Gene: MGP

4256
GIG36|MGLAP|NTI
matrix Gla protein
protein-coding
12p12.3
Ensembl:ENSG00000111341 MIM:154870 Vega:OTTHUMG00000168740 UniprotKB:P08493
NG_023331.1
PubMed
0   ANCO-SNPs
ND
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.809e-1 (AD)  5.160e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL8A10.856
COL3A10.851
ACTA20.838
COL14A10.819
PLN0.803
MYH110.797
GJA50.796
OGN0.791
MYL90.785
AOC30.778

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYADML2-0.389
BCL11A-0.375
FEZF2-0.375
ZNF835-0.375
CHRNA4-0.368
NEUROD6-0.367
MYH7B-0.354
DRD5-0.352
ASPDH-0.35
FGF22-0.348

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01373CalciumSmall Molecule7440-70-2Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of MGP mRNA"26377693
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of MGP mRNA"26377693
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of MGP mRNA"19162173
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of MGP mRNA"20453058
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of MGP mRNA"21920950
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MGP mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MGP mRNA"19167446
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MGP mRNA"20406850
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MGP mRNA"12376462
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of MGP mRNA"23196670
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MGP mRNA"20959002
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in decreased expression of MGP mRNA25716159
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MGP mRNA"18289764
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MGP mRNA"25380136
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of MGP mRNA"28591870
D000082AcetaminophenAcetaminophen results in decreased expression of MGP mRNA29067470
C014949acetylhydrazineacetylhydrazine results in decreased expression of MGP mRNA15282401
C016601afimoxifeneafimoxifene results in decreased expression of MGP mRNA16514628
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MGP mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of MGP mRNA"22863853
C006632arsenic trioxidearsenic trioxide results in decreased expression of MGP mRNA26705709
C006632arsenic trioxidearsenic trioxide results in increased expression of MGP mRNA20458559
D001280AtrazineAtrazine results in increased expression of MGP mRNA23358194
D001414BacitracinBacitracin results in increased expression of MGP mRNA18289764
C447119bazedoxifenebazedoxifene results in decreased expression of MGP mRNA19914376
D001507BeclomethasoneBeclomethasone results in increased expression of MGP mRNA23656298
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of MGP mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of MGP mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to MGP promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MGP mRNA22228805
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MGP mRNA19619570
D004958EstradiolEstradiol results in increased expression of MGP mRNA16202921|1651462
D004958EstradiolRaloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of MGP mRNA]21185374
C031463beta-glycerophosphoric acidbeta-glycerophosphoric acid results in decreased expression of MGP mRNA17171500
C031463beta-glycerophosphoric acidCalcitriol promotes the reaction [beta-glycerophosphoric acid results in decreased expression of MGP mRNA]17171500
C031463beta-glycerophosphoric acidparicalcitol promotes the reaction [beta-glycerophosphoric acid results in decreased expression of MGP mRNA]17171500
C095105bexarotene[bexarotene co-treated with Tamoxifen] results in decreased expression of MGP mRNA17630414
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of MGP mRNA28591870
C006780bisphenol Abisphenol A results in increased expression of MGP mRNA28591870|2871154
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MGP mRNA28628672
C006780bisphenol Abisphenol A affects the expression of MGP mRNA25181051
C492482bisphenol Bbisphenol B results in increased expression of MGP mRNA28591870
C000611646bisphenol Fbisphenol F results in increased expression of MGP mRNA28591870
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of MGP mRNA18958704
C514178BMS 961BMS 961 results in increased expression of MGP mRNA18703560
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of MGP mRNA12766906|1533650
D002104CadmiumCadmium results in increased expression of MGP mRNA17327699
D019256Cadmium ChlorideCadmium Chloride affects the expression of MGP mRNA18974090
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MGP mRNA17327699|2599309
D002118CalciumCalcium binds to MGP protein18369157
D002118Calcium[Calcium binds to MGP protein] which binds to and results in decreased activity of BMP4 protein18369157
D002118CalciumEdetic Acid inhibits the reaction [Calcium binds to MGP protein]18369157
D002118Calcium[Edetic Acid inhibits the reaction [Calcium binds to MGP protein]] inhibits the reaction [MGP protein binds to BMP4 protein]18369157
