenzene"1,2-diamino-4-nitrobenzene results in increased expression of MGMT mRNA"17070881
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of MGMT mRNA"19162173
C5822861-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)ureaMGMT mutant form promotes the reaction [1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased phosphorylation of CHEK1 protein]26208482
C5822861-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)ureaMGMT mutant form promotes the reaction [1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased phosphorylation of CHEK2 protein]26208482
C0252231,4-dioxane"1,4-dioxane results in increased expression of MGMT mRNA"22084566
C0353141-nitropropane1-nitropropane results in increased expression of MGMT mRNA17070881
C0445652-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamideMGMT protein mutant form results in decreased susceptibility to [2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide co-treated with O(6)-benzylguanine]12850483
C0109142,4-diaminotoluene"2,4-diaminotoluene affects the expression of MGMT mRNA"22084566
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of MGMT mRNA"17070881
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MGMT mRNA"21346803
C0252352,6-diaminotoluene"2,6-diaminotoluene results in increased expression of MGMT mRNA"17070881
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MGMT mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MGMT mRNA"12706856|1521517
C0065932-anthramine2-anthramine results in increased expression of MGMT mRNA23038007
C0147062-nitro-4-phenylenediamine2-nitro-4-phenylenediamine results in decreased expression of MGMT mRNA17070881
C0194992-nitrofluorene2-nitrofluorene results in increased expression of MGMT mRNA14600272|1589037
C0166172-nitropropane2-nitropropane results in increased expression of MGMT mRNA17070881
C0295362-oxothiazolidine-4-carboxylic acid2-oxothiazolidine-4-carboxylic acid results in decreased activity of MGMT protein16950796
C0295362-oxothiazolidine-4-carboxylic acid2-oxothiazolidine-4-carboxylic acid results in increased expression of and results in increased activity of MGMT protein16950796
C0295362-oxothiazolidine-4-carboxylic acid2-oxothiazolidine-4-carboxylic acid results in increased expression of MGMT mRNA16950796
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MGMT mRNA"25380136
C0075424,4'-dipyridyl disulfide"4,4'-dipyridyl disulfide binds to MGMT protein"12974631
C5830744,4'-hexafluorisopropylidene diphenol"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MGMT protein modified form]"28751236
C0815104-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanoneMGMT protein affects the susceptibility to 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone19601657
C0286764-acetylaminofluorene4-acetylaminofluorene results in increased expression of MGMT mRNA17070881
C0086514-nitrosodimethylaniline4-nitrosodimethylaniline results in decreased expression of MGMT protein15542103
C0086514-nitrosodimethylaniline4-nitrosodimethylaniline results in decreased expression of MGMT protein15542103
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MGMT mRNA14600272|1589037
C1052604-tert-octylphenol4-tert-octylphenol results in decreased expression of MGMT mRNA20965277
C5248145-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one results in increased expression of MGMT protein28720507
D000082AcetaminophenAcetaminophen results in decreased expression of MGMT mRNA29067470
D000082AcetaminophenAcetaminophen results in decreased expression of MGMT mRNA12883083
D000082AcetaminophenAcetaminophen results in increased expression of MGMT mRNA16751229
D000111AcetylcysteineAcetylcysteine results in decreased activity of MGMT protein16950796
D000111AcetylcysteineAcetylcysteine results in increased expression of and results in increased activity of MGMT protein16950796
D000111AcetylcysteineAcetylcysteine results in increased expression of MGMT mRNA16950796
D000171AcroleinMGMT protein results in decreased susceptibility to Acrolein17485251
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MGMT protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MGMT mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MGMT mRNA14600272|1589037
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased methylation of MGMT promoter"26410583
D000477Alkylating AgentsMGMT protein results in decreased susceptibility to Alkylating Agents15943786|1607885
C041635alpha-caroteneMGMT gene SNP affects the susceptibility to alpha-carotene16014702
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MGMT mRNA16483693
D018906Antineoplastic Agents, Alkylating"MGMT protein affects the susceptibility to Antineoplastic Agents, Alkylating"15870861|1603383
C000228aristolochic acid I[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of MGMT mRNA23912714
C042310aristolochic acid II[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of MGMT mRNA23912714
D001151ArsenicArsenic affects the expression of MGMT mRNA17450239
D001151ArsenicArsenic affects the methylation of MGMT gene25304211
C015001arsenitearsenite results in decreased expression of MGMT mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in decreased expression of MGMT mRNA]18929588
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [[kojic acid co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA]18544905
D001374AzacitidineAzacitidine results in decreased methylation of MGMT protein7511991
D001374AzacitidineAzacitidine results in increased expression of MGMT mRNA12807730
C547126AZM551248AZM551248 results in decreased expression of MGMT mRNA22323515
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MGMT mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MGMT mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of MGMT mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MGMT mRNA20064835|2569089
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MGMT mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to MGMT promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MGMT mRNA22228805|2261060
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tamoxifen results in increased degradation of MGMT protein]17597106
D019207beta CaroteneMGMT gene SNP affects the susceptibility to beta Carotene16014702
D004958EstradiolEstradiol results in decreased expression of MGMT mRNA20965277
D001629BezafibrateBezafibrate results in increased expression of MGMT mRNA15447978
C522781biflorinbiflorin affects the expression of MGMT mRNA27079618
C006780bisphenol A[bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MGMT protein modified form]28751236
C006780bisphenol Abisphenol A results in decreased expression of MGMT mRNA20965277
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of MGMT mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of MGMT mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MGMT gene28505145
D000069286BortezomibBortezomib inhibits the reaction [Disulfiram results in increased degradation of MGMT protein]24193513
D019328Buthionine SulfoximineButhionine Sulfoximine inhibits the reaction [MGMT protein results in increased susceptibility to Mitomycin]16039682
