Gene info: ID 4257

Gene: MGST1

GENE ID: 4257

Synonyms: GST12|MGST|MGST-I

Description: microsomal glutathione S-transferase 1

Gene type: protein-coding

Location: 12p12.3

dbXrefs: Ensembl:ENSG00000008394 MIM:138330 Vega:OTTHUMG00000168816 UniprotKB:P10620

RefSeq: NC_000012.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.547e-1 (AD) 9.439e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ABHD4	0.878
PLCD1	0.868
RFX4	0.866
TMBIM1	0.862
TRAF3IP2	0.858
MRVI1	0.851
CNN3	0.851
SLC44A3	0.847
AQP4	0.84
FGF2	0.839

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZNF860	-0.516
NXPH2	-0.514
ABCC12	-0.513
ADRA1D	-0.511
AGMAT	-0.502
LHX6	-0.496
LGI2	-0.493
TYRP1	-0.488
PPEF1	-0.485
KCNS3	-0.483

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00143	Glutathione	Small Molecule	70-18-8	Approved\|Investigational\|Nutraceutical	Target

ID	Drug Name	Action	PubMed
C004931	1,1-diphenyl-2-picrylhydrazyl	"1,1-diphenyl-2-picrylhydrazyl inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]"	16125204
C114535	1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene	[1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein	16386761
C114535	1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene	Dithiothreitol inhibits the reaction [[1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]	16386761
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of MGST1 mRNA"	11509743
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in increased expression of MGST1 mRNA"	11509743
C078765	2,3,5-(triglutathion-S-yl)hydroquinone	"2,3,5-(triglutathion-S-yl)hydroquinone results in increased expression of MGST1 mRNA"	14587099
C079315	2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid	2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid results in decreased activity of MGST1 protein	9890956
C096092	2-(acetoxyamino)-1-methyl-6-phenylimidazo(4,5-b)pyridine	"MGST1 protein affects the metabolism of and results in decreased activity of 2-(acetoxyamino)-1-methyl-6-phenylimidazo(4,5-b)pyridine"	8069858
C012180	2-aminopyrimidine	2-aminopyrimidine analog binds to MGST1 protein	19317514
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MGST1 mRNA"	21703328
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of MGST1 mRNA	12958071
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of MGST1 mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MGST1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MGST1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MGST1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MGST1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MGST1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MGST1 mRNA"	27188386
C122155	6-bromoacetyl-2-dimethylaminonaphthalene	MGST1 protein affects the metabolism of [6-bromoacetyl-2-dimethylaminonaphthalene co-treated with Glutathione]	12470677
C478192	6-chloroacetyl-2-dimethylaminonaphthalene	MGST1 protein affects the metabolism of 6-chloroacetyl-2-dimethylaminonaphthalene	12470677
D000082	Acetaminophen	Acetaminophen affects the expression of MGST1 mRNA	25704631
D000082	Acetaminophen	Acetaminophen results in decreased expression of MGST1 mRNA	11793227\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of MGST1 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in decreased expression of MGST1 protein	21329376
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of MGST1 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MGST1 mRNA]	17585979
D000108	Acetylcarnitine	Acetylcarnitine results in increased expression of MGST1 mRNA	14654561
D000108	Acetylcarnitine	[Acetylcarnitine co-treated with NGF protein] results in increased expression of MGST1 mRNA	14654561
D000171	Acrolein	Acrolein affects the activity of MGST1 protein	28780321
C038518	acrylodan	MGST1 protein affects the metabolism of [acrylodan co-treated with Glutathione]	12470677
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of MGST1 gene	27153756
D000638	Amiodarone	Amiodarone results in increased expression of MGST1 mRNA	19774075
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MGST1 mRNA	16483693
D003913	Dextroamphetamine	Dextroamphetamine results in increased expression of MGST1 mRNA	16715494
D001151	Arsenic	Arsenic results in increased expression of MGST1 mRNA	19945496
C006632	arsenic trioxide	arsenic trioxide promotes the reaction [Lutein results in increased expression of MGST1 mRNA]	25815309
C006632	arsenic trioxide	arsenic trioxide results in increased expression of MGST1 mRNA	26187899
C006632	arsenic trioxide	Lutein promotes the reaction [arsenic trioxide results in increased expression of MGST1 mRNA]	26187899
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of MGST1 mRNA	15372504
D001280	Atrazine	Atrazine results in decreased expression of MGST1 mRNA	25929836
C406592	azaspiracid	azaspiracid results in increased expression of MGST1 mRNA	28939011
C547126	AZM551248	AZM551248 results in decreased expression of MGST1 mRNA	22323515
C051597	Bandrowski's base	Bandrowski's base results in increased expression of MGST1 mRNA	20566472
