Gene: MID1

4281
BBBG1|FXY|GBBB1|MIDIN|OGS1|OS|OSX|RNF59|TRIM18|XPRF|ZNFXY
midline 1
protein-coding
Xp22.2
Ensembl:ENSG00000101871 MIM:300552 Vega:OTTHUMG00000021127 UniprotKB:O15344
NG_008197.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MERTK0.882
GRAMD1C0.879
CYBRD10.876
PARD30.874
CDC14A0.874
STK17B0.871
S1PR10.869
EGFR0.868
ARHGAP310.867
NOTCH20.863

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RTP1-0.51
MCHR1-0.489
DUSP27-0.48
AGMAT-0.48
CRHBP-0.478
RAB33A-0.455
TMEFF2-0.455
CACNA1F-0.447
SMIM18-0.446
MYOZ3-0.446

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of MID1 mRNA"25614096
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MID1 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of MID1 mRNA"20406850
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of MID1 mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MID1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MID1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MID1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MID1 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of MID1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MID1 mRNA21641981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MID1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MID1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MID1 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of MID1 mRNA26518232
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of MID1 mRNA25690898
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MID1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MID1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of MID1 mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MID1 mRNA"19150397
D004958EstradiolEstradiol affects the expression of MID1 mRNA22574217
D004958EstradiolEstradiol results in increased expression of MID1 mRNA21185374
D004958EstradiolRaloxifene Hydrochloride promotes the reaction [Estradiol results in increased expression of MID1 mRNA]21185374
C006780bisphenol Abisphenol A results in decreased methylation of MID1 promoter27312807
D002220CarbamazepineCarbamazepine affects the expression of MID1 mRNA25979313
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of MID1 mRNA19395590
C018021cobaltous chloridecobaltous chloride results in decreased expression of MID1 mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of MID1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of MID1 mRNA20106945|2798913
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of MID1 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of MID1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of MID1 mRNA22023808
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of MID1 mRNA22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MID1 mRNA22079256
D000431EthanolEthanol results in decreased expression of MID1 mRNA29018328
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MID1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MID1 mRNA17942748
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of MID1 mRNA20044591
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of MID1 mRNA27392435
C008261lead acetatelead acetate results in increased expression of MID1 mRNA20542052
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of MID1 mRNA26378955
D008345ManganeseManganese results in decreased expression of MID1 mRNA23976782
D008345ManganeseManganese results in increased methylation of MID1 promoter23976782
D008713MethimazoleMethimazole results in decreased expression of MID1 mRNA25539664
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of MID1 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MID1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MID1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MID1 mRNA"25620056
D009532NickelNickel results in decreased expression of MID1 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in decreased expression of MID1 mRNA22714537
D009966OrphenadrineOrphenadrine affects the expression of MID1 mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of MID1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of MID1 mRNA25729387
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MID1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of MID1 mRNA26272509
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MID1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MID1 mRNA22079256|2271453
D011374ProgesteroneProgesterone results in decreased expression of MID1 mRNA21795739
D011441PropylthiouracilPropylthiouracil results in increased expression of MID1 mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride promotes the reaction [Estradiol results in increased expression of MID1 mRNA]21185374
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of MID1 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in decreased expression of MID1 mRNA25351596
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of MID1 mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MID1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MID1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MID1 mRNA16922920
D013849ThimerosalThimerosal results in decreased expression of MID1 mRNA24675092
C009495titanium dioxidetitanium dioxide results in decreased expression of MID1 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MID1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of MID1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of MID1 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of MID1 mRNA"19682533
C012589trichostatin Atrichostatin A results in increased expression of MID1 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MID1 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MID1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MID1 mRNA23179753|2597931
D014635Valproic AcidValproic Acid results in decreased expression of MID1 mRNA24383497|2493525
D014635Valproic AcidValproic Acid results in increased expression of MID1 mRNA24935251|2915479
D014638VanadatesVanadates results in increased expression of MID1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of MID1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of MID1 mRNA22615374
D015032ZincZinc binds to MID1 protein16529770
C088658zoledronic acidzoledronic acid results in increased expression of MID1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19549727  21516116  25416956  25910212  26496610  
GO:0008017microtubule binding-IMP11806752  
GO:0008270zinc ion binding-IEA-  
GO:0016740transferase activity-IEA-  
GO:0031625ubiquitin protein ligase binding-IPI17438131  
GO:0042802identical protein binding-IPI22493164  22829933  25416956  
GO:0042803protein homodimerization activity-IDA11806752  
GO:0046982protein heterodimerization activity-IDA11806752  
GO:0051219phosphoprotein binding-IPI11806752  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-TAS10077590  
GO:0007026negative regulation of microtubule depolymerization-IEA-  
GO:0007389pattern specification process-TAS9354791  
GO:0032874positive regulation of stress-activated MAPK cascade-IMP17438131  
GO:0035372protein localization to microtubule-IMP11806752  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005819spindle-IEA-  
GO:0005829cytosol-TAS-  
GO:0005874microtubule-IDA11806752  
GO:0005875microtubule associated complex-TAS10077590  
GO:0005881cytoplasmic microtubulecolocalizes_withIDA18949047  
KEGG ID KEGG Term
hsa04120Ubiquitin mediated proteolysis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29450633MID1-PP2A complex functions as new insights in human lung adenocarcinoma. (2018 May)Zhang LJ Cancer Res Clin Oncol