D019328Buthionine SulfoximineButhionine Sulfoximine results in decreased activity of MGMT protein16950796
D002087ButyratesButyrates results in increased expression of MGMT mRNA14674679
C584509C646 compoundC646 compound results in increased expression of MGMT mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MGMT mRNA12160620
D019256Cadmium ChlorideMGMT gene SNP affects the susceptibility to Cadmium Chloride25622337
C053400cafestol[cafestol co-treated with kahweol] results in increased activity of MGMT protein12517412
C053400cafestolcafestol results in increased activity of MGMT protein12517412
D002166CamptothecinCamptothecin results in decreased expression of MGMT mRNA18492797
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MGMT mRNA17484886
D002330CarmustineMGMT protein mutant form results in decreased susceptibility to Carmustine15053863
D002330CarmustineMGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]14617759
D002330CarmustineMGMT protein results in decreased susceptibility to Carmustine15053863
D002330CarmustineCarmustine results in increased alkylation of MGMT protein8823159
D002330CarmustineMGMT gene modified form affects the susceptibility to Carmustine12684420
D002330CarmustineMGMT mRNA results in decreased susceptibility to Carmustine16365179
D002330CarmustineMGMT mutant form results in increased susceptibility to Carmustine26208482
D002330CarmustineMGMT promoter modified form affects the susceptibility to Carmustine19637364
D002330CarmustineMGMT protein affects the susceptibility to Carmustine12394182|1603383
D002330Carmustine[MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Carmustine11792417
D002330Carmustine[MGMT protein mutant form co-treated with FECH protein] results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]12950064
D002330CarmustineMGMT protein mutant form results in decreased susceptibility to Carmustine20450874
D002330CarmustineMGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]11945064|1247936
D002330CarmustineMGMT protein mutant form results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]12036916|1467012
D002330CarmustineMGMT protein results in decreased susceptibility to Carmustine12479369|1474274
D002330CarmustineMGMT protein results in decreased susceptibility to Carmustine analog20654586
D002330CarmustineMGMT protein results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]19415780
D002330CarmustineMGMT protein results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]15319033
D002330CarmustineMGMT results in decreased susceptibility to Carmustine9918549
D002330Carmustine[O(6)-benzyl-2'-deoxyguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine14506174
D002330Carmustine[O(6)-benzylguanine co-treated with Carmustine] results in decreased activity of MGMT protein16278409
D002330CarmustineO(6)-benzylguanine inhibits the reaction [MGMT protein mutant form results in decreased susceptibility to Carmustine]20450874
D002330Carmustine[O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine14506174|1470727
D002330Carmustine[O(6)-benzyl-N-acetylguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine12394182
D002330Carmustine[Tamoxifen results in increased degradation of MGMT protein] which results in increased susceptibility to Carmustine17597106
D002330CarmustineCarmustine results in decreased activity of MGMT protein16126841
D002330CarmustineMGMT protein affects the susceptibility to Carmustine19844954
D002330CarmustineMGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]14707273
D002330CarmustineMGMT protein results in decreased susceptibility to Carmustine15284838
D002330CarmustineMGMT protein results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]19415780
D002330Carmustine[O(6)-benzylguanine results in decreased activity of MGMT protein] which affects the susceptibility to Carmustine19844954
D002330CarmustineCarmustine results in decreased expression of MGMT protein15104113
D002330Carmustine[MGMT protein mutant form co-treated with ABCB1 protein] results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]16733832
D002330Carmustine[MGMT protein mutant form co-treated with ABCC1 protein] results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]16733832
D002330CarmustineMGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]16733832
D002330CarmustineMGMT protein results in decreased susceptibility to Carmustine16126841
D002330CarmustineMGMT protein results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]15494421
D002330CarmustineMGMT results in decreased susceptibility to Carmustine19048410
D002330Carmustine[O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine21955333
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of MGMT mRNA18636392
C004656chloroacetaldehydeMGMT protein results in decreased susceptibility to chloroacetaldehyde17485251
D002725ChloroformChloroform results in increased expression of MGMT mRNA21813463
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MGMT mRNA27858113
D002992ClofenapateClofenapate results in increased expression of MGMT mRNA12971794
D002994ClofibrateClofibrate results in increased expression of MGMT mRNA16081524
D002995Clofibric AcidClofibric Acid results in decreased expression of MGMT mRNA17602206
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MGMT mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of MGMT mRNA19376846
D003077CokeCoke results in decreased expression of MGMT mRNA23543013
D003077CokeCoke results in decreased expression of MGMT protein23543013
D003077CokeCoke results in decreased methylation of MGMT promoter23543013
D003077CokeCoke results in increased methylation of MGMT promoter23543013
D003078Colchicine[MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Colchicine11792417
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of and results in decreased activity of MGMT protein24193513
D003300CopperCopper deficiency results in increased expression of MGMT mRNA17418555
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of MGMT mRNA21878529
C029892cupric chloride[Disulfiram co-treated with cupric chloride] affects the expression of and affects the activity of MGMT protein24193513
D003471CuprizoneCuprizone results in increased expression of MGMT mRNA26577399
D003474CurcuminCurcumin results in decreased activity of MGMT protein16950796
D003474CurcuminCurcumin results in decreased expression of MGMT mRNA17596214
D003474CurcuminCurcumin results in increased expression of and results in increased activity of MGMT protein16950796
D003474CurcuminCurcumin results in increased expression of MGMT mRNA16950796
D003520CyclophosphamideCyclophosphamide results in decreased expression of MGMT mRNA17403535
D003520CyclophosphamideMGMT protein results in decreased susceptibility to Cyclophosphamide15741301
D016572CyclosporineCyclosporine results in decreased expression of MGMT mRNA20106945
C017160cypermethrincypermethrin results in increased expression of MGMT mRNA21142847
D003606DacarbazineDacarbazine results in decreased activity of MGMT protein12494480
D003606DacarbazineDacarbazine results in decreased expression of MGMT protein12494480
