Gene: MICB

4277
PERB11.2
MHC class I polypeptide-related sequence B
protein-coding
6p21.33
Ensembl:ENSG00000204516 MIM:602436 Vega:OTTHUMG00000031074 UniprotKB:Q29980
NG_021405.1
PubMed
0   ANCO-SNPs
ND
1   
1.116e-1 (AD)  1.716e-1 (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLIC20.795
EVC20.742
BACE20.74
SERPINH10.73
MLKL0.725
CASP10.701
MTHFD20.698
IL3RA0.693
TICAM20.693
CLEC2B0.691

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZSCAN1-0.492
SLC7A4-0.428
SLC25A10-0.428
NUDT18-0.427
DYRK1B-0.409
BFSP1-0.401
TPBGL-0.399
PCYOX1L-0.397
CHRNB2-0.387
MARCH4-0.383

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICB mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of MICB mRNA22230336
D020106AcrylamideAcrylamide results in decreased expression of MICB mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MICB protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MICB mRNA22100608
D000447AldehydesAldehydes results in increased expression of MICB mRNA25014914
D001151ArsenicArsenic affects the methylation of MICB gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of MICB mRNA18463537|2670570
C006632arsenic trioxidearsenic trioxide results in increased expression of MICB protein18463537
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MICB mRNA20106945|2163298
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in increased expression of MICB mRNA]24758408
D004958EstradiolEstradiol results in increased expression of MICB mRNA24758408
C006780bisphenol Abisphenol A results in increased expression of MICB mRNA28079927
C006780bisphenol Abisphenol A affects the expression of MICB mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MICB gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of MICB mRNA22079614
C018475butyraldehydebutyraldehyde results in increased expression of MICB mRNA26079696
C584509C646 compoundC646 compound results in increased expression of MICB mRNA26191083
D002110CaffeineCaffeine inhibits the reaction [[decitabine results in decreased methylation of MICB promoter] which results in increased expression of MICB protein]18395517|1839551
D002220CarbamazepineCarbamazepine affects the expression of MICB mRNA25979313
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of MICB mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of MICB mRNA21632981|2556210
C089595cylindrospermopsincylindrospermopsin results in decreased expression of MICB mRNA24921660
C014347decitabineCaffeine inhibits the reaction [[decitabine results in decreased methylation of MICB promoter] which results in increased expression of MICB protein]18395517|1839551
C014347decitabine[decitabine results in decreased methylation of MICB promoter] which results in increased expression of MICB mRNA18395517|1839551
D002945CisplatinCisplatin results in increased expression of MICB mRNA27594783
C118739entinostatentinostat results in increased expression of MICB mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICB mRNA"27188386
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in increased expression of MICB protein21951556
D005472FluorouracilMICB protein affects the susceptibility to Fluorouracil16217747
D005557FormaldehydeFormaldehyde results in increased expression of MICB mRNA23649840
C419708gefitinibgefitinib results in increased expression of MICB protein21951556
C004312glycidolglycidol results in increased expression of MICB mRNA24915197
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MICB mRNA23086925
D008727MethotrexateMethotrexate results in increased expression of MICB mRNA21678067
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MICB mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICB mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MICB mRNA23649840
D009532NickelNickel results in increased expression of MICB mRNA24768652|2558310
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of MICB mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of MICB mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of MICB mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of MICB mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of MICB mRNA]17655762
D017239PaclitaxelMICB protein results in increased susceptibility to Paclitaxel16734730
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICB mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of MICB mRNA26272509
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of MICB mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of MICB mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of MICB mRNA]17655762
C046012pentanalpentanal results in increased expression of MICB mRNA26079696
C005556propionaldehydepropionaldehyde results in increased expression of MICB mRNA26079696
D011794QuercetinQuercetin results in increased expression of MICB mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of MICB mRNA19167446
C059514resveratrolresveratrol results in increased expression of MICB mRNA22406996
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of MICB mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of MICB mRNA25351596
C017947sodium arsenitesodium arsenite affects the methylation of MICB gene28589171
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MICB mRNA28065790
C032910triadimefontriadimefon results in decreased expression of MICB mRNA26705709
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICB mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of MICB mRNA24935251|2627250
D014520UrethaneUrethane results in increased expression of MICB mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MICB mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MICB mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MICB mRNA19101580|2317975
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of MICB mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of MICB mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of MICB mRNA]17655762
C111237vorinostatvorinostat results in increased expression of MICB mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0046703natural killer cell lectin-like receptor binding-IBA21873635  
GO:0046703natural killer cell lectin-like receptor binding-IDA11491531  
GO ID GO Term Qualifier Evidence PubMed
GO:0001913T cell mediated cytotoxicity-IBA21873635  
GO:0002429immune response-activating cell surface receptor signaling pathway-IDA11491531  
GO:0006955immune response-IBA21873635  
GO:0006979response to oxidative stress-IDA11287116  
GO:0009408response to heat-IDA9497295  
GO:0016032viral process-IEA-  
GO:0019835cytolysis-IEA-  
GO:0030101natural killer cell activation-IBA21873635  
GO:0032526response to retinoic acid-IDA12569559  
GO:0042267natural killer cell mediated cytotoxicity-IBA21873635  
GO:0042271susceptibility to natural killer cell mediated cytotoxicity-IBA21873635  
GO:0046629gamma-delta T cell activation-IDA9497295  
GO:0050689negative regulation of defense response to virus by host-IDA11239445  12782710  
GO:0050776regulation of immune response-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-ISS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04650Natural killer cell mediated cytotoxicity
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20863413Cytotoxic T cells expressing the co-stimulatory receptor NKG2 D are increased in cigarette smoking and COPD. (2010 Sep 24)Roos-Engstrand ERespir Res