C071435	BAY u9773	BAY u9773 results in decreased activity of MGST1 protein	9890956
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MGST1 mRNA	26001963
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of MGST1 mRNA	21632023
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MGST1 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MGST1 mRNA	15034205\|2222880
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of MGST1 mRNA"	17944540
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of MGST1 mRNA	20061341
C038328	BEP protocol	BEP protocol results in increased expression of MGST1 mRNA	18987330\|2320077
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of MGST1 mRNA	20660070
D004958	Estradiol	Estradiol results in decreased expression of MGST1 mRNA	17982697
D004958	Estradiol	[Parathion co-treated with Estradiol] results in increased expression of MGST1 mRNA	17982697
D004958	Estradiol	"[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in increased expression of MGST1 mRNA"	11509743
D004958	Estradiol	[Estradiol co-treated with Methoxychlor metabolite] results in increased expression of MGST1 mRNA	11509743
D004958	Estradiol	Estradiol results in increased expression of MGST1 mRNA	11509743
C006780	bisphenol A	bisphenol A affects the expression of MGST1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of MGST1 mRNA	22576693
C006780	bisphenol A	bisphenol A results in increased methylation of MGST1 gene	22576693
C006780	bisphenol A	bisphenol A results in increased expression of MGST1 mRNA	28123100
C006780	bisphenol A	[LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of MGST1 mRNA	28123100
C006780	bisphenol A	bisphenol A results in decreased expression of MGST1 mRNA	12075121
C006780	bisphenol A	bisphenol A results in increased expression of MGST1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of MGST1 gene	28505145
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of MGST1 mRNA	18958704
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of MGST1 mRNA	22079614
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of MGST1 mRNA	18804290
D002087	Butyrates	Butyrates results in increased expression of MGST1 mRNA	14674679
D002101	Cacodylic Acid	Cacodylic Acid results in increased expression of MGST1 mRNA	16122865
D002104	Cadmium	Cadmium results in decreased expression of MGST1 mRNA	24084258
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of MGST1 mRNA	18804290
C040048	caffeic acid	caffeic acid results in increased activity of MGST1 protein	16125204
D002110	Caffeine	Caffeine results in decreased expression of MGST1 mRNA	11793227
D002220	Carbamazepine	Carbamazepine affects the expression of MGST1 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of MGST1 mRNA	15056808
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of MGST1 mRNA	12734012\|1780597
C099555	CD 437	CD 437 results in decreased expression of MGST1 mRNA	12958071
D002713	Chlorine	Chlorine results in decreased expression of MGST1 mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] affects the expression of MGST1 mRNA	18636392
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of MGST1 mRNA	23650126
D002726	Chlorogenic Acid	Chlorogenic Acid results in decreased activity of MGST1 protein	16125204
C020722	cinnamyl alcohol	cinnamyl alcohol results in increased expression of MGST1 mRNA	20566472
C019304	ciprofibrate	ciprofibrate results in increased expression of MGST1 mRNA	18723825
D002994	Clofibrate	Clofibrate results in increased expression of MGST1 mRNA	19952500
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of MGST1 mRNA	17585979
D002994	Clofibrate	Clofibrate results in increased expression of MGST1 mRNA	18723825
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MGST1 mRNA]	17585979
C018021	cobaltous chloride	cobaltous chloride results in increased expression of MGST1 mRNA	17553155
C007164	cumene hydroperoxide	MGST1 results in decreased susceptibility to cumene hydroperoxide	17306223
C029892	cupric chloride	cupric chloride results in increased expression of MGST1 mRNA	24650576
D003474	Curcumin	Curcumin results in increased expression of MGST1 mRNA	18299980
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of MGST1 mRNA	11906922
D016572	Cyclosporine	Cyclosporine results in increased expression of MGST1 mRNA	25562108
D016572	Cyclosporine	Cyclosporine inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]	19111564
D003907	Dexamethasone	Dexamethasone results in increased expression of MGST1 mRNA	25047013
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGST1 mRNA	16054899
D003907	Dexamethasone	Dexamethasone results in increased expression of MGST1 mRNA	18723825\|2273378
D003907	Dexamethasone	EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGST1 mRNA]	16054899
D003907	Dexamethasone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGST1 mRNA]	16054899
D003976	Diazinon	Diazinon results in increased expression of MGST1 mRNA	19440498
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of MGST1 mRNA	21266533
D002945	Cisplatin	MGST1 protein results in decreased susceptibility to Cisplatin	20727966