D003606DacarbazineMGMT protein affects the susceptibility to Dacarbazine14562026
D003606DacarbazineMGMT protein results in decreased susceptibility to Dacarbazine10751609|1217018
D003606DacarbazineMGMT gene mutant form results in increased susceptibility to Dacarbazine11023546|1501031
C014347decitabine[decitabine co-treated with trichostatin A] results in increased expression of MGMT mRNA15657354
C014347decitabinedecitabine promotes the reaction [HIST3H3 protein binds to MGMT promoter]15657354
C014347decitabinedecitabine promotes the reaction [HIST4H4 protein binds to MGMT promoter]15657354
C014347decitabinedecitabine results in decreased expression of MGMT protein18021753
C014347decitabinedecitabine results in decreased methylation of MGMT promoter15703815
C014347decitabinedecitabine results in increased expression of MGMT mRNA15657354|1570381
C107676deguelindeguelin results in decreased expression of MGMT mRNA22227970
D003849DeoxyguanosineDeoxyguanosine analog results in decreased activity of MGMT protein17880193
D003907DexamethasoneDexamethasone promotes the reaction [MGMT protein results in decreased susceptibility to Nimustine]15481722
D003907DexamethasoneDexamethasone results in increased expression of MGMT mRNA15481722
D003907Dexamethasone[Nimustine co-treated with Dexamethasone] results in increased expression of MGMT mRNA15481722
D003907DexamethasoneDexamethasone results in increased activity of MGMT protein20308330
D003907DexamethasoneDexamethasone results in increased expression of MGMT mRNA20308330
D003907DexamethasoneMifepristone inhibits the reaction [Dexamethasone results in increased expression of MGMT mRNA]20308330
D016190CarboplatinCarboplatin results in decreased expression of MGMT mRNA18172885
D003976DiazinonDiazinon results in increased methylation of MGMT gene22964155
D015946Ethylene DibromideEthylene Dibromide binds to and results in decreased activity of MGMT protein12151404
D015946Ethylene DibromideEthylene Dibromide binds to MGMT protein17226938
D015946Ethylene DibromideMGMT protein affects the metabolism of and results in increased activity of Ethylene Dibromide14645247
D015946Ethylene DibromideMGMT protein results in increased activity of and results in increased susceptibility to Ethylene Dibromide10894884|1215140
D015946Ethylene DibromideMGMT protein results in increased susceptibility to Ethylene Dibromide17226938
D002945CisplatinCisplatin results in decreased activity of MGMT protein15015788|2766459
D002945CisplatinCisplatin results in decreased expression of MGMT mRNA15809756|1604338
D002945CisplatinCisplatin results in decreased expression of MGMT protein16043385
D002945CisplatinMGMT protein results in decreased susceptibility to Cisplatin16043385
D002945CisplatinCisplatin results in decreased activity of MGMT protein15865103
D004006DichlorvosDichlorvos results in increased expression of MGMT mRNA21813463
C014476diethyl maleatediethyl maleate results in decreased activity of MGMT protein16950796
D004052DiethylnitrosamineAscorbic Acid inhibits the reaction [[kojic acid co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA]18544905
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MGMT mRNA17602206
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of MGMT mRNA11599795|1760220
D004052Diethylnitrosamine[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA18253720
D004052Diethylnitrosamine[kojic acid co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA18544905
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of MGMT mRNA15890375
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of MGMT mRNA27638505
D0151279,10-Dimethyl-1,2-benzanthracene"MGMT protein results in decreased susceptibility to [Methylnitrosourea co-treated with 9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate]"12663516
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in increased expression of MGMT mRNA"27840820
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of MGMT mRNA14600272|1589037
C007482dimethyl sulfatedimethyl sulfate results in increased alkylation of MGMT protein8823159
D004137DinitrochlorobenzeneDinitrochlorobenzene binds to MGMT protein12974631
D004221DisulfiramBortezomib inhibits the reaction [Disulfiram results in increased degradation of MGMT protein]24193513
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of and results in decreased activity of MGMT protein24193513
D004221Disulfiram[Disulfiram co-treated with cupric chloride] affects the expression of and affects the activity of MGMT protein24193513
D004221DisulfiramDisulfiram inhibits the reaction [O(6)-benzylguanine binds to MGMT protein]24193513
D004221DisulfiramDisulfiram results in decreased expression of and results in decreased activity of MGMT protein24193513
D004221DisulfiramDisulfiram results in increased degradation of MGMT protein24193513
D004221DisulfiramDisulfiram results in decreased expression of and results in decreased activity of MGMT protein24193513
D004221DisulfiramDisulfiram results in increased degradation of MGMT protein24193513
D004221DisulfiramDisulfiram inhibits the reaction [O(6)-benzylguanine binds to MGMT protein]24193513
D004221DisulfiramDisulfiram results in decreased activity of MGMT protein24193513
D004317DoxorubicinMGMT promoter modified form results in decreased susceptibility to Doxorubicin16356834
D004317DoxorubicinDoxorubicin results in increased expression of MGMT mRNA22712078
D004391DustDust results in decreased expression of MGMT mRNA17805423
D004642EmodinEmodin results in increased expression of MGMT mRNA19549930
C045651epigallocatechin gallateepigallocatechin gallate results in decreased methylation of MGMT promoter14633667
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of MGMT mRNA14633667|1570381
D005038EthylnitrosoureaEthylnitrosourea results in increased alkylation of MGMT protein8823159
D005038EthylnitrosoureaEthylnitrosourea results in increased expression of MGMT mRNA11599795|1595408
D005047Etoposide[ABCB1 protein co-treated with MGMT protein mutant form] results in decreased susceptibility to Etoposide16733832
D005047Etoposide[ABCC1 protein co-treated with MGMT protein mutant form] results in decreased susceptibility to Etoposide16733832
D005047EtoposideVerapamil inhibits the reaction [[ABCB1 protein co-treated with MGMT protein mutant form] results in decreased susceptibility to Etoposide]16733832
D005047EtoposideVerapamil inhibits the reaction [[ABCC1 protein co-treated with MGMT protein mutant form] results in decreased susceptibility to Etoposide]16733832
D011345Fenofibrate[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA18253720
D011345FenofibrateFenofibrate results in increased expression of MGMT mRNA17264098
D018120FinasterideFinasteride results in increased expression of MGMT mRNA24136188
D005395Fish OilsFish Oils results in increased expression of MGMT mRNA28659405
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased expression of MGMT mRNA22213190
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of MGMT mRNA17070881
D005472FluorouracilFluorouracil results in decreased expression of MGMT mRNA17487405
D005472FluorouracilFluorouracil results in decreased expression of MGMT protein17487405