D002118CalciumCalcium affects the expression of MGP mRNA15913539
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MGP mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MGP mRNA16239168
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of MGP mRNA19395590
D002273CarcinogensCarcinogens results in increased expression of MGP mRNA16316942
D004390ChlorpyrifosChlorpyrifos affects the expression of MGP mRNA26775027
D002794CholineCholine affects the expression of MGP mRNA17616785
C418118CI 1044CI 1044 results in increased expression of MGP mRNA17569694
D002994ClofibrateClofibrate results in decreased expression of MGP mRNA17585979
C030123coumarincoumarin results in decreased expression of MGP mRNA19350115
C030123coumarincoumarin results in decreased expression of MGP mRNA19350115
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MGP mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of MGP mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of MGP mRNA20106945
D003561CytarabineCytarabine results in decreased expression of MGP mRNA21198554
D000069439DasatinibDasatinib results in increased expression of MGP mRNA20579391
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MGP mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of MGP mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of MGP mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MGP mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MGP mRNA24893172
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MGP mRNA15829613|2126653
D002945CisplatinCisplatin results in decreased expression of MGP mRNA21151649
D002945CisplatinCisplatin results in increased expression of MGP mRNA18289764
D004041Dietary FatsDietary Fats results in increased expression of MGP mRNA22609946
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of MGP mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of MGP mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of MGP mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of MGP mRNA17394237
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of MGP mRNA21658437
D002117CalcitriolCalcitriol promotes the reaction [beta-glycerophosphoric acid results in decreased expression of MGP mRNA]17171500
D002117CalcitriolCalcitriol results in decreased expression of MGP protein19092814
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of MGP mRNA"12376462
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of MGP mRNA25380136
D004237DiuronDiuron results in decreased expression of MGP mRNA21551480|2515243
D017886DurapatiteMGP protein binds to Durapatite21705322
D004492Edetic AcidEdetic Acid inhibits the reaction [Calcium binds to MGP protein]18369157
D004492Edetic Acid[Edetic Acid inhibits the reaction [Calcium binds to MGP protein]] inhibits the reaction [MGP protein binds to BMP4 protein]18369157
C118739entinostatentinostat results in increased expression of MGP mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of MGP mRNA19400957
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of MGP mRNA12655037|1755790
D012968Etidronic AcidEtidronic Acid results in increased expression of MGP mRNA17270170
D005485FlutamideFlutamide results in decreased expression of MGP mRNA21126777
C069837fullerene C60fullerene C60 results in decreased expression of MGP mRNA19167457
C070081fulvestrantfulvestrant results in decreased expression of MGP mRNA16514628
C039281furanfuran results in increased expression of MGP mRNA27387713
D019833GenisteinESR1 promotes the reaction [Genistein results in increased expression of MGP protein]20884965
D019833GenisteinESR2 promotes the reaction [Genistein results in increased expression of MGP protein]20884965
D019833GenisteinGenistein results in increased expression of MGP protein20884965
D005839GentamicinsGentamicins results in increased expression of MGP mRNA18289764
D017313FenretinideFenretinide results in increased expression of MGP mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of MGP mRNA17183730
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MGP mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of MGP mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MGP mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MGP mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of MGP mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of MGP mRNA20003209
D007654KetoconazoleKetoconazole affects the expression of MGP mRNA18289764
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of MGP mRNA25613284
D019808LosartanLosartan results in decreased expression of MGP mRNA15100363
D008627Mercuric ChlorideMercuric Chloride affects the expression of MGP mRNA20353558
C500085muraglitazarmuraglitazar results in decreased expression of MGP mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MGP mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MGP mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MGP mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MGP mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of MGP mRNA18289764|2538013
