Gene: ASAH1

427
AC|ACDase|ASAH|PHP|PHP32|SMAPME
N-acylsphingosine amidohydrolase 1
protein-coding
8p22
Ensembl:ENSG00000104763 MIM:613468 Vega:OTTHUMG00000096997 UniprotKB:Q13510
NG_008985.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.686e-1 (AD)  2.335e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NCOA40.931
GLO10.93
ITM2B0.93
TM9SF30.924
FBXL50.922
HNRNPK0.922
LMBRD10.921
RAB5A0.919
SDCBP0.917
ANXA70.917

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.818
OR4F29-0.793
MTRNR2L6-0.17
HMHB1-0.152
NANOS2-0.147
TCL1A-0.143
MTRNR2L10-0.141
MMP23B-0.14
MTRNR2L9-0.134
RNF223-0.133

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of ASAH1 mRNA"19162173
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ASAH1 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ASAH1 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ASAH1 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASAH1 mRNA"27188386
C0293704-toluidine4-toluidine results in increased expression of ASAH1 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASAH1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ASAH1 mRNA22230336
D000638AmiodaroneAmiodarone results in increased expression of ASAH1 mRNA15342952|1756758
D000638AmiodaroneAmiodarone results in increased expression of ASAH1 mRNA19224547
D000639AmitriptylineAmitriptyline results in increased expression of ASAH1 mRNA15342952|1717555
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ASAH1 mRNA16483693
C004984apocarotenalapocarotenal results in increased expression of ASAH1 mRNA17034753
C006632arsenic trioxidearsenic trioxide results in increased expression of ASAH1 mRNA20458559|2782922
D001280AtrazineAtrazine results in increased expression of ASAH1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of ASAH1 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of ASAH1 mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ASAH1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ASAH1 mRNA"20382639
D019207beta Carotenebeta Carotene results in increased expression of ASAH1 mRNA17034753
C006780bisphenol Abisphenol A results in decreased expression of ASAH1 mRNA19371625
C006780bisphenol Abisphenol A results in decreased methylation of ASAH1 gene28582417
C006780bisphenol Abisphenol A results in increased expression of ASAH1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of ASAH1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ASAH1 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of ASAH1 promoter22457795
D002220CarbamazepineCarbamazepine affects the expression of ASAH1 mRNA25979313
D002518CeramidesASAH1 gene mutant form results in increased abundance of Ceramides10399097
C084597chlorcyclizinechlorcyclizine results in increased expression of ASAH1 mRNA15342952
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ASAH1 mRNA23650126
D002746ChlorpromazineChlorpromazine results in increased expression of ASAH1 mRNA17175557
D017291ClarithromycinClarithromycin results in increased expression of ASAH1 mRNA15342952
D002994ClofibrateClofibrate results in increased expression of ASAH1 mRNA25270620
D003024ClozapineClozapine results in increased expression of ASAH1 mRNA15342952|1717555
C018021cobaltous chloridecobaltous chloride results in decreased expression of ASAH1 protein24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of ASAH1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of ASAH1 mRNA25562108
C093628cyproconazolecyproconazole results in increased expression of ASAH1 mRNA22334560
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ASAH1 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of ASAH1 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ASAH1 mRNA26924002
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ASAH1 mRNA19638242
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ASAH1 mRNA"22485181
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene affects the expression of ASAH1 mRNA"21785161
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of ASAH1 mRNA25380136
D004147DioxinsDioxins affects the expression of ASAH1 mRNA20463971
D004206DisopyramideDisopyramide results in increased expression of ASAH1 mRNA15342952
C109476epoxiconazoleepoxiconazole results in increased expression of ASAH1 mRNA22334560
D004917ErythromycinErythromycin results in increased expression of ASAH1 mRNA17175557
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of ASAH1 mRNA17347304
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ASAH1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ASAH1 mRNA16174780
D005047EtoposideASAH1 protein affects the susceptibility to Etoposide16217747
D015025ZearalenoneZearalenone results in decreased expression of ASAH1 mRNA19371625
C540355fenamidonefenamidone results in increased expression of ASAH1 mRNA27029645
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of ASAH1 mRNA17347304
D005419FlavonoidsFlavonoids results in decreased expression of ASAH1 mRNA18035473
D005424FlecainideFlecainide results in increased expression of ASAH1 mRNA15342952|1717555
D005472FluorouracilASAH1 protein affects the susceptibility to Fluorouracil16217747
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of ASAH1 mRNA]15016801
D005473FluoxetineFluoxetine results in increased expression of ASAH1 mRNA15342952|1756758