D005472FluorouracilMGMT protein results in decreased susceptibility to Fluorouracil17487405
D005472FluorouracilO(6)-benzylguanine inhibits the reaction [MGMT protein results in decreased susceptibility to Fluorouracil]17487405
D005492Folic Acid[Folic Acid co-treated with MTHFR gene SNP] affects the methylation of MGMT promoter17301267
D004397FonofosFonofos results in increased methylation of MGMT promoter22847954
C054368fotemustineMGMT protein results in decreased susceptibility to fotemustine12970393|1603968
C039281furanfuran results in increased expression of MGMT mRNA22507866|2619464
D005707Gallic AcidGallic Acid results in decreased expression of MGMT mRNA21887735
C001277geldanamycingeldanamycin results in increased expression of and results in increased activity of MGMT protein16950796
C056507gemcitabinegemcitabine results in decreased expression of MGMT mRNA17039268
D019833GenisteinGenistein results in increased expression of MGMT mRNA15703815
D005897GlafenineGlafenine results in decreased expression of MGMT mRNA24136188
D005938GlucocorticoidsGlucocorticoids affects the expression of MGMT mRNA20308330
D005978GlutathioneGlutathione affects the reaction [MGMT protein results in increased susceptibility to Mitomycin]16039682
C004312glycidolglycidol results in increased expression of MGMT mRNA24915197
D006147GuanineGuanine analog results in decreased activity of MGMT protein17880193|1878371
D017313FenretinideFenretinide results in increased expression of and results in increased activity of MGMT protein16950796
D017313FenretinideFenretinide results in increased expression of MGMT mRNA16950796
D017313FenretinideFenretinide results in increased expression of MGMT protein15059897
D006830HydralazineHydralazine results in decreased methylation of MGMT promoter15862127
D006830HydralazineHydralazine results in increased expression of MGMT mRNA15862127
D006843Hydrocarbons, Chlorinated"Hydrocarbons, Chlorinated results in decreased methylation of MGMT promoter"25585924
D006918HydroxyureaHydroxyurea results in increased expression of MGMT mRNA12929121
C492448ICG 001ICG 001 results in increased expression of MGMT mRNA26191083
C051890irinotecanirinotecan metabolite results in decreased expression of MGMT mRNA18492797
C051890irinotecanMGMT mRNA results in increased susceptibility to irinotecan15239142
C544151jinfukangjinfukang results in increased expression of MGMT mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MGMT mRNA23086925
C053401kahweol[cafestol co-treated with kahweol] results in increased activity of MGMT protein12517412
C011890kojic acidAscorbic Acid inhibits the reaction [[kojic acid co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA]18544905
C011890kojic acid[kojic acid co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA18544905
C483604laromustinelaromustine analog results in decreased activity of MGMT protein14704831
C483604laromustineMGMT protein results in decreased susceptibility to laromustine analog14685775|2065458
C483604laromustineMGMT protein results in decreased susceptibility to laromustine analog20654586
C495400lime-piper betel quidlime-piper betel quid results in increased methylation of MGMT promoter25520135
C521206lomeguatriblomeguatrib results in decreased activity of MGMT protein16278661
D008130LomustineMGMT mRNA results in decreased susceptibility to Lomustine15448748
D008130LomustineMGMT protein affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine]16033832
C552857lysomustineMGMT protein mutant form results in decreased susceptibility to lysomustine20450874
C025340manganese chloridemanganese chloride results in increased methylation of MGMT gene27913844
D008701MethapyrileneMethapyrilene results in increased expression of MGMT mRNA15890375|2181346
C014055methyl iodidemethyl iodide results in increased alkylation of MGMT protein8823159
C014055methyl iodide[methyl iodide results in increased alkylation of MGMT protein] which affects the folding of MGMT protein modified form8823159
C008461methyl isocyanatemethyl isocyanate results in decreased activity of MGMT protein14685775
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MGMT mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased alkylation of MGMT protein8823159
D008741Methyl MethanesulfonateMGMT mutant form results in increased susceptibility to Methyl Methanesulfonate26208482
D008741Methyl MethanesulfonateMGMT protein results in decreased susceptibility to Methyl Methanesulfonate15833865
D008769MethylnitronitrosoguanidineMGMT protein results in decreased susceptibility to Methylnitronitrosoguanidine16043385|1727384
D008769MethylnitronitrosoguanidineMGMT protein results in decreased susceptibility to Methylnitronitrosoguanidine15010311
D008770MethylnitrosoureaMethylnitrosourea results in increased alkylation of MGMT protein8823159
D008770MethylnitrosoureaMGMT protein results in decreased susceptibility to Methylnitrosourea15870882|1750729
D008770Methylnitrosourea"MGMT protein results in decreased susceptibility to [Methylnitrosourea co-treated with 9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate]"12663516
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of MGMT mRNA20965277
D008770MethylnitrosoureaMGMT protein affects the reaction [Methylnitrosourea results in increased activity of CASP3 protein]13679151
D008770MethylnitrosoureaMGMT protein inhibits the reaction [TRP53 gene mutant form results in increased susceptibility to Methylnitrosourea]11536039
D008770MethylnitrosoureaMGMT protein results in decreased susceptibility to Methylnitrosourea11276365|1153603
D008770MethylnitrosoureaMLH1 affects the reaction [MGMT protein affects the reaction [Methylnitrosourea results in increased activity of CASP3 protein]]13679151
D008770MethylnitrosoureaMLH1 protein promotes the reaction [MGMT protein results in decreased susceptibility to Methylnitrosourea]13679151
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of MGMT mRNA28688903
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of MGMT mRNA24810058
D015741Metribolone[Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MGMT protein modified form]28751236
D008825MiconazoleMiconazole results in decreased expression of MGMT mRNA22262564
D015735MifepristoneMifepristone inhibits the reaction [Dexamethasone results in increased expression of MGMT mRNA]20308330
D016685MitomycinButhionine Sulfoximine inhibits the reaction [MGMT protein results in increased susceptibility to Mitomycin]16039682
D016685MitomycinGlutathione affects the reaction [MGMT protein results in increased susceptibility to Mitomycin]16039682
D016685MitomycinMGMT protein results in increased susceptibility to Mitomycin16039682
C040369mitozolomideMGMT protein affects the susceptibility to mitozolomide10880022
C040369mitozolomideMGMT protein results in decreased susceptibility to mitozolomide10022554|1035581
C040369mitozolomideMGMT results in decreased susceptibility to mitozolomide9918549
C051263N'-(2-chloroethyl)-N-(2-(methylsulfonyl)ethyl)-N'-nitrosoureaMGMT protein affects the susceptibility to N'-(2-chloroethyl)-N-(2-(methylsulfonyl)ethyl)-N'-nitrosourea12394182