D002945	Cisplatin	Cisplatin results in increased expression of MGST1 mRNA	21151649
C121718	dicyclanil	dicyclanil results in increased expression of MGST1 mRNA	15664270
D004026	Dieldrin	Dieldrin results in increased expression of MGST1 mRNA	20438755
D004041	Dietary Fats	Dietary Fats results in decreased expression of MGST1 mRNA	18042831
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MGST1 mRNA	18544905
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid] results in increased expression of MGST1 mRNA	18544905
D004052	Diethylnitrosamine	[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of MGST1 protein	20935162
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of MGST1 mRNA	20566472
C051904	dinophysistoxin 1	dinophysistoxin 1 results in increased expression of MGST1 mRNA	28939011
D004221	Disulfiram	Disulfiram results in increased expression of MGST1 mRNA	20566472
D004229	Dithiothreitol	Dithiothreitol inhibits the reaction [[1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]	16386761
D004229	Dithiothreitol	Dithiothreitol inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]	16125204
D004229	Dithiothreitol	Dithiothreitol inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]	16386761
D004229	Dithiothreitol	Dithiothreitol inhibits the reaction [[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]	16386761
D004229	Dithiothreitol	Dithiothreitol inhibits the reaction [[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]	16386761
D004317	Doxorubicin	Doxorubicin results in increased expression of MGST1 mRNA	19915844
D004610	Ellagic Acid	Ellagic Acid results in decreased activity of MGST1 protein	16125204
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of MGST1 mRNA	22037546
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased activity of MGST1 protein	23010222
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of MGST1 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of MGST1 mRNA	16174780\|1794274
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of MGST1 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of MGST1 mRNA	12075121\|1617478
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of MGST1 mRNA	17108234
D005015	Ethoxyquin	Ethoxyquin results in increased expression of MGST1 mRNA	18723825
D005054	Eugenol	Eugenol results in increased expression of MGST1 mRNA	20566472
C436526	EUK-189	EUK-189 inhibits the reaction [SOD2 gene mutant form results in increased expression of MGST1 mRNA]	15964507
C024555	ferric chloride	ferric chloride inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]	16125204
C007738	fluoranthene	fluoranthene results in decreased expression of MGST1 mRNA	18522720
D005485	Flutamide	Flutamide results in decreased expression of MGST1 mRNA	11509743
C473894	fujiflavone P40	fujiflavone P40 results in increased expression of MGST1 mRNA	14656947
C039281	furan	furan results in increased methylation of MGST1 gene	22079235
D005707	Gallic Acid	"1,1-diphenyl-2-picrylhydrazyl inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]"	16125204
D005707	Gallic Acid	Cyclosporine inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]	19111564
D005707	Gallic Acid	Dithiothreitol inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]	16125204
D005707	Gallic Acid	ferric chloride inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]	16125204
D005707	Gallic Acid	Gallic Acid results in increased activity of MGST1 protein	16125204\|1911156
D005707	Gallic Acid	Gallic Acid results in increased oxidation of and results in increased activity of MGST1 protein	19111564
D005707	Gallic Acid	Hemin inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]	19111564
D005707	Gallic Acid	sodium arsenite inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]	16125204
D005707	Gallic Acid	triethylenediamine inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]	19111564
D005707	Gallic Acid	CAT protein inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]	16125204
C546771	gardiquimod	gardiquimod results in decreased expression of MGST1 mRNA	28003376
C546771	gardiquimod	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of MGST1 mRNA]	28003376
D019833	Genistein	Genistein results in decreased expression of MGST1 mRNA	24967385
D019833	Genistein	[Genistein co-treated with Methoxychlor] results in decreased expression of MGST1 mRNA	21782745
D019833	Genistein	Genistein results in decreased expression of MGST1 mRNA	12075121
D005839	Gentamicins	Gentamicins results in increased expression of MGST1 mRNA	22061828
D005978	Glutathione	Dithiothreitol inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]	16386761
D005978	Glutathione	Glutathione binds to and results in increased activity of MGST1 protein	9890956
D005978	Glutathione	Leukotriene C4 inhibits the reaction [Glutathione binds to and results in increased activity of MGST1 protein]	9890956
D005978	Glutathione	MGST1 protein affects the metabolism of [6-bromoacetyl-2-dimethylaminonaphthalene co-treated with Glutathione]	12470677