D017965gamma-Linolenic Acidgamma-Linolenic Acid results in increased expression of ASAH1 mRNA20664735
C546771gardiquimodgardiquimod results in decreased expression of ASAH1 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of ASAH1 mRNA]28003376
D019833GenisteinGenistein results in decreased expression of ASAH1 mRNA19371625
D007099ImipramineImipramine results in increased expression of ASAH1 mRNA15342952|1756758
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ASAH1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ASAH1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of ASAH1 mRNA27392435
C410337K 7174K 7174 results in increased expression of ASAH1 mRNA24086573
D007854LeadLead affects the expression of ASAH1 mRNA28903495
C008261lead acetatelead acetate results in increased expression of ASAH1 mRNA21829687
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ASAH1 mRNA25613284
D008701MethapyrileneMethapyrilene results in increased expression of ASAH1 mRNA28935588
D008701MethapyrileneMethapyrilene results in increased expression of ASAH1 mRNA28935588
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ASAH1 mRNA23649840
D016685MitomycinASAH1 protein affects the susceptibility to Mitomycin16217747
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of ASAH1 mRNA22956148
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ASAH1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ASAH1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ASAH1 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of ASAH1 mRNA25380136
C029938nickel sulfatenickel sulfate results in decreased expression of ASAH1 mRNA16780908
D015242OfloxacinOfloxacin results in increased expression of ASAH1 mRNA17175557
D010480PerhexilinePerhexiline results in increased expression of ASAH1 mRNA15342952|1717555
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASAH1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ASAH1 mRNA26272509
D011374ProgesteroneProgesterone results in increased expression of ASAH1 mRNA23012394|2301818
C045950propiconazolepropiconazole results in increased expression of ASAH1 mRNA22334560
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of ASAH1 mRNA]28003376
D011794QuercetinQuercetin results in increased expression of ASAH1 mRNA21632981
C059514resveratrolresveratrol results in decreased expression of ASAH1 mRNA19371625
D012402RotenoneRotenone results in increased expression of ASAH1 mRNA23186747
D020280SertralineSertraline results in increased expression of ASAH1 mRNA15342952
C017947sodium arsenitesodium arsenite affects the expression of ASAH1 mRNA20816728
D012969Sodium FluorideSodium Fluoride results in decreased expression of ASAH1 protein28918527
D013015SotalolSotalol results in increased expression of ASAH1 mRNA17175557
D010042OuabainOuabain affects the expression of ASAH1 protein17268060
C025462sulindac sulfidesulindac sulfide results in decreased expression of ASAH1 mRNA16184548
D013629TamoxifenTamoxifen results in increased expression of ASAH1 mRNA15342952|1717555
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ASAH1 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ASAH1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ASAH1 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ASAH1 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of ASAH1 mRNA23411599
D013881ThioridazineThioridazine results in increased expression of ASAH1 mRNA17175557
C009495titanium dioxidetitanium dioxide results in increased expression of ASAH1 mRNA23409001
D001371trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride"trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in increased expression of ASAH1 mRNA"15342952|1717555
D014212TretinoinTretinoin results in increased expression of ASAH1 mRNA21934132
D014635Valproic AcidValproic Acid affects the expression of ASAH1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of ASAH1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ASAH1 mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ASAH1 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of ASAH1 mRNA26682919
D015031ZimeldineZimeldine results in increased expression of ASAH1 mRNA15342952|1717555

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003824catalytic activity-TAS8955159  
GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds-IBA21873635  
GO:0017040N-acylsphingosine amidohydrolase activity-IBA21873635  
GO:0017040N-acylsphingosine amidohydrolase activity-TAS-  
GO:0102121ceramidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006672ceramide metabolic process-TAS8955159  
GO:0006687glycosphingolipid metabolic process-TAS-  
GO:0043312neutrophil degranulation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA25645918  
GO:0043202lysosomal lumen-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:1904724tertiary granule lumen-TAS-  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
hsa00600Sphingolipid metabolism
hsa01100Metabolic pathways
hsa04142Lysosome
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1660662Glycosphingolipid metabolismTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-428157Sphingolipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23590301Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease. (2013 Aug)Bahr TMAm J Respir Cell Mol Biol