C051263N'-(2-chloroethyl)-N-(2-(methylsulfonyl)ethyl)-N'-nitrosourea[O(6)-benzyl-N-acetylguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to N'-(2-chloroethyl)-N-(2-(methylsulfonyl)ethyl)-N'-nitrosourea12394182
C554954N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochlorideN-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride results in increased expression of MGMT mRNA28174063
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MGMT mRNA"25554681
D015376NimustineDexamethasone promotes the reaction [MGMT protein results in decreased susceptibility to Nimustine]15481722
D015376NimustineMGMT protein results in decreased susceptibility to Nimustine15809756
D015376Nimustine[Nimustine co-treated with Dexamethasone] results in increased expression of MGMT mRNA15481722
D015376NimustineNimustine results in increased expression of MGMT mRNA15481722
D015376Nimustine[O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to Nimustine12014639
D015376NimustineMGMT gene mutant form results in increased susceptibility to Nimustine11023546
D009588Nitrogen Mustard CompoundsMGMT protein affects the reaction [Nitrogen Mustard Compounds results in increased expression of H2AFX protein]27342729
D009588Nitrogen Mustard CompoundsMGMT protein affects the reaction [Nitrogen Mustard Compounds results in increased expression of SPRTN protein]27342729
D009588Nitrogen Mustard CompoundsNitrogen Mustard Compounds results in decreased expression of MGMT mRNA27342729
D009602NitrosaminesNitrosamines results in increased methylation of MGMT promoter25520135
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of MGMT mRNA17616710
D009607Nitrosourea CompoundsMGMT affects the susceptibility to [Procarbazine co-treated with Vincristine co-treated with Nitrosourea Compounds]16936459
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of MGMT mRNA19716841
C403290O(6)-(4-bromothenyl)guanineMGMT protein mutant form results in decreased susceptibility to [O(6)-(4-bromothenyl)guanine co-treated with temozolomide]16075413
C403290O(6)-(4-bromothenyl)guanineO(6)-(4-bromothenyl)guanine inhibits the reaction [MGMT protein results in decreased susceptibility to temozolomide]15486188
C403290O(6)-(4-bromothenyl)guanineO(6)-(4-bromothenyl)guanine results in decreased activity of MGMT protein15486188|1583153
C088636O(6)-benzyl-2'-deoxyguanosine[O(6)-benzyl-2'-deoxyguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine14506174
C088636O(6)-benzyl-2'-deoxyguanosine[O(6)-benzyl-2'-deoxyguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to temozolomide14506174
C064976O(6)-benzylguanineMGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]14617759
C064976O(6)-benzylguanineDisulfiram inhibits the reaction [O(6)-benzylguanine binds to MGMT protein]24193513
C064976O(6)-benzylguanine[MGMT protein mutant form co-treated with FECH protein] results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]12950064
C064976O(6)-benzylguanineMGMT protein mutant form results in decreased susceptibility to [2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide co-treated with O(6)-benzylguanine]12850483
C064976O(6)-benzylguanineMGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]11945064|1247936
C064976O(6)-benzylguanineMGMT protein mutant form results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]12036916|1467012
C064976O(6)-benzylguanineMGMT protein mutant form results in decreased susceptibility to [O(6)-benzylguanine co-treated with temozolomide]15319033|1643217
C064976O(6)-benzylguanineMGMT protein results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]19415780
C064976O(6)-benzylguanineMGMT protein results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]15319033
C064976O(6)-benzylguanineMGMT protein results in decreased susceptibility to [O(6)-benzylguanine co-treated with temozolomide]15319033
C064976O(6)-benzylguanineO(6)-benzylguanine analog affects the metabolism of MGMT protein18783719
C064976O(6)-benzylguanineO(6)-benzylguanine analog results in decreased activity of MGMT protein15993610|1878371
C064976O(6)-benzylguanineO(6)-benzylguanine binds to MGMT protein24193513
C064976O(6)-benzylguanine[O(6)-benzylguanine co-treated with Carmustine] results in decreased activity of MGMT protein16278409
C064976O(6)-benzylguanineO(6)-benzylguanine inhibits the reaction [MGMT protein mutant form results in decreased susceptibility to Carmustine]20450874
C064976O(6)-benzylguanineO(6)-benzylguanine inhibits the reaction [MGMT protein results in decreased susceptibility to Fluorouracil]17487405
C064976O(6)-benzylguanineO(6)-benzylguanine results in decreased activity of MGMT protein12014639|1253881
C064976O(6)-benzylguanine[O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine14506174|1470727
C064976O(6)-benzylguanine[O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to Nimustine12014639
C064976O(6)-benzylguanine[O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to temozolomide12538819|1450617
C064976O(6)-benzylguanineO(6)-benzylguanine results in decreased expression of and results in decreased activity of MGMT protein24193513
C064976O(6)-benzylguanineO(6)-benzylguanine results in increased alkylation of MGMT protein8823159
C064976O(6)-benzylguanine[O(6)-benzylguanine results in increased alkylation of MGMT protein] which affects the folding of MGMT protein modified form8823159
C064976O(6)-benzylguanineMGMT protein affects the susceptibility to [temozolomide co-treated with O(6)-benzylguanine]19509470
C064976O(6)-benzylguanineMGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]14707273
C064976O(6)-benzylguanineMGMT protein mutant form results in decreased susceptibility to O(6)-benzylguanine12842427
C064976O(6)-benzylguanineMGMT protein results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]19415780
C064976O(6)-benzylguanineO(6)-benzylguanine analog affects the metabolism of MGMT protein18783719
C064976O(6)-benzylguanineO(6)-benzylguanine results in decreased activity of MGMT protein10753191|1501031
C064976O(6)-benzylguanine[O(6)-benzylguanine results in decreased activity of MGMT protein] which affects the susceptibility to Carmustine19844954
C064976O(6)-benzylguanineDisulfiram inhibits the reaction [O(6)-benzylguanine binds to MGMT protein]24193513
C064976O(6)-benzylguanineO(6)-benzylguanine binds to MGMT protein24193513
C064976O(6)-benzylguanine[MGMT protein mutant form co-treated with ABCB1 protein] results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]16733832
C064976O(6)-benzylguanine[MGMT protein mutant form co-treated with ABCC1 protein] results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]16733832
C064976O(6)-benzylguanineMGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]16733832
C064976O(6)-benzylguanineMGMT protein results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]15494421
C064976O(6)-benzylguanineMGMT protein results in decreased susceptibility to [O(6)-benzylguanine co-treated with temozolomide]15494421
C064976O(6)-benzylguanineMGMT results in decreased susceptibility to O(6)-benzylguanine19048410
C064976O(6)-benzylguanineO(6)-benzylguanine results in decreased activity of MGMT protein11751525|2195533
