Gene: MGST3

4259
GST-III
microsomal glutathione S-transferase 3
protein-coding
1q24.1
Ensembl:ENSG00000143198 MIM:604564 Vega:OTTHUMG00000034627 UniprotKB:O14880
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.780e-1 (AD)  4.382e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COX7B0.952
NDUFA40.951
UQCRH0.949
EMC40.947
HINT10.945
MORF4L10.941
NDUFV20.941
NDUFB60.941
COX7A20.938
COX6C0.938

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.787
OR4F29-0.75
MTRNR2L6-0.317
MTRNR2L9-0.295
MTRNR2L10-0.286
MAGEA12-0.276
MMP9-0.274
KCNJ15-0.264
EBF1-0.261
ZBTB20-0.259

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00143GlutathioneSmall Molecule70-18-8Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MGST3 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MGST3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MGST3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of MGST3 mRNA"16984957
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MGST3 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MGST3 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MGST3 mRNA"25510870
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of MGST3 mRNA"20206263
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of MGST3 mRNA"18723825
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of MGST3 mRNA"16984957
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of MGST3 mRNA"19692669|2095900
D000082AcetaminophenAcetaminophen affects the expression of MGST3 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of MGST3 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MGST3 mRNA]17585979
D020106AcrylamideAcrylamide results in decreased expression of MGST3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MGST3 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MGST3 mRNA19770486
D000638AmiodaroneAmiodarone results in increased expression of MGST3 mRNA24535564
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MGST3 mRNA24449571
C000228aristolochic acid Iaristolochic acid I results in increased expression of MGST3 protein21658425
C000228aristolochic acid IU 0126 inhibits the reaction [aristolochic acid I results in increased expression of MGST3 protein]21658425
C039726artesunateMGST3 mRNA affects the susceptibility to artesunate15796179
D001280AtrazineAtrazine results in decreased expression of MGST3 mRNA18522720
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of MGST3 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MGST3 mRNA19770486
D004958EstradiolEstradiol results in decreased expression of MGST3 mRNA23019147
D004958EstradiolEstradiol results in increased expression of MGST3 mRNA15289156
C099952bifenthrinbifenthrin results in increased expression of MGST3 mRNA26071804
C006780bisphenol Abisphenol A results in increased expression of MGST3 mRNA28159858
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of MGST3 gene28505145
C006780bisphenol Abisphenol A results in increased expression of MGST3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MGST3 gene28505145
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of MGST3 mRNA18723825
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of MGST3 mRNA15336504
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of MGST3 mRNA14729362|1533650
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of MGST3 mRNA18804290
D002104CadmiumCadmium results in increased expression of MGST3 mRNA24915613
D019256Cadmium ChlorideCadmium Chloride affects the expression of MGST3 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MGST3 mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MGST3 mRNA17484886
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of MGST3 mRNA18804290
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of MGST3 mRNA18178546
C100187chloropicrinchloropicrin affects the expression of MGST3 mRNA26352163
D004390ChlorpyrifosChlorpyrifos results in decreased expression of MGST3 mRNA19440498
D019826Cholic AcidCholic Acid results in increased expression of MGST3 mRNA17521389
D002922CiguatoxinsCiguatoxins affects the expression of MGST3 mRNA18353800
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of MGST3 mRNA17585979
D002994Clofibrate[Clofibrate results in increased activity of PPARA protein] which results in increased expression of MGST3 mRNA22496397
D002994ClofibrateClofibrate results in increased expression of MGST3 mRNA18723825|2249639
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MGST3 mRNA]17585979
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of MGST3 mRNA15467011
D003300CopperCopper affects the expression of MGST3 mRNA23825565
C030123coumarincoumarin results in decreased expression of MGST3 mRNA18480146
D003407CreosoteCreosote results in increased expression of MGST3 mRNA19389177
D003471CuprizoneCuprizone results in decreased expression of MGST3 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of MGST3 mRNA25562108
D003907DexamethasoneDexamethasone results in increased expression of MGST3 mRNA25047013
D003907DexamethasoneDexamethasone results in decreased expression of MGST3 mRNA18723825
D003907DexamethasoneDexamethasone results in increased expression of MGST3 mRNA22733784
D003976DiazinonDiazinon results in decreased expression of MGST3 mRNA19440498
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MGST3 mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of MGST3 mRNA28962523
C000944dicrotophosdicrotophos results in decreased expression of MGST3 mRNA28302478
D004041Dietary FatsDietary Fats affects the expression of MGST3 mRNA19680557
D004042Dietary Fats, Unsaturated"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in increased expression of MGST3 mRNA"23626681
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of MGST3 mRNA15289156
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of MGST3 mRNA21658437
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of MGST3 mRNA28939011
D004237DiuronDiuron results in increased expression of MGST3 mRNA21551480
D000431EthanolEthanol results in increased expression of MGST3 mRNA19167417
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MGST3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MGST3 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MGST3 mRNA17557909
D005015EthoxyquinEthoxyquin results in increased expression of MGST3 mRNA18723825
D011345FenofibrateFenofibrate results in increased expression of MGST3 mRNA11798191
C007738fluoranthenefluoranthene results in decreased expression of MGST3 mRNA18522720
D005485FlutamideFlutamide results in decreased expression of MGST3 mRNA24793618
D019833GenisteinGenistein results in increased expression of MGST3 mRNA15289156
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of MGST3 gene28505145
D005897GlafenineGlafenine results in decreased expression of MGST3 mRNA24136188
D012739Gonadal Steroid HormonesGonadal Steroid Hormones results in decreased expression of MGST3 mRNA21453500
D017313FenretinideFenretinide results in decreased expression of MGST3 mRNA16467112|2897369
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of MGST3 mRNA18951874
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of MGST3 mRNA14729362
D007529IsoflavonesIsoflavones affects the expression of MGST3 mRNA16365062
C544151jinfukangjinfukang results in increased expression of MGST3 mRNA27392435
C045463leflunomideleflunomide results in decreased expression of MGST3 mRNA28988120
C045463leflunomideleflunomide results in decreased expression of MGST3 mRNA24136188
C482199lipopolysaccharide, E coli O55-B5"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of MGST3 mRNA"20371263
D008701MethapyrileneMethapyrilene results in decreased expression of MGST3 mRNA16393664
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MGST3 mRNA23103053
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of MGST3 mRNA19840844
C058346N-(4-methoxyphenyl)retinamideN-(4-methoxyphenyl)retinamide results in decreased expression of MGST3 mRNA16467112
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MGST3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MGST3 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MGST3 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of MGST3 mRNA19812364
C051752nefazodonenefazodone results in decreased expression of MGST3 mRNA24136188
D009532NickelNickel results in increased expression of MGST3 mRNA24915613
D009532NickelNickel affects the expression of MGST3 mRNA19440498
C012655nimesulidenimesulide results in decreased expression of MGST3 mRNA24136188
D009585Nitrogen DioxideNitrogen Dioxide results in increased expression of MGST3 mRNA27206323
D019319Okadaic AcidOkadaic Acid results in increased expression of MGST3 mRNA28939011
D019319Okadaic Acid[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of MGST3 mRNA19840844
C026209oltipraz[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of MGST3 mRNA22496397
C026209oltiprazoltipraz results in increased expression of MGST3 mRNA18723825|2249639
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MGST3 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of MGST3 mRNA25729387
D000073878Palm OilPalm Oil affects the expression of MGST3 mRNA19680557
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MGST3 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of MGST3 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of MGST3 mRNA26300304
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of MGST3 mRNA20936131
C023036perfluorooctanoic acid"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in increased expression of MGST3 mRNA"23626681
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MGST3 mRNA20118188|2362668
C023036perfluorooctanoic acidPPARA promotes the reaction [perfluorooctanoic acid results in decreased expression of MGST3 mRNA]20118188
D010578PetroleumPetroleum affects the expression of MGST3 mRNA25208076
D010634PhenobarbitalPhenobarbital results in decreased expression of MGST3 mRNA19952500
D010634PhenobarbitalPhenobarbital affects the expression of MGST3 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of MGST3 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MGST3 mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of MGST3 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of MGST3 mRNA11798191|1622196
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of MGST3 mRNA18723825
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of MGST3 mRNA19162173
C045362prochlorazprochloraz results in increased expression of MGST3 mRNA21470553
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of MGST3 mRNA27029645
C052785rebamipiderebamipide results in increased expression of MGST3 mRNA18299717
C059514resveratrolresveratrol results in increased expression of MGST3 mRNA19228061
C089730rosiglitazonerosiglitazone affects the expression of MGST3 mRNA17245590
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of MGST3 mRNA21427059
D012906SmokeSmoke results in increased expression of MGST3 mRNA21095227
C017947sodium arsenitesodium arsenite results in increased expression of MGST3 mRNA28229933
C016104sodium bichromatesodium bichromate results in decreased expression of MGST3 mRNA24612858
C016104sodium bichromatesodium bichromate results in decreased expression of MGST3 mRNA25993096
D013467Sulindac"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of MGST3 mRNA"20371263
C013698tallowtallow affects the expression of MGST3 mRNA19680557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MGST3 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with AHR protein mutant form] results in increased expression of MGST3 mRNA22496397
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MGST3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MGST3 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MGST3 mRNA18465118|1879615
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MGST3 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MGST3 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of MGST3 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased expression of MGST3 mRNA25549359
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of MGST3 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MGST3 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of MGST3 mRNA25572481
C057693troglitazonetroglitazone results in increased expression of MGST3 mRNA28973697
D014415TunicamycinTunicamycin results in decreased expression of MGST3 mRNA17127020
C113580U 0126U 0126 inhibits the reaction [aristolochic acid I results in increased expression of MGST3 protein]21658425
C406224valdecoxibvaldecoxib results in decreased expression of MGST3 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of MGST3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of MGST3 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of MGST3 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of MGST3 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of MGST3 mRNA21427059|2453556
D002762CholecalciferolCholecalciferol results in decreased expression of MGST3 mRNA16508948
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of MGST3 mRNA"25208076
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of MGST3 mRNA"23246600