D005978	Glutathione	MGST1 protein affects the metabolism of [acrylodan co-treated with Glutathione]	12470677
D005978	Glutathione	[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein	16386761
D005978	Glutathione	sodium arsenite inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]	16386761
C510946	glutathione sulfinamide	glutathione sulfinamide results in decreased activity of MGST1 protein	19038239
C071834	glycidamide	glycidamide results in increased expression of MGST1 mRNA	17822822
D006427	Hemin	Hemin inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]	19111564
D007975	Leukotriene B4	Leukotriene B4 results in decreased activity of MGST1 protein	9890956
C080043	hexyl cinnamic aldehyde	hexyl cinnamic aldehyde results in increased expression of MGST1 mRNA	20566472
D006861	Hydrogen Peroxide	MGST1 results in decreased susceptibility to Hydrogen Peroxide	17306223
C031927	hydroquinone	hydroquinone results in increased expression of MGST1 mRNA	15452088
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MGST1 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGST1 mRNA	16054899
D015056	1-Methyl-3-isobutylxanthine	EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGST1 mRNA]	16054899
D015056	1-Methyl-3-isobutylxanthine	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGST1 mRNA]	16054899
C036643	isoeugenol	isoeugenol results in increased expression of MGST1 mRNA	20566472
D007545	Isoproterenol	Isoproterenol results in increased expression of MGST1 mRNA	20003209\|2133504
C410337	K 7174	K 7174 results in increased expression of MGST1 mRNA	24086573
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MGST1 mRNA	18544905
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid] results in increased expression of MGST1 mRNA	18544905
C008261	lead acetate	lead acetate results in increased expression of MGST1 mRNA	11578147\|2264161
C017461	lead nitrate	lead nitrate affects the reaction [MGST1 affects the expression of MT1 mRNA]	11891201
C017461	lead nitrate	lead nitrate affects the reaction [MGST1 affects the expression of MT2 mRNA]	11891201
D017999	Leukotriene E4	Leukotriene E4 results in decreased activity of MGST1 protein	9890956
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of MGST1 mRNA"	19264136
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of MGST1 mRNA	25613284
D017572	Leukotriene A4	Leukotriene A4 results in decreased activity of MGST1 protein	9890956
D017997	Leukotriene C4	Leukotriene C4 binds to and results in decreased activity of MGST1 protein	9890956
D017997	Leukotriene C4	Leukotriene C4 inhibits the reaction [Glutathione binds to and results in increased activity of MGST1 protein]	9890956
D017998	Leukotriene D4	Leukotriene D4 results in decreased activity of MGST1 protein	9890956
D014975	Lutein	arsenic trioxide promotes the reaction [Lutein results in increased expression of MGST1 mRNA]	25815309
D014975	Lutein	Lutein promotes the reaction [arsenic trioxide results in increased expression of MGST1 mRNA]	26187899
D014975	Lutein	Lutein results in increased expression of MGST1 mRNA	25815309\|2618789
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of MGST1 mRNA	20843944
D008713	Methimazole	Methimazole results in increased expression of MGST1 mRNA	20144635
C013598	methoxyacetic acid	methoxyacetic acid affects the expression of MGST1 mRNA	20864626
D008731	Methoxychlor	[Estradiol co-treated with Methoxychlor metabolite] results in increased expression of MGST1 mRNA	11509743
D008731	Methoxychlor	Methoxychlor metabolite results in increased expression of MGST1 mRNA	11509743
D008731	Methoxychlor	[Genistein co-treated with Methoxychlor] results in decreased expression of MGST1 mRNA	21782745
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of MGST1 mRNA	28001369
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of MGST1 mRNA	20061341
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of MGST1 mRNA	23649840
D052998	Microcystins	Microcystins affects the expression of MGST1 mRNA	19790251
D052998	Microcystins	Microcystins results in increased expression of MGST1 mRNA	19790251
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of MGST1 mRNA	19945496
D009151	Mustard Gas	Mustard Gas results in increased expression of MGST1 mRNA	15674843\|1895507
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of MGST1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of MGST1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of MGST1 mRNA"	25620056
D009532	Nickel	Nickel results in decreased expression of MGST1 mRNA	24768652\|2558310
D009532	Nickel	Nickel results in decreased expression of MGST1 mRNA	24084258
C029938	nickel sulfate	nickel sulfate results in increased expression of MGST1 mRNA	20566472\|2271453
D009569	Nitric Oxide	[1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein	16386761
D009569	Nitric Oxide	Dithiothreitol inhibits the reaction [[1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]	16386761
D009569	Nitric Oxide	Dithiothreitol inhibits the reaction [[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]	16386761