C064976O(6)-benzylguanine[O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine21955333
C090349O(6)-benzyl-N-acetylguanosineO(6)-benzyl-N-acetylguanosine results in decreased activity of MGMT protein12394182
C090349O(6)-benzyl-N-acetylguanosine[O(6)-benzyl-N-acetylguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine12394182
C090349O(6)-benzyl-N-acetylguanosine[O(6)-benzyl-N-acetylguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to N'-(2-chloroethyl)-N-(2-(methylsulfonyl)ethyl)-N'-nitrosourea12394182
C025589ochratoxin Aochratoxin A results in increased expression of MGMT mRNA23358140
C026209oltiprazoltipraz results in increased expression of and results in increased activity of MGMT protein16950796
C026209oltiprazoltipraz results in increased expression of MGMT mRNA16950796
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of MGMT mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of MGMT mRNA25729387
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of MGMT mRNA18636392
D017239PaclitaxelPaclitaxel results in increased expression of MGMT mRNA12929121
D010278ParathionParathion results in increased methylation of MGMT promoter22847954
C011272perfosfamideperfosfamide results in decreased expression of MGMT mRNA11754170
D010575PesticidesPesticides results in decreased methylation of MGMT promoter25585924
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of MGMT mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of MGMT mRNA19482888
D010672PhenytoinPhenytoin results in increased methylation of MGMT promoter15949900
C030090phosphoramide mustardphosphoramide mustard results in increased expression of MGMT mRNA26708502
D010862PilocarpinePilocarpine results in increased expression of MGMT mRNA17971868
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of MGMT mRNA15890375
C006253pirinixic acidpirinixic acid results in increased expression of MGMT mRNA15890375|1916217
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the methylation of MGMT promoter25585924
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons results in decreased methylation of MGMT promoter23543013
D011192Potassium DichromatePotassium Dichromate results in increased expression of MGMT mRNA18332044
D011223PraziquantelPraziquantel results in increased expression of MGMT mRNA21813463
D011344ProcarbazineMGMT affects the susceptibility to [Procarbazine co-treated with Vincristine co-treated with Nitrosourea Compounds]16936459
D011344ProcarbazineMGMT protein affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine]16033832
D011441PropylthiouracilPropylthiouracil results in increased expression of MGMT mRNA24780913
D011886RadonRadon results in increased methylation of MGMT promoter16902270
C059514resveratrolresveratrol results in increased expression of and results in increased activity of MGMT protein16950796
C440975silybinsilybin results in increased expression of and results in increased activity of MGMT protein16950796
D012838SilymarinSilymarin results in decreased activity of MGMT protein16950796
D012838SilymarinSilymarin results in increased expression of and results in increased activity of MGMT protein16950796
D012838SilymarinSilymarin results in increased expression of MGMT mRNA16950796
D012906SmokeSmoke analog affects the expression of MGMT23174910
D012906SmokeSmoke analog affects the methylation of MGMT promoter23174910
C017947sodium arsenitesodium arsenite results in decreased expression of MGMT mRNA12760830|2587980
C017947sodium arsenitesodium arsenite results in increased expression of MGMT mRNA11241755
C016104sodium bichromatesodium bichromate results in increased expression of MGMT mRNA25993096
D013311StreptozocinMGMT protein results in decreased susceptibility to Streptozocin16039682
C016766sulforafansulforafan results in increased expression of and results in increased activity of MGMT protein16950796
D013629Tamoxifenbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tamoxifen results in increased degradation of MGMT protein]17597106
D013629TamoxifenTamoxifen inhibits the reaction [ESR1 protein binds to MGMT protein]23665804
D013629TamoxifenTamoxifen results in decreased activity of MGMT protein17597106
D013629TamoxifenTamoxifen results in decreased expression of MGMT protein17597106
D013629TamoxifenTamoxifen results in increased degradation of MGMT protein17597106
D013629Tamoxifen[Tamoxifen results in increased degradation of MGMT protein] which results in increased susceptibility to Carmustine17597106
D013629TamoxifenTamoxifen results in decreased expression of MGMT mRNA20965277
C047246temozolomideMGMT mRNA results in decreased susceptibility to temozolomide16365179
C047246temozolomideMGMT promoter modified form affects the susceptibility to temozolomide15297393|2016708
C047246temozolomideMGMT protein affects the reaction [BCL2L1 protein affects the susceptibility to temozolomide]16405512
C047246temozolomideMGMT protein affects the susceptibility to temozolomide15865885|1843078
C047246temozolomideMGMT protein mutant form results in decreased susceptibility to [O(6)-(4-bromothenyl)guanine co-treated with temozolomide]16075413
C047246temozolomideMGMT protein mutant form results in decreased susceptibility to [O(6)-benzylguanine co-treated with temozolomide]15319033|1643217
C047246temozolomideMGMT protein promotes the reaction [IL24 protein results in increased susceptibility to temozolomide]19056673
C047246temozolomideMGMT protein results in decreased susceptibility to [O(6)-benzylguanine co-treated with temozolomide]15319033
C047246temozolomideMGMT protein results in decreased susceptibility to temozolomide15758010|1581465
C047246temozolomideMGMT results in decreased susceptibility to temozolomide9918549
C047246temozolomideO(6)-(4-bromothenyl)guanine inhibits the reaction [MGMT protein results in decreased susceptibility to temozolomide]15486188
C047246temozolomide[O(6)-benzyl-2'-deoxyguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to temozolomide14506174
C047246temozolomide[O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to temozolomide12538819|1450617
C047246temozolomidetemozolomide results in decreased activity of MGMT protein19056673
C047246temozolomideMGMT protein affects the susceptibility to [temozolomide co-treated with O(6)-benzylguanine]19509470
C047246temozolomideMGMT protein inhibits the reaction [temozolomide results in increased mutagenesis of HPRT1 gene]17116724
C047246temozolomidetemozolomide results in decreased activity of MGMT protein10753191
C047246temozolomideMGMT protein results in decreased susceptibility to [O(6)-benzylguanine co-treated with temozolomide]15494421
C047246temozolomidetemozolomide results in decreased activity of MGMT protein17024124
C012568terbufosterbufos results in increased methylation of MGMT promoter22847954
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of MGMT mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MGMT mRNA21215274
D013755Tetradecanoylphorbol Acetate"MGMT protein results in decreased susceptibility to [Methylnitrosourea co-treated with 9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate]"12663516