C017096n-butoxyethanoln-butoxyethanol results in increased expression of MGP mRNA19812364
D019829NevirapineNevirapine results in increased expression of MGP mRNA23947594
D009532NickelNickel affects the expression of MGP mRNA14575637
D009532NickelNickel results in decreased expression of MGP mRNA24768652|2558310
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of MGP mRNA]14575637
D009538Nicotine[Cholecalciferol co-treated with Nicotine] results in decreased expression of MGP protein19910445
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of MGP mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of MGP mRNA25729387
D010269ParaquatParaquat results in increased expression of MGP mRNA21371552
C084656paricalcitolparicalcitol promotes the reaction [beta-glycerophosphoric acid results in decreased expression of MGP mRNA]17171500
C084656paricalcitol[Phosphorus co-treated with paricalcitol] results in increased expression of MGP mRNA17715259
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of MGP mRNA26705709
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of MGP mRNA22790973
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of MGP mRNA17560707
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MGP mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of MGP mRNA19159669
D010758Phosphorus[Phosphorus co-treated with paricalcitol] results in increased expression of MGP mRNA17715259
D011192Potassium DichromatePotassium Dichromate results in increased expression of MGP mRNA23608068
C035988procymidoneprocymidone results in increased expression of MGP mRNA15686871
D011374ProgesteroneProgesterone results in decreased expression of MGP mRNA18070364
D011374ProgesteroneProgesterone results in increased expression of MGP mRNA21795739
D011441PropylthiouracilPropylthiouracil results in decreased expression of MGP mRNA24780913
D011794Quercetin[Quercetin co-treated with Warfarin] results in decreased carboxylation of MGP protein23223575
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of MGP mRNA]21185374
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of MGP mRNA16514628
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of MGP mRNA19167446
D012402RotenoneRotenone results in increased expression of MGP mRNA27900601
D012715Sesame OilSesame Oil results in decreased expression of MGP mRNA29191790
D012822Silicon DioxideSilicon Dioxide results in increased expression of MGP mRNA18685790
C009277sodium arsenatesodium arsenate results in decreased expression of MGP mRNA23104429
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of MGP mRNA25879800
C017947sodium arsenitesodium arsenite results in decreased expression of MGP mRNA23104429
D012999SomanSoman results in increased expression of MGP mRNA19281266
D014284TriiodothyronineTriiodothyronine results in increased expression of MGP mRNA22281776
D013629TamoxifenTamoxifen affects the expression of MGP mRNA20937368
D013629TamoxifenTamoxifen results in decreased expression of MGP mRNA19400957
D013629Tamoxifen[bexarotene co-treated with Tamoxifen] results in decreased expression of MGP mRNA17630414
D013629TamoxifenTamoxifen results in decreased expression of MGP mRNA19400957
C501413tesaglitazartesaglitazar results in decreased expression of MGP mRNA21515302
D013739TestosteroneTestosterone results in increased expression of MGP mRNA15788153
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MGP mRNA26854739
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MGP mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MGP mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to MGP promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MGP mRNA11752688
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MGP mRNA20959002
C582340tetradecabromodiphenoxybenzenetetradecabromodiphenoxybenzene analog results in increased expression of MGP mRNA26854739
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MGP mRNA25613284
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of MGP mRNA28943392
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of MGP mRNA25729387
D019772TopotecanTopotecan results in increased expression of MGP mRNA25729387
D014212TretinoinTretinoin results in increased expression of MGP mRNA23724009|2383079
D014212TretinoinTretinoin results in increased expression of MGP mRNA18703560
C011559tributyltintributyltin results in increased expression of MGP mRNA29191790
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of MGP mRNA]14575637
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of MGP mRNA17982090
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MGP mRNA"26743178
C057693troglitazonetroglitazone results in decreased expression of MGP mRNA25572481
C057693troglitazonetroglitazone results in decreased expression of MGP mRNA21515302
C022884undecaneundecane results in increased expression of MGP protein17337753
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of MGP mRNA17183730