D009569	Nitric Oxide	Dithiothreitol inhibits the reaction [[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]	16386761
D009569	Nitric Oxide	[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein	16386761
D009569	Nitric Oxide	[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein	16386761
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in decreased expression of MGST1 mRNA	17616710
D026422	S-Nitrosoglutathione	Dithiothreitol inhibits the reaction [[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]	16386761
D026422	S-Nitrosoglutathione	S-Nitrosoglutathione affects the metabolism of MGST1 protein	16899233
D026422	S-Nitrosoglutathione	[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein	16386761
C025589	ochratoxin A	ochratoxin A results in decreased expression of MGST1 mRNA	17483316\|2212462
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of MGST1 mRNA]"	21673326
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of MGST1 mRNA"	21673326
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of MGST1 mRNA]"	21673326
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of MGST1 mRNA	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of MGST1 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of MGST1 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of MGST1 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of MGST1 mRNA]	17655762
C005290	oxybenzone	oxybenzone results in increased expression of MGST1 mRNA	22721600
D010100	Oxygen	AHR protein affects the reaction [Oxygen results in increased expression of MGST1 protein]	23337360
D010100	Oxygen	Oxygen results in increased expression of MGST1 mRNA	23337360
D010100	Oxygen	Oxygen results in increased expression of MGST1 protein	23337360
D010126	Ozone	[Ozone co-treated with Chlorine] affects the expression of MGST1 mRNA	18636392
D000073878	Palm Oil	Palm Oil results in decreased expression of MGST1 mRNA	18042831
D010269	Paraquat	Paraquat results in increased expression of MGST1 mRNA	17935786
D010278	Parathion	[Parathion co-treated with Estradiol] results in increased expression of MGST1 mRNA	17982697
D010278	Parathion	Parathion results in increased expression of MGST1 mRNA	17982697
D052638	Particulate Matter	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of MGST1 mRNA]	17655762
D052638	Particulate Matter	Particulate Matter affects the expression of MGST1 mRNA	17655762
D052638	Particulate Matter	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of MGST1 mRNA]	17655762
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in decreased expression of MGST1 mRNA	23602845
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of MGST1 mRNA	18804290
D030421	Peroxynitrous Acid	Dithiothreitol inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]	16386761
D030421	Peroxynitrous Acid	[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein	16386761
D030421	Peroxynitrous Acid	Peroxynitrous Acid promotes the reaction [MGST1 protein binds to MGST1 protein]	16386761
D030421	Peroxynitrous Acid	Peroxynitrous Acid results in increased activity of MGST1 protein	16386761
D030421	Peroxynitrous Acid	sodium arsenite inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]	16386761
D010634	Phenobarbital	Phenobarbital results in increased expression of MGST1 mRNA	19952500
D010634	Phenobarbital	[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of MGST1 protein	20935162
D010695	Phlorhizin	Phlorhizin results in increased expression of MGST1 mRNA	22538082
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of MGST1 mRNA	15728792
C006253	pirinixic acid	pirinixic acid results in increased expression of MGST1 mRNA	17426115
C052393	pobilukast	pobilukast results in decreased activity of MGST1 protein	9890956
C047681	pranlukast	pranlukast results in decreased activity of MGST1 protein	9890956
D011374	Progesterone	Progesterone results in decreased expression of MGST1 mRNA	23018184
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of MGST1 mRNA	20660070
D011374	Progesterone	Progesterone results in increased expression of MGST1 mRNA	20726854
C045950	propiconazole	propiconazole results in increased expression of MGST1 mRNA	21278054
D011441	Propylthiouracil	Propylthiouracil results in increased expression of MGST1 mRNA	24780913
D047428	Protein Kinase Inhibitors	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of MGST1 mRNA]	28003376
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of MGST1 mRNA	27029645
D011763	Pyrrolizidine Alkaloids	Pyrrolizidine Alkaloids results in decreased expression of MGST1 mRNA	26100227
D011794	Quercetin	Quercetin affects the expression of MGST1 mRNA	18178720
D011794	Quercetin	Quercetin results in decreased activity of MGST1 protein	16125204
D017382	Reactive Oxygen Species	Reactive Oxygen Species results in increased activity of MGST1 protein	16386761
C009166	retinol acetate	[LRAT gene mutant form affects the susceptibility to [bisphenol A co-treated with retinol acetate]] which results in increased expression of MGST1 mRNA	28123100
C009166	retinol acetate	retinol acetate results in increased expression of MGST1 mRNA	28123100