D013849ThimerosalThimerosal results in decreased expression of MGMT mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of MGMT mRNA22084566
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of MGMT promoter25214829
D019772TopotecanTopotecan results in decreased expression of MGMT mRNA18492797
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of MGMT mRNA25729387
D014226TriazenesTriazenes analog results in decreased activity of MGMT protein15615536
C012589trichostatin A[decitabine co-treated with trichostatin A] results in increased expression of MGMT mRNA15657354
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of MGMT mRNA29024780
D014635Valproic AcidValproic Acid affects the expression of MGMT mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MGMT promoter26410583
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MGMT gene25560391
D014700VerapamilVerapamil inhibits the reaction [[ABCB1 protein co-treated with MGMT protein mutant form] results in decreased susceptibility to Etoposide]16733832
D014700VerapamilVerapamil inhibits the reaction [[ABCC1 protein co-treated with MGMT protein mutant form] results in decreased susceptibility to Etoposide]16733832
D014750VincristineMGMT affects the susceptibility to [Procarbazine co-treated with Vincristine co-treated with Nitrosourea Compounds]16936459
D014750VincristineMGMT protein affects the susceptibility to [Procarbazine co-treated with Lomustine co-treated with Vincristine]16033832
D014750Vincristine[MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Vincristine11792417
D014752Vinyl ChlorideVinyl Chloride results in decreased expression of MGMT protein15256147
D015032ZincZinc binds to and results in increased activity of and results in increased stability of MGMT protein12549918
D015032ZincZinc binds to and results in increased activity of MGMT protein12974631

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003908methylated-DNA-[protein]-cysteine S-methyltransferase activity-IEA-  
GO:0005509calcium ion binding-IEA-  
GO:0008168methyltransferase activity-TAS2188979  
GO:0009008DNA-methyltransferase activity-TAS2405387  
GO ID GO Term Qualifier Evidence PubMed
GO:0006266DNA ligation-TAS2188979  
GO:0006306DNA methylation-IEA-  
GO:0006307DNA dealkylation involved in DNA repair-TAS-  
GO:0034599cellular response to oxidative stress-IEA-  
GO:0043066negative regulation of apoptotic process-IDA24147153  
GO:0043281regulation of cysteine-type endopeptidase activity involved in apoptotic process-IEA-  
GO:0045471response to ethanol-IEA-  
GO:0051593response to folic acid-IEA-  
GO:0060644mammary gland epithelial cell differentiation-IEA-  
GO:0071407cellular response to organic cyclic compound-IEA-  
GO:0071479cellular response to ionizing radiation-IEA-  
GO:2000781positive regulation of double-strand break repair-IDA24147153  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-TAS2188979  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-5657655MGMT-mediated DNA damage reversalTAS
R-HSA-73894DNA RepairTAS
R-HSA-73942DNA Damage ReversalTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21575478[Role of heterogeneous nuclear ribonucleoprotein A2/B1 protein in the pathogenesis of non-small cell lung cancer]. (2011 Feb)Shi YZhonghua Zhong Liu Za Zhi
20979814[The expression of O6-methylguanine DNA methyltransferase and p53 in non-small cell lung cancer and the association with the prognosis]. (2010 Jun)Liu YZhonghua Jie He He Hu Xi Za Zhi
28421310Comparison of Selected Protein Levels in Tumour and Surgical Margin in a Group of Patients with Oral Cavity Cancer. (2017 Aug)Strzelczyk JKBiochem Genet
15831994DNA hypermethylation of tumor-related genes in gastric carcinoma. (2005 Apr)Hong SHJ Korean Med Sci
16007001The L84F and the I143V polymorphisms in the O6-methylguanine-DNA-methyltransferase (MGMT) gene increase human sensitivity to the genotoxic effects of the tobacco-specific nitrosamine carcinogen NNK. (2005 Aug)Hill CEPharmacogenet Genomics
20451846Loss expression of O6-methylguanine DNA methyltransferase by promoter hypermethylation and its relationship to betel quid chewing in oral squamous cell carcinoma. (2010 Jun)Huang SHOral Surg Oral Med Oral Pathol Oral Radiol Endod
17285579Aberrant promoter methylation in pleural fluid DNA for diagnosis of malignant pleural effusion. (2007 May 15)Katayama HInt J Cancer
16533425Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients. (2006 Jan)Liu YNeoplasia
26688266DNA methylation is differentially associated with environmental cadmium exposure based on sex and smoking status. (2016 Feb)Virani SChemosphere
21146512Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake. (2011 Apr)Lambert MPJ Hepatol
17158087Polymorphisms of phase II xenobiotic-metabolizing and DNA repair genes and in vitro N-ethyl-N-nitrosourea-induced O6-ethylguanine levels in human lymphocytes. (2007 Mar 5)Jiao LMutat Res
11956099Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers. (2002 Apr 15)Belinsky SACancer Res
24376999Analysis of O6-methylguanine-DNA methyltransferase methylation status in sporadic colon polyps. (2012)Kycler WRep Pract Oncol Radiother
28371614Hypermutations in gliomas: a potential immunotherapy target. (2017 Feb)Finocchiaro GDiscov Med
20682983MGMT activity in mucosal epithelium and squamous cell carcinoma of the head and neck. (2010 Jul)Jacob RAnticancer Res
15885889Exon 3 polymorphisms and haplotypes of O6-methylguanine-DNA methyltransferase and risk of bladder cancer in southern China: a case-control analysis. (2005 Sep 8)Li CCancer Lett
27494112Expression profiles of MGMT, p16, and APC genes in tumor and matching surgical margin from patients with oral squamous cell carcinoma. (2016)Strzelczyk JKActa Biochim Pol
12455028Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer. (2003 Jan 10)Toyooka SInt J Cancer
23047041Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide. (2012 Oct)Triscott JOncotarget
22217548Similar DNA methylation pattern in lung tumours from smokers and never-smokers with second-hand tobacco smoke exposure. (2012 Jul)Scesnaite AMutagenesis
29258097Clinical Significance of O-6-Methylguanine-DNA-Methyltransferase Promoter Methylation in Patients with Esophageal Carcinoma: A Systematic Meta-Analysis. (2018)Zhang YDig Dis
19902366Genetic variation in DNA repair genes and prostate cancer risk: results from a population-based study. (2010 Feb)Agalliu ICancer Causes Control
11479891Molecular genetics of small cell lung carcinoma. (2001 Apr)Wistuba IISemin Oncol
12104047Smoking-related increase of O(6)-methylguanine-DNA methyltransferase expression in squamous cell carcinoma of the esophagus. (2002 Oct 8)Nozoe TCancer Lett
17285603Genetic variants in MGMT and risk of lung cancer in Southeastern Chinese: a haplotype-based analysis. (2007 May)Hu ZHum Mutat
15635575Aberrant promoter hypermethylation of multiple genes in head and neck squamous cell carcinoma. (2005 Jan-Feb)Puri SKAm J Otolaryngol
18712569Association of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation with p53 mutation occurrence in non-small cell lung cancer with different histology, gender, and smoking status. (2008 Nov)Wu JYAnn Surg Oncol