D014635Valproic AcidValproic Acid results in decreased expression of MGP mRNA29154799
D014640VancomycinVancomycin results in decreased expression of MGP mRNA18930951
D014640VancomycinVancomycin results in increased expression of MGP mRNA18289764
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of MGP mRNA19165385
C025643vinclozolinvinclozolin affects the expression of MGP mRNA19015723
D002762Cholecalciferol[Cholecalciferol co-treated with Nicotine] results in decreased expression of MGP protein19910445
D014810Vitamin EVitamin E results in increased expression of MGP mRNA19244175
D014812Vitamin K[Vitamin K co-treated with Warfarin] results in increased carboxylation of MGP protein23223575
D010837Vitamin K 1[Warfarin co-treated with Vitamin K 1] results in decreased activity of MGP protein23990204
D010837Vitamin K 1[Warfarin co-treated with Vitamin K 1] results in decreased carboxylation of MGP protein23990204
D010837Vitamin K 1[[Warfarin co-treated with Vitamin K 1] results in decreased carboxylation of MGP protein] which results in decreased activity of MGP protein23990204
D010837Vitamin K 1[Warfarin co-treated with Vitamin K 1] results in decreased expression of MGP mRNA23990204
D010837Vitamin K 1Vitamin K 1 results in increased expression of and results in increased secretion of MGP protein modified form21705322
D010837Vitamin K 1Warfarin inhibits the reaction [Vitamin K 1 results in increased expression of and results in increased secretion of MGP protein modified form]21705322
D014859WarfarinWarfarin results in increased expression of MGP mRNA25094061
D014859Warfarin[Warfarin co-treated with Vitamin K 1] results in decreased activity of MGP protein23990204
D014859Warfarin[Warfarin co-treated with Vitamin K 1] results in decreased carboxylation of MGP protein23990204
D014859Warfarin[[Warfarin co-treated with Vitamin K 1] results in decreased carboxylation of MGP protein] which results in decreased activity of MGP protein23990204
D014859Warfarin[Warfarin co-treated with Vitamin K 1] results in decreased expression of MGP mRNA23990204
D014859Warfarin[Quercetin co-treated with Warfarin] results in decreased carboxylation of MGP protein23223575
D014859Warfarin[Vitamin K co-treated with Warfarin] results in increased carboxylation of MGP protein23223575
D014859WarfarinWarfarin inhibits the reaction [Vitamin K 1 results in increased expression of and results in increased secretion of MGP protein modified form]21705322
D014859WarfarinWarfarin results in decreased carboxylation of MGP protein23223575
D014859WarfarinWarfarin results in decreased expression of and results in decreased secretion of MGP protein21705322
D014859WarfarinWarfarin results in decreased expression of and results in decreased secretion of MGP protein modified form21705322
D014859WarfarinWarfarin results in decreased carboxylation of MGP protein18495950
D015032ZincZinc deficiency results in increased expression of MGP mRNA16140947
D015032ZincZinc inhibits the reaction [Zinc deficiency results in increased expression of MGP mRNA]16140947

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005201extracellular matrix structural constituent-TAS9916809  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI15607035  
GO:0008147structural constituent of bone-TAS9916809  
GO ID GO Term Qualifier Evidence PubMed
GO:0001502cartilage condensation-TAS9916809  
GO:0001503ossification-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0030500regulation of bone mineralization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0031012extracellular matrix-IBA21873635  
GO:0031012extracellular matrix-TAS9916809  
GO:0062023collagen-containing extracellular matrix-HDA23979707  27068509  27559042  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19204017Association of kidney function and uncarboxylated matrix Gla protein: data from the Heart and Soul Study. (2009 Jul)Parker BDNephrol Dial Transplant
25987667Inactive Matrix Gla-Protein Is Associated With Arterial Stiffness in an Adult Population-Based Study. (2015 Jul)Pivin EHypertension
15045141Matrix Gla protein is associated with coronary artery calcification as assessed by electron-beam computed tomography. (2004 Apr)Jono SThromb Haemost
23317172Calcification of coronary arteries and abdominal aorta in relation to traditional and novel risk factors of atherosclerosis in hemodialysis patients. (2013 Jan 14)Pencak PBMC Nephrol
19345526[Origin of the mediacalcosis in kidney failure]. (2009 May)Torres PAJ Mal Vasc
20486996Calcium scores and matrix Gla protein levels: association with vitamin K status. (2010 Apr)Rennenberg RJEur J Clin Invest
261027381D.03: INACTIVE MATRIX GLA PROTEIN IS ASSOCIATED WITH RENAL RESISTIVE INDEX IN A POPULATION-BASED STUDY. (2015 Jun)Pivin EJ Hypertens
19551318Antioxidant status and smoking habits: relationship with diet. (2009 Jun)Jain ASingapore Med J
16918372Molecular determinants of vascular calcification: a bench to bedside view. (2006 Aug)Dellegrottaglie SCurr Mol Med