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGST1 mRNA	16054899
C089730	rosiglitazone	EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGST1 mRNA]	16054899
C089730	rosiglitazone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGST1 mRNA]	16054899
D012402	Rotenone	Rotenone affects the expression of MGST1 mRNA	23186747
D012834	Silver	Silver results in increased expression of MGST1 mRNA	27131904
C021315	S-nitrosocysteine	Dithiothreitol inhibits the reaction [[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]	16386761
C021315	S-nitrosocysteine	[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein	16386761
C009277	sodium arsenate	sodium arsenate results in increased expression of MGST1 mRNA	23922661
C017947	sodium arsenite	sodium arsenite results in increased expression of MGST1 mRNA	20308225
C017947	sodium arsenite	sodium arsenite results in increased expression of MGST1 mRNA	22714537
C017947	sodium arsenite	sodium arsenite inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]	16125204
C017947	sodium arsenite	sodium arsenite inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]	16386761
C016104	sodium bichromate	[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of MGST1 mRNA	21632023
C016104	sodium bichromate	sodium bichromate results in increased expression of MGST1 mRNA	12325037
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of MGST1 mRNA	16705456
D018038	Sodium Selenite	Sodium Selenite results in increased expression of MGST1 mRNA	18175754
D013148	Spironolactone	Spironolactone results in increased expression of MGST1 mRNA	18723825
D013629	Tamoxifen	Tamoxifen affects the expression of MGST1 mRNA	17555576
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MGST1 mRNA	17101203
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MGST1 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	NFE2L2 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of MGST1 mRNA]	19474220
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MGST1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of MGST1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGST1 mRNA]	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to MGST1 promoter]	19654925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MGST1 mRNA	15034205\|1947422
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of MGST1 mRNA	28973375
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MGST1 mRNA	25613284
D013853	Thioacetamide	Thioacetamide results in decreased expression of MGST1 mRNA	11793227
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of MGST1 mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of MGST1 mRNA	22363418
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of MGST1 mRNA	15289447
C066340	tolcapone	tolcapone binds to MGST1 protein	19783845
C056583	tolmetin glucuronide	tolmetin glucuronide results in increased expression of MGST1 mRNA	26528891
D014212	Tretinoin	Tretinoin results in decreased expression of MGST1 mRNA	20530235
D014212	Tretinoin	Tretinoin results in decreased expression of MGST1 mRNA	21934132\|2372400
D014212	Tretinoin	Tretinoin results in decreased expression of MGST1 mRNA	20488242
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MGST1 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of MGST1 mRNA	24935251\|2627250
C007306	triethylenediamine	triethylenediamine inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]	19111564
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of MGST1 mRNA	19042947
C057693	troglitazone	troglitazone results in increased expression of MGST1 mRNA	28973697
D014415	Tunicamycin	Tunicamycin results in decreased expression of MGST1 mRNA	17127020
D014520	Urethane	Urethane results in decreased expression of MGST1 mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MGST1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of MGST1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of MGST1 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of MGST1 mRNA	26272509
D001335	Vehicle Emissions	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of MGST1 mRNA]	17655762
D001335	Vehicle Emissions	Vehicle Emissions affects the expression of MGST1 mRNA	17655762
D001335	Vehicle Emissions	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of MGST1 mRNA]	17655762
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of MGST1 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of MGST1 mRNA	19015723
C025643	vinclozolin	vinclozolin results in increased expression of MGST1 mRNA	22570695\|2261537
D014800	Vitallium	Vitallium analog results in increased expression of MGST1 mRNA	23825117
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MGST1 mRNA"	27188386
C063449	zileuton	zileuton results in decreased activity of MGST1 protein	9890956
D015032	Zinc	Zinc deficiency results in decreased expression of MGST1 mRNA	11717422
C088658	zoledronic acid	zoledronic acid results in decreased expression of MGST1 mRNA	24714768
C027368	zomepirac glucuronide	zomepirac glucuronide results in increased expression of MGST1 mRNA	26528891