19302287Methylation of estrogen receptor 1 in colorectal adenomas is not age-dependent, but is correlated with K-ras mutation. (2009 Jun)Horii JCancer Sci
10207610Activity of O6-methylguanine DNA methyltransferase in mononuclear blood cells of formaldehyde-exposed medical students. (1999 Feb)Schlink KArch Toxicol
21288129Determination of O(6)-methylguanine DNA methyltransferase promoter methylation in non-small cell lung cancer. (2011 May)Ekim MGenet Test Mol Biomarkers
23278137The expression of O(6) -methylguanine-DNA methyltransferase in human oral keratinocytes stimulated with arecoline. (2013 Sep)Lee SSJ Oral Pathol Med
22757675Cigarette smoke-induced failure of apoptosis resulting in enhanced neoplastic transformation in human bronchial epithelial cells. (2012)Du HJ Toxicol Environ Health A
29362385A systematic review and meta-analysis: Association between MGMT hypermethylation and the clinicopathological characteristics of non-small-cell lung carcinoma. (2018 Jan 23)Chen LSci Rep
19861513Association between lifestyle factors and CpG island methylation in a cancer-free population. (2009 Nov)Brait MCancer Epidemiol Biomarkers Prev
25520135Promoter methylation of MGMT gene in serum of patients with esophageal squamous cell carcinoma in North East India. (2014)Das MAsian Pac J Cancer Prev
26410583Associations between DNA methylation in DNA damage response-related genes and cytokinesis-block micronucleus cytome index in diesel engine exhaust-exposed workers. (2016 Aug)Zhang XArch Toxicol
16284370DNA repair polymorphisms and risk of colorectal adenomatous or hyperplastic polyps. (2005 Nov)Bigler JCancer Epidemiol Biomarkers Prev
21708177O(6)-methylguanine-DNA methyltransferase (MGMT): impact on cancer risk in response to tobacco smoke. (2012 Aug 1)Christmann MMutat Res
28592103[Association of etheno-DNA adduct and DNA methylation level among workers exposed to diesel engine exhaust]. (2017 Jun 6)Shen MLZhonghua Yu Fang Yi Xue Za Zhi
23665414Topographical study of O(6)-alkylguanine DNA alkyltransferase repair activity and N7-methylguanine levels in resected lung tissue. (2013 Jul 5)Crosbie PAChem Biol Interact
16777993Polymorphisms in O6-methylguanine DNA methyltransferase and endometrial cancer risk. (2006 Nov)Han JCarcinogenesis
11297252Aberrant methylation during cervical carcinogenesis. (2001 Mar)Virmani AKClin Cancer Res
11856482Inactivation of O6-methylguanine-DNA methyltransferase in human lung adenocarcinoma relates to high-grade histology and worse prognosis among smokers. (2002 Feb)Hayashi HJpn J Cancer Res
19506903RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China. (2009 Dec)Lin QJ Cancer Res Clin Oncol
16517062Loss of expression of DNA repair enzyme MGMT in oral leukoplakia and early oral squamous cell carcinoma. A prognostic tool? (2007 Jan 8)Rodriguez MJCancer Lett
15709192Identification of epigenetic aberrant promoter methylation in serum DNA is useful for early detection of lung cancer. (2005 Feb 1)Fujiwara KClin Cancer Res
9683184Smoking-related increase of O6-methylguanine-DNA methyltransferase expression in human lung carcinomas. (1998 Jul)Mattern JCarcinogenesis
19596925O6-Methylguanine-DNA methyltransferase hypermethylation modulated by 17beta-estradiol in lung cancer cells. (2009 Jul)Lai JCAnticancer Res
23788902Cytological examination of pleural cavity lavage accompanied by the study of gene promoter hypermethylation of p16 and O6-methylguanine-DNA-methyltransferase genes in diagnostics of non-small cell lung cancer metastatic changes into pleura. (2012)Kaczmarczyk GContemp Oncol (Pozn)
27110300The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma. (2016)Ma KClin Epigenetics
11196170Aberrant promoter methylation of multiple genes in non-small cell lung cancers. (2001 Jan 1)Zochbauer-Muller SCancer Res
25754026Meta-analyses of gene methylation and smoking behavior in non-small cell lung cancer patients. (2015 Mar 10)Huang TSci Rep
18386788Polymorphisms in MGMT and DNA repair genes and the risk of esophageal adenocarcinoma. (2008 Jul 1)Doecke JInt J Cancer
27042875Cigarette Smoking, BPDE-DNA Adducts, and Aberrant Promoter Methylations of Tumor Suppressor Genes (TSGs) in NSCLC from Chinese Population. (2016)Jin YCancer Invest
16014702MGMT genotype modulates the associations between cigarette smoking, dietary antioxidants and breast cancer risk. (2005 Dec)Shen JCarcinogenesis
7926865O6-methylguanine-DNA methyltransferase activity in the human lung persists with advancing age. (1994)Nakatsuru YGerontology
28404957Gene methylation as a powerful biomarker for detection and screening of non-small cell lung cancer in blood. (2017 May 9)Wang BHOncotarget
25813726Gene promoter methylation and DNA repair capacity in monozygotic twins with discordant smoking habits. (2015 Feb)Ottini LMutat Res Genet Toxicol Environ Mutagen
19807915Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylation. (2009 Oct 6)Taioli EBMC Cancer
16844323Selected polymorphisms of DNA repair genes and risk of pancreatic cancer. (2006)Jiao LCancer Detect Prev
18006925DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study. (2007 Nov)Stern MCCancer Epidemiol Biomarkers Prev
23573237Kras gene mutation and RASSF1A, FHIT and MGMT gene promoter hypermethylation: indicators of tumor staging and metastasis in adenocarcinomatous sporadic colorectal cancer in Indian population. (2013)Sinha RPLoS One
21078381Frequent gene hypermethylation in laryngeal cancer cell lines and the resistance to demethylation induction by plant polyphenols. (2011 Feb)Paluszczak JToxicol In Vitro
19079989[Correlation of aberrant methylation of MGMT gene to MTHFR C677T genetic polymorphisms in esophageal squamous cell carcinoma]. (2008 Dec)Xue HCAi Zheng
28468586Alteration in the expression of MGMT and RUNX3 due to non-CpG promoter methylation and their correlation with different risk factors in esophageal cancer patients. (2017 May)Saikia STumour Biol
24084248The GSTM1null (deletion) and MGMT84 rs12917 (Phe/Phe) haplotype are associated with bulky DNA adduct levels in human leukocytes. (2013 Dec 12)Molina EMutat Res
18632757Aberrant promoter hypermethylation in serum DNA from patients with silicosis. (2008 Sep)Umemura SCarcinogenesis
16052427Molecular epidemiology of non-small cell lung cancer. (2005 Jun)Liu GSemin Respir Crit Care Med
16788379Polymorphisms in O6-methylguanine DNA methyltransferase and breast cancer risk. (2006 Jul)Han JPharmacogenet Genomics
20572039Relation between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomas. (2010 Oct 1)Paun BCCancer
25443735The anti-cancer actions of O6-methylguanine-DNA-methyltransferase in relation to colon polyps. (2014 Dec)Kycler WPharmacol Rep
11221887Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients. (2001 Feb 1)Rosas SLCancer Res
16038584Influence of polymorphisms in DNA repair genes XPD, XRCC1 and MGMT on DNA damage induced by gamma radiation and its repair in lymphocytes in vitro. (2005 Aug)Rzeszowska-Wolny JRadiat Res
18349282DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients. (2008 Mar)Feng QCancer Epidemiol Biomarkers Prev