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004364glutathione transferase activity-IBA21873635  
GO:0004364glutathione transferase activityNOTIDA9278457  
GO:0004364glutathione transferase activity-TAS-  
GO:0004464leukotriene-C4 synthase activity-IDA9278457  
GO:0004602glutathione peroxidase activity-IBA21873635  
GO:0004602glutathione peroxidase activity-IDA9278457  
GO:0005515protein binding-IPI25416956  29568061  
GO ID GO Term Qualifier Evidence PubMed
GO:0006629lipid metabolic process-IDA9278457  
GO:0006805xenobiotic metabolic process-TAS-  
GO:0010243response to organonitrogen compound-IEA-  
GO:0019370leukotriene biosynthetic process-IDA9278457  
GO:0098869cellular oxidant detoxification-IEA-  
GO:1901687glutathione derivative biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005635nuclear envelope-IBA21873635  
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016020membrane-IDA9278457  
GO:0016021integral component of membrane-IEA-  
GO:0031090organelle membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA9278457  
KEGG ID KEGG Term
hsa00480Glutathione metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156590Glutathione conjugationTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-5423646Aflatoxin activation and detoxificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23688726Genetic variation in antioxidant enzymes, cigarette smoking, and longitudinal change in lung function. (2013 Oct)Tang WFree Radic Biol Med