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004364	glutathione transferase activity	-	IBA	21873635
GO:0004364	glutathione transferase activity	-	IDA	20727966
GO:0004364	glutathione transferase activity	-	TAS	-
GO:0004602	glutathione peroxidase activity	-	IDA	20727966
GO:0005515	protein binding	-	IPI	20195357
GO:0042803	protein homodimerization activity	-	IEA	-
GO:0043295	glutathione binding	-	IEA	-
GO:0050220	prostaglandin-E synthase activity	-	IBA	21873635
GO:0050220	prostaglandin-E synthase activity	NOT	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001516	prostaglandin biosynthetic process	-	IBA	21873635
GO:0001516	prostaglandin biosynthetic process	NOT	IBA	21873635
GO:0006749	glutathione metabolic process	-	IBA	21873635
GO:0006805	xenobiotic metabolic process	-	TAS	-
GO:0010243	response to organonitrogen compound	-	IEA	-
GO:0032496	response to lipopolysaccharide	-	IEA	-
GO:0033327	Leydig cell differentiation	-	IEA	-
GO:0042493	response to drug	-	IEA	-
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0055114	oxidation-reduction process	-	IBA	21873635
GO:0055114	oxidation-reduction process	-	IDA	20727966
GO:0070207	protein homotrimerization	-	ISS	-
GO:0071449	cellular response to lipid hydroperoxide	-	IDA	20727966
GO:0098869	cellular oxidant detoxification	-	IEA	-
GO:1901687	glutathione derivative biosynthetic process	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IEA	-
GO:0005739	mitochondrion	-	IBA	21873635
GO:0005739	mitochondrion	-	IDA	20727966
GO:0005741	mitochondrial outer membrane	-	IEA	-
GO:0005778	peroxisomal membrane	-	ISS	-
GO:0005783	endoplasmic reticulum	-	ISS	-
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0016021	integral component of membrane	-	ISS	-
GO:0035577	azurophil granule membrane	-	TAS	-
GO:0045177	apical part of cell	-	IEA	-

KEGG ID	KEGG Term
hsa00480	Glutathione metabolism
hsa00980	Metabolism of xenobiotics by cytochrome P450
hsa00982	Drug metabolism - cytochrome P450

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-156580	Phase II - Conjugation of compounds	TAS
R-HSA-156590	Glutathione conjugation	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-211859	Biological oxidations	TAS
R-HSA-5423646	Aflatoxin activation and detoxification	TAS
R-HSA-6798695	Neutrophil degranulation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27486097	Germline variation in inflammation-related pathways and risk of Barrett's oesophagus and oesophageal adenocarcinoma. (2017 Oct)	Buas